Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes and selected clinical features
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and selected clinical features.

Summary

Testing the association between copy number variation of 98 peak regions and 5 clinical features across 443 patients, 159 significant findings detected with Q value < 0.25.

- Amp Peak 1(1p35.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 2(1p34.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 3(1p22.3) cnvs correlated to 'AGE'.

- Amp Peak 4(1q21.3) cnvs correlated to 'AGE'.

- Amp Peak 5(1q22) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 7(2p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 8(2q13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 9(3p25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 11(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 12(3q26.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 13(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 14(5p15.33) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 15(5q35.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 16(6p24.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 17(6q25.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 18(7q22.1) cnvs correlated to 'Time to Death'.

- Amp Peak 19(8p11.21) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 20(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 21(8q24.21) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 22(9p24.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 23(9q34.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 25(11p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 26(11q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 27(12p12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 28(12q13.11) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 29(12q13.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 30(13q34) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 31(14q24.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 32(14q32.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 33(16p11.2) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Amp Peak 34(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 35(17q12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 36(17q25.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 37(18p11.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 38(18q11.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Amp Peak 39(19p13.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 40(19p13.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 41(19q12) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Amp Peak 42(20p13) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 43(20q11.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 44(20q13.12) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 45(20q13.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Amp Peak 46(22q12.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 1(1p36.21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 2(1p36.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 5(2q22.1) cnvs correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

- Del Peak 6(2q37.3) cnvs correlated to 'AGE'.

- Del Peak 7(3p14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 8(3q13.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 9(4p16.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 10(4p15.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 11(4q22.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 12(4q34.3) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Del Peak 13(5q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 14(6q26) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 15(7p22.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 16(7q11.22) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 17(7q31.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 18(7q36.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 19(8p23.2) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 20(9p23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 21(9q34.11) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 22(10q23.31) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 23(11p15.5) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 24(11q14.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 25(11q25) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 26(12q23.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 27(12q24.33) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 28(13q11) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 29(13q14.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 30(14q13.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 31(15q15.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 32(15q23) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 33(16p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 34(16q21) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 35(16q23.1) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Del Peak 36(17p13.3) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 37(17p12) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Del Peak 38(17p11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 39(17q11.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 40(17q21.2) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 41(18q23) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 42(19p13.3) cnvs correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOADJUVANT.THERAPY'.

- Del Peak 43(19p12) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 44(19q13.43) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 46(22q11.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 47(22q12.1) cnvs correlated to 'HISTOLOGICAL.TYPE'.

- Del Peak 48(22q13.31) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 49(22q13.32) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

- Del Peak 50(Xp21.1) cnvs correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results
Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 98 regions and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 159 significant findings detected.

