rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(5), NRG2(2), NRG3(4), PRKCA(2)	933406	14	9	14	1	4	5	1	1	3	0	0.000893	0.241
2	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	921900	11	10	11	2	3	5	1	0	2	0	0.00117	0.241
3	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	921900	11	10	11	2	3	5	1	0	2	0	0.00117	0.241
4	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(1), NT5C2(1), NT5E(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PRIM2(3), RFC5(1), RRM1(1), TK2(1), TXNRD1(1), TXNRD2(1), TYMS(1), UMPS(1), UPB1(2), UPP2(1), UPRT(1)	8537733	67	28	65	15	18	26	10	0	13	0	0.00266	0.350
5	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NFKB1(3), PIK3R1(5), RB1(3)	1817823	21	10	21	3	7	4	4	1	3	2	0.00284	0.350
6	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), FHL5(3), FSHB(1), FSHR(1), XPO1(1)	969112	10	9	10	4	4	1	3	1	1	0	0.00414	0.425
7	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(4), ARHGEF1(1), F2(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3R1(5), PPP1R12B(4), PRKCA(2), ROCK1(7)	2455051	29	13	29	7	8	7	5	0	7	2	0.00515	0.453
8	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNGT1(1), PRKACA(1), PRKAR1A(4)	661717	10	8	10	1	3	4	1	0	2	0	0.00626	0.482
9	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	74796	4	3	4	0	3	1	0	0	0	0	0.00839	0.535
10	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(2), HDC(5), TPH1(2)	608603	10	7	10	2	3	5	1	0	1	0	0.00868	0.535
11	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	4975748	42	18	42	9	9	19	6	1	7	0	0.0113	0.623
12	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD80(1), CTLA4(1), GRB2(1), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(3), LCK(1), PIK3R1(5), PTPN11(3)	1073018	19	7	19	3	8	7	0	0	2	2	0.0121	0.623
13	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(4), GNAI1(1), GNGT1(1), ITGAV(4), ITGB3(2), MAPK3(1), PDGFRA(4), PIK3R1(5), PRKCA(2), SPHK1(1)	2602541	25	12	25	8	7	8	3	0	5	2	0.0164	0.680
14	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), ACVR1B(2), ACVRL1(1), BMPR2(3), BUB1(2), CDKL1(2), CDS1(1), CLK1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), INPP4A(1), INPP4B(2), INPPL1(1), MAP3K10(1), MOS(1), NEK1(2), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKG1(5), RAF1(2), RPS6KA2(2), RPS6KA3(2), TGFBR1(3), VRK1(1)	11658792	92	30	92	28	30	32	17	1	12	0	0.0173	0.680
15	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CDC42(1), CREB3(1), CREB5(2), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK13(1), MKNK2(1), NFKB1(3)	3476951	27	14	27	5	10	8	3	2	4	0	0.0206	0.680
16	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(1), AKT3(1), CD40(1), CD80(1), CHUK(2), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA10(2), IFNA2(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(1), IL8(1), IRAK4(2), IRF3(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MYD88(1), NFKB1(3), NFKB2(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), TBK1(1), TICAM1(1), TLR1(3), TLR2(4), TLR3(1), TLR4(3), TLR5(1), TLR7(3), TLR8(3), TLR9(3), TRAF3(2)	9028226	92	23	92	17	26	33	16	2	12	3	0.0265	0.680
17	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL2(2), AKT2(1), AKT3(1), BRAF(2), CAMK2D(1), CBL(3), CBLB(2), CDKN1B(2), EGFR(1), ERBB3(3), ERBB4(5), GRB2(1), GSK3B(1), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), NCK1(1), NRG1(6), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), RAF1(2), RPS6KB2(1), SHC2(1), SOS1(2), SOS2(2), STAT5B(1)	10119891	90	27	90	18	26	26	16	2	18	2	0.0267	0.680
18	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CHUK(2), CRADD(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK8(5), NFKB1(3), TANK(3)	2520680	28	11	28	7	9	10	6	2	1	0	0.0290	0.680
19	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(3), HLA-A(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3R1(5), SYK(3), VAV1(2)	1715869	20	8	20	1	4	5	4	0	4	3	0.0290	0.680
20	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(3), RELN(9), VLDLR(2)	1442622	18	8	18	5	4	8	3	1	2	0	0.0308	0.680
21	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	ATF1(1), BRAF(2), CREB3(1), CREB5(2), CREBBP(4), DAG1(1), EGR1(1), EGR2(2), FRS2(2), GNAQ(1), MAP1B(12), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), OPN1LW(1), PIK3C2G(2), PIK3CD(1), PIK3R1(5), PTPN11(3), RPS6KA3(2), TERF2IP(1)	5105821	59	17	59	15	18	21	6	2	10	2	0.0312	0.680
22	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA6(1), CYP11A1(2), EDNRB(5), PLA2G4A(3), PRL(1), PTGDR(1), PTGFR(1), PTGIS(1), PTGS1(2), PTGS2(1)	2134737	19	11	19	5	8	6	3	0	2	0	0.0314	0.680
23	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(4), CAMK2D(1), GRB2(1), MAPK3(1), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RPS6KA5(3), SOS1(2)	2771817	25	12	25	3	10	7	3	0	3	2	0.0316	0.680
24	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(1), JAK2(3), JAK3(2), PTPRU(6), REG1A(2)	1607046	16	10	16	4	10	3	0	0	2	1	0.0316	0.680
25	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(3), JAK3(2), PIAS1(1), PTPRU(6), REG1A(2)	1456819	15	9	15	2	8	3	1	0	2	1	0.0317	0.680
26	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	GORASP1(1), MAP2K4(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), NFKB1(3), NFKB2(2), PIK3CD(1), PIK3R1(5), TRAF3(2), TRAF5(2)	3146679	32	13	32	8	10	6	3	1	10	2	0.0322	0.680
27	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AXIN1(1), CTNNB1(4), FZD1(1), GJA1(4), GNAI1(1), GSK3B(1), MYD88(1), NFKB1(3), PIK3R1(5), TLR4(3)	2281610	24	11	24	3	10	8	3	0	1	2	0.0324	0.680
28	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(2), LTB4R(1), P2RY1(3), P2RY2(1), P2RY6(1)	576046	11	6	11	0	5	5	1	0	0	0	0.0330	0.680
29	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD80(1), CDH1(1), CDH15(1), CDH2(6), CDH3(2), CDH4(4), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CNTN1(5), CNTN2(2), CNTNAP1(1), CNTNAP2(4), CTLA4(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGB2(1), ITGB8(1), L1CAM(2), MAG(2), NCAM1(4), NCAM2(7), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(1), NRXN3(2), PECAM1(1), PTPRC(8), PTPRF(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(1), SDC2(1), SDC3(1), SELE(2), SELL(3), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(13)	15162025	163	35	163	47	48	70	23	3	19	0	0.0342	0.680
30	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	AXIN1(1), AXIN2(2), BTRC(3), CACYBP(1), CAMK2D(1), CHD8(2), CREBBP(4), CTNNB1(4), CUL1(1), DAAM1(1), DAAM2(4), DKK1(2), DKK2(1), DKK4(3), DVL2(1), DVL3(2), EP300(2), FBXW11(1), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GSK3B(1), LRP6(7), MAP3K7(2), MAPK10(4), MAPK8(5), MAPK9(2), MMP7(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PLCB3(1), PLCB4(1), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(1), SMAD3(3), TBL1X(1), TBL1Y(1), TCF7(3), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	15609428	132	37	130	33	44	48	19	1	20	0	0.0349	0.680
31	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	FOS(1), GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SOS1(2)	2310097	29	10	29	4	9	8	5	1	4	2	0.0384	0.680
32	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNAQ(1), GNGT1(1), MYLK(3), PPP1R12B(4), PRKCA(2), ROCK1(7)	2157851	22	10	22	5	6	7	4	0	5	0	0.0394	0.680
33	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(3), PTPRU(6), REG1A(2)	1196690	13	8	13	2	9	2	0	0	1	1	0.0403	0.680
34	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(1), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(4), F2(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(1), MAPK3(1), MAPK8(5), MEF2C(2), MYH2(3), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAF1(2)	4967934	50	17	50	14	22	14	3	1	8	2	0.0405	0.680
35	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(3), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(4), EDNRB(5), F2RL1(1), F2RL2(1), FSHR(1), GALR1(1), GPR174(1), GPR37(1), GPR6(1), GPR63(2), GPR77(1), GPR87(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MAS1(1), MC4R(1), MC5R(2), NMUR2(3), NPY5R(1), NTSR2(1), OPRM1(2), OR12D3(3), OR1C1(2), OR2H1(1), OR5V1(1), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY14(2), P2RY2(1), P2RY6(1), PPYR1(3), PTGDR(1), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(1), SSTR4(2), SUCNR1(2), TRHR(2)	12213019	126	34	127	42	44	50	24	2	6	0	0.0430	0.680
36	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(1), IL1R1(1), MAP2K4(2), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(5), MAPK9(2), NFATC3(1), PAPPA(5), ZAK(2)	5116885	45	18	45	10	15	13	6	1	10	0	0.0445	0.680
37	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(2), CUL1(1), NEDD8(1), RB1(3), RBX1(1)	902254	8	6	8	4	3	0	1	0	4	0	0.0460	0.680
38	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ARHGAP5(3), CDC42(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), CXCR4(1), CYBB(1), GNAI1(1), GRLF1(5), ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), ITK(3), MAPK13(1), MLLT4(3), MMP2(3), MMP9(5), MSN(3), MYL9(2), NCF2(1), NCF4(1), NOX3(3), PECAM1(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), PTPN11(3), RAP1A(1), RAPGEF3(1), RHOA(1), ROCK1(7), ROCK2(4), TXK(1), VAV1(2), VAV2(2), VAV3(2), VCAM1(2), VCL(1)	12784752	117	32	117	33	47	44	15	0	9	2	0.0465	0.680
39	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	FOS(1), GRB2(1), INSR(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SLC2A4(1), SOS1(2)	2388814	30	10	30	2	9	8	5	1	5	2	0.0467	0.680
40	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(1), AXIN1(1), BTRC(3), CTNNB1(4), DLL1(3), FZD1(1), GSK3B(1)	1459812	14	9	14	1	5	4	2	0	3	0	0.0467	0.680
41	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(4), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1181028	13	8	13	4	6	4	1	1	1	0	0.0467	0.680
42	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	FOS(1), FYN(1), GRB2(1), LAT(1), LCK(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(2), RASA1(4), SOS1(2), VAV1(2)	4697517	46	16	46	8	20	13	4	1	6	2	0.0474	0.680
43	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GRB2(1), INPP5D(2), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MS4A2(2), PDK1(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PRKCA(2), PRKCE(2), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2), VAV2(2), VAV3(2)	7148738	76	20	76	18	27	21	10	2	14	2	0.0475	0.680
44	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(4), CAP1(1), CDC25C(1), GNAI1(1), GNGT1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	2102799	21	11	21	4	8	9	2	0	2	0	0.0506	0.690
45	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(4), IGF1R(1), KIT(2), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), YWHAH(1)	1944303	19	9	19	10	8	6	1	0	2	2	0.0523	0.690
46	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(1)	546767	6	5	6	4	2	2	1	0	1	0	0.0539	0.690
47	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), FOS(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(2)	3536984	31	15	31	8	15	9	2	0	5	0	0.0544	0.690
48	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(2), CPEB1(3), EGFR(1), ERBB4(5), ETS1(1), ETS2(1), ETV6(1), FMN2(3), GRB2(1), MAP2K1(1), MAPK3(1), NOTCH2(2), NOTCH3(3), NOTCH4(4), PIWIL1(3), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(2), SOS1(2), SOS2(2), SPIRE1(1)	4923255	47	16	47	8	9	18	12	1	7	0	0.0548	0.690
49	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(2), CALCRL(1), CD97(2), CRHR1(1), CRHR2(1), ELTD1(2), EMR1(3), EMR2(4), GLP1R(5), GLP2R(2), GPR64(1), LPHN2(3), LPHN3(7), VIPR1(1)	2878193	36	13	36	11	15	14	5	0	2	0	0.0563	0.690
50	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), DBH(1), GAD1(2), HDC(5), MAOA(1), TPH1(2)	1486949	13	9	13	6	3	6	2	0	2	0	0.0594	0.690
51	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(6), REG1A(2), STAT2(2)	1303088	11	8	11	2	9	1	0	0	1	0	0.0600	0.690
52	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), HGD(1), HPD(1), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), MYST3(5), MYST4(5), PRMT3(1), PRMT7(1), PRMT8(2), SH3GLB1(1), TAT(2), TPO(3), TYR(1)	6105915	54	18	54	18	11	25	9	1	8	0	0.0602	0.690
53	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(5), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CX3CR1(1), CXCR4(1), EDNRB(5), FSHR(1), GALR1(1), GPR77(1), MC2R(3), MC4R(1), MC5R(2), NPY5R(1), NTSR2(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR4(2), TACR3(3), TRHR(2), TSHR(1)	5248433	55	19	55	21	22	18	11	1	3	0	0.0602	0.690
54	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB2(1), C1R(1), C1S(3), C2(4), C3(1), C3AR1(2), C4BPA(5), C5(4), C5AR1(1), C6(3), C7(3), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(6), CPB2(1), CR1(3), CR2(2), F13A1(2), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), KLKB1(2), KNG1(1), MASP1(3), PLAT(1), PLAU(1), PLAUR(1), PLG(2), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(5)	9353473	103	25	103	27	27	41	22	0	13	0	0.0605	0.690
55	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	188288	2	2	2	1	1	0	1	0	0	0	0.0634	0.710
56	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5B(1), GPRC5C(1), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM7(4), GRM8(2)	2076832	21	11	21	11	6	10	2	0	3	0	0.0648	0.713
57	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ASPA(2), HAL(1), HARS2(2), HDC(5), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), PRPS1(1), UROC1(2)	4102334	32	15	32	13	11	13	3	1	4	0	0.0671	0.720
58	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1)	1334406	15	7	15	3	4	6	2	0	3	0	0.0729	0.720
59	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM17(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(2), CSK(2), EGFR(1), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(2), MAP3K14(1), MAPK10(4), MAPK13(1), MAPK8(5), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG2(4), PTPN11(3), PTPRZ1(5), TJP1(2)	7329270	65	21	65	11	20	23	11	1	9	1	0.0730	0.720
60	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(1), CHKA(2), CHPT1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), ESCO1(4), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(1), GPD1L(1), GPD2(1), MYST3(5), MYST4(5), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1), PTDSS1(3), SH3GLB1(1)	6844399	63	21	63	17	23	19	13	0	8	0	0.0733	0.720
61	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2)	1419292	13	7	13	6	3	7	1	0	2	0	0.0738	0.720
62	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	CDKN1B(2), GRB2(1), MAPK3(1), PDK2(1), PIK3R1(5), PTEN(4), SOS1(2)	1763696	16	7	16	1	3	4	2	0	5	2	0.0764	0.720
63	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNGT1(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2B(1)	1563078	17	9	17	3	10	5	1	0	1	0	0.0775	0.720
