Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.164 -9999.0 0.0 -0.546 4.0 4.0 IHH -0.138 0.187 -9999.0 0.0 -0.375 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.042 0.089 -9999.0 0.0 -0.185 14.0 14.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.088 0.184 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.107 0.185 -9999.0 0.0 -0.338 17.0 17.0 SMO -0.129 0.179 -9999.0 0.0 -0.341 19.0 19.0 AKT1 -0.061 0.154 -9999.0 0.0 -0.463 5.0 5.0 ARRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.123 0.181 -9999.0 0.0 -0.337 19.0 19.0 STIL -0.072 0.141 0.187 2.0 -0.277 12.0 14.0 DHH N/PTCH2 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.073 0.122 -9999.0 0.0 -0.228 19.0 19.0 PIK3CA 0.019 0.053 -9999.0 0.0 -0.358 1.0 1.0 DHH 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.13 0.198 -9999.0 0.0 -0.471 9.0 9.0 determination of left/right symmetry -0.123 0.181 -9999.0 0.0 -0.337 19.0 19.0 PIK3R1 -0.001 0.091 -9999.0 0.0 -0.358 3.0 3.0 skeletal system development -0.129 0.197 -9999.0 0.0 -0.468 9.0 9.0 IHH N/Hhip -0.107 0.145 -9999.0 0.0 -0.268 21.0 21.0 DHH N/Hhip -0.002 0.094 -9999.0 0.0 -0.252 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.123 0.181 -9999.0 0.0 -0.337 19.0 19.0 pancreas development -0.026 0.122 -9999.0 0.0 -0.358 6.0 6.0 HHAT -0.027 0.13 -9999.0 0.0 -0.358 7.0 7.0 PI3K 0.012 0.088 -9999.0 0.0 -0.32 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.051 0.143 -9999.0 0.0 -0.358 9.0 9.0 somite specification -0.123 0.181 -9999.0 0.0 -0.337 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.087 0.13 -9999.0 0.0 -0.25 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.006 0.071 -9999.0 0.0 -0.185 7.0 7.0 SHH Np/Cholesterol/Megalin -0.01 0.072 -9999.0 0.0 -0.188 7.0 7.0 SHH -0.015 0.077 -9999.0 0.0 -0.252 5.0 5.0 catabolic process -0.098 0.128 -9999.0 0.0 -0.255 20.0 20.0 SMO/Vitamin D3 -0.102 0.166 0.194 2.0 -0.315 17.0 19.0 SHH Np/Cholesterol/Hhip -0.032 0.092 -9999.0 0.0 -0.2 11.0 11.0 LRP2 0.021 0.026 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.094 0.171 -9999.0 0.0 -0.317 16.0 16.0 SHH Np/Cholesterol/BOC -0.006 0.067 -9999.0 0.0 -0.188 6.0 6.0 SHH Np/Cholesterol/CDO -0.008 0.072 -9999.0 0.0 -0.188 7.0 7.0 mesenchymal cell differentiation 0.032 0.091 0.199 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.076 0.141 0.198 2.0 -0.251 18.0 20.0 IHH N/PTCH2 -0.065 0.115 -9999.0 0.0 -0.23 16.0 16.0 CDON 0.023 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.09 0.136 -9999.0 0.0 -0.257 20.0 20.0 Megalin/LRPAP1 0.034 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.067 -9999.0 0.0 -0.182 7.0 7.0 PTCH1 -0.098 0.129 -9999.0 0.0 -0.255 20.0 20.0 HHIP -0.026 0.123 -9999.0 0.0 -0.358 6.0 6.0