|  | Clinical Features | Time to Death | AGE | HISTOLOGICAL TYPE | RADIATIONS RADIATION REGIMENINDICATION | NEOADJUVANT THERAPY
| nCNV (%) | nWild-Type | logrank test | t-test | Chi-square test | Fisher's exact test | Fisher's exact test
Amp Peak 33(16p11 2) | 46 (10%) | 397 | 0.0814 (1.00) | 0.000137 (0.0486) | 5.3e-14 (2.37e-11) | 1 (1.00) | 0.000162 (0.0569)
Amp Peak 41(19q12) | 80 (18%) | 363 | 0.00193 (0.615) | 2.8e-10 (1.2e-07) | 8.43e-37 (4.12e-34) | 0.686 (1.00) | 0.000405 (0.137)
Del Peak 12(4q34 3) | 90 (20%) | 353 | 0.0248 (1.00) | 2.13e-05 (0.00804) | 1.43e-23 (6.93e-21) | 0.52 (1.00) | 4.2e-05 (0.0156)
Del Peak 35(16q23 1) | 126 (28%) | 317 | 0.0591 (1.00) | 1e-07 (4.09e-05) | 1.19e-24 (5.79e-22) | 0.422 (1.00) | 0.0003 (0.103)
Del Peak 37(17p12) | 96 (22%) | 347 | 0.0692 (1.00) | 3.09e-07 (0.000125) | 1.12e-24 (5.47e-22) | 0.53 (1.00) | 0.000622 (0.207)
Del Peak 42(19p13 3) | 115 (26%) | 328 | 0.0133 (1.00) | 5.3e-12 (2.33e-09) | 1.23e-44 (6.03e-42) | 0.344 (1.00) | 0.00032 (0.109)
Amp Peak 1(1p35 2) | 40 (9%) | 403 | 0.959 (1.00) | 0.000124 (0.0443) | 3.33e-10 (1.42e-07) | 1 (1.00) | 0.049 (1.00)
Amp Peak 2(1p34 2) | 50 (11%) | 393 | 0.574 (1.00) | 0.000133 (0.0473) | 3.57e-16 (1.64e-13) | 0.413 (1.00) | 0.0349 (1.00)
Amp Peak 5(1q22) | 204 (46%) | 239 | 0.0367 (1.00) | 1.65e-07 (6.72e-05) | 0.000233 (0.08) | 0.533 (1.00) | 0.823 (1.00)
Amp Peak 8(2q13) | 88 (20%) | 355 | 0.015 (1.00) | 0.000163 (0.0571) | 1e-14 (4.54e-12) | 0.795 (1.00) | 0.0506 (1.00)
Amp Peak 9(3p25 1) | 60 (14%) | 383 | 0.368 (1.00) | 0.000188 (0.0658) | 2.57e-09 (1.08e-06) | 0.172 (1.00) | 0.624 (1.00)
Amp Peak 11(3q26 2) | 128 (29%) | 315 | 0.143 (1.00) | 3.51e-09 (1.48e-06) | 6.17e-22 (2.96e-19) | 0.17 (1.00) | 0.00126 (0.409)
Amp Peak 12(3q26 2) | 121 (27%) | 322 | 0.0815 (1.00) | 3.66e-07 (0.000147) | 1.03e-22 (4.95e-20) | 0.245 (1.00) | 0.00577 (1.00)
Amp Peak 13(4p16 3) | 39 (9%) | 404 | 0.916 (1.00) | 1.74e-06 (0.000684) | 5.89e-15 (2.68e-12) | 0.715 (1.00) | 0.0298 (1.00)
Amp Peak 15(5q35 3) | 39 (9%) | 404 | 0.11 (1.00) | 0.000489 (0.165) | 3.21e-07 (0.000129) | 0.365 (1.00) | 0.554 (1.00)
Amp Peak 16(6p24 2) | 83 (19%) | 360 | 0.844 (1.00) | 9.78e-07 (0.000387) | 1.61e-17 (7.52e-15) | 0.232 (1.00) | 0.152 (1.00)
Amp Peak 19(8p11 21) | 130 (29%) | 313 | 1.61e-05 (0.00615) | 0.466 (1.00) | 1.23e-06 (0.000483) | 0.0411 (1.00) | 0.221 (1.00)
Amp Peak 23(9q34 3) | 31 (7%) | 412 | 0.0816 (1.00) | 0.000508 (0.171) | 2.26e-06 (0.000887) | 0.839 (1.00) | 0.125 (1.00)
Amp Peak 25(11p11 2) | 37 (8%) | 406 | 0.0376 (1.00) | 0.00022 (0.0761) | 2.91e-07 (0.000118) | 0.852 (1.00) | 0.225 (1.00)
Amp Peak 30(13q34) | 40 (9%) | 403 | 0.665 (1.00) | 7e-07 (0.000278) | 9.91e-11 (4.27e-08) | 1 (1.00) | 0.176 (1.00)
Amp Peak 31(14q24 3) | 48 (11%) | 395 | 0.504 (1.00) | 1.78e-05 (0.00675) | 2.5e-11 (1.09e-08) | 0.182 (1.00) | 0.0108 (1.00)
Amp Peak 32(14q32 33) | 57 (13%) | 386 | 0.182 (1.00) | 0.000211 (0.0731) | 6.76e-09 (2.84e-06) | 0.124 (1.00) | 0.0186 (1.00)
Amp Peak 34(17q11 2) | 52 (12%) | 391 | 0.0461 (1.00) | 0.000221 (0.0763) | 6.6e-17 (3.06e-14) | 0.748 (1.00) | 0.0246 (1.00)
Amp Peak 35(17q12) | 53 (12%) | 390 | 0.0649 (1.00) | 5.99e-05 (0.0221) | 7.29e-18 (3.43e-15) | 0.75 (1.00) | 0.00563 (1.00)
Amp Peak 36(17q25 1) | 74 (17%) | 369 | 0.0443 (1.00) | 5.73e-05 (0.0211) | 8.63e-16 (3.95e-13) | 1 (1.00) | 0.00674 (1.00)
Amp Peak 37(18p11 31) | 66 (15%) | 377 | 0.488 (1.00) | 0.000145 (0.0512) | 1.67e-18 (7.86e-16) | 0.0578 (1.00) | 0.877 (1.00)
Amp Peak 39(19p13 2) | 69 (16%) | 374 | 0.665 (1.00) | 3.81e-11 (1.65e-08) | 6.72e-18 (3.16e-15) | 0.2 (1.00) | 0.644 (1.00)
Amp Peak 40(19p13 11) | 68 (15%) | 375 | 0.607 (1.00) | 1.15e-10 (4.93e-08) | 3.14e-20 (1.5e-17) | 0.0837 (1.00) | 0.539 (1.00)
Amp Peak 42(20p13) | 86 (19%) | 357 | 0.175 (1.00) | 9.5e-05 (0.0343) | 2.52e-12 (1.11e-09) | 0.239 (1.00) | 0.00443 (1.00)
Amp Peak 43(20q11 21) | 106 (24%) | 337 | 0.0389 (1.00) | 1.53e-07 (6.24e-05) | 1.65e-23 (7.95e-21) | 0.0682 (1.00) | 0.0126 (1.00)
Amp Peak 44(20q13 12) | 111 (25%) | 332 | 0.304 (1.00) | 4.41e-08 (1.81e-05) | 1.8e-19 (8.54e-17) | 0.0164 (1.00) | 0.00956 (1.00)
Amp Peak 45(20q13 33) | 109 (25%) | 334 | 0.333 (1.00) | 1.72e-07 (6.98e-05) | 2.45e-15 (1.12e-12) | 0.00545 (1.00) | 0.0199 (1.00)
Del Peak 1(1p36 21) | 53 (12%) | 390 | 0.412 (1.00) | 6.57e-05 (0.0241) | 3.13e-08 (1.29e-05) | 0.525 (1.00) | 0.0376 (1.00)
Del Peak 2(1p36 11) | 58 (13%) | 385 | 0.321 (1.00) | 7.28e-05 (0.0266) | 8.44e-12 (3.7e-09) | 0.759 (1.00) | 0.0972 (1.00)
Del Peak 5(2q22 1) | 34 (8%) | 409 | 1.1e-08 (4.6e-06) | 0.00772 (1.00) | 9.51e-05 (0.0343) | 0.0181 (1.00) | 1 (1.00)
Del Peak 7(3p14 2) | 56 (13%) | 387 | 0.797 (1.00) | 2.76e-05 (0.0103) | 2.58e-14 (1.16e-11) | 0.437 (1.00) | 0.13 (1.00)
Del Peak 9(4p16 3) | 65 (15%) | 378 | 0.139 (1.00) | 6.87e-05 (0.0252) | 6.17e-13 (2.73e-10) | 0.558 (1.00) | 0.026 (1.00)
Del Peak 10(4p15 31) | 64 (14%) | 379 | 0.137 (1.00) | 9.3e-05 (0.0337) | 8.54e-12 (3.73e-09) | 0.141 (1.00) | 0.427 (1.00)
Del Peak 11(4q22 1) | 76 (17%) | 367 | 0.00763 (1.00) | 1.31e-05 (0.00503) | 5.34e-24 (2.59e-21) | 0.217 (1.00) | 0.00178 (0.568)
Del Peak 13(5q11 2) | 76 (17%) | 367 | 0.0615 (1.00) | 7.58e-05 (0.0276) | 5.75e-23 (2.77e-20) | 0.681 (1.00) | 0.0531 (1.00)
Del Peak 15(7p22 3) | 56 (13%) | 387 | 0.0101 (1.00) | 2.62e-05 (0.00986) | 2.18e-13 (9.7e-11) | 0.642 (1.00) | 0.0643 (1.00)
Del Peak 16(7q11 22) | 31 (7%) | 412 | 0.55 (1.00) | 1.91e-05 (0.00723) | 3.17e-07 (0.000128) | 0.688 (1.00) | 0.0495 (1.00)
Del Peak 17(7q31 1) | 39 (9%) | 404 | 0.696 (1.00) | 3.24e-06 (0.00127) | 1.01e-17 (4.72e-15) | 0.715 (1.00) | 0.00128 (0.414)
Del Peak 18(7q36 3) | 49 (11%) | 394 | 0.582 (1.00) | 3.53e-08 (1.45e-05) | 2.76e-17 (1.28e-14) | 1 (1.00) | 0.0122 (1.00)
Del Peak 20(9p23) | 50 (11%) | 393 | 0.397 (1.00) | 0.000379 (0.129) | 6.75e-10 (2.86e-07) | 0.413 (1.00) | 0.158 (1.00)
Del Peak 21(9q34 11) | 101 (23%) | 342 | 0.319 (1.00) | 2.55e-10 (1.09e-07) | 1.18e-16 (5.45e-14) | 0.324 (1.00) | 0.011 (1.00)
Del Peak 23(11p15 5) | 76 (17%) | 367 | 0.00871 (1.00) | 2.81e-08 (1.16e-05) | 1.03e-21 (4.91e-19) | 0.13 (1.00) | 0.0255 (1.00)