64	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CHN1(1), LIMK1(1), MAP3K1(2), MYLK(3), NCF2(1), PAK1(1), PDGFRA(4), PIK3R1(5), PLD1(3), PPP1R12B(4), RALBP1(2), TRIO(1), VAV1(2), WASF1(2)	3412459	32	12	32	5	10	11	5	0	4	2	0.0779	0.720
65	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(1), ACTN3(1), CSK(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), PECAM1(1), VCL(1)	2092613	16	11	16	4	8	6	2	0	0	0	0.0783	0.720
66	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PAK1(1), PRKCA(2), RAF1(2), SOS1(2)	2950645	25	11	25	5	6	8	6	2	3	0	0.0811	0.720
67	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(10), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(1), FSHR(1), MLH1(3), MSH5(1), NCOR1(5), NRIP1(1), PRLR(2), VDR(1), ZP2(1)	3583059	32	12	32	9	7	11	6	1	6	1	0.0815	0.720
68	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(1), ADORA1(3), ADORA2A(2), ADRA1B(1), ADRA2B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR2(1), DRD2(2), DRD5(4), EDNRB(5), F2(1), F2RL1(1), F2RL2(1), FSHB(1), FSHR(1), GABBR1(2), GABBR2(4), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB2(3), GABRB3(4), GABRG1(2), GABRG2(3), GABRP(2), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(2), GRIA1(1), GRIA2(3), GRIA3(3), GRIA4(7), GRID1(1), GRID2(2), GRIK2(4), GRIK3(4), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRIN3A(3), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM6(1), GRM7(4), GRM8(2), GZMA(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LEPR(4), LTB4R(1), MAS1(1), MC2R(3), MC4R(1), MC5R(2), MCHR2(1), NMUR2(3), NPFFR2(1), NPY5R(1), NR3C1(1), NTSR2(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(1), P2RY14(2), P2RY2(1), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PTGDR(1), PTGER3(1), PTGFR(1), PTH2R(1), RXFP1(1), RXFP2(2), SSTR1(1), SSTR2(1), SSTR4(2), TAAR1(1), TAAR5(1), TAAR6(3), TAAR8(1), TAAR9(2), TACR3(3), TRHR(2), TRPV1(1), TSHB(1), TSHR(1), VIPR1(1)	22712255	247	45	246	98	94	92	39	3	18	1	0.0816	0.720
69	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2), VNN1(1)	1778864	14	8	14	8	3	8	1	0	2	0	0.0821	0.720
70	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C8B(1), C9(1), MASP1(3)	2165174	27	10	27	5	9	11	4	0	3	0	0.0822	0.720
71	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTR(1)	1814576	24	9	24	5	11	8	1	1	3	0	0.0838	0.720
72	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(2)	733253	8	6	8	4	1	2	4	0	1	0	0.0847	0.720
73	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), FCER1A(1), FOS(1), GRB2(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(1), PIK3R1(5), PLA2G4A(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SOS1(2), SYK(3), VAV1(2)	4166210	42	14	42	9	16	10	4	1	9	2	0.0854	0.720
74	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(10), CDC25C(1), CDK4(1), MYT1(5), RB1(3), YWHAH(1)	1760555	21	8	21	4	5	10	3	0	2	1	0.0890	0.741
75	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1), MASP1(3)	2227705	26	10	26	6	9	10	4	0	3	0	0.0945	0.776
76	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(2), CREB3(1), CREB5(2), RAF1(2), SNX13(3), TERF2IP(1)	1212148	11	5	11	1	5	2	3	1	0	0	0.0962	0.780
77	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	CAT(1), GH1(1), IGF1R(1), PIK3R1(5)	1141868	8	6	8	6	3	1	1	0	1	2	0.102	0.791
78	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	AXIN1(1), CTNNB1(4), DVL2(1), DVL3(2), FBXW2(1), FZD1(1), FZD10(2), FZD3(3), FZD6(3), GSK3B(1), LDLR(1), MAPK10(4), MAPK9(2), PLAU(1), PPP2R5C(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RHOA(1), SFRP4(1), TCF7(3), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1)	5474150	51	19	51	13	14	23	4	0	10	0	0.102	0.791
79	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(1), EGFR(1), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK13(1), MAPK3(1), MAPK8(5), NFKB1(3), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), RAF1(2)	5088007	41	15	41	12	15	13	8	2	3	0	0.103	0.791
80	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	2699198	19	11	19	5	4	10	1	0	4	0	0.104	0.791
81	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(1), ERBB3(3), NRG1(6)	1063036	10	7	10	1	2	2	4	0	2	0	0.105	0.791
82	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), MMP9(5), RECK(2), TIMP1(1), TIMP3(1)	784606	12	6	12	3	6	3	2	0	1	0	0.106	0.791
83	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT1(2), METTL2B(1), METTL6(3), PCYT1A(1), PRMT3(1), PRMT7(1), PRMT8(2)	1462893	12	7	12	2	3	4	2	1	2	0	0.107	0.791
84	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(1), EIF4G1(1), EIF4G3(3), IRS1(3), MAPK3(1), PDK2(1), PIK3R1(5), PRKCA(2), PTEN(4)	2669615	21	9	21	5	6	4	3	1	5	2	0.109	0.800
85	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), ST3GAL6(3)	1576171	14	7	14	4	5	3	3	1	2	0	0.112	0.810
86	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PDGFRA(4), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2)	3384403	33	11	33	5	10	11	5	1	4	2	0.113	0.810
87	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	GRB2(1), PIK3R1(5), PRKCA(2), SOS1(2)	1393558	10	6	10	2	3	3	1	0	1	2	0.127	0.857
88	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), RB1(3), SP3(1)	693346	6	4	6	1	2	2	1	0	1	0	0.129	0.857
89	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(2), CHUK(2), DAXX(1), FOS(1), GRB2(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK6(1), MAPK8(5), MAPK9(2), MEF2A(1), MEF2C(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KB2(1), TGFB2(4), TGFBR1(3)	10078464	84	23	84	16	20	24	21	2	17	0	0.129	0.857
90	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	CDC42(1), CHUK(2), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3R1(5), RAF1(2), RALA(1), RALBP1(2), RHOA(1)	1770491	19	7	19	3	8	1	5	0	3	2	0.131	0.857
91	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(10), CDR1(1), DGKI(4), FAU(1), IL6ST(1), PIGK(1), RPL10(1), RPL11(1), RPL19(1), RPL28(1), RPL5(1), RPL6(2), RPL9(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS4X(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), SLC36A2(1), UBB(1)	5423732	40	18	40	11	13	12	9	1	5	0	0.131	0.857
92	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1F(2), CACNA1S(4), CAMK2D(1), CDC42(1), CGA(1), EGFR(1), FSHB(1), GNAQ(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MMP2(3), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PLD1(3), PLD2(1), PRKACA(1), PRKACG(1), PRKCA(2), RAF1(2), SOS1(2), SOS2(2)	13433016	100	31	100	25	36	30	13	2	18	1	0.132	0.857
93	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(1), CTH(1), LCMT1(2), MARS(3), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT3(1), PRMT7(1), PRMT8(2), SEPHS1(2)	2574184	22	10	22	4	5	8	4	1	4	0	0.134	0.857
94	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2L11(1), CASP8AP2(6), CES1(1)	1191433	9	7	9	2	2	5	1	0	1	0	0.135	0.857
95	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	PIK3R1(5), PRKCA(2), VAV1(2)	1114545	9	5	9	3	3	3	0	0	1	2	0.135	0.857
96	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(4), AKAP4(2), AKAP6(6), AKAP7(1), AKAP9(6), ARHGEF1(1), GNA14(1), GNAL(1), GNAQ(1), GNG4(1), GNGT1(1), IL18BP(2), ITPR1(8), PDE1A(1), PDE1B(1), PDE1C(2), PDE4B(3), PDE4D(1), PDE7B(1), PDE8B(1), PLCB3(1), PPP3CA(2), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKD3(2), RHOA(1), SLC9A1(2), USP5(1)	12156709	97	29	96	27	27	40	12	0	17	1	0.136	0.857
97	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2)	1485674	11	7	11	3	4	3	1	1	2	0	0.138	0.857
98	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), NOS1(6), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2)	2639045	31	11	31	10	16	10	2	0	2	1	0.140	0.857
99	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(10), CDC25C(1), MYT1(5), YWHAH(1)	1441844	17	6	17	3	3	10	2	0	1	1	0.141	0.857
100	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT2(1), AKT3(1), AXIN1(1), AXIN2(2), CTNNB1(4), DACT1(1), DKK1(2), DKK2(1), DKK4(3), FSTL1(1), GSK3B(1), LRP1(3), SENP2(1), SFRP1(1), TSHB(1)	3590771	24	13	24	4	7	10	7	0	0	0	0.142	0.857
101	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), FAH(1), GOT1(1), HGD(1), HPD(1), MAOA(1), MAOB(1), TAT(2), TPO(3), TYR(1)	3231925	28	12	28	12	4	16	3	0	5	0	0.147	0.857
102	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRB(1), CP(3), CPOX(1), EPRS(2), FECH(1), HCCS(2), HMOX2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1)	2696948	19	10	19	3	5	9	3	0	2	0	0.149	0.857
103	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), GCDH(2), HADHA(1), HSD17B10(1), INMT(1), KMO(2), KYNU(1), LCMT1(2), LNX1(4), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), NFX1(3), OGDHL(3), PRMT3(1), PRMT7(1), PRMT8(2), TDO2(2), TPH1(2), TPH2(3), WARS(1), WARS2(1)	6225135	54	17	54	18	13	23	8	1	9	0	0.149	0.857
104	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	GSK3B(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3R1(5), PTEN(4)	1824051	13	7	13	4	3	4	1	0	3	2	0.152	0.857
105	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTAP(1), MTFMT(1), MTR(1), TAT(2)	2163774	29	9	29	5	11	13	1	1	3	0	0.153	0.857
106	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	FOS(1), GRB2(1), MAP2K1(1), MAPK3(1), MAPK8(5), NGFR(1), PIK3R1(5), RAF1(2), SOS1(2)	1739550	19	7	19	3	6	5	3	1	2	2	0.153	0.857
107	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), CFTR(4), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1317832	14	7	14	3	5	6	1	0	2	0	0.155	0.857
108	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), DNMT1(7), PTGDR(1), PTGFR(1)	1141950	11	7	11	1	7	3	0	1	0	0	0.155	0.857
109	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGFR(1), FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2)	3657469	30	11	30	3	10	9	4	1	4	2	0.157	0.857
110	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1)	1824828	23	8	23	5	7	9	4	0	3	0	0.157	0.857
111	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(1), CIITA(1), CTSB(3), CTSL1(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFNA10(2), IFNA2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), LGMN(2), NFYA(2), PDIA3(1), TAP1(2), TAP2(1), TAPBP(2)	4559458	42	12	42	12	7	20	7	1	5	2	0.158	0.857
112	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT2(1), AKT3(1), CDC42(1), KDR(2), MAP2K1(1), MAP2K2(1), MAPK13(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTGS2(1), RAF1(2), SH2D2A(1), SHC2(1), SPHK1(1)	7120394	49	19	49	18	26	8	4	0	9	2	0.161	0.857
113	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(2), SNCAIP(2), UBE2E2(1)	656463	6	4	6	1	1	4	1	0	0	0	0.161	0.857
114	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), PIK3R1(5), RAF1(2), SOS1(2), YWHAH(1)	1706308	17	7	17	3	5	4	3	0	3	2	0.162	0.857
115	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(2), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2)	3996042	33	12	33	11	12	11	5	1	4	0	0.165	0.857
116	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	2528280	25	9	25	9	6	9	8	0	2	0	0.166	0.857
117	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(2), GLI3(4), GSK3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), SMO(1)	1661442	15	8	15	3	4	8	0	0	3	0	0.166	0.857
118	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), GZMB(1), HLA-A(2), ITGAL(3), ITGB2(1)	873728	10	5	10	3	2	3	2	0	2	1	0.166	0.857
119	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8)	2340908	28	10	28	5	12	11	2	0	3	0	0.167	0.857
120	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8)	2340908	28	10	28	5	12	11	2	0	3	0	0.167	0.857
121	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1)	2418424	23	10	23	8	11	8	2	0	2	0	0.170	0.866
122	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABLIM1(1), ARHGEF12(2), CDC42(1), CXCR4(1), DCC(2), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(1), EPHA1(3), EPHA3(3), EPHA4(2), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(3), EPHB2(1), EPHB4(3), FYN(1), GNAI1(1), GSK3B(1), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK3(1), MET(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NTN1(1), NTN4(2), NTNG1(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASA1(4), RGS3(2), RHOA(1), ROBO1(9), ROBO2(3), ROBO3(3), ROCK1(7), ROCK2(4), SEMA3A(3), SEMA3C(1), SEMA3D(4), SEMA3E(4), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(4), SEMA6B(2), SEMA6C(1), SEMA6D(4), SLIT1(2), SLIT2(3), SLIT3(2), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(3)	20251740	163	39	163	37	68	48	22	2	23	0	0.174	0.876
123	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	5347332	48	16	48	10	17	17	8	0	6	0	0.176	0.876
124	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	5347332	48	16	48	10	17	17	8	0	6	0	0.176	0.876
125	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C5(4), C6(3), C7(3), IL6(1), IL8(1), ITGA4(5), ITGAL(3), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2)	2578107	27	9	27	9	9	10	3	0	5	0	0.181	0.881
126	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(2), HSD3B1(1), HSD3B2(1)	713979	4	4	4	2	1	2	0	0	1	0	0.182	0.881
127	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFS1(2), NDUFS2(3)	724637	6	4	6	2	3	2	0	0	1	0	0.186	0.881
128	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(5), ATP4A(2), ATP5A1(3), ATP5C1(2), ATP5L(2), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX15(2), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(1), UQCRC2(1)	5834296	48	17	48	12	17	17	9	0	5	0	0.186	0.881
129	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(1), ATF2(1), AXIN1(1), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), MEF2C(2), NPPB(1), RFC1(4), TGFB2(4), TGFBR1(3), TGFBR3(3)	3115692	36	11	36	3	12	15	5	0	4	0	0.187	0.881
130	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	CASP3(1), CREB3(1), CREB5(2), DAG1(1), EPHB2(1), FOS(1), GNAQ(1), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2)	2288777	22	9	22	3	6	5	3	2	6	0	0.187	0.881
131	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3R1(5), RAF1(2), RB1(3)	1890946	18	7	18	4	9	0	2	0	5	2	0.187	0.881
132	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), NT5E(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), RRM1(1), TK2(1), TXNRD1(1), TYMS(1), UMPS(1), UPB1(2)	5987713	38	18	37	12	11	13	7	0	7	0	0.190	0.885
133	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(1), DLST(1), IDH3A(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1)	2150888	16	9	16	9	3	8	2	0	3	0	0.191	0.885
134	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1)	1506928	15	6	15	7	7	5	2	0	1	0	0.203	0.918
135	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	BCR(1), FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1)	2636016	27	9	27	3	8	8	3	1	4	3	0.203	0.918
