Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	9.0	491.0	52.0	-0.138	0.042	1000.0	-1000.0	-0.017	-1000.0
HIF-1-alpha transcription factor network	9.0	743.0	76.0	-0.27	0.033	1000.0	-1000.0	-0.025	-1000.0
Ephrin B reverse signaling	8.0	400.0	48.0	-0.224	0.029	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	560.0	78.0	-0.235	0.089	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.053	0.021	1000.0	-1000.0	-0.005	-1000.0
TCGA08_retinoblastoma	6.0	48.0	8.0	-0.04	0.022	1000.0	-1000.0	-0.006	-1000.0
IGF1 pathway	6.0	343.0	57.0	-0.065	0.049	1000.0	-1000.0	-0.025	-1000.0
FOXM1 transcription factor network	6.0	352.0	51.0	-0.429	0.029	1000.0	-1000.0	-0.071	-1000.0
Noncanonical Wnt signaling pathway	5.0	143.0	26.0	-0.081	0.029	1000.0	-1000.0	-0.029	-1000.0
IL4-mediated signaling events	5.0	501.0	91.0	-0.577	0.388	1000.0	-1000.0	-0.076	-1000.0
Glypican 1 network	5.0	267.0	48.0	-0.062	0.03	1000.0	-1000.0	-0.016	-1000.0
Nectin adhesion pathway	5.0	344.0	63.0	-0.089	0.062	1000.0	-1000.0	-0.034	-1000.0
Endothelins	5.0	550.0	96.0	-0.164	0.036	1000.0	-1000.0	-0.033	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	357.0	68.0	-0.208	0.122	1000.0	-1000.0	-0.043	-1000.0
IL23-mediated signaling events	5.0	322.0	60.0	-0.328	0.029	1000.0	-1000.0	-0.051	-1000.0
Plasma membrane estrogen receptor signaling	5.0	505.0	86.0	-0.159	0.149	1000.0	-1000.0	-0.035	-1000.0
IL12-mediated signaling events	4.0	426.0	87.0	-0.263	0.048	1000.0	-1000.0	-0.034	-1000.0
Syndecan-1-mediated signaling events	4.0	146.0	34.0	-0.091	0.039	1000.0	-1000.0	-0.017	-1000.0
Osteopontin-mediated events	4.0	181.0	38.0	-0.1	0.029	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	187.0	44.0	-0.07	0.029	1000.0	-1000.0	-0.008	-1000.0
EPHB forward signaling	4.0	353.0	85.0	-0.08	0.053	1000.0	-1000.0	-0.046	-1000.0
Wnt signaling	4.0	33.0	7.0	-0.077	0.024	1000.0	-1000.0	-0.011	-1000.0
Caspase cascade in apoptosis	3.0	256.0	74.0	-0.04	0.041	1000.0	-1000.0	-0.031	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	442.0	136.0	-0.425	0.071	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	3.0	342.0	105.0	-0.092	0.048	1000.0	-1000.0	-0.029	-1000.0
BMP receptor signaling	3.0	249.0	81.0	-0.104	0.049	1000.0	-1000.0	-0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	296.0	97.0	-0.063	0.045	1000.0	-1000.0	-0.061	-1000.0
Reelin signaling pathway	3.0	174.0	56.0	-0.046	0.048	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.038	0.023	1000.0	-1000.0	-0.003	-1000.0
FAS signaling pathway (CD95)	3.0	165.0	47.0	-0.088	0.036	1000.0	-1000.0	-0.027	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.01	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	3.0	184.0	52.0	-0.101	0.048	1000.0	-1000.0	-0.022	-1000.0
IL27-mediated signaling events	3.0	154.0	51.0	-0.107	0.055	1000.0	-1000.0	-0.045	-1000.0
LPA receptor mediated events	3.0	328.0	102.0	-0.099	0.029	1000.0	-1000.0	-0.053	-1000.0
VEGFR1 specific signals	3.0	176.0	56.0	-0.055	0.029	1000.0	-1000.0	-0.024	-1000.0
Regulation of Androgen receptor activity	3.0	213.0	70.0	-0.144	0.034	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	2.0	205.0	76.0	-0.127	0.049	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	2.0	82.0	38.0	-0.016	0.044	1000.0	-1000.0	-0.0	-1000.0
Syndecan-2-mediated signaling events	2.0	141.0	69.0	-0.039	0.042	1000.0	-1000.0	-0.037	-1000.0
Cellular roles of Anthrax toxin	2.0	115.0	39.0	-0.057	0.029	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	2.0	181.0	76.0	-0.079	0.043	1000.0	-1000.0	-0.032	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	189.0	65.0	-0.321	0.068	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	143.0	61.0	-0.092	0.055	1000.0	-1000.0	-0.031	-1000.0
FOXA2 and FOXA3 transcription factor networks	2.0	126.0	46.0	-0.169	0.035	1000.0	-1000.0	-0.057	-1000.0