Del Peak 24(11q14 1) | 50 (11%) | 393 | 0.052 (1.00) | 1.04e-05 (0.00399) | 1.73e-13 (7.73e-11) | 0.624 (1.00) | 0.0204 (1.00)
Del Peak 25(11q25) | 68 (15%) | 375 | 0.00338 (1.00) | 8.41e-05 (0.0305) | 3.19e-14 (1.44e-11) | 0.0433 (1.00) | 0.0431 (1.00)
Del Peak 27(12q24 33) | 43 (10%) | 400 | 0.0812 (1.00) | 0.000113 (0.0405) | 4.79e-14 (2.15e-11) | 0.114 (1.00) | 0.0371 (1.00)
Del Peak 29(13q14 2) | 71 (16%) | 372 | 0.034 (1.00) | 0.000606 (0.202) | 0.000306 (0.105) | 0.158 (1.00) | 0.761 (1.00)
Del Peak 31(15q15 1) | 102 (23%) | 341 | 0.0318 (1.00) | 1.54e-08 (6.4e-06) | 2.67e-20 (1.27e-17) | 0.0654 (1.00) | 0.0116 (1.00)
Del Peak 32(15q23) | 82 (19%) | 361 | 0.0562 (1.00) | 8.73e-06 (0.00336) | 6.75e-20 (3.21e-17) | 0.233 (1.00) | 0.0431 (1.00)
Del Peak 33(16p13 3) | 61 (14%) | 382 | 0.0325 (1.00) | 2.74e-08 (1.13e-05) | 1.77e-15 (8.08e-13) | 0.549 (1.00) | 0.259 (1.00)
Del Peak 34(16q21) | 116 (26%) | 327 | 0.0479 (1.00) | 1.51e-08 (6.32e-06) | 4.27e-21 (2.04e-18) | 0.289 (1.00) | 0.00499 (1.00)
Del Peak 36(17p13 3) | 84 (19%) | 359 | 0.115 (1.00) | 4.09e-05 (0.0152) | 3.11e-16 (1.43e-13) | 0.292 (1.00) | 0.00257 (0.814)
Del Peak 38(17p11 2) | 87 (20%) | 356 | 0.0388 (1.00) | 3.63e-06 (0.00141) | 1.97e-17 (9.2e-15) | 0.437 (1.00) | 0.0908 (1.00)
Del Peak 39(17q11 2) | 77 (17%) | 366 | 0.581 (1.00) | 1.6e-05 (0.00612) | 3.05e-10 (1.3e-07) | 0.174 (1.00) | 0.184 (1.00)
Del Peak 40(17q21 2) | 82 (19%) | 361 | 0.13 (1.00) | 2.13e-05 (0.00804) | 5.08e-14 (2.28e-11) | 0.144 (1.00) | 0.115 (1.00)
Del Peak 46(22q11 1) | 65 (15%) | 378 | 0.405 (1.00) | 4.63e-05 (0.0171) | 0.000195 (0.068) | 0.0283 (1.00) | 0.637 (1.00)
Del Peak 48(22q13 31) | 99 (22%) | 344 | 0.0156 (1.00) | 1.78e-08 (7.4e-06) | 1.75e-16 (8.07e-14) | 0.264 (1.00) | 0.0313 (1.00)
Del Peak 49(22q13 32) | 105 (24%) | 338 | 0.0141 (1.00) | 4.1e-07 (0.000164) | 2.5e-17 (1.16e-14) | 0.0688 (1.00) | 0.0668 (1.00)
Del Peak 50(Xp21 1) | 62 (14%) | 381 | 0.00386 (1.00) | 0.000137 (0.0486) | 4.19e-13 (1.86e-10) | 0.55 (1.00) | 0.519 (1.00)
Amp Peak 3(1p22 3) | 73 (16%) | 370 | 0.702 (1.00) | 0.000573 (0.192) | 0.00943 (1.00) | 0.889 (1.00) | 0.229 (1.00)
Amp Peak 4(1q21 3) | 192 (43%) | 251 | 0.165 (1.00) | 3.55e-06 (0.00138) | 0.00431 (1.00) | 0.602 (1.00) | 0.176 (1.00)
Amp Peak 7(2p23 2) | 93 (21%) | 350 | 0.00562 (1.00) | 0.00263 (0.827) | 2.21e-10 (9.47e-08) | 0.0557 (1.00) | 0.173 (1.00)
Amp Peak 14(5p15 33) | 64 (14%) | 379 | 0.051 (1.00) | 0.00529 (1.00) | 2.61e-16 (1.2e-13) | 0.558 (1.00) | 0.265 (1.00)
Amp Peak 17(6q25 1) | 64 (14%) | 379 | 0.818 (1.00) | 0.00919 (1.00) | 0.000161 (0.0567) | 0.558 (1.00) | 0.634 (1.00)
Amp Peak 18(7q22 1) | 69 (16%) | 374 | 0.000492 (0.166) | 0.0361 (1.00) | 0.0437 (1.00) | 0.117 (1.00) | 1 (1.00)
Amp Peak 20(8q24 21) | 161 (36%) | 282 | 0.00107 (0.35) | 0.594 (1.00) | 5.85e-11 (2.53e-08) | 0.0523 (1.00) | 0.00362 (1.00)
Amp Peak 21(8q24 21) | 169 (38%) | 274 | 0.00576 (1.00) | 0.263 (1.00) | 1.1e-11 (4.79e-09) | 0.014 (1.00) | 0.0155 (1.00)
Amp Peak 22(9p24 2) | 48 (11%) | 395 | 0.753 (1.00) | 0.00528 (1.00) | 3.9e-07 (0.000156) | 0.182 (1.00) | 0.0491 (1.00)
Amp Peak 26(11q13 2) | 56 (13%) | 387 | 0.0967 (1.00) | 0.00107 (0.35) | 1.07e-06 (0.000424) | 1 (1.00) | 0.029 (1.00)
Amp Peak 27(12p12 1) | 67 (15%) | 376 | 0.756 (1.00) | 0.49 (1.00) | 2.29e-06 (0.000896) | 0.664 (1.00) | 1 (1.00)
Amp Peak 28(12q13 11) | 66 (15%) | 377 | 0.804 (1.00) | 0.855 (1.00) | 6.59e-06 (0.00255) | 0.191 (1.00) | 0.754 (1.00)
Amp Peak 29(12q13 2) | 74 (17%) | 369 | 0.908 (1.00) | 0.0707 (1.00) | 7.53e-06 (0.00291) | 0.0515 (1.00) | 0.882 (1.00)
Amp Peak 38(18q11 2) | 49 (11%) | 394 | 0.119 (1.00) | 0.013 (1.00) | 6.55e-13 (2.9e-10) | 0.624 (1.00) | 1 (1.00)
Amp Peak 46(22q12 2) | 41 (9%) | 402 | 0.606 (1.00) | 0.00374 (1.00) | 7.21e-19 (3.41e-16) | 0.285 (1.00) | 0.246 (1.00)
Del Peak 6(2q37 3) | 38 (9%) | 405 | 0.484 (1.00) | 0.000706 (0.234) | 0.0374 (1.00) | 0.461 (1.00) | 0.428 (1.00)
Del Peak 8(3q13 31) | 21 (5%) | 422 | 0.92 (1.00) | 0.00321 (1.00) | 3.18e-05 (0.0119) | 0.631 (1.00) | 0.297 (1.00)
Del Peak 14(6q26) | 34 (8%) | 409 | 0.224 (1.00) | 0.00929 (1.00) | 8.63e-09 (3.62e-06) | 0.846 (1.00) | 0.406 (1.00)
Del Peak 19(8p23 2) | 79 (18%) | 364 | 0.312 (1.00) | 0.00294 (0.922) | 2.72e-25 (1.33e-22) | 0.686 (1.00) | 0.00195 (0.618)
Del Peak 22(10q23 31) | 52 (12%) | 391 | 0.108 (1.00) | 0.0141 (1.00) | 0.000137 (0.0486) | 0.0775 (1.00) | 0.386 (1.00)
Del Peak 26(12q23 1) | 33 (7%) | 410 | 0.0484 (1.00) | 0.00319 (0.999) | 5.45e-11 (2.36e-08) | 0.556 (1.00) | 0.0171 (1.00)
Del Peak 28(13q11) | 67 (15%) | 376 | 0.0122 (1.00) | 0.000947 (0.312) | 1.11e-09 (4.7e-07) | 0.251 (1.00) | 0.213 (1.00)
Del Peak 30(14q13 1) | 54 (12%) | 389 | 0.000909 (0.301) | 0.00139 (0.45) | 8.18e-12 (3.59e-09) | 0.53 (1.00) | 0.0877 (1.00)
Del Peak 41(18q23) | 73 (16%) | 370 | 0.0118 (1.00) | 0.00171 (0.547) | 6.41e-15 (2.91e-12) | 0.00509 (1.00) | 0.452 (1.00)
Del Peak 43(19p12) | 37 (8%) | 406 | 0.1 (1.00) | 0.0484 (1.00) | 5.16e-07 (0.000205) | 0.268 (1.00) | 0.225 (1.00)
Del Peak 44(19q13 43) | 47 (11%) | 396 | 0.00148 (0.478) | 0.00121 (0.396) | 1.63e-14 (7.38e-12) | 1 (1.00) | 0.00642 (1.00)
Del Peak 47(22q12 1) | 70 (16%) | 373 | 0.206 (1.00) | 0.00151 (0.483) | 3.78e-05 (0.0141) | 0.0904 (1.00) | 0.125 (1.00)
Amp Peak 6(1q42 3) | 182 (41%) | 261 | 0.256 (1.00) | 0.00113 (0.369) | 0.182 (1.00) | 0.6 (1.00) | 0.651 (1.00)
Amp Peak 10(3p14 1) | 48 (11%) | 395 | 0.00429 (1.00) | 0.00881 (1.00) | 0.00376 (1.00) | 0.0441 (1.00) | 1 (1.00)
Amp Peak 24(10q22 2) | 121 (27%) | 322 | 0.198 (1.00) | 0.431 (1.00) | 0.18 (1.00) | 0.642 (1.00) | 0.0446 (1.00)
Amp Peak 47(Xp11 23) | 71 (16%) | 372 | 0.432 (1.00) | 0.31 (1.00) | 0.09 (1.00) | 0.0473 (1.00) | 0.224 (1.00)
Amp Peak 48(Xq28) | 72 (16%) | 371 | 0.00898 (1.00) | 0.101 (1.00) | 0.00591 (1.00) | 1 (1.00) | 1 (1.00)
Del Peak 3(1q43) | 7 (2%) | 436 | 0.0284 (1.00) | 0.0217 (1.00) | 0.75 (1.00) | 0.108 (1.00) | 1 (1.00)
Del Peak 4(2p25 3) | 22 (5%) | 421 | 0.0276 (1.00) | 0.118 (1.00) | 0.042 (1.00) | 0.0981 (1.00) | 0.314 (1.00)
Del Peak 45(20p12 1) | 24 (5%) | 419 | 0.0777 (1.00) | 0.032 (1.00) | 0.0503 (1.00) | 0.819 (1.00) | 0.81 (1.00)