136	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	BRAF(2), CASP3(1), FAS(2), FCGR3A(1), FYN(1), GRB2(1), GZMB(1), HLA-A(2), HLA-G(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), ITGAL(3), ITGB2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MICB(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PAK1(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTPN11(3), RAF1(2), SH3BP2(1), SHC2(1), SOS1(2), SOS2(2), SYK(3), TNFRSF10B(4), TNFRSF10D(1), TYROBP(1), VAV1(2), VAV2(2), VAV3(2)	11351974	89	25	89	29	34	25	15	0	13	2	0.204	0.918
137	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), UPB1(2)	3002676	22	11	22	12	6	8	2	0	6	0	0.204	0.918
138	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1(1), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR1B(1), BMPR2(3), CREBBP(4), CUL1(1), DCN(1), EP300(2), FST(1), GDF5(1), GDF6(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(1), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), RBL1(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RPS6KB2(1), SMAD3(3), SMAD5(1), SMAD9(1), SMURF1(2), TGFB2(4), TGFBR1(3), THBS1(2), THBS2(5), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(4)	10062747	84	24	83	16	29	30	13	0	11	1	0.209	0.931
139	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNGT1(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2)	976829	9	6	9	1	4	4	0	0	1	0	0.211	0.937
140	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(10), CDK4(1), PCNA(1), RB1(3), TIMP3(1)	1816210	17	7	17	5	2	8	3	0	3	1	0.217	0.949
141	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), ALAS2(1), BLVRB(1), COX15(2), CP(3), CPOX(1), EPRS(2), FECH(1), FTMT(1), HCCS(2), HMOX2(2), MMAB(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UROD(1)	4156604	35	12	35	7	9	18	5	0	3	0	0.217	0.949
142	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST4(2), FUT8(1)	1226888	9	5	9	3	4	1	1	1	2	0	0.219	0.949
143	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	PIK3R1(5), POLR1A(3), POLR1B(2), RB1(3)	1748636	13	7	13	3	6	2	1	0	2	2	0.220	0.949
144	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), EPX(1), LPO(1), MPO(2), MTHFR(1), SHMT1(1), TPO(3)	1211963	10	7	10	6	6	3	1	0	0	0	0.222	0.950
145	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADSS(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP3(1), ENTPD5(1), ENTPD6(1), GMPR(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NME6(1), NME7(2), NPR2(1), NT5C1B(1), NT5C2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(5), PDE11A(1), PDE1A(1), PDE1C(2), PDE3B(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE7B(1), PDE8B(1), PDE9A(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PPAT(3), PRIM2(3), PRPS1(1), PRUNE(1), RFC5(1), RRM1(1)	17173958	128	34	126	38	40	49	16	0	23	0	0.229	0.968
146	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(3), FYN(1), MAP2K1(1), MAPK3(1), MYLK(3), PIK3R1(5), RAF1(2), ROCK1(7), TLN1(2)	3706964	25	10	25	5	8	7	5	0	3	2	0.231	0.968
147	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MPL(1), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2), STAT5B(1), THPO(1)	2886356	25	8	25	2	7	8	3	0	4	3	0.231	0.968
148	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), EPX(1), LPO(1), MPO(2), PRDX1(1), SHMT1(1), TPO(3)	1233384	10	7	10	7	5	3	1	0	1	0	0.233	0.968
149	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(2), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	1023567	13	6	13	3	5	3	2	0	3	0	0.234	0.968
150	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(2), CREB3(1), CREB5(2), DUSP6(1), EEF2K(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TRAF3(2)	3099188	28	10	28	2	8	9	7	1	3	0	0.237	0.972
151	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ANXA1(1), GNGT1(1), NFKB1(3), NR3C1(1), PIK3R1(5)	1605524	11	6	11	3	6	1	0	0	2	2	0.240	0.975
152	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	447954	2	2	2	1	0	2	0	0	0	0	0.242	0.975
153	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(1), CAV1(1), CHRNA1(2), FLT1(3), FLT4(1), KDR(2), PDE3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKG1(5), PRKG2(2), RYR2(11)	4241398	36	13	36	12	7	17	9	0	3	0	0.244	0.975
154	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), NDST1(1), NDST3(3)	2164228	17	9	17	9	5	6	3	1	2	0	0.245	0.975
155	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1)	834294	6	4	6	2	1	3	1	0	1	0	0.245	0.975
156	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), PLCE1(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAP2B(1)	1488089	13	7	13	2	5	6	1	0	1	0	0.250	0.975
157	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(1), HADHB(1), HSD17B10(1), PPT2(1)	874545	5	4	5	4	1	2	0	0	2	0	0.251	0.975
158	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), DARS(1), EPRS(2), FARS2(1), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1)	3313083	23	10	23	5	3	9	7	1	3	0	0.252	0.975
159	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), HIBCH(1), UPB1(2)	2790554	22	10	22	11	5	9	2	0	6	0	0.252	0.975
160	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(4), PIK3R1(5), WASL(2)	1166614	16	4	16	3	5	2	4	0	3	2	0.256	0.986
161	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), SDHA(1)	676873	5	4	5	0	1	1	3	0	0	0	0.259	0.991
162	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(2)	492269	3	3	3	2	0	0	2	0	1	0	0.263	0.998
163	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3R1(5), PRKCA(2), RAF1(2)	2688938	20	8	20	5	8	5	2	0	3	2	0.265	0.998
164	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	157941	3	2	3	1	0	2	1	0	0	0	0.266	0.998
165	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	FOS(1), GRB2(1), IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(3), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(3), RAF1(2), SOS1(2)	2486050	20	9	20	3	6	7	3	0	3	1	0.269	1.000
166	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(1), DOCK1(2), FOS(1), GRB2(1), HGF(3), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(5), MET(1), PAK1(1), PIK3R1(5), PTEN(4), PTPN11(3), RAF1(2), RAP1A(1), RASA1(4), SOS1(2)	4477148	40	11	40	7	13	11	8	1	5	2	0.272	1.000
167	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG1(1), ALG10B(3), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST4(2), DPAGT1(1), EXT1(1), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), NDST1(1), NDST3(3), OGT(1), RPN2(1), ST6GALNAC1(1), STT3B(2), WBSCR17(2), XYLT1(2)	11366322	79	23	79	31	22	30	17	2	8	0	0.272	1.000
168	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	AXIN1(1), BTRC(3), CREBBP(4), CSNK1D(1), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), PPARD(1)	2414701	18	9	18	4	7	5	4	0	2	0	0.276	1.000
169	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(2)	223070	2	2	2	1	0	2	0	0	0	0	0.280	1.000
170	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(2), YWHAH(1)	871035	10	5	10	3	1	6	0	0	3	0	0.282	1.000
171	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(2), SOS1(2), SYK(3), VAV1(2)	3926455	34	12	34	8	12	12	4	1	5	0	0.282	1.000
172	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), MPO(2), PRDX1(1), TPO(3), TYR(1)	1009707	9	6	9	5	6	2	0	0	1	0	0.283	1.000
173	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(1), FGA(2), FGB(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2)	1393926	14	5	14	0	7	4	1	0	2	0	0.283	1.000
174	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(5), ATM(10), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(5)	2015798	27	7	27	3	7	12	3	1	3	1	0.285	1.000
175	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(1), INPP4B(2), INPPL1(1), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4)	4475024	27	13	27	10	9	10	5	0	3	0	0.286	1.000
176	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), DERA(1), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1), TKTL1(1), TKTL2(2)	2510791	17	10	17	5	7	7	2	0	1	0	0.288	1.000
177	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), KERA(2), LUM(1)	376414	5	3	5	1	3	0	2	0	0	0	0.289	1.000
178	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD22(2), CD72(1), CD79B(1), CHUK(2), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASGRP3(3), SYK(3), VAV1(2), VAV2(2), VAV3(2)	7391342	65	18	65	16	29	22	5	0	7	2	0.290	1.000
179	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA7(1), PSMB3(1), PSMB8(3)	872784	6	4	6	0	0	5	0	1	0	0	0.299	1.000
180	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), CAPN11(1), CAPN2(1), CAPN6(1), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(1), GIT2(1), GRB2(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), RAPGEF1(2), RHO(1), ROCK1(7), ROCK2(4), SEPP1(1), SORBS1(4), SOS1(2), TLN1(2), TNS1(3), VAV2(2), VAV3(2), VCL(1), ZYX(1)	14132327	105	27	105	32	29	43	16	4	13	0	0.301	1.000
181	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CUL1(1), RB1(3)	708132	4	3	4	3	1	0	1	0	2	0	0.302	1.000
182	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(3), CRY1(3)	888954	9	4	9	1	1	3	2	0	2	1	0.303	1.000
183	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1580765	11	6	11	2	3	5	2	0	1	0	0.303	1.000
184	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1580765	11	6	11	2	3	5	2	0	1	0	0.303	1.000
185	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1580765	11	6	11	2	3	5	2	0	1	0	0.303	1.000
186	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(3), CBX3(2), CLOCK(3), CRY1(3), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(1), MYF6(1), NCKAP1(1), NCOA4(1), NR1D2(3), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(1), UGP2(2), ZFR(5)	3799487	40	11	40	5	5	15	13	0	6	1	0.305	1.000
187	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1)	581877	5	3	5	4	0	2	2	0	1	0	0.314	1.000
188	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF1(1), ATF2(1), ATF4(1), ATP2A2(1), ATP2A3(1), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(1), DGKZ(1), ETS2(1), FOS(1), GABPB2(1), GJA1(4), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), GUCY1A3(5), IGFBP3(2), IL1B(1), IL6(1), ITPR1(8), ITPR2(6), ITPR3(1), MIB1(3), MYL4(1), MYLK2(1), NFKB1(3), NOS1(6), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(1), PRKD1(5), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), TNXB(3), USP5(1), YWHAH(1)	18102940	158	36	158	47	56	71	11	1	18	1	0.316	1.000
189	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	CHUK(2), GH1(1), NFKB1(3), PIK3R1(5), YWHAH(1)	1244934	12	4	12	2	6	2	1	0	1	2	0.320	1.000
190	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT2(3), CPS1(6), DAO(4), EPRS(2), GLUD2(2), GOT1(1), LAP3(1), NOS1(6), OAT(1), OTC(1), P4HA1(1), P4HA3(1), RARS(2), RARS2(2)	3674702	39	10	39	12	13	14	5	1	6	0	0.321	1.000
191	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD2(2), GRM1(3), PPP3CA(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1639986	14	7	14	6	8	3	1	0	2	0	0.324	1.000
192	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(6), GOT1(1)	790158	9	4	9	2	2	3	1	0	3	0	0.329	1.000
193	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(1), CTH(1), MUT(1)	503229	4	3	4	0	1	2	0	0	1	0	0.329	1.000
194	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT3(1)	493494	4	3	4	1	3	1	0	0	0	0	0.332	1.000
195	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A2(1), EIF4B(1), EIF4G1(1), EIF4G3(3), PDK2(1), PIK3R1(5), PTEN(4), TSC1(1), TSC2(1)	2610764	18	7	18	4	6	3	2	1	4	2	0.333	1.000
196	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGFR(1), TF(4), TFRC(1)	1327975	10	5	10	1	3	5	1	0	1	0	0.334	1.000
197	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(5), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(1), SHMT1(1)	3833909	26	11	26	9	7	13	3	0	3	0	0.339	1.000
198	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DAK(1), DGAT2(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(5), LIPC(1), LIPF(2), MGLL(1), PNLIP(2), PNLIPRP2(1)	6071385	52	16	52	16	20	19	8	0	5	0	0.342	1.000
199	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1)	2106811	13	8	13	3	6	6	1	0	0	0	0.343	1.000
200	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), SP3(1)	2111404	13	7	13	5	8	2	0	0	3	0	0.348	1.000
201	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1673779	11	6	11	2	3	5	2	0	1	0	0.350	1.000
202	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(3), JAK3(2), MAPK3(1)	1234284	7	5	7	1	0	3	0	0	3	1	0.351	1.000
203	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), LDHA(1), LDHB(2), NCL(1)	919319	8	5	8	4	3	5	0	0	0	0	0.353	1.000
204	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(1), GTF2F2(1), GTF2H1(2), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3B(5), POLR3E(3), POLR3K(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1)	3650174	26	11	26	4	10	8	3	0	5	0	0.353	1.000
205	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS3(1)	324309	3	2	3	1	2	1	0	0	0	0	0.357	1.000
206	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(4), ADCY8(1), ATF4(1), BRAF(2), CACNA1C(2), CAMK2D(1), CAMK4(1), CREBBP(4), EP300(2), GNAQ(1), GRIA1(1), GRIA2(3), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAP2K2(1), MAPK3(1), PLCB3(1), PLCB4(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2)	10556061	84	24	84	29	32	28	13	0	9	2	0.360	1.000
207	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(1), EIF2B2(1), FLT1(3), FLT4(1), HIF1A(2), KDR(2), PIK3R1(5), PRKCA(2), VHL(1)	3246533	18	9	18	6	7	3	3	0	3	2	0.365	1.000
208	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1L(2)	1397283	6	5	6	5	2	2	0	1	1	0	0.366	1.000
209	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AR(2), BRAF(2), DAG1(1), EGFR(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), MAPK10(4), PHKA2(1), PIK3CD(1), PIK3R1(5), RAF1(2)	4784736	38	12	38	6	16	8	4	0	7	3	0.371	1.000
210	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(1), MAP2K6(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(2), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), YWHAH(1)	3340498	26	10	26	11	10	8	0	0	6	2	0.371	1.000
211	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CLYBL(1), DLD(1), DLST(1), IDH3A(3), OGDHL(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1)	3108673	20	10	20	11	4	8	5	0	3	0	0.371	1.000
212	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PLCG2(4), SARDH(1), SARS(1), SHMT1(1), TARS(3)	4399262	32	13	32	13	14	12	3	0	3	0	0.373	1.000
213	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ASPA(2), HAL(1), HDC(5), MAOA(1), MAOB(1), PRPS1(1)	2540877	17	9	17	12	5	8	2	0	2	0	0.377	1.000
214	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), HADHA(1)	560426	6	3	6	3	2	1	0	0	3	0	0.377	1.000
215	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3), SELP(2)	1768100	20	7	20	6	3	11	3	0	3	0	0.378	1.000
216	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1)	1564856	6	6	6	2	4	2	0	0	0	0	0.384	1.000
217	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP3(1), DAXX(1), FAS(2), HSPB2(1)	1153636	7	5	7	1	1	1	4	0	1	0	0.387	1.000
218	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(1)	778871	9	4	9	1	2	6	0	0	1	0	0.390	1.000