PDGFR-alpha signaling pathway	2.0	116.0	44.0	-0.135	0.041	1000.0	-1000.0	-0.029	-1000.0
mTOR signaling pathway	2.0	116.0	53.0	-0.019	0.035	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	2.0	182.0	68.0	-0.044	0.041	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	2.0	157.0	76.0	-0.05	0.067	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	2.0	102.0	48.0	-0.02	0.033	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	2.0	159.0	62.0	-0.05	0.063	1000.0	-1000.0	-0.024	-1000.0
ceramide signaling pathway	2.0	131.0	49.0	-0.035	0.043	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	2.0	112.0	43.0	-0.051	0.052	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	2.0	97.0	36.0	-0.106	0.028	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	36.0	15.0	-0.027	0.026	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	2.0	170.0	58.0	-0.105	0.057	1000.0	-1000.0	-0.013	-1000.0
Syndecan-3-mediated signaling events	2.0	73.0	35.0	-0.061	0.055	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by PI3K	2.0	136.0	58.0	-0.101	0.029	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	2.0	212.0	84.0	-0.087	0.055	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	271.0	93.0	-0.035	0.039	1000.0	-1000.0	-0.027	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	97.0	45.0	-0.039	0.044	1000.0	-1000.0	-0.032	-1000.0
Canonical Wnt signaling pathway	2.0	134.0	51.0	-0.091	0.069	1000.0	-1000.0	-0.029	-1000.0
IL6-mediated signaling events	2.0	206.0	75.0	-0.079	0.056	1000.0	-1000.0	-0.032	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	177.0	74.0	-0.059	0.053	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	2.0	44.0	22.0	-0.072	0.036	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events	2.0	184.0	73.0	-0.031	0.04	1000.0	-1000.0	-0.018	-1000.0
BCR signaling pathway	2.0	207.0	99.0	-0.041	0.054	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	2.0	197.0	67.0	-0.065	0.039	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Rods	2.0	108.0	52.0	-0.081	0.063	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in keratinocytes	2.0	104.0	43.0	-0.029	0.043	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	37.0	17.0	-0.017	0.045	1000.0	-1000.0	-0.009	-1000.0
Aurora B signaling	2.0	159.0	67.0	-0.06	0.039	1000.0	-1000.0	-0.037	-1000.0
LPA4-mediated signaling events	1.0	22.0	12.0	-0.026	0.007	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	1.0	71.0	65.0	-0.044	0.064	1000.0	-1000.0	-0.041	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	24.0	23.0	-0.002	0.038	1000.0	-1000.0	-0.007	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	65.0	34.0	-0.024	0.062	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	1.0	57.0	57.0	-0.052	0.067	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	33.0	28.0	-0.026	0.04	1000.0	-1000.0	-0.008	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	78.0	54.0	-0.038	0.041	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.002	0.033	1000.0	-1000.0	0.0	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	32.0	17.0	-0.036	0.046	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.011	0.028	1000.0	-1000.0	0.014	-1000.0
Arf6 signaling events	1.0	95.0	62.0	-0.01	0.046	1000.0	-1000.0	-0.011	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	132.0	85.0	-0.133	0.055	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	1.0	68.0	60.0	-0.023	0.061	1000.0	-1000.0	-0.01	-1000.0
p75(NTR)-mediated signaling	1.0	244.0	125.0	-0.092	0.063	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	1.0	93.0	55.0	-0.073	0.04	1000.0	-1000.0	-0.022	-1000.0
PLK1 signaling events	1.0	131.0	85.0	-0.034	0.032	1000.0	-1000.0	-0.018	-1000.0
amb2 Integrin signaling	1.0	157.0	82.0	-0.029	0.064	1000.0	-1000.0	-0.025	-1000.0