'Amp Peak 1(1p35.2) mutation analysis' versus 'AGE'

P value = 0.000124 (t-test), Q value = 0.044

Table S1. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 1(1P35.2) MUTATED | 40 | 69.0 (8.5)
AMP PEAK 1(1P35.2) WILD-TYPE | 402 | 63.0 (11.3)

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 1(1p35.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.33e-10 (Chi-square test), Q value = 1.4e-07

Table S2. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 1(1P35.2) MUTATED | 13 | 0 | 0 | 0 | 0 | 4 | 23
AMP PEAK 1(1P35.2) WILD-TYPE | 314 | 3 | 8 | 2 | 7 | 14 | 55

Figure S2. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'AGE'

P value = 0.000133 (t-test), Q value = 0.047

Table S3. Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 2(1P34.2) MUTATED | 50 | 68.8 (9.5)
AMP PEAK 2(1P34.2) WILD-TYPE | 392 | 62.9 (11.3)

Figure S3. Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.57e-16 (Chi-square test), Q value = 1.6e-13

Table S4. Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 2(1P34.2) MUTATED | 14 | 0 | 0 | 0 | 0 | 6 | 30
AMP PEAK 2(1P34.2) WILD-TYPE | 313 | 3 | 8 | 2 | 7 | 12 | 48

Figure S4. Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 3(1p22.3) mutation analysis' versus 'AGE'

P value = 0.000573 (t-test), Q value = 0.19

Table S5. Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 3(1P22.3) MUTATED | 73 | 67.4 (9.9)
AMP PEAK 3(1P22.3) WILD-TYPE | 369 | 62.8 (11.3)

Figure S5. Get High-res Image Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 4(1q21.3) mutation analysis' versus 'AGE'

P value = 3.55e-06 (t-test), Q value = 0.0014

Table S6. Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 4(1Q21.3) MUTATED | 192 | 66.3 (10.5)
AMP PEAK 4(1Q21.3) WILD-TYPE | 250 | 61.4 (11.4)

Figure S6. Get High-res Image Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'AGE'

P value = 1.65e-07 (t-test), Q value = 6.7e-05

Table S7. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 5(1Q22) MUTATED | 204 | 66.5 (10.4)
AMP PEAK 5(1Q22) WILD-TYPE | 238 | 61.0 (11.3)

Figure S7. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000233 (Chi-square test), Q value = 0.08

Table S8. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 5(1Q22) MUTATED | 138 | 0 | 1 | 1 | 2 | 8 | 54
AMP PEAK 5(1Q22) WILD-TYPE | 189 | 3 | 7 | 1 | 5 | 10 | 24

Figure S8. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 7(2p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.21e-10 (Chi-square test), Q value = 9.5e-08

Table S9. Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 7(2P23.2) MUTATED | 44 | 0 | 1 | 1 | 1 | 7 | 39
AMP PEAK 7(2P23.2) WILD-TYPE | 283 | 3 | 7 | 1 | 6 | 11 | 39

Figure S9. Get High-res Image Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 8(2q13) mutation analysis' versus 'AGE'

P value = 0.000163 (t-test), Q value = 0.057

Table S10. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 8(2Q13) MUTATED | 87 | 67.1 (9.1)
AMP PEAK 8(2Q13) WILD-TYPE | 355 | 62.7 (11.6)

Figure S10. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 8(2q13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1e-14 (Chi-square test), Q value = 4.5e-12

Table S11. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 8(2Q13) MUTATED | 39 | 0 | 1 | 1 | 0 | 4 | 43
AMP PEAK 8(2Q13) WILD-TYPE | 288 | 3 | 7 | 1 | 7 | 14 | 35

Figure S11. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'AGE'

P value = 0.000188 (t-test), Q value = 0.066

Table S12. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 9(3P25.1) MUTATED | 60 | 68.6 (10.7)
AMP PEAK 9(3P25.1) WILD-TYPE | 382 | 62.7 (11.1)

Figure S12. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.57e-09 (Chi-square test), Q value = 1.1e-06

Table S13. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 9(3P25.1) MUTATED | 28 | 0 | 0 | 0 | 1 | 1 | 30
AMP PEAK 9(3P25.1) WILD-TYPE | 299 | 3 | 8 | 2 | 6 | 17 | 48