219	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGT(1), AGTR2(1), EDNRB(5), EGFR(1), FOS(1), NFKB1(3), PRKCA(2)	2126702	17	8	17	5	7	6	3	0	1	0	0.390	1.000
220	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), CYP4F3(1), EPX(1), LPO(1), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGIS(1), PTGS1(2), PTGS2(1), TPO(3)	2893287	20	10	20	9	12	5	1	0	2	0	0.393	1.000
221	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(1), BIN1(1), DNM1(3), EPN1(1), EPS15(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYNJ1(3), SYNJ2(1)	2350664	19	8	19	3	8	7	0	0	4	0	0.396	1.000
222	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(4), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), HADHA(1), LDHA(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1)	3433782	31	10	31	8	9	11	3	0	8	0	0.397	1.000
223	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(1), BMP7(1), BTRC(3), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(2), GLI3(4), GSK3B(1), HHIP(1), LRP2(13), PRKACA(1), PRKACG(1), PTCH1(1), PTCH2(2), RAB23(1), SMO(1), STK36(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	6176949	47	17	47	14	19	18	3	0	7	0	0.397	1.000
224	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), CES1(1), CES7(1), DDHD1(2), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	2625276	21	8	21	9	5	8	6	0	2	0	0.400	1.000
225	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(1), PON2(1), RDH11(1), RDH12(1)	872594	5	4	5	3	3	2	0	0	0	0	0.403	1.000
226	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(1), ADCY9(2), ARF4(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), PDIA4(1), PLCG2(4), PRKCA(2), TRIM23(4)	3825030	28	10	28	5	12	8	5	0	3	0	0.403	1.000
227	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAQ(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK3(1), PIK3C2G(2), PPP1R12B(4), PRKCA(2), RAF1(2), ROCK2(4)	2649446	20	8	20	5	6	6	2	0	6	0	0.404	1.000
228	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(1), CSK(2), GRB2(1), PRKCA(2)	965430	6	4	6	1	2	4	0	0	0	0	0.405	1.000
229	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), PON1(1)	3037416	24	9	24	7	8	5	8	0	2	1	0.405	1.000
230	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), AOX1(3), HADHA(1), HADHB(1), HMGCL(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1)	3748527	28	11	28	9	8	10	3	0	7	0	0.408	1.000
231	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	188292	3	2	3	0	0	2	1	0	0	0	0.408	1.000
232	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(2), CREBBP(4), CTNNB1(4), DCT(4), DVL2(1), DVL3(2), EDNRB(5), EP300(2), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GNAI1(1), GNAQ(1), GSK3B(1), KIT(2), MAP2K1(1), MAP2K2(1), MAPK3(1), MITF(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), TCF7(3), TYR(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	11016650	84	25	84	34	28	37	8	1	10	0	0.410	1.000
233	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), MPO(2), TPO(3)	881355	7	5	7	4	5	2	0	0	0	0	0.411	1.000
234	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT2(1), AKT3(1), BRAF(2), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRKAA1(1), PRKAA2(3), RICTOR(3), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), TSC1(1), TSC2(1), ULK1(1), VEGFC(3)	5224623	43	12	43	11	16	11	6	0	8	2	0.412	1.000
235	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(1), CHKA(2), CLC(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), GNPAT(1), GPD2(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLCG2(4)	5192979	38	14	38	14	18	7	7	0	6	0	0.412	1.000
236	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), GRHPR(1), HAO2(1), MTHFD1L(2)	1332086	5	4	5	5	1	2	0	1	1	0	0.415	1.000
237	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), INPP4A(1), INPP4B(2), INPP5D(2), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), OCRL(4), PI4KA(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3C3(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(4), SYNJ1(3), SYNJ2(1)	12928847	95	25	95	25	37	33	10	0	12	3	0.415	1.000
238	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(8)	860171	10	4	10	3	1	4	5	0	0	0	0.416	1.000
239	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1B(1), ADRB1(1), CHRM2(3), CHRM4(1), CHRM5(1), DRD2(2), DRD5(4), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1)	2590718	27	9	27	14	13	9	3	1	1	0	0.416	1.000
240	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(5), CASP3(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKB2(2), RALBP1(2), TNFAIP3(1)	2744904	22	8	22	5	9	5	4	0	4	0	0.417	1.000
241	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT2(1), AKT3(1), GRB2(1), GSK3B(1), IRS1(3), JAK1(1), JAK3(2), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CD(1), PIK3R1(5), PPP1R13B(1), RAF1(2), SOS1(2), SOS2(2)	3462455	27	9	27	4	8	8	4	0	5	2	0.418	1.000
242	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1)	1251150	14	5	14	2	3	9	2	0	0	0	0.420	1.000
243	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(1), ACTN3(1), ACTN4(1), DMD(11), FAM48A(2), MYBPC1(2), MYBPC3(1), MYH3(5), MYH6(4), MYH7(4), MYH8(3), MYL4(1), MYL9(2), MYOM1(4), NEB(16), TMOD1(1), TPM2(1), TPM3(1), TPM4(1), TTN(87), VIM(1)	14574470	151	26	151	41	45	63	30	0	11	2	0.422	1.000
244	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(4), ADCY2(3), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(2), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), ATP2B4(3), AVPR1A(1), BDKRB2(1), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CAMK2D(1), CAMK4(1), CCKAR(1), CCKBR(2), CD38(1), CHRM2(3), CHRM5(1), CHRNA7(1), CYSLTR2(1), EDNRB(5), EGFR(1), ERBB3(3), ERBB4(5), GNA14(1), GNAL(1), GNAQ(1), GRIN2A(6), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), ITPR1(8), ITPR2(6), ITPR3(1), MYLK(3), MYLK2(1), NOS1(6), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), PDE1A(1), PDE1B(1), PDE1C(2), PDGFRA(4), PDGFRB(1), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A2(1), SLC8A3(3), SPHK1(1), TACR3(3), TRHR(2), TRPC1(1)	28279947	225	47	225	82	87	88	27	1	20	2	0.423	1.000
245	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	1650219	17	6	17	4	5	6	5	0	1	0	0.424	1.000
246	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2)	337034	2	2	2	0	0	1	1	0	0	0	0.424	1.000
247	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CUL1(1), RB1(3)	909957	6	3	6	4	1	0	2	0	3	0	0.425	1.000
248	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(3), OPHN1(3), PIP5K1B(1), PPP1R12B(4), ROCK1(7), TLN1(2), VCL(1)	4834081	33	12	33	7	8	9	9	0	7	0	0.426	1.000
249	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1)	349623	1	1	1	1	1	0	0	0	0	0	0.426	1.000
250	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(1), ST6GALNAC1(1), WBSCR17(2)	3350529	28	9	28	7	5	14	7	0	2	0	0.427	1.000
251	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), ABCG2(4), BCHE(2), CES1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1)	2358383	17	7	17	3	5	8	2	1	1	0	0.427	1.000
252	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	CHRNG(1), MUSK(2), PIK3R1(5), YWHAH(1)	1506414	9	5	9	2	3	2	0	0	2	2	0.429	1.000
253	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(1), AASS(2)	723285	4	3	4	3	0	1	2	0	1	0	0.430	1.000
254	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(2), PC(3), PDHA1(1)	959216	6	4	6	3	4	2	0	0	0	0	0.430	1.000
255	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	CES1(1), ESD(1)	607156	2	2	2	5	0	2	0	0	0	0	0.431	1.000
256	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1)	3387174	23	10	23	6	11	9	2	0	1	0	0.434	1.000
257	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	GRB2(1), MAPK3(1), MEF2A(1), MEF2C(2), PIK3R1(5)	1799112	10	5	10	2	3	2	0	0	3	2	0.434	1.000
258	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(6), MAP2(4), PRKACG(1), PRKAR2B(1), PRKCE(2)	1894613	14	6	13	7	2	7	3	0	2	0	0.435	1.000
259	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLB(2), POLE(4), POLE2(1), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(1), POLQ(4), PRIM2(3), REV1(3), REV3L(7), RFC5(1)	4349939	36	11	34	10	7	14	5	0	9	1	0.446	1.000
260	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT5(2), FUT1(3), FUT3(1)	741030	6	3	6	2	4	1	1	0	0	0	0.452	1.000
261	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(1), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), HADHA(1), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1)	4499750	31	12	31	9	9	11	3	0	8	0	0.453	1.000
262	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOC(2)	392439	3	2	3	0	2	0	1	0	0	0	0.456	1.000
263	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(2), FOS(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TLR10(3), TLR2(4), TLR3(1), TLR4(3), TLR7(3), TLR9(3)	3790894	43	9	43	8	11	17	9	2	3	1	0.459	1.000
264	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(3), ABCB4(3), ABCC1(3)	1509011	14	5	14	3	4	6	2	1	1	0	0.463	1.000
265	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE2(3), AGT(1), AGTR1(2), AGTR2(1), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(2), REN(2)	2183198	25	7	25	7	8	11	4	0	2	0	0.466	1.000
266	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	CBL(3), CFLAR(1), FOS(1), GRB2(1), IL2RB(1), IRS1(3), JAK1(1), JAK3(2), MAPK3(1), NMI(1), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3)	3487566	28	9	28	6	8	9	2	0	7	2	0.467	1.000
267	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	BRAF(2), CACNA1A(9), CRHR1(1), GNAI1(1), GNAQ(1), GRIA1(1), GRIA2(3), GRIA3(3), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(1), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAP2K2(1), MAPK3(1), NOS1(6), NPR2(1), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), RYR1(6)	11541640	107	25	106	38	40	36	20	0	10	1	0.468	1.000
268	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(2), HEXB(2), LCT(5), MANBA(1), NEU1(1)	1691523	13	6	13	3	5	4	1	0	3	0	0.473	1.000
269	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), MARS(3), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SEPHS1(2)	1281961	12	5	12	2	2	5	3	0	2	0	0.474	1.000
270	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AMD1(1), ARG2(1), ASL(2), ASS1(1), CPS1(6), MAOA(1), MAOB(1), NAGS(1), ODC1(3), OTC(1), SAT2(1)	3082757	29	9	28	7	10	11	3	0	5	0	0.476	1.000
271	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACMSD(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), GCDH(2), HADHA(1), KMO(2), KYNU(1), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS(1), WARS2(1)	5657681	45	14	45	18	11	19	10	0	5	0	0.477	1.000
272	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), HADHB(1), RDH11(1), RDH12(1), SLC27A5(1), SRD5A2(1)	3332649	22	9	22	13	4	11	5	0	2	0	0.480	1.000
273	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(1), PLA2G4A(3), PLA2G6(2)	1074095	8	5	8	3	6	1	0	0	1	0	0.481	1.000
274	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), PRKCE(2)	821648	12	3	12	3	2	8	1	0	1	0	0.482	1.000
275	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT2(1), AKT3(1), CBL(3), CBLB(2), CREBBP(4), CSF3R(1), EP300(2), GH1(1), GH2(2), GRB2(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL13RA2(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(1), JAK2(3), JAK3(2), LEPR(4), LIFR(5), MPL(1), OSMR(2), PIAS1(1), PIAS2(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRL(1), PRLR(2), PTPN11(3), SOCS2(1), SOCS4(1), SOCS5(2), SOS1(2), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT2(2), STAT4(3), STAT5B(1), TPO(3)	14485871	106	25	106	38	27	48	13	1	14	3	0.483	1.000
276	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(2)	782655	2	2	2	0	0	1	0	1	0	0	0.484	1.000
277	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), GNAI1(1), GNGT1(1), MAP2K1(1), MAPK3(1), PLA2G4A(3), PRKCA(2), PTGS1(2), RAF1(2), SYK(3)	2528848	17	8	17	5	6	5	2	0	4	0	0.484	1.000
278	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(10), ATR(4), CDC25C(1), YWHAH(1)	1567656	16	4	16	5	3	10	1	0	1	1	0.486	1.000
279	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	CREBBP(4), EP300(2), MAPK3(1), ME1(2), NCOA1(2), NCOR1(5), NR2F1(1), NRIP1(1), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PTGS2(1), RB1(3), STAT5B(1)	6209807	36	13	36	12	17	9	3	0	5	2	0.486	1.000
280	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), MAPK8(5), NFE2L2(3), PRKCA(2)	901011	11	4	11	0	4	4	1	1	1	0	0.487	1.000
281	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PRKCA(2)	698032	3	3	3	2	2	1	0	0	0	0	0.487	1.000
282	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ATM(10), ATR(4), CCNA1(2), CDK4(1), CDKN1B(2), DHFR(1), GSK3B(1), RB1(3), TGFB2(4)	3023484	28	8	28	10	5	12	4	0	6	1	0.488	1.000
283	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK4(1), CDKN1B(2), PRB1(1)	741999	4	4	4	1	1	0	0	0	3	0	0.488	1.000
284	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(3)	827924	5	3	5	3	1	2	1	0	1	0	0.490	1.000
285	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), PPAT(3), QARS(1)	4087798	22	10	22	9	5	10	3	1	3	0	0.492	1.000
286	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL1RN(1), IL6(1), IRAK3(2), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TGFB2(4)	3068645	34	7	34	6	10	12	7	2	3	0	0.493	1.000
287	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(1), PAX3(2), PML(1), RB1(3), SIRT1(1)	1875594	12	6	12	4	7	1	2	0	2	0	0.495	1.000
288	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), BCR(1), CAV1(1), CSK(2), FYN(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), PPP1R12B(4), RAF1(2), RAP1A(1), ROCK1(7), SOS1(2), TLN1(2), VCL(1), ZYX(1)	4902174	39	12	39	7	13	14	7	1	4	0	0.496	1.000
289	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(1), ADCY8(1), CACNA1A(9), CACNA1B(4), GNAT3(1), ITPR3(1), KCNB1(3), PDE1A(1), PRKACA(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(3), TAS2R14(1), TAS2R16(2), TAS2R38(1), TAS2R39(1), TAS2R4(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2)	5892145	48	15	48	21	23	14	9	0	2	0	0.501	1.000
290	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F3(1), F5(7), F7(1), FGA(2), FGB(1), PROS1(3), TFPI(3)	1676830	19	5	19	7	5	6	6	0	2	0	0.505	1.000
291	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(2), IL10(1), IL12A(1), ITGAX(2), TLR2(4), TLR4(3), TLR7(3), TLR9(3)	1925986	23	6	23	3	7	10	5	0	1	0	0.505	1.000
292	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), HADHA(1), HADHB(1)	871498	3	3	3	5	0	2	0	0	1	0	0.505	1.000
293	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(2), TGM2(2)	522622	6	3	6	2	3	3	0	0	0	0	0.507	1.000
294	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), ACTR3(1), DAG1(1), ETFA(1), ITGA9(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CD(1), PIK3R1(5), RPS4X(1), SGCB(4)	4927845	40	11	40	6	13	12	5	0	6	4	0.508	1.000
295	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3B1(1), EPX(1), ESCO1(4), ESCO2(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), MYST3(5), MYST4(5), SH3GLB1(1), TAT(2), TPO(3)	3545939	32	10	32	12	10	14	5	0	3	0	0.509	1.000