Glucocorticoid receptor regulatory network	1.0	207.0	114.0	-0.139	0.076	1000.0	-1000.0	-0.039	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	55.0	37.0	-0.027	0.05	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class III	1.0	71.0	40.0	-0.054	0.055	1000.0	-1000.0	-0.024	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	97.0	82.0	-0.02	0.048	1000.0	-1000.0	-0.034	-1000.0
S1P5 pathway	1.0	30.0	17.0	-0.026	0.028	1000.0	-1000.0	-0.007	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	92.0	52.0	-0.059	0.066	1000.0	-1000.0	-0.016	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	104.0	83.0	-0.032	0.052	1000.0	-1000.0	-0.017	-1000.0
FoxO family signaling	1.0	79.0	64.0	-0.041	0.038	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	47.0	36.0	-0.039	0.054	1000.0	-1000.0	-0.027	-1000.0
Regulation of p38-alpha and p38-beta	1.0	58.0	54.0	-0.024	0.063	1000.0	-1000.0	-0.015	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	51.0	31.0	-0.034	0.04	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	184.0	125.0	-0.026	0.045	1000.0	-1000.0	-0.025	-1000.0
TCGA08_rtk_signaling	1.0	28.0	26.0	-0.036	0.042	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	123.0	76.0	-0.028	0.057	1000.0	-1000.0	-0.037	-1000.0
Regulation of Telomerase	1.0	150.0	102.0	-0.068	0.058	1000.0	-1000.0	-0.016	-1000.0
EGFR-dependent Endothelin signaling events	1.0	37.0	21.0	-0.004	0.041	1000.0	-1000.0	-0.019	-1000.0
Insulin Pathway	1.0	131.0	74.0	-0.046	0.063	1000.0	-1000.0	-0.019	-1000.0
S1P3 pathway	1.0	58.0	42.0	-0.032	0.04	1000.0	-1000.0	-0.036	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	168.0	120.0	-0.037	0.079	1000.0	-1000.0	-0.031	-1000.0
PDGFR-beta signaling pathway	1.0	158.0	97.0	-0.047	0.059	1000.0	-1000.0	-0.041	-1000.0
S1P4 pathway	1.0	47.0	25.0	-0.027	0.04	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.015	0.043	1000.0	-1000.0	0.014	-1000.0
p38 MAPK signaling pathway	1.0	53.0	44.0	-0.051	0.05	1000.0	-1000.0	-0.021	-1000.0
Canonical NF-kappaB pathway	0.0	23.0	39.0	-0.0	0.065	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class II	0.0	60.0	75.0	-0.068	0.068	1000.0	-1000.0	-0.025	-1000.0
ErbB4 signaling events	0.0	40.0	69.0	-0.037	0.053	1000.0	-1000.0	-0.022	-1000.0
Circadian rhythm pathway	0.0	9.0	22.0	-0.01	0.057	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	0.0	24.0	43.0	-0.039	0.052	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	0.0	5.0	7.0	0.0	0.037	1000.0	-1000.0	-0.01	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.004	0.036	1000.0	-1000.0	-0.015	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.043	0.06	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	69.0	104.0	-0.035	0.067	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	0.0	22.0	31.0	-0.001	0.031	1000.0	-1000.0	-0.011	-1000.0
Effects of Botulinum toxin	0.0	7.0	26.0	-0.004	0.046	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	14.0	27.0	-0.014	0.066	1000.0	-1000.0	-0.028	-1000.0
Arf6 trafficking events	0.0	24.0	71.0	-0.049	0.052	1000.0	-1000.0	-0.018	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	84.0	88.0	-0.046	0.047	1000.0	-1000.0	-0.057	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	30.0	33.0	-0.046	0.065	1000.0	-1000.0	-0.024	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.036	1000.0	-1000.0	-0.0	-1000.0
Signaling events mediated by PRL	0.0	24.0	34.0	-0.029	0.042	1000.0	-1000.0	-0.027	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.029	0.029	1000.0	-1000.0	-0.016	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.001	0.05	1000.0	-1000.0	-0.013	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Total	273	19082	7203	-9.68032834675	6.54478401604	131000	-131000	-3.21443625313	-131000