Figure S13. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'AGE'

P value = 3.51e-09 (t-test), Q value = 1.5e-06

Table S14. Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 11(3Q26.2) MUTATED | 128 | 68.1 (9.4)
AMP PEAK 11(3Q26.2) WILD-TYPE | 314 | 61.7 (11.4)

Figure S14. Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.17e-22 (Chi-square test), Q value = 3e-19

Table S15. Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 11(3Q26.2) MUTATED | 59 | 0 | 0 | 0 | 2 | 7 | 60
AMP PEAK 11(3Q26.2) WILD-TYPE | 268 | 3 | 8 | 2 | 5 | 11 | 18

Figure S15. Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'AGE'

P value = 3.66e-07 (t-test), Q value = 0.00015

Table S16. Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 12(3Q26.2) MUTATED | 121 | 67.6 (9.4)
AMP PEAK 12(3Q26.2) WILD-TYPE | 321 | 62.0 (11.5)

Figure S16. Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-22 (Chi-square test), Q value = 4.9e-20

Table S17. Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 12(3Q26.2) MUTATED | 54 | 0 | 0 | 0 | 2 | 6 | 59
AMP PEAK 12(3Q26.2) WILD-TYPE | 273 | 3 | 8 | 2 | 5 | 12 | 19

Figure S17. Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'AGE'

P value = 1.74e-06 (t-test), Q value = 0.00068

Table S18. Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 13(4P16.3) MUTATED | 39 | 70.5 (8.2)
AMP PEAK 13(4P16.3) WILD-TYPE | 403 | 62.9 (11.3)

Figure S18. Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.89e-15 (Chi-square test), Q value = 2.7e-12

Table S19. Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 13(4P16.3) MUTATED | 11 | 0 | 0 | 0 | 0 | 1 | 27
AMP PEAK 13(4P16.3) WILD-TYPE | 316 | 3 | 8 | 2 | 7 | 17 | 51

Figure S19. Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 14(5p15.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.61e-16 (Chi-square test), Q value = 1.2e-13

Table S20. Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 14(5P15.33) MUTATED | 24 | 0 | 0 | 0 | 0 | 3 | 37
AMP PEAK 14(5P15.33) WILD-TYPE | 303 | 3 | 8 | 2 | 7 | 15 | 41

Figure S20. Get High-res Image Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'AGE'

P value = 0.000489 (t-test), Q value = 0.17

Table S21. Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 15(5Q35.3) MUTATED | 39 | 69.7 (10.7)
AMP PEAK 15(5Q35.3) WILD-TYPE | 403 | 62.9 (11.1)

Figure S21. Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.21e-07 (Chi-square test), Q value = 0.00013

Table S22. Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 15(5Q35.3) MUTATED | 15 | 0 | 0 | 0 | 1 | 2 | 21
AMP PEAK 15(5Q35.3) WILD-TYPE | 312 | 3 | 8 | 2 | 6 | 16 | 57

Figure S22. Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'AGE'

P value = 9.78e-07 (t-test), Q value = 0.00039

Table S23. Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 16(6P24.2) MUTATED | 83 | 68.7 (9.9)
AMP PEAK 16(6P24.2) WILD-TYPE | 359 | 62.3 (11.2)

Figure S23. Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.61e-17 (Chi-square test), Q value = 7.5e-15

Table S24. Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 16(6P24.2) MUTATED | 35 | 0 | 0 | 0 | 0 | 4 | 44
AMP PEAK 16(6P24.2) WILD-TYPE | 292 | 3 | 8 | 2 | 7 | 14 | 34

Figure S24. Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 17(6q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000161 (Chi-square test), Q value = 0.057

Table S25. Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 17(6Q25.1) MUTATED | 35 | 0 | 0 | 0 | 2 | 2 | 25
AMP PEAK 17(6Q25.1) WILD-TYPE | 292 | 3 | 8 | 2 | 5 | 16 | 53

Figure S25. Get High-res Image Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 18(7q22.1) mutation analysis' versus 'Time to Death'

P value = 0.000492 (logrank test), Q value = 0.17

Table S26. Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

| nPatients | nDeath | Duration Range (Median), Month
--- | --- | --- | ---
ALL | 438 | 41 | 0.0 - 187.1 (15.8)
AMP PEAK 18(7Q22.1) MUTATED | 67 | 13 | 0.0 - 113.2 (13.0)
AMP PEAK 18(7Q22.1) WILD-TYPE | 371 | 28 | 0.1 - 187.1 (16.3)

Figure S26. Get High-res Image Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'Time to Death'

P value = 1.61e-05 (logrank test), Q value = 0.0062

Table S27. Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

| nPatients | nDeath | Duration Range (Median), Month
--- | --- | --- | ---
ALL | 438 | 41 | 0.0 - 187.1 (15.8)
AMP PEAK 19(8P11.21) MUTATED | 128 | 22 | 0.0 - 113.2 (11.5)
AMP PEAK 19(8P11.21) WILD-TYPE | 310 | 19 | 0.0 - 187.1 (16.9)

Figure S27. Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.23e-06 (Chi-square test), Q value = 0.00048

Table S28. Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 19(8P11.21) MUTATED | 76 | 1 | 0 | 0 | 4 | 6 | 43
AMP PEAK 19(8P11.21) WILD-TYPE | 251 | 2 | 8 | 2 | 3 | 12 | 35

Figure S28. Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 20(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.85e-11 (Chi-square test), Q value = 2.5e-08

Table S29. Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 20(8Q24.21) MUTATED | 92 | 1 | 0 | 0 | 4 | 8 | 56
AMP PEAK 20(8Q24.21) WILD-TYPE | 235 | 2 | 8 | 2 | 3 | 10 | 22

Figure S29. Get High-res Image Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 21(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.1e-11 (Chi-square test), Q value = 4.8e-09

Table S30. Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 21(8Q24.21) MUTATED | 98 | 1 | 0 | 0 | 4 | 7 | 59
AMP PEAK 21(8Q24.21) WILD-TYPE | 229 | 2 | 8 | 2 | 3 | 11 | 19

Figure S30. Get High-res Image Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 22(9p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.9e-07 (Chi-square test), Q value = 0.00016

Table S31. Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 22(9P24.2) MUTATED | 21 | 0 | 0 | 0 | 1 | 2 | 24
AMP PEAK 22(9P24.2) WILD-TYPE | 306 | 3 | 8 | 2 | 6 | 16 | 54

Figure S31. Get High-res Image Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'AGE'

P value = 0.000508 (t-test), Q value = 0.17

Table S32. Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 23(9Q34.3) MUTATED | 31 | 69.0 (8.0)
AMP PEAK 23(9Q34.3) WILD-TYPE | 411 | 63.1 (11.4)

Figure S32. Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.26e-06 (Chi-square test), Q value = 0.00089

Table S33. Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 23(9Q34.3) MUTATED | 11 | 0 | 0 | 0 | 0 | 4 | 16
AMP PEAK 23(9Q34.3) WILD-TYPE | 316 | 3 | 8 | 2 | 7 | 14 | 62

Figure S33. Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'AGE'

P value = 0.00022 (t-test), Q value = 0.076

Table S34. Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 25(11P11.2) MUTATED | 37 | 69.7 (9.6)
AMP PEAK 25(11P11.2) WILD-TYPE | 405 | 63.0 (11.2)