296	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(1), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACG(1), PRKG1(5), PRKG2(2)	3204918	26	9	26	11	6	14	4	0	2	0	0.509	1.000
297	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1)	2414568	19	8	19	3	8	8	2	0	1	0	0.510	1.000
298	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GRB2(1), INSR(1), IRS1(3), JAK2(3), MAP2K1(1), MAPK3(1), PIK3R1(5), PRKCA(2), RAF1(2), SLC2A4(1), SOS1(2), STAT5B(1)	3183540	24	8	24	4	7	6	3	0	5	3	0.510	1.000
299	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(1), TPK1(3)	663490	6	3	6	1	4	1	1	0	0	0	0.512	1.000
300	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(2), ACVR1C(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BRAF(2), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CACNA2D1(3), CACNA2D3(3), CACNB2(1), CACNB3(1), CACNB4(2), CACNG2(1), CACNG3(3), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(2), DAXX(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(1), ECSIT(1), EGFR(1), ELK4(1), FAS(2), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FLNA(1), FLNB(2), FLNC(2), FOS(1), GRB2(1), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), MAPT(1), MEF2C(2), MKNK2(1), MOS(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(4), PDGFRB(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN7(1), PTPRR(4), RAF1(2), RAP1A(1), RAPGEF2(5), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KA6(2), RRAS2(1), SOS1(2), SOS2(2), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), ZAK(2)	30137969	249	42	249	77	94	68	49	3	31	4	0.513	1.000
301	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PSAT1(1), RDH11(1), RDH12(1), SARDH(1), SARS(1), SHMT1(1), TARS(3), TARS2(1)	4486547	32	12	32	14	13	14	3	0	2	0	0.514	1.000
302	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH4A1(1), AMD1(1), ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), DAO(4), GOT1(1), MAOA(1), MAOB(1), NOS1(6), OAT(1), ODC1(3), OTC(1), P4HA1(1), P4HA3(1), RARS(2)	4528492	46	11	45	16	18	14	5	1	8	0	0.518	1.000
303	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	163366	1	1	1	0	0	0	1	0	0	0	0.521	1.000
304	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(1), IL2(1), IL2RB(1), JAK1(1), JAK3(2), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3)	2444646	23	7	23	3	5	9	3	1	5	0	0.521	1.000
305	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), SUCLA2(2)	926068	3	3	3	5	0	2	0	0	1	0	0.522	1.000
306	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(1), CAV3(1), DAG1(1), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(6)	4259406	31	12	31	9	13	11	2	0	4	1	0.523	1.000
307	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGPAT1(1), AGPAT4(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), LCT(5), LIPC(1), LIPF(2), PNLIP(2), PNLIPRP2(1)	4970369	38	12	38	14	15	12	6	0	5	0	0.525	1.000
308	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3B1(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), TAT(2), TPO(3)	2286769	17	8	17	10	6	8	0	0	3	0	0.528	1.000
309	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(1), ARHGEF11(2), CDC42(1), DLG4(1), LPA(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PI3(1), PLD1(3), PLD2(1), RDX(1), ROCK1(7), ROCK2(4), SERPINA4(3)	5042120	45	11	45	11	17	15	5	1	7	0	0.531	1.000
310	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKTL1(1), TKTL2(2)	2046293	11	7	11	11	6	3	1	0	1	0	0.532	1.000
311	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(1), CMAS(3), CYB5R1(2), GFPT1(1), GFPT2(1), HEXB(2), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), NANS(1), NPL(1), PGM3(1)	2977927	17	8	17	7	7	5	3	1	1	0	0.533	1.000
312	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(1), RPL11(1), RPL19(1), RPL28(1), RPL6(2), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1)	2308987	14	7	14	4	0	5	7	1	1	0	0.536	1.000
313	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), GNAQ(1), MAPK8(5), PRKCA(2)	1390115	10	5	10	3	3	4	1	1	1	0	0.539	1.000
314	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(3), CD1A(1), CD1B(1), CD1C(1), CD1D(1), CD1E(1), CD22(2), CD33(1), CD38(1), CD5(2), CD55(1), CR1(3), CR2(2), CSF1(1), CSF3R(1), DNTT(2), FLT3(2), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(4), IL5RA(2), IL6(1), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGAM(3), ITGB3(2), KIT(2), MME(4), TFRC(1), THPO(1), TPO(3)	8411864	67	18	67	28	22	31	10	1	3	0	0.543	1.000
315	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(1), BTK(1), EEA1(4), GSK3B(1), PFKM(3), PRKCE(2), VAV2(2)	2641449	14	7	14	7	2	9	1	0	2	0	0.546	1.000
316	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(10), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CREB3(1), CREB3L3(2), E2F3(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MYT1(5), PCNA(1), POLE(4), POLE2(1), RB1(3), RBL1(2), TNXB(3)	7714006	46	16	45	15	12	19	6	1	7	1	0.547	1.000
317	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(3), FYN(1), L1CAM(2), SELP(2)	1633073	11	5	11	6	5	4	1	0	1	0	0.549	1.000
318	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPN2(1), EP300(2), NFATC1(1), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2)	2453746	14	8	14	5	7	4	1	0	2	0	0.551	1.000
319	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT9(1), HEXB(2)	1024738	6	4	6	3	4	1	1	0	0	0	0.554	1.000
320	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(3)	208242	3	1	3	0	1	1	1	0	0	0	0.554	1.000
321	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1316366	8	5	8	3	4	2	0	0	2	0	0.556	1.000
322	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTR2(1), ACTR3(1), CDC42(1), FLNA(1), FLNC(2), LIMK1(1), MYH2(3), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	4901391	38	13	38	6	17	8	4	0	9	0	0.556	1.000
323	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRA1B(1), ADRB1(1), ANXA6(1), ATP1A4(2), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(4), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(3), CHRM2(3), CHRM4(1), CHRM5(1), GJA1(4), GJB3(1), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(3), MYCBP(1), NME7(2), PLCB3(1), PLN(1), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A3(3), USP5(1), YWHAH(1)	20062212	174	36	174	62	67	73	17	0	16	1	0.557	1.000
324	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT2(1), AKT3(1), GRB2(1), MAPK3(1), PDK1(2), PIK3CD(1), PTEN(4), SOS1(2)	1882249	13	6	13	4	3	4	3	0	3	0	0.558	1.000
325	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), TAT(2), TYR(1)	486294	4	2	4	2	1	2	0	0	1	0	0.561	1.000
326	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), UROD(1)	801780	6	3	6	2	3	2	1	0	0	0	0.562	1.000
327	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	AXIN1(1), CREBBP(4), CTNNB1(4), EP300(2), FZD1(1), GSK3B(1), LDB1(2), TRRAP(4)	2780166	19	8	19	4	7	8	2	0	2	0	0.566	1.000
328	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), PRB1(1)	903444	7	4	7	3	1	1	1	0	4	0	0.571	1.000
329	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BCL2L11(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), CHUK(2), DFFA(1), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF3(2), IRF4(2), MAP2K4(2), MAP3K1(2), MAPK10(4), NFKB1(3), TNFRSF10B(4), TNFRSF21(1), TRAF1(1), TRAF3(2)	5801244	45	14	45	12	16	13	6	0	10	0	0.573	1.000
330	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3)	1193363	13	5	13	4	2	8	1	0	2	0	0.574	1.000
331	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(2), FUT1(3), FUT9(1), HEXB(2)	1088001	9	4	9	4	6	1	2	0	0	0	0.579	1.000
332	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	CCKBR(2), CCR3(1), CELSR2(1), CHRM2(3), EMR2(4), EMR3(1), FSHR(1), GPR116(4), GPR133(1), GPR18(2), GPR56(1), GPR77(1), GPR84(3), GRM1(3), LPHN2(3), LPHN3(7), PTGFR(1), SMO(1), SSTR2(1), TAAR5(1), TSHR(1)	6770145	43	16	43	23	18	14	8	1	2	0	0.581	1.000
333	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2)	1039589	6	4	6	3	2	1	3	0	0	0	0.583	1.000
334	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACPP(1), ALPPL2(1), CYP3A43(2), CYP3A7(2), DHRS2(1), PON1(1), PON2(1)	1801057	9	5	9	4	3	4	1	0	0	1	0.586	1.000
335	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHB(1), SRD5A2(1)	2430000	15	7	15	12	2	7	4	0	2	0	0.586	1.000
336	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1)	1053462	6	4	6	1	3	3	0	0	0	0	0.586	1.000
337	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(3), FUT9(1), GCNT2(2)	625550	6	3	6	3	4	1	0	0	1	0	0.588	1.000
338	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(4), EP300(2), IKBKB(2), IL1B(1), IL8(1), MAP2K3(4), MAP2K6(1), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), NR3C1(1), TGFBR1(3), TLR2(4)	3079635	32	7	32	7	9	10	8	1	4	0	0.590	1.000
339	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1), RDH11(1), RDH12(1), UGP2(2)	3995593	28	10	28	7	11	12	4	0	1	0	0.593	1.000
340	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(1), ATM(10), ATR(4), CASP3(1), CCNB3(3), CCNE2(1), CCNG1(1), CDK4(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGFBP3(2), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53I3(2), TSC2(1), ZMAT3(2)	6573136	53	14	53	13	16	24	7	0	5	1	0.594	1.000
341	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(1), AKT2(1), AKT3(1), APAF1(1), ATM(10), BIRC2(2), BIRC3(5), CAPN2(1), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TNFRSF10B(4), TNFRSF10D(1)	8322935	74	15	74	19	25	25	10	0	11	3	0.597	1.000
342	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACYP1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2)	3819614	29	9	29	15	10	11	3	1	4	0	0.597	1.000
343	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXB(2), LCT(5), SLC33A1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2)	1706350	15	6	15	5	7	6	2	0	0	0	0.598	1.000
344	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(3), G6PD(1), GPX3(2), GPX6(1), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), TXNDC12(2)	2235987	13	7	13	2	3	7	3	0	0	0	0.598	1.000
345	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(1), LDLR(1)	549324	3	2	3	2	3	0	0	0	0	0	0.607	1.000
346	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), IL2(1), TGFB2(4), TGFBR1(3), TGFBR3(3), TOB1(2)	1111347	14	4	14	2	3	5	3	0	3	0	0.609	1.000
347	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(2), ESRRA(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D2(3), NR1I3(1), NR2E1(1), NR2F1(1), NR2F6(1), NR3C1(1), NR4A2(2), PPARD(1), RARB(2), ROR1(4), RXRB(1), RXRG(1), VDR(1)	4301651	32	12	32	7	11	9	9	0	3	0	0.611	1.000
348	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), MAP2K1(1), MAPK3(1), NFKB1(3), PRKCA(2), RAF1(2)	1584282	13	4	13	5	7	2	2	0	2	0	0.611	1.000
349	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ACTN1(2), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(3), BRAF(2), CAV1(1), CDC42(1), DOCK1(2), EPHB2(1), FYN(1), GRB2(1), GRLF1(5), ITGA10(4), ITGA11(2), ITGA2(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PLCG2(4), PTEN(4), RAF1(2), RALA(1), RHO(1), ROCK1(7), ROCK2(4), SOS1(2), SOS2(2), TERF2IP(1), TLN1(2), TLN2(3), ZYX(1)	12507754	102	22	102	36	34	30	17	3	18	0	0.616	1.000
350	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K1(1), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(2)	846885	7	3	7	2	3	1	2	0	1	0	0.618	1.000
351	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(2), BTK(1), CDC42(1), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PPP1R13B(1), PTEN(4), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	7140217	68	14	68	9	28	17	6	0	14	3	0.619	1.000
352	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), CASP6(1), CFLAR(1), DAXX(1), DFFA(1), LMNB1(2), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), PTPN13(9), RB1(3), SPTAN1(4)	4461213	41	10	41	9	9	13	9	1	9	0	0.620	1.000
353	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(1), PIR(1), PSMA7(1), WASF1(2), WASF3(2), WASL(2)	1606039	14	5	14	2	5	5	2	0	2	0	0.620	1.000
354	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFKB1(3), NSMAF(2), RAF1(2)	2138165	18	6	18	8	7	6	2	1	2	0	0.621	1.000
355	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(4), ACACB(1), ACADM(3), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), HIBCH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1)	4114672	35	10	35	7	8	14	4	0	9	0	0.623	1.000
356	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(1)	419210	3	2	3	0	0	2	0	0	1	0	0.628	1.000
357	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1B2(1), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(1), EIF2B2(1), EIF4A2(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(2), PAIP1(3)	4583750	21	10	21	6	5	7	4	1	4	0	0.629	1.000
358	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(4), EP300(2), FYN(1), IL7(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3R1(5), STAT5B(1)	2699440	20	6	20	5	6	10	0	0	2	2	0.631	1.000
359	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADHA(1), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1)	1217545	7	4	7	4	1	2	1	0	3	0	0.631	1.000
360	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	AKT2(1), AKT3(1), BTK(1), DAPP1(1), GRB2(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(1), PTEN(4), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TEC(2), YWHAH(1)	3514816	27	9	27	7	7	10	7	0	3	0	0.634	1.000
361	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(1), TAF1(5), TAF1L(6), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1)	3726636	28	9	28	3	7	9	5	0	7	0	0.636	1.000
362	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(3), ITGB2(1), PTPRC(8)	1103542	13	4	13	5	3	6	1	0	3	0	0.637	1.000
363	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRB1(1), CSNK1D(1), DRD2(2), EGFR(1), GJA1(4), GJD2(1), GNAI1(1), GNAQ(1), GRB2(1), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(1), HTR2C(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR2(1), PDGFC(1), PDGFRA(4), PDGFRB(1), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), SOS1(2), SOS2(2), TJP1(2), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1)	13675071	123	27	123	35	42	47	19	0	13	2	0.643	1.000
364	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(3), SPN(1), TGFB2(4), TNFRSF8(1)	1417332	13	5	13	4	3	4	3	0	3	0	0.646	1.000
365	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8IP3(1), PAPPA(5), RPS6KA3(2), SOS1(2), SYK(3), VAV1(2), VAV2(2), VAV3(2)	3281130	28	9	28	3	8	15	2	0	3	0	0.647	1.000
366	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP3(1), CRADD(1), DFFA(1), LMNB1(2), MADD(1), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), RB1(3), SPTAN1(4)	4139843	31	10	31	10	10	6	7	1	7	0	0.649	1.000
367	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(2), F2(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), LPA(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2), VWF(5)	3612160	30	9	30	13	10	13	4	0	3	0	0.650	1.000
368	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	2589488	19	6	19	2	2	11	3	0	3	0	0.653	1.000
369	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(1), ENPP3(1), LHPP(1), MTMR1(1), MTMR2(1), TYR(1)	1562482	6	4	6	6	4	1	0	0	0	1	0.656	1.000
370	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(3), CD28(1), CSK(2), CTLA4(1), DAG1(1), DTYMK(1), EPHB2(1), GRAP2(3), GRB2(1), ITK(3), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PTPRC(8), RAF1(2), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), SOS1(2), SOS2(2), VAV1(2)	5608754	58	13	58	9	23	22	6	0	7	0	0.657	1.000
371	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(3), ITGB2(1), PTPRC(8)	1165152	13	4	13	5	3	6	1	0	3	0	0.657	1.000
372	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(2)	272049	3	1	3	1	0	2	0	0	1	0	0.657	1.000
373	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(1), DLD(1), DLST(1), IDH3A(3), PC(3), PDHA1(1), PDHA2(2), PDK1(2), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SUCLA2(2), SUCLG1(1)	2969819	22	8	22	11	7	8	4	0	3	0	0.657	1.000
374	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(1), FUT8(1)	809447	3	3	3	2	1	1	0	0	1	0	0.660	1.000
375	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(5), ITGAL(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3)	1350187	15	4	15	3	1	9	3	0	2	0	0.661	1.000
376	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), IL2(1), IL6(1), IL7(1), IL8(1), IL9(1)	649225	6	2	6	4	2	4	0	0	0	0	0.662	1.000
377	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(5), PGM1(2), PYGM(2)	1408399	9	5	9	2	8	1	0	0	0	0	0.665	1.000
378	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3)	1084914	6	3	6	3	1	3	0	0	1	1	0.667	1.000
379	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3)	1084914	6	3	6	3	1	3	0	0	1	1	0.667	1.000
380	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	SDHA(1), SUCLA2(2)	979996	3	3	3	4	0	3	0	0	0	0	0.667	1.000
381	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2B(3), POLR2K(1)	1372058	6	4	6	1	3	2	1	0	0	0	0.667	1.000
382	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(10), ATR(4), BRCA1(1), BRCA2(11), FANCA(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(5), RAD17(2), RAD50(6)	4498321	48	8	48	6	8	25	10	0	4	1	0.674	1.000
383	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GNS(3), HEXB(2), LCT(5), NAGLU(1)	1505826	11	5	11	3	5	4	1	0	1	0	0.676	1.000
384	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(10), ATR(4), BRCA1(1), CDC25C(1), EP300(2), MYT1(5), PRKDC(5), YWHAH(1)	4404728	29	9	29	7	8	14	4	0	2	1	0.677	1.000
385	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(1), ANAPC4(3), ANAPC5(1), BTRC(3), CDC16(1), CDC27(4), CUL1(1), CUL2(1), FBXW11(1), RBX1(1), SMURF1(2), UBA1(1), UBE2D3(1), UBE2E2(1), VHL(1), WWP1(3)	4032333	26	8	26	12	8	9	5	0	4	0	0.677	1.000
386	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1)	446940	1	1	1	1	0	1	0	0	0	0	0.679	1.000
387	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	390132	3	2	3	2	1	0	2	0	0	0	0.683	1.000
388	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(2), HEXB(2), LCT(5), MAN2B1(1), MANBA(1), NEU1(1)	2085183	14	6	14	6	6	4	1	0	3	0	0.683	1.000
389	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(1), GAD1(2)	599279	3	2	3	3	1	2	0	0	0	0	0.684	1.000
390	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(4), ACACB(1), AKT2(1), AKT3(1), BRAF(2), CBL(3), CBLB(2), EXOC7(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GRB2(1), GSK3B(1), GYS1(1), GYS2(3), IKBKB(2), INPP5D(2), INSR(1), IRS1(3), IRS4(4), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MKNK2(1), PCK1(3), PDE3B(1), PFKM(3), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R3A(5), PPP1R3C(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKACG(1), PRKAG2(1), PRKAG3(2), PRKAR1A(4), PRKAR2B(1), PTPN1(1), PTPRF(1), PYGM(2), RAF1(2), RAPGEF1(2), RPS6KB2(1), SHC2(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(4), SOS1(2), SOS2(2), TSC1(1), TSC2(1)	16096696	127	27	127	36	47	37	19	1	21	2	0.687	1.000
391	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(2), FARS2(1), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), MTFMT(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(2), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1)	5494247	35	11	35	10	7	16	8	1	3	0	0.688	1.000
392	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1)	1193575	6	4	6	1	3	3	0	0	0	0	0.691	1.000
393	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), DHFR(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1)	1866340	10	5	10	4	4	5	0	0	1	0	0.691	1.000
394	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), CASP3(1), GZMB(1)	1332071	6	4	6	1	0	1	3	0	2	0	0.691	1.000
395	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), NAGS(1), OAT(1), ODC1(3), OTC(1)	1797467	19	5	19	4	8	5	3	0	3	0	0.693	1.000
396	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL18(1), CCL22(1), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(2), EGFR(1), FAS(2), FLT1(3), FLT3(2), FLT4(1), GDF5(1), GH1(1), GH2(2), HGF(3), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(2), LEPR(4), LIFR(5), LTBR(1), MET(1), MPL(1), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF13B(1), TPO(3), VEGFC(3), XCR1(1)	18006642	148	28	148	46	36	63	26	1	21	1	0.693	1.000
397	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(1), GPX3(2), GSTA3(1), GSTM3(1), GSTO2(1)	1866994	9	5	9	2	2	5	2	0	0	0	0.695	1.000
398	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(3), CRY1(3), CSNK1D(1), PER3(2)	1770505	12	5	12	1	2	3	3	0	3	1	0.700	1.000
399	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), FAS(2), GZMB(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), MAPK10(4), NFKB1(3), TRAF1(1)	3779030	26	9	26	7	8	6	5	0	7	0	0.703	1.000
400	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(2), UXS1(1)	527333	5	2	5	0	0	3	1	0	1	0	0.704	1.000
401	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSS(1), ASL(2), ASPA(2), CAD(1), DARS(1), GAD1(2), GOT1(1), NARS(1), PC(3)	2707382	15	6	15	11	7	5	2	0	1	0	0.704	1.000
402	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT2(1), AKT3(1), CARD11(3), CBL(3), CBLB(2), CD28(1), CDC42(1), CDK4(1), CHUK(2), CTLA4(1), FOS(1), FYN(1), GRAP2(3), GRB2(1), IKBKB(2), IL10(1), IL2(1), ITK(3), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCQ(1), PTPRC(8), RASGRP1(3), RHOA(1), SOS1(2), SOS2(2), TEC(2), VAV1(2), VAV2(2), VAV3(2)	10196908	95	19	95	19	40	32	11	0	10	2	0.704	1.000
403	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CDK4(1), CDKN1B(2), RB1(3), RBL1(2)	1652652	10	5	10	3	3	1	2	0	4	0	0.705	1.000
404	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4)	1761784	12	5	11	5	2	4	3	0	3	0	0.708	1.000
405	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1)	1162243	7	4	7	2	3	1	3	0	0	0	0.711	1.000
406	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), EGFR(1), GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), MEF2A(1), MEF2C(2), PAK1(1), PRKCA(2), RAF1(2), SOS1(2)	3536762	29	8	29	4	7	11	5	1	5	0	0.712	1.000
407	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), B4GALT3(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), RPN2(1)	2009446	8	5	8	7	2	2	1	0	3	0	0.713	1.000
408	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(1), MAP2K5(2), MAPK8(5), PLD1(3), PLD2(1), RAF1(2), RASAL1(1), TEC(2), VAV1(2)	2892926	24	7	24	6	10	8	4	1	1	0	0.716	1.000
409	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT2(1), AKT3(1), CAP1(1), CBL(3), CDC42(1), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(2), PDK1(2), PIK3CD(1), PIK3R1(5), PPYR1(3), PTEN(4), PTPN1(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), SERPINB6(1), SLC2A4(1), SORBS1(4), SOS1(2), SOS2(2), YWHAH(1)	5746160	58	11	58	10	23	15	9	0	9	2	0.717	1.000
410	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CHUK(2), CPT1A(1), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(4), JAK1(1), JAK2(3), JAK3(2), LEPR(4), MAPK10(4), MAPK8(5), MAPK9(2), NFKB1(3), NFKB2(2), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(3), RXRB(1), RXRG(1), SLC2A1(1), SLC2A4(1)	8446597	66	16	66	16	19	26	7	2	11	1	0.723	1.000
411	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), DHFR(1), MTFMT(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1)	1964714	11	5	11	4	4	6	0	0	1	0	0.727	1.000
412	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK8(5), NFKB1(3), TNFSF13B(1), TRAF3(2), TRAF5(2)	1528752	16	4	16	4	4	5	4	1	2	0	0.729	1.000
413	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(1), ENPP3(1), NADK(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5C1B(1), NT5C2(1), NT5E(1)	2251735	15	6	15	7	5	5	2	0	3	0	0.729	1.000
414	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), DHFR(1), IMPDH1(1), POLB(2), POLG(1), RRM1(1)	1334227	7	4	7	3	4	1	1	0	1	0	0.729	1.000
415	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2)	1389687	11	4	11	5	1	5	3	0	2	0	0.730	1.000
416	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(3), FURIN(1)	858391	5	3	5	1	2	0	0	0	3	0	0.731	1.000
417	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1)	629855	2	2	2	3	2	0	0	0	0	0	0.732	1.000
418	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(1), HMGCS2(1)	751997	2	2	2	2	2	0	0	0	0	0	0.736	1.000
419	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1), HLA-DRB1(1)	224517	3	1	3	0	2	1	0	0	0	0	0.737	1.000
420	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GNS(3), HEXB(2), HPSE2(3), LCT(5), NAGLU(1), SPAM1(3)	2148768	17	6	17	4	8	6	2	0	1	0	0.739	1.000
421	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUD2(2), GLUL(1), HAL(1)	2182587	14	5	14	6	4	8	0	0	2	0	0.741	1.000
422	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), AMY2A(2), AMY2B(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(1), ENPP3(1), EP400(2), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), MOV10L1(7), PGM1(2), PGM3(1), PYGM(2), RAD54B(2), SETX(9), SI(3), SKIV2L2(1), SMARCA2(2), SMARCA5(4), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UXS1(1)	12753461	89	21	89	17	22	30	18	0	19	0	0.741	1.000
423	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(1), ENPP3(1), TYR(1)	1011230	3	2	3	5	1	1	0	0	0	1	0.741	1.000
424	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNGT1(1), HTR2C(2), TUB(1)	738892	5	2	5	2	1	2	1	0	1	0	0.746	1.000
425	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A7(2), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	5727549	47	11	47	12	8	18	14	0	7	0	0.747	1.000
426	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), RAF1(2), SOS1(2), STAT5B(1)	1761812	12	4	12	2	3	4	2	0	2	1	0.749	1.000
427	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(1), DHDDS(1), DPAGT1(1), FUT8(1), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), RPN2(1), STT3B(2)	4383801	25	8	25	11	7	9	5	0	4	0	0.752	1.000
428	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(1), GRB2(1), GSK3B(1), INPP5D(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PTPRC(8), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2)	7423918	72	14	72	9	28	25	5	0	11	3	0.755	1.000
429	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2)	680113	6	2	6	1	3	1	0	1	1	0	0.759	1.000
430	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2)	680113	6	2	6	1	3	1	0	1	1	0	0.759	1.000
431	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12A(1), IL12RB2(1), IL18R1(2), JAK2(3), MAP2K6(1), MAPK8(5), STAT4(3)	1926374	17	4	17	3	1	8	4	1	2	1	0.760	1.000
432	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1)	945861	8	3	8	2	1	5	2	0	0	0	0.761	1.000
433	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B4GALNT1(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2), ST3GAL6(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2)	5024214	38	10	38	14	12	17	6	1	2	0	0.762	1.000
434	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS2(1), SUCLA2(2)	1377449	4	3	4	6	0	3	0	0	1	0	0.766	1.000
435	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(1), EPHB2(1), GRB2(1), MAP2K1(1), MAP2K2(1), NFKB1(3), NFKB2(2), PI3(1), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(3), SOS1(2), SOS2(2), SYK(3), VAV1(2)	5152312	43	10	43	6	18	12	5	0	6	2	0.766	1.000
436	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(1)	175407	1	1	1	0	0	1	0	0	0	0	0.769	1.000
437	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), MAPK8(5), NFKB1(3), TNFRSF11A(1)	1137337	12	3	12	3	5	5	1	1	0	0	0.769	1.000
438	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(1), ATM(10), CASP3(1), CASP6(1), PRKCA(2), TLN1(2)	2787839	17	6	17	4	1	10	2	0	3	1	0.770	1.000
439	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(1)	597755	1	1	1	2	0	1	0	0	0	0	0.771	1.000
440	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(1), THBS1(2)	759323	5	2	5	1	2	2	1	0	0	0	0.776	1.000
441	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(5), NEU1(1), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SPHK1(1), UGT8(2)	3609863	20	8	20	8	10	5	2	0	2	1	0.776	1.000
442	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1)	1828269	7	4	7	8	5	1	0	0	1	0	0.777	1.000
443	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TNFAIP3(1), TRAF3(2)	1906657	13	5	13	3	3	7	2	0	1	0	0.777	1.000
444	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(1), HDAC5(1), MEF2A(1), MEF2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), SLC2A4(1), YWHAH(1)	2161965	17	5	17	6	7	7	0	0	3	0	0.777	1.000
445	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(2), CAMK4(1), CD69(1), CNR1(2), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(5), GSK3B(1), IL10(1), IL1B(1), IL2(1), IL6(1), IL8(1), ITK(3), MAPK8(5), MAPK9(2), MEF2A(1), MYF5(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(2), NPPB(1), NUP214(2), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(1), PTPRC(8), SP3(1), TRPV6(2), VAV1(2), VAV2(2), VAV3(2), XPO5(1)	9385994	74	17	74	23	29	25	8	1	11	0	0.779	1.000
446	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12A(1), IL12RB2(1), JAK2(3), STAT4(3)	1520373	8	3	8	2	0	3	3	0	1	1	0.780	1.000
447	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1)	5023122	34	10	34	17	11	12	7	0	4	0	0.782	1.000
448	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1)	5023122	34	10	34	17	11	12	7	0	4	0	0.782	1.000