Figure S34. Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.91e-07 (Chi-square test), Q value = 0.00012

Table S35. Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 25(11P11.2) MUTATED | 14 | 0 | 0 | 0 | 0 | 3 | 20
AMP PEAK 25(11P11.2) WILD-TYPE | 313 | 3 | 8 | 2 | 7 | 15 | 58

Figure S35. Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 26(11q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.07e-06 (Chi-square test), Q value = 0.00042

Table S36. Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 26(11Q13.2) MUTATED | 28 | 0 | 0 | 0 | 0 | 2 | 26
AMP PEAK 26(11Q13.2) WILD-TYPE | 299 | 3 | 8 | 2 | 7 | 16 | 52

Figure S36. Get High-res Image Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 27(12p12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.29e-06 (Chi-square test), Q value = 9e-04

Table S37. Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 27(12P12.1) MUTATED | 34 | 0 | 1 | 0 | 1 | 2 | 29
AMP PEAK 27(12P12.1) WILD-TYPE | 293 | 3 | 7 | 2 | 6 | 16 | 49

Figure S37. Get High-res Image Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 28(12q13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.59e-06 (Chi-square test), Q value = 0.0026

Table S38. Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 28(12Q13.11) MUTATED | 33 | 0 | 1 | 0 | 1 | 3 | 28
AMP PEAK 28(12Q13.11) WILD-TYPE | 294 | 3 | 7 | 2 | 6 | 15 | 50

Figure S38. Get High-res Image Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 29(12q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.53e-06 (Chi-square test), Q value = 0.0029

Table S39. Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 29(12Q13.2) MUTATED | 40 | 0 | 1 | 0 | 0 | 3 | 30
AMP PEAK 29(12Q13.2) WILD-TYPE | 287 | 3 | 7 | 2 | 7 | 15 | 48

Figure S39. Get High-res Image Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 30(13q34) mutation analysis' versus 'AGE'

P value = 7e-07 (t-test), Q value = 0.00028

Table S40. Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 30(13Q34) MUTATED | 40 | 69.9 (7.1)
AMP PEAK 30(13Q34) WILD-TYPE | 402 | 62.9 (11.4)

Figure S40. Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 30(13q34) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.91e-11 (Chi-square test), Q value = 4.3e-08

Table S41. Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 30(13Q34) MUTATED | 13 | 0 | 0 | 0 | 0 | 3 | 24
AMP PEAK 30(13Q34) WILD-TYPE | 314 | 3 | 8 | 2 | 7 | 15 | 54

Figure S41. Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'AGE'

P value = 1.78e-05 (t-test), Q value = 0.0067

Table S42. Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 31(14Q24.3) MUTATED | 48 | 69.0 (8.4)
AMP PEAK 31(14Q24.3) WILD-TYPE | 394 | 62.9 (11.4)

Figure S42. Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-11 (Chi-square test), Q value = 1.1e-08

Table S43. Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 31(14Q24.3) MUTATED | 17 | 0 | 0 | 0 | 0 | 4 | 27
AMP PEAK 31(14Q24.3) WILD-TYPE | 310 | 3 | 8 | 2 | 7 | 14 | 51

Figure S43. Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'AGE'

P value = 0.000211 (t-test), Q value = 0.073

Table S44. Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 32(14Q32.33) MUTATED | 57 | 68.2 (9.4)
AMP PEAK 32(14Q32.33) WILD-TYPE | 385 | 62.9 (11.3)

Figure S44. Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.76e-09 (Chi-square test), Q value = 2.8e-06

Table S45. Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 32(14Q32.33) MUTATED | 25 | 0 | 0 | 0 | 0 | 4 | 28
AMP PEAK 32(14Q32.33) WILD-TYPE | 302 | 3 | 8 | 2 | 7 | 14 | 50

Figure S45. Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'AGE'

P value = 0.000137 (t-test), Q value = 0.049

Table S46. Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 33(16P11.2) MUTATED | 46 | 68.5 (8.5)
AMP PEAK 33(16P11.2) WILD-TYPE | 396 | 63.0 (11.4)

Figure S46. Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.3e-14 (Chi-square test), Q value = 2.4e-11

Table S47. Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 33(16P11.2) MUTATED | 15 | 0 | 0 | 0 | 0 | 2 | 29
AMP PEAK 33(16P11.2) WILD-TYPE | 312 | 3 | 8 | 2 | 7 | 16 | 49

Figure S47. Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000162 (Fisher's exact test), Q value = 0.057

Table S48. Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
AMP PEAK 33(16P11.2) MUTATED | 24 | 22
AMP PEAK 33(16P11.2) WILD-TYPE | 314 | 83

Figure S48. Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 34(17q11.2) mutation analysis' versus 'AGE'

P value = 0.000221 (t-test), Q value = 0.076

Table S49. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 34(17Q11.2) MUTATED | 52 | 68.0 (8.5)
AMP PEAK 34(17Q11.2) WILD-TYPE | 390 | 62.9 (11.4)

Figure S49. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.6e-17 (Chi-square test), Q value = 3.1e-14

Table S50. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 34(17Q11.2) MUTATED | 14 | 0 | 0 | 0 | 1 | 5 | 32
AMP PEAK 34(17Q11.2) WILD-TYPE | 313 | 3 | 8 | 2 | 6 | 13 | 46

Figure S50. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 35(17q12) mutation analysis' versus 'AGE'

P value = 5.99e-05 (t-test), Q value = 0.022

Table S51. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 35(17Q12) MUTATED | 53 | 68.8 (9.4)
AMP PEAK 35(17Q12) WILD-TYPE | 389 | 62.8 (11.3)

Figure S51. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 35(17q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.29e-18 (Chi-square test), Q value = 3.4e-15

Table S52. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 35(17Q12) MUTATED | 15 | 0 | 1 | 0 | 0 | 3 | 34
AMP PEAK 35(17Q12) WILD-TYPE | 312 | 3 | 7 | 2 | 7 | 15 | 44

Figure S52. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'AGE'

P value = 5.73e-05 (t-test), Q value = 0.021

Table S53. Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 36(17Q25.1) MUTATED | 74 | 67.6 (8.8)
AMP PEAK 36(17Q25.1) WILD-TYPE | 368 | 62.7 (11.5)

Figure S53. Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.63e-16 (Chi-square test), Q value = 4e-13

Table S54. Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 36(17Q25.1) MUTATED | 27 | 0 | 0 | 0 | 2 | 8 | 37
AMP PEAK 36(17Q25.1) WILD-TYPE | 300 | 3 | 8 | 2 | 5 | 10 | 41

Figure S54. Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'AGE'

P value = 0.000145 (t-test), Q value = 0.051

Table S55. Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 37(18P11.31) MUTATED | 66 | 67.8 (9.2)
AMP PEAK 37(18P11.31) WILD-TYPE | 376 | 62.8 (11.4)

Figure S55. Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.67e-18 (Chi-square test), Q value = 7.9e-16

Table S56. Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 37(18P11.31) MUTATED | 22 | 0 | 0 | 0 | 1 | 4 | 39
AMP PEAK 37(18P11.31) WILD-TYPE | 305 | 3 | 8 | 2 | 6 | 14 | 39

Figure S56. Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 38(18q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.55e-13 (Chi-square test), Q value = 2.9e-10