449	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(1), ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARPC2(1), ARPC5L(1), BAIAP2(1), BDKRB2(1), BRAF(2), CDC42(1), CHRM2(3), CHRM4(1), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGFR(1), F2(1), FGD1(2), FGD3(1), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FN1(4), GIT1(1), GRLF1(5), IQGAP1(3), IQGAP2(3), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MOS(1), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(2), MYLK(3), MYLK2(1), NCKAP1(1), NCKAP1L(4), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFRA(4), PDGFRB(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), RAF1(2), RDX(1), RHOA(1), ROCK1(7), ROCK2(4), RRAS2(1), SCIN(1), SLC9A1(2), SOS1(2), SOS2(2), SSH1(2), SSH3(1), TIAM1(5), TIAM2(2), VAV1(2), VAV2(2), VAV3(2), VCL(1), WASF1(2), WASL(2)	28232609	216	36	216	69	72	78	28	4	32	2	0.784	1.000
450	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(8)	921740	12	3	12	1	3	6	1	0	2	0	0.787	1.000
451	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1)	301230	1	1	1	0	1	0	0	0	0	0	0.788	1.000
452	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	CDH1(1), CREBBP(4), EP300(2), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(4), TGFBR1(3)	2084086	19	5	19	4	4	6	4	0	5	0	0.791	1.000
453	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT2(1), GALNT6(1), GALNT7(1), GALNT8(1), GCNT1(2), WBSCR17(2)	1489580	8	3	8	3	3	3	2	0	0	0	0.791	1.000
454	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), DIAPH2(3), MCM10(2), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), POLE(4), POLE2(1), RFC1(4), RFC5(1), RPA4(1), UBB(1)	5280323	27	10	26	8	7	16	1	0	3	0	0.792	1.000
455	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(2), NFKB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	2811350	23	7	23	8	12	7	1	0	3	0	0.794	1.000
456	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACYP1(1), DHRS2(1), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1)	2629022	21	6	21	7	6	7	6	0	2	0	0.794	1.000
457	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	1680451	9	4	9	1	2	5	0	0	2	0	0.795	1.000
458	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), PRKCA(2)	856733	6	2	6	4	4	1	0	0	1	0	0.796	1.000
459	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP4A11(1), CYP4F3(1), GPX3(2), GPX6(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1)	4074909	24	9	24	9	11	6	5	0	2	0	0.797	1.000
460	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTTN(1), EPB41L1(1), EPB41L3(3), EXOC4(3), GNAI1(1), HCLS1(1), IGSF5(2), INADL(2), LLGL2(2), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(7), MYH10(2), MYH11(6), MYH13(5), MYH14(3), MYH15(4), MYH2(3), MYH3(5), MYH4(1), MYH6(4), MYH7(4), MYH7B(2), MYH8(3), MYH9(3), MYL9(2), PARD3(2), PARD6A(2), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP2R3A(2), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PTEN(4), RHOA(1), RRAS2(1), SPTAN1(4), TJAP1(1), TJP1(2), ZAK(2)	20122081	158	31	157	54	59	58	17	0	23	1	0.798	1.000
461	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(1)	530187	7	2	7	3	4	3	0	0	0	0	0.799	1.000
462	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), UGDH(1)	882392	7	3	7	1	1	3	1	0	2	0	0.805	1.000
463	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(1)	1250523	6	3	6	2	2	2	0	0	2	0	0.806	1.000
464	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(1), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), PGM1(2), PGM3(1), PYGM(2), SI(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1)	5829365	35	10	35	10	10	12	6	0	7	0	0.808	1.000
465	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), IFNGR2(1), JAK1(1), JAK2(3)	854289	6	2	6	1	1	2	0	0	2	1	0.810	1.000
466	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(1), GRB2(1), HSPB2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MEF2A(1), MEF2C(2), PLA2G4A(3), RPS6KA5(3), TGFB2(4), TGFBR1(3)	3841159	31	8	31	9	10	9	5	0	7	0	0.813	1.000
467	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(1), PTPRC(8)	1555123	20	4	20	6	4	10	3	0	3	0	0.813	1.000
468	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ATM(10), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDAN1(2), CDC14A(3), CDC14B(1), CDC25C(1), CDC6(1), CDC7(1), CDH1(1), CDK4(1), E2F3(1), EP300(2), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MPEG1(2), MPL(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2)	11447430	63	18	63	20	18	25	11	1	7	1	0.815	1.000
469	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(1), PSMD2(1), PSMD6(1)	1663407	12	3	12	0	5	5	1	0	1	0	0.816	1.000
470	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO3(1), FARS2(1), GOT1(1), TAT(2)	856962	5	2	5	2	0	3	0	0	2	0	0.817	1.000
471	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(2), WASL(2)	849834	9	2	9	1	4	1	2	0	2	0	0.817	1.000
472	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BTK(1), CAD(1), CASP3(1), CASP8AP2(6), DAXX(1), DEDD(1), DFFA(1), EGFR(1), EPHB2(1), IL8(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), PTPN13(9), RALBP1(2), ROCK1(7), TPX2(1)	7517531	57	13	57	16	15	22	11	1	8	0	0.818	1.000
473	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ANKRD1(2), IFRD1(3), IL1R1(1), MYOG(1), NR4A3(2)	1143542	9	3	9	1	4	3	1	0	1	0	0.819	1.000
474	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1)	285259	3	1	3	2	2	1	0	0	0	0	0.820	1.000
475	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1)	2252124	17	5	17	2	4	6	3	1	2	1	0.820	1.000
476	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2), HSPB2(1), MTA3(1), TUBA8(1)	1100771	5	3	5	2	2	2	1	0	0	0	0.820	1.000
477	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), PPAT(3), QARS(1)	3428010	19	7	19	6	5	8	3	0	3	0	0.827	1.000
478	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA7(1), PSMB3(1), PSMD14(1), RPN2(1), UBE3A(5)	1357020	10	3	10	1	2	6	2	0	0	0	0.828	1.000
479	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL12A(1), IL2(1), IL6(1), IL7(1), IL8(1), TGFB2(4)	1350769	13	3	13	5	3	8	1	0	1	0	0.830	1.000
480	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(3), ATP5C1(2), DCK(1), ENPP3(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NPR2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE6C(2), PDE7B(1), PDE9A(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), PPAT(3), PRPS1(1), PRUNE(1), RRM1(1)	13427681	96	24	95	31	31	34	15	0	16	0	0.832	1.000
481	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CFLAR(1)	394525	2	1	2	0	0	1	1	0	0	0	0.833	1.000
482	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(3), EGFR(1), GRB2(1), MAP2K1(1), MAPK3(1), RAF1(2), RASA1(4), SOS1(2), SPRY1(1)	2545826	16	4	16	6	7	4	3	0	2	0	0.833	1.000
483	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(1), ACOT12(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2)	4833706	37	9	37	14	10	16	4	1	6	0	0.833	1.000
484	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSB(1), GOT1(1), TAT(2), YARS2(1)	902256	6	2	6	2	0	5	0	0	1	0	0.836	1.000
485	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(3), NFKB1(3), RB1(3), USH1C(3), WT1(2)	1789811	19	4	19	5	6	8	1	0	3	1	0.841	1.000
486	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	643831	4	2	4	1	1	1	2	0	0	0	0.841	1.000
487	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), SQLE(1)	347094	2	1	2	0	0	1	1	0	0	0	0.841	1.000
488	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), ALAS2(1), FECH(1), GATA1(1), HBB(1), UROD(1)	853818	7	3	7	1	3	4	0	0	0	0	0.844	1.000
489	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), SOS1(2)	912443	3	2	3	1	0	2	1	0	0	0	0.845	1.000
490	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP1A2(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A43(2), CYP3A7(2), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1)	2487146	20	5	20	6	9	4	5	0	2	0	0.847	1.000
491	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), BECN1(1), IFNA10(2), IFNA2(1), PIK3C3(2), PRKAA1(1), PRKAA2(3), ULK1(1)	2158174	13	4	13	3	3	5	2	0	3	0	0.850	1.000
492	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB9A(1)	449053	3	1	3	0	1	1	0	0	1	0	0.851	1.000
493	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), DFFA(1)	1413104	11	3	11	1	3	4	1	0	3	0	0.852	1.000
494	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT2(1), AKT3(1), GRB2(1), IARS(1), IL13RA1(1), INPP5D(2), JAK1(1), JAK2(3), JAK3(2), PI3(1), PPP1R13B(1), SERPINA4(3), SOS1(2), SOS2(2)	3620765	22	7	22	1	5	9	4	0	3	1	0.855	1.000
495	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(1), ETS1(1), ETS2(1), ETV3(1), FOS(1), HDAC5(1), RBL1(2), SIN3A(6), SIN3B(1)	2745639	16	5	16	9	7	7	2	0	0	0	0.856	1.000
496	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), STAT2(2)	1117513	4	2	4	2	1	2	0	0	1	0	0.857	1.000
497	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP3(1), WT1(2)	630710	3	2	3	1	2	1	0	0	0	0	0.858	1.000
498	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(1), OXSM(1)	1546745	6	4	6	3	3	1	0	0	2	0	0.858	1.000
499	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(1), LDHA(1), LDHB(2)	693110	6	2	6	2	2	3	0	0	1	0	0.858	1.000
500	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), JAK1(1), JAK2(3), JAK3(2), STAT5B(1)	1918838	8	4	8	3	0	4	0	0	3	1	0.863	1.000
501	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2D(1), F2(1), FYN(1), GNAI1(1), GNGT1(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), MAPT(1), MYLK(3), PRKCA(2), RAF1(2), SOS1(2)	4357168	29	8	29	10	7	13	5	1	2	1	0.864	1.000
502	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ATM(10), BRCA1(1), MAPK8(5), MRE11A(5), NFKB1(3), RAD50(6)	2981708	30	5	30	6	7	16	4	1	1	1	0.865	1.000
503	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), SLC23A2(1), SLC2A1(1)	2688954	10	5	10	5	4	3	0	0	3	0	0.867	1.000
504	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	GPI(1)	905773	1	1	1	4	0	0	1	0	0	0	0.867	1.000
505	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ6(1)	432408	2	1	2	0	0	1	1	0	0	0	0.869	1.000
506	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CREB3(1), CREB5(2), ERBB4(5), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), MET(1), NOLC1(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PARD3(2), PARD6A(2), PDK1(2), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(4), PTPN1(1), RPS6KA2(2), RPS6KA3(2), SLC2A4(1), SOS1(2), SOS2(2), TSC1(1), TSC2(1), YWHAH(1)	7571703	60	12	60	15	18	20	9	1	12	0	0.869	1.000
507	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHFR(1), DHX58(1), EP400(2), ERCC3(1), MOV10L1(7), RAD54B(2), SETX(9), SKIV2L2(1), SMARCA2(2), SMARCA5(4)	6552695	44	12	44	4	12	13	8	0	11	0	0.872	1.000
508	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK3(1), PFKFB1(1), PFKM(3), PMM1(2), SORD(2)	2512407	17	6	17	3	6	9	2	0	0	0	0.872	1.000
509	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CSNK1D(1), GSK3B(1), MAPT(1)	981430	4	2	4	4	3	1	0	0	0	0	0.873	1.000
510	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(2), IL6(1), IL9(1), TGFB2(4)	879053	8	2	8	5	1	5	1	0	1	0	0.875	1.000
511	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), GSK3B(1)	1196839	3	2	3	2	0	3	0	0	0	0	0.876	1.000
512	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL2(1)	316089	2	1	2	1	0	2	0	0	0	0	0.880	1.000
513	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1)	390117	6	1	6	0	2	4	0	0	0	0	0.882	1.000
514	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC3F(1), APOBEC3G(1), APOBEC4(2)	761460	5	2	5	2	2	2	1	0	0	0	0.883	1.000
515	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CYP2C9(3), DHRS2(1), ESCO1(4), ESCO2(1), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1)	3151963	27	6	27	7	7	10	7	0	3	0	0.884	1.000
516	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(1), GFPT1(1), HEXB(2), HK3(1), PGM3(1)	1765852	9	3	9	1	2	5	2	0	0	0	0.887	1.000
517	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST6GALNAC2(1), ST6GALNAC4(1)	583702	2	2	2	2	0	2	0	0	0	0	0.887	1.000
518	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(2), FADS2(1), HADHA(1)	1394068	4	4	4	6	2	1	0	0	1	0	0.891	1.000
519	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ADSS(1), ASL(2), ASPA(2), ASS1(1), CAD(1), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GOT1(1), NARS(1), NARS2(3), PC(3), PDHA1(1), PDHA2(2)	3938694	25	7	25	15	12	7	4	0	2	0	0.891	1.000
520	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TANK(3), TNFAIP3(1), TRAF1(1), TRAF3(2)	2341968	17	5	17	5	6	7	3	0	1	0	0.891	1.000
521	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1)	1213896	6	2	6	2	1	4	0	0	1	0	0.892	1.000
522	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKACG(1), PRKAR2B(1)	1049906	4	3	4	2	2	1	0	0	1	0	0.892	1.000
523	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(1), XPO1(1)	900622	2	2	2	2	1	1	0	0	0	0	0.894	1.000
524	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IRS1(3), JAK1(1), JAK3(2)	1518907	7	3	7	2	1	3	1	0	2	0	0.894	1.000
525	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2A1(3), CASP3(1), CASP4(2), CASP6(1), CD40(1), CRADD(1), DAXX(1), DFFA(1), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(1), PTPN13(9), TRAF1(1), TRAF3(2)	4580192	32	8	32	13	7	12	7	0	6	0	0.897	1.000
526	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	1384980	7	3	7	3	3	2	2	0	0	0	0.897	1.000
527	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT2(1), AKT3(1), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), PIK3CD(1), SOS1(2)	1464745	9	3	9	3	2	4	3	0	0	0	0.898	1.000
528	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PSAT1(1)	503223	4	1	4	0	0	3	0	0	1	0	0.900	1.000
529	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), FUCA1(2), GNS(3), HEXB(2), HPSE2(3), LCT(5), MAN2B1(1), MANBA(1), NAGLU(1), NEU1(1), SPAM1(3)	3577556	24	7	24	9	10	8	2	0	4	0	0.902	1.000
530	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(1), GCDH(2), HADHA(1)	813961	4	2	4	2	1	1	1	0	1	0	0.903	1.000
531	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1), PGM1(2), PGM3(1)	5954183	40	10	40	18	11	17	8	0	4	0	0.904	1.000
532	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), NCOA1(2), NCOA2(3)	1914638	11	4	11	2	6	3	2	0	0	0	0.908	1.000
533	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2)	1797879	6	4	6	6	2	1	3	0	0	0	0.909	1.000
534	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1), SQLE(1)	458529	3	1	3	1	0	2	1	0	0	0	0.910	1.000
535	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GOT1(1), GPI(1), HK3(1), LDHA(1), LDHAL6B(1), LDHB(2), PC(3), PCK1(3), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1)	4332244	28	8	28	17	9	12	3	0	4	0	0.910	1.000
536	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(1), ENPP3(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5E(1)	1520657	12	3	12	6	2	5	2	0	3	0	0.912	1.000
537	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CPT1A(1), CPT2(1), CYP4A11(1), GCDH(2), HADHA(1), HADHB(1), HSD17B10(1)	5074012	28	8	28	13	5	12	4	1	6	0	0.913	1.000
538	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), CTCFL(1), EHMT2(2), EZH1(1), FBXO11(1), HSF4(1), MEN1(1), MLL(6), MLL2(3), MLL3(6), MLL4(3), MLL5(6), NSD1(3), OGT(1), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(6), PRMT7(1), PRMT8(2), SATB1(1), SETD1A(1), SETD2(6), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(1), SUV39H2(1), SUV420H1(3), SUZ12(1), WHSC1(1)	12525939	79	18	79	12	23	28	10	0	17	1	0.913	1.000