Table S57. Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 38(18Q11.2) MUTATED | 16 | 0 | 0 | 0 | 1 | 3 | 29
AMP PEAK 38(18Q11.2) WILD-TYPE | 311 | 3 | 8 | 2 | 6 | 15 | 49

Figure S57. Get High-res Image Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'AGE'

P value = 3.81e-11 (t-test), Q value = 1.7e-08

Table S58. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 39(19P13.2) MUTATED | 69 | 70.7 (8.4)
AMP PEAK 39(19P13.2) WILD-TYPE | 373 | 62.2 (11.2)

Figure S58. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.72e-18 (Chi-square test), Q value = 3.2e-15

Table S59. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 39(19P13.2) MUTATED | 23 | 0 | 0 | 0 | 1 | 7 | 38
AMP PEAK 39(19P13.2) WILD-TYPE | 304 | 3 | 8 | 2 | 6 | 11 | 40

Figure S59. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'AGE'

P value = 1.15e-10 (t-test), Q value = 4.9e-08

Table S60. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 40(19P13.11) MUTATED | 68 | 71.0 (9.0)
AMP PEAK 40(19P13.11) WILD-TYPE | 374 | 62.2 (11.1)

Figure S60. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.14e-20 (Chi-square test), Q value = 1.5e-17

Table S61. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 40(19P13.11) MUTATED | 22 | 0 | 0 | 0 | 0 | 6 | 40
AMP PEAK 40(19P13.11) WILD-TYPE | 305 | 3 | 8 | 2 | 7 | 12 | 38

Figure S61. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'AGE'

P value = 2.8e-10 (t-test), Q value = 1.2e-07

Table S62. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 41(19Q12) MUTATED | 80 | 69.5 (8.1)
AMP PEAK 41(19Q12) WILD-TYPE | 362 | 62.2 (11.4)

Figure S62. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 41(19q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.43e-37 (Chi-square test), Q value = 4.1e-34

Table S63. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 41(19Q12) MUTATED | 18 | 0 | 0 | 0 | 0 | 9 | 53
AMP PEAK 41(19Q12) WILD-TYPE | 309 | 3 | 8 | 2 | 7 | 9 | 25

Figure S63. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000405 (Fisher's exact test), Q value = 0.14

Table S64. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
AMP PEAK 41(19Q12) MUTATED | 48 | 32
AMP PEAK 41(19Q12) WILD-TYPE | 290 | 73

Figure S64. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Amp Peak 42(20p13) mutation analysis' versus 'AGE'

P value = 9.5e-05 (t-test), Q value = 0.034

Table S65. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 42(20P13) MUTATED | 86 | 67.9 (11.1)
AMP PEAK 42(20P13) WILD-TYPE | 356 | 62.5 (11.0)

Figure S65. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 42(20p13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.52e-12 (Chi-square test), Q value = 1.1e-09

Table S66. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 42(20P13) MUTATED | 41 | 0 | 0 | 1 | 0 | 4 | 40
AMP PEAK 42(20P13) WILD-TYPE | 286 | 3 | 8 | 1 | 7 | 14 | 38

Figure S66. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'AGE'

P value = 1.53e-07 (t-test), Q value = 6.2e-05

Table S67. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 43(20Q11.21) MUTATED | 106 | 68.3 (10.0)
AMP PEAK 43(20Q11.21) WILD-TYPE | 336 | 62.0 (11.2)

Figure S67. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.65e-23 (Chi-square test), Q value = 7.9e-21

Table S68. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 43(20Q11.21) MUTATED | 44 | 0 | 0 | 1 | 0 | 6 | 55
AMP PEAK 43(20Q11.21) WILD-TYPE | 283 | 3 | 8 | 1 | 7 | 12 | 23

Figure S68. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'AGE'

P value = 4.41e-08 (t-test), Q value = 1.8e-05

Table S69. Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 44(20Q13.12) MUTATED | 111 | 68.5 (10.3)
AMP PEAK 44(20Q13.12) WILD-TYPE | 331 | 61.9 (11.1)

Figure S69. Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.8e-19 (Chi-square test), Q value = 8.5e-17

Table S70. Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 44(20Q13.12) MUTATED | 49 | 0 | 0 | 1 | 1 | 7 | 53
AMP PEAK 44(20Q13.12) WILD-TYPE | 278 | 3 | 8 | 1 | 6 | 11 | 25

Figure S70. Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'AGE'

P value = 1.72e-07 (t-test), Q value = 7e-05

Table S71. Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
AMP PEAK 45(20Q13.33) MUTATED | 109 | 68.3 (10.5)
AMP PEAK 45(20Q13.33) WILD-TYPE | 333 | 62.0 (11.1)

Figure S71. Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.45e-15 (Chi-square test), Q value = 1.1e-12

Table S72. Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 45(20Q13.33) MUTATED | 51 | 0 | 0 | 1 | 2 | 6 | 49
AMP PEAK 45(20Q13.33) WILD-TYPE | 276 | 3 | 8 | 1 | 5 | 12 | 29

Figure S72. Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 46(22q12.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.21e-19 (Chi-square test), Q value = 3.4e-16

Table S73. Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
AMP PEAK 46(22Q12.2) MUTATED | 9 | 0 | 0 | 0 | 0 | 2 | 30
AMP PEAK 46(22Q12.2) WILD-TYPE | 318 | 3 | 8 | 2 | 7 | 16 | 48

Figure S73. Get High-res Image Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 1(1p36.21) mutation analysis' versus 'AGE'

P value = 6.57e-05 (t-test), Q value = 0.024

Table S74. Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 1(1P36.21) MUTATED | 53 | 69.2 (10.2)
DEL PEAK 1(1P36.21) WILD-TYPE | 389 | 62.8 (11.2)

Figure S74. Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 1(1p36.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.13e-08 (Chi-square test), Q value = 1.3e-05

Table S75. Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 1(1P36.21) MUTATED | 23 | 0 | 0 | 0 | 0 | 4 | 26
DEL PEAK 1(1P36.21) WILD-TYPE | 304 | 3 | 8 | 2 | 7 | 14 | 52

Figure S75. Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 2(1p36.11) mutation analysis' versus 'AGE'

P value = 7.28e-05 (t-test), Q value = 0.027

Table S76. Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 2(1P36.11) MUTATED | 58 | 68.5 (9.5)
DEL PEAK 2(1P36.11) WILD-TYPE | 384 | 62.8 (11.3)

Figure S76. Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 2(1p36.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.44e-12 (Chi-square test), Q value = 3.7e-09

Table S77. Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 2(1P36.11) MUTATED | 23 | 0 | 0 | 0 | 0 | 4 | 31
DEL PEAK 2(1P36.11) WILD-TYPE | 304 | 3 | 8 | 2 | 7 | 14 | 47

Figure S77. Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 5(2q22.1) mutation analysis' versus 'Time to Death'

P value = 1.1e-08 (logrank test), Q value = 4.6e-06

Table S78. Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

| nPatients | nDeath | Duration Range (Median), Month
--- | --- | --- | ---
ALL | 438 | 41 | 0.0 - 187.1 (15.8)
DEL PEAK 5(2Q22.1) MUTATED | 34 | 10 | 0.1 - 113.2 (7.9)
DEL PEAK 5(2Q22.1) WILD-TYPE | 404 | 31 | 0.0 - 187.1 (16.6)