539	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), MAPK3(1)	1578558	7	3	7	2	3	3	0	0	1	0	0.914	1.000
540	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(2), AGTR2(1), COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), REN(2)	2697611	17	5	17	5	5	8	1	0	3	0	0.915	1.000
541	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), DFFA(1), GZMB(1), SCAP(1)	1871719	12	4	12	2	3	5	1	0	3	0	0.915	1.000
542	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP3(1), INSR(1), MAGI1(3), MAGI2(5), WWP1(3)	2437286	15	5	15	3	5	2	5	0	3	0	0.918	1.000
543	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), CRADD(1), DAXX(1), DFFA(1), LMNB1(2), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK8(5), NFKB1(3), NUMA1(2), PAK2(1), PRKDC(5), RASA1(4), RB1(3), SPTAN1(4), TRAF1(1)	7263620	50	11	50	10	17	14	9	1	9	0	0.920	1.000
544	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), EGFR(1), EP300(2), FER(2), FGFR1(1), FYN(1), IGF1R(1), INSR(1), IQGAP1(3), LMO7(1), MAP3K7(2), MAPK3(1), MET(1), MLLT4(3), PARD3(2), PTPN1(1), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), RHOA(1), SMAD3(3), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TGFBR1(3), TJP1(2), VCL(1), WASF1(2), WASF3(2), WASL(2)	11835140	86	18	86	22	32	35	9	0	9	1	0.921	1.000
545	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(1), BRAF(2), DAG1(1), DRD2(2), EGFR(1), EPHB2(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), PI3(1), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(2), SOS2(2), TERF2IP(1)	6141485	38	10	38	6	18	10	5	0	4	1	0.921	1.000
546	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPPL2(1), DHFR(1)	661507	2	2	2	0	0	2	0	0	0	0	0.922	1.000
547	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFA(1), GZMB(1), TOP2A(3), TOP2B(4)	1080557	10	2	10	2	1	4	3	0	2	0	0.922	1.000
548	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), GOSR2(1), SEC22B(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1)	1695963	15	4	15	3	4	4	3	0	4	0	0.923	1.000
549	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	GAL3ST1(2), LCT(5), NEU1(1)	2451793	8	5	8	6	5	2	0	0	1	0	0.924	1.000
550	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(4), DFFA(1), GZMA(1), GZMB(1)	1111386	9	3	9	3	5	3	0	0	1	0	0.928	1.000
551	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2)	830564	5	2	5	2	1	2	1	0	1	0	0.929	1.000
552	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2)	830564	5	2	5	2	1	2	1	0	1	0	0.929	1.000
553	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), DFFA(1), GZMB(1), LMNB1(2)	1998616	16	4	16	3	4	6	1	0	5	0	0.931	1.000
554	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN2(1), EGFR(1), MAPK3(1), MYLK(3), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TLN1(2)	3452323	15	6	15	7	6	6	1	0	2	0	0.931	1.000
555	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), GNGT1(1), GRB2(1), IGF1R(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), NGFR(1), PDGFRA(4), PTPRR(4), RAF1(2), RPS6KA5(3), SOS1(2)	3443297	24	6	24	7	7	8	7	0	1	1	0.932	1.000
556	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), MAP3K14(1), NFKB1(3)	970373	6	2	6	2	3	1	2	0	0	0	0.933	1.000
557	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(3), BIRC2(2), BIRC3(5), BRAF(2), CAPN2(1), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), CTNNB1(4), DOCK1(2), EGFR(1), FIGF(2), FLNA(1), FLNB(2), FLNC(2), FLT1(3), FN1(4), FYN(1), GRB2(1), GRLF1(5), GSK3B(1), HGF(3), IGF1R(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KDR(2), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), MAP2K1(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MET(1), MYL9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFC(1), PDGFRA(4), PDGFRB(1), PGF(1), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(2), PTEN(4), RAF1(2), RAP1A(1), RAPGEF1(2), RELN(9), RHOA(1), ROCK1(7), ROCK2(4), SHC2(1), SOS1(2), SOS2(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TLN1(2), TLN2(3), TNC(3), TNN(2), TNR(2), TNXB(3), VAV1(2), VAV2(2), VAV3(2), VCL(1), VEGFC(3), VTN(3), VWF(5), ZYX(1)	37906722	292	42	292	112	103	102	42	4	38	3	0.933	1.000
558	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(2), NCOA3(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	2120312	17	4	17	4	6	8	1	0	2	0	0.939	1.000
559	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	INPP4A(1), INPP4B(2), INPPL1(1), MINPP1(1), OCRL(4), PI4KA(4), PIK3C3(2), PIK3CD(1), PIK3CG(2), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PTEN(4), SYNJ1(3), SYNJ2(1)	7511299	38	12	38	15	9	17	5	0	7	0	0.939	1.000
560	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), CPT1A(1), CPT2(1), HADHA(1), SLC25A20(1)	1741765	9	3	9	3	2	3	1	0	3	0	0.939	1.000
561	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(1), COPS5(1), EP300(2), HIF1A(2), LDHA(1), VHL(1)	1719183	9	3	9	1	4	2	1	0	2	0	0.942	1.000
562	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUL(1), HAL(1)	1950093	12	3	12	5	4	6	0	0	2	0	0.943	1.000
563	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(1), CCR4(1), CCR7(2), CD28(1), CXCR4(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1), TGFB2(4)	2040347	17	4	17	4	4	9	2	0	2	0	0.943	1.000
564	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT2(1), AKT3(1), DAG1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PLD1(3), PLD2(1)	4645072	32	7	32	4	14	9	1	1	6	1	0.948	1.000
565	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ANAPC1(1), ANAPC4(3), ANAPC5(1), ATM(10), ATR(4), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC25C(1), CDC27(4), CDC6(1), CDC7(1), CDK4(1), CDKN1B(2), CREBBP(4), CUL1(1), DBF4(3), E2F3(1), EP300(2), GSK3B(1), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), RBX1(1), SMAD3(3), SMC1B(2), TGFB2(4), YWHAH(1)	13956229	89	18	89	31	23	37	16	1	11	1	0.948	1.000
566	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(2), IKBKB(2), IL2(1), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), TNFRSF9(1)	2059451	18	3	18	4	4	11	2	1	0	0	0.949	1.000
567	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), GAD1(2), HADHA(1), HMGCL(1), PDHA1(1), PDHA2(2)	2681351	13	5	13	11	5	4	2	0	2	0	0.949	1.000
568	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2)	2561752	18	4	18	6	5	10	2	0	1	0	0.949	1.000
569	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), HIF1A(2), JAK2(3), NFKB1(3)	1330552	9	2	9	4	4	1	0	0	3	1	0.950	1.000
570	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	401481	1	1	1	1	0	1	0	0	0	0	0.952	1.000
571	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(1), CHST11(1), CHST12(1), CHST13(1), DSE(1), XYLT1(2)	1446504	7	3	7	3	3	3	1	0	0	0	0.953	1.000
572	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOC1(1), APOC2(1), CETP(1), HMGCR(1), LDLR(1), LIPC(1), LRP1(3), SCARB1(1)	2692048	15	5	15	5	9	4	1	0	1	0	0.954	1.000
573	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(5)	848148	5	2	5	2	2	2	0	0	1	0	0.957	1.000
574	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	2019745	11	4	11	5	5	4	2	0	0	0	0.958	1.000
575	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GMPPA(1), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), PFKFB1(1), PFKM(3), PMM1(2), RDH11(1), RDH12(1), SORD(2)	3893809	21	7	21	7	9	10	2	0	0	0	0.958	1.000
576	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(1)	609504	2	1	2	1	0	1	0	0	1	0	0.959	1.000
577	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(3), ABCA12(11), ABCA13(17), ABCA3(1), ABCA4(4), ABCA5(2), ABCA6(5), ABCA8(7), ABCA9(6), ABCB1(5), ABCB11(3), ABCB4(3), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(1), ABCC1(3), ABCC11(2), ABCC12(4), ABCC2(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(4), ABCD2(1), ABCG1(1), ABCG2(4), CFTR(4), TAP1(2), TAP2(1)	12216133	113	16	113	31	29	51	17	1	14	1	0.959	1.000
578	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), CPT1A(1), CPT2(1), CYP4A11(1), CYP8B1(1), FABP2(1), FABP7(1), FADS2(1), GK2(3), HMGCS2(1), ME1(2), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(1), SLC27A6(5), SORBS1(4)	6696765	42	10	42	11	17	14	6	1	4	0	0.959	1.000
579	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), MAP3K14(1), NFKB1(3), SPTAN1(4), TNFRSF10B(4)	3501705	26	6	26	6	10	7	4	0	5	0	0.960	1.000
580	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	EGFR(1), IGF1R(1), PRKCA(2), RB1(3), TERF1(1), XRCC5(2)	2837538	10	5	10	5	3	3	3	0	1	0	0.962	1.000
581	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3), CLTA(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1)	1683220	9	2	9	3	4	2	1	0	2	0	0.966	1.000
582	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDE6A(1), PDE6C(2), SLC6A13(1), TF(4)	3771123	25	6	25	1	9	11	1	0	3	1	0.967	1.000
583	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), EGFR(1), GRB2(1), MET(1), PDGFRA(4), PRKCA(2), SH3GLB1(1)	2027909	13	3	13	4	6	5	2	0	0	0	0.970	1.000
584	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(1), AASS(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(2)	3747127	23	6	23	8	7	7	4	0	5	0	0.970	1.000
585	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), HSD17B10(1), NSD1(3), OGDHL(3), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(1), SETDB1(1), SHMT1(1), SPCS3(1), SUV39H2(1), TMLHE(2)	5948349	37	9	37	10	13	11	6	0	7	0	0.971	1.000
586	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	AGT(1), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(1), REN(2)	1008723	8	2	8	4	1	5	0	0	2	0	0.972	1.000
587	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(2), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), TLR4(3), TNFAIP3(1)	2516408	18	4	18	3	5	7	5	0	1	0	0.973	1.000
588	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1)	1299774	10	2	10	2	3	5	1	0	1	0	0.975	1.000
589	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), GP5(1), GP6(1), HMMR(2), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), RELN(9), SDC1(1), SDC2(1), SDC3(1), SV2A(1), SV2B(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VTN(3), VWF(5)	23347672	163	30	163	74	56	61	20	4	21	1	0.978	1.000
590	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	PDE1A(1), PDE1B(1), PRL(1), TRH(1)	1155503	4	2	4	3	1	3	0	0	0	0	0.978	1.000
591	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(1)	506761	1	1	1	2	0	0	0	0	1	0	0.979	1.000
592	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), F2(1), F5(7), F8(3), FGA(2), FGB(1), KLKB1(2), PROS1(3), SERPING1(2)	4663016	29	6	29	9	8	12	5	0	4	0	0.980	1.000
593	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), ITGB3(2), SPTAN1(4), TLN1(2)	3016452	13	5	13	6	6	6	0	0	1	0	0.980	1.000
594	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(1), AKT3(1), BCR(1), BTK(1), DAPP1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDK1(2), PLCG2(4), PPP1R13B(1), PREX1(2), PTEN(4), PTPRC(8), RPS6KA2(2), RPS6KA3(2), SYK(3), TEC(2), VAV1(2)	5566353	52	8	52	10	17	19	5	0	10	1	0.980	1.000
595	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CTH(1), GOT1(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), SULT1B1(1), SULT1C2(1)	1295310	10	2	10	4	3	4	2	0	1	0	0.983	1.000
596	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DDHD1(2), GAD1(2), HADHA(1), HMGCL(1), HMGCS2(1), HSD17B10(1), PDHA1(1), PDHA2(2), RDH11(1), RDH12(1)	4253932	23	6	23	15	8	8	3	0	4	0	0.983	1.000
597	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH12(1)	500230	2	1	2	1	1	1	0	0	0	0	0.985	1.000
598	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2F1(2), NCOA1(2), NCOA2(3), NCOA3(5)	2611578	13	4	13	4	4	4	4	0	1	0	0.986	1.000
599	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHA(1)	1267635	6	2	6	4	1	2	1	0	2	0	0.987	1.000
600	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	CHAD(1), COL11A1(6), COL11A2(1), COL17A1(2), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DSC1(1), DSC3(1), DSG1(2), DSG4(4), FN1(4), GJA1(4), GJA10(4), GJA8(1), GJA9(1), GJB3(1), GJB7(1), GJC3(1), GJD2(1), ITGA6(1), ITGB4(1), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT20(1), KRT24(2), KRT27(1), KRT3(1), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT5(1), KRT6A(1), KRT7(2), KRT73(2), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT82(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), LMNB1(2), NES(1), PRPH(1), RELN(9), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VIM(1), VTN(3), VWF(5)	25514719	182	33	182	88	71	66	21	3	20	1	0.989	1.000
601	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1)	628786	5	1	5	0	0	4	1	0	0	0	0.989	1.000
602	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(1)	567042	2	1	2	1	1	0	1	0	0	0	0.990	1.000
603	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	NR3C1(1)	576879	1	1	1	1	0	0	0	0	1	0	0.990	1.000
604	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(2), CSTF3(2), DDX20(1), DHX15(2), DHX38(1), DHX9(1), DICER1(1), LSM2(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), PRPF18(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(2), RNMT(1), RNPS1(1), SF3A1(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(1), XRN2(2)	10899539	56	14	56	13	16	23	11	0	6	0	0.991	1.000
605	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1), IL6(1), IL8(1)	658336	3	1	3	2	1	1	1	0	0	0	0.992	1.000
606	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H4(1)	555480	2	1	2	0	2	0	0	0	0	0	0.993	1.000
607	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), CREBBP(4), DLL1(3), DLL3(1), DLL4(1), DTX2(1), DTX3(1), DVL2(1), DVL3(2), EP300(2), JAG1(1), MAML1(2), NOTCH2(2), NOTCH3(3), NOTCH4(4), PTCRA(1), RBPJ(4), SNW1(1)	6970229	35	9	35	12	14	11	4	0	6	0	0.997	1.000
608	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(4), EP300(2), IKBKB(2), NFKB1(3)	2308900	13	2	13	4	6	6	1	0	0	0	0.997	1.000
609	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL10(1), IL12A(1), IL16(4), IL2(1), IL6(1), IL8(1), IL9(1)	1002307	10	1	10	5	2	7	0	0	1	0	0.999	1.000
610	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	IL8(1), NFKB1(3)	1026866	4	1	4	2	3	1	0	0	0	0	1.000	1.000
611	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2D3(1), UBE2I(1), UBE3A(5)	1083070	8	1	8	0	2	4	2	0	0	0	1.000	1.000
612	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(4), EP300(2), ERCC3(1), GRIP1(1), GTF2F1(2), HDAC5(1), HDAC6(2), MEF2C(2), NR0B1(1), NRIP1(1)	4918334	18	4	18	8	7	10	1	0	0	0	1.000	1.000
613	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(3), SCAP(1)	1218484	5	1	5	2	3	2	0	0	0	0	1.000	1.000
614	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(1), MAP2K1(1), MAP3K1(2)	1792067	4	1	4	2	1	2	1	0	0	0	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		52302	0	0	0	0	0	0	0	0	0	0	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		119779	0	0	0	0	0	0	0	0	0	0	1.000	1.000