Figure S78. Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Del Peak 5(2q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.51e-05 (Chi-square test), Q value = 0.034

Table S79. Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 5(2Q22.1) MUTATED | 15 | 0 | 0 | 0 | 1 | 1 | 17
DEL PEAK 5(2Q22.1) WILD-TYPE | 312 | 3 | 8 | 2 | 6 | 17 | 61

Figure S79. Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 6(2q37.3) mutation analysis' versus 'AGE'

P value = 0.000706 (t-test), Q value = 0.23

Table S80. Gene #54: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 6(2Q37.3) MUTATED | 38 | 67.9 (7.5)
DEL PEAK 6(2Q37.3) WILD-TYPE | 404 | 63.1 (11.5)

Figure S80. Get High-res Image Gene #54: 'Del Peak 6(2q37.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'AGE'

P value = 2.76e-05 (t-test), Q value = 0.01

Table S81. Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 7(3P14.2) MUTATED | 56 | 67.8 (7.1)
DEL PEAK 7(3P14.2) WILD-TYPE | 386 | 62.9 (11.6)

Figure S81. Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.58e-14 (Chi-square test), Q value = 1.2e-11

Table S82. Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 7(3P14.2) MUTATED | 18 | 0 | 0 | 0 | 1 | 6 | 31
DEL PEAK 7(3P14.2) WILD-TYPE | 309 | 3 | 8 | 2 | 6 | 12 | 47

Figure S82. Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 8(3q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.18e-05 (Chi-square test), Q value = 0.012

Table S83. Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 8(3Q13.31) MUTATED | 7 | 0 | 0 | 0 | 0 | 1 | 13
DEL PEAK 8(3Q13.31) WILD-TYPE | 320 | 3 | 8 | 2 | 7 | 17 | 65

Figure S83. Get High-res Image Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 9(4p16.3) mutation analysis' versus 'AGE'

P value = 6.87e-05 (t-test), Q value = 0.025

Table S84. Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 9(4P16.3) MUTATED | 65 | 68.0 (9.1)
DEL PEAK 9(4P16.3) WILD-TYPE | 377 | 62.8 (11.4)

Figure S84. Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 9(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.17e-13 (Chi-square test), Q value = 2.7e-10

Table S85. Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 9(4P16.3) MUTATED | 25 | 0 | 0 | 0 | 2 | 4 | 34
DEL PEAK 9(4P16.3) WILD-TYPE | 302 | 3 | 8 | 2 | 5 | 14 | 44

Figure S85. Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 10(4p15.31) mutation analysis' versus 'AGE'

P value = 9.3e-05 (t-test), Q value = 0.034

Table S86. Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 10(4P15.31) MUTATED | 64 | 68.0 (9.2)
DEL PEAK 10(4P15.31) WILD-TYPE | 378 | 62.8 (11.4)

Figure S86. Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 10(4p15.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.54e-12 (Chi-square test), Q value = 3.7e-09

Table S87. Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 10(4P15.31) MUTATED | 26 | 0 | 0 | 0 | 2 | 3 | 33
DEL PEAK 10(4P15.31) WILD-TYPE | 301 | 3 | 8 | 2 | 5 | 15 | 45

Figure S87. Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 11(4q22.1) mutation analysis' versus 'AGE'

P value = 1.31e-05 (t-test), Q value = 0.005

Table S88. Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 11(4Q22.1) MUTATED | 76 | 68.1 (9.2)
DEL PEAK 11(4Q22.1) WILD-TYPE | 366 | 62.6 (11.4)

Figure S88. Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 11(4q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.34e-24 (Chi-square test), Q value = 2.6e-21

Table S89. Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 11(4Q22.1) MUTATED | 24 | 0 | 0 | 0 | 1 | 5 | 46
DEL PEAK 11(4Q22.1) WILD-TYPE | 303 | 3 | 8 | 2 | 6 | 13 | 32

Figure S89. Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(4q34.3) mutation analysis' versus 'AGE'

P value = 2.13e-05 (t-test), Q value = 0.008

Table S90. Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 12(4Q34.3) MUTATED | 90 | 67.7 (9.9)
DEL PEAK 12(4Q34.3) WILD-TYPE | 352 | 62.5 (11.3)

Figure S90. Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 12(4q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.43e-23 (Chi-square test), Q value = 6.9e-21

Table S91. Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 12(4Q34.3) MUTATED | 32 | 0 | 0 | 0 | 2 | 6 | 50
DEL PEAK 12(4Q34.3) WILD-TYPE | 295 | 3 | 8 | 2 | 5 | 12 | 28

Figure S91. Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(4q34.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 4.2e-05 (Fisher's exact test), Q value = 0.016

Table S92. Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
DEL PEAK 12(4Q34.3) MUTATED | 53 | 37
DEL PEAK 12(4Q34.3) WILD-TYPE | 285 | 68

Figure S92. Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 13(5q11.2) mutation analysis' versus 'AGE'

P value = 7.58e-05 (t-test), Q value = 0.028

Table S93. Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 13(5Q11.2) MUTATED | 76 | 67.8 (9.6)
DEL PEAK 13(5Q11.2) WILD-TYPE | 366 | 62.7 (11.4)

Figure S93. Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 13(5q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.75e-23 (Chi-square test), Q value = 2.8e-20

Table S94. Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 13(5Q11.2) MUTATED | 27 | 0 | 0 | 0 | 1 | 2 | 46
DEL PEAK 13(5Q11.2) WILD-TYPE | 300 | 3 | 8 | 2 | 6 | 16 | 32

Figure S94. Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 14(6q26) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.63e-09 (Chi-square test), Q value = 3.6e-06

Table S95. Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 14(6Q26) MUTATED | 10 | 0 | 1 | 0 | 0 | 3 | 20
DEL PEAK 14(6Q26) WILD-TYPE | 317 | 3 | 7 | 2 | 7 | 15 | 58

Figure S95. Get High-res Image Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 15(7p22.3) mutation analysis' versus 'AGE'

P value = 2.62e-05 (t-test), Q value = 0.0099

Table S96. Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 15(7P22.3) MUTATED | 55 | 68.9 (9.2)
DEL PEAK 15(7P22.3) WILD-TYPE | 387 | 62.8 (11.3)

Figure S96. Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 15(7p22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.18e-13 (Chi-square test), Q value = 9.7e-11

Table S97. Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 15(7P22.3) MUTATED | 19 | 0 | 0 | 0 | 1 | 5 | 31
DEL PEAK 15(7P22.3) WILD-TYPE | 308 | 3 | 8 | 2 | 6 | 13 | 47

Figure S97. Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 16(7q11.22) mutation analysis' versus 'AGE'

P value = 1.91e-05 (t-test), Q value = 0.0072

Table S98. Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 16(7Q11.22) MUTATED | 31 | 71.0 (8.6)
DEL PEAK 16(7Q11.22) WILD-TYPE | 411 | 63.0 (11.2)

Figure S98. Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 16(7q11.22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.17e-07 (Chi-square test), Q value = 0.00013

Table S99. Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 16(7Q11.22) MUTATED | 10 | 0 | 0 | 0 | 1 | 2 | 18
DEL PEAK 16(7Q11.22) WILD-TYPE | 317 | 3 | 8 | 2 | 6 | 16 | 60

Figure S99. Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(7q31.1) mutation analysis' versus 'AGE'

P value = 3.24e-06 (t-test), Q value = 0.0013

Table S100. Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 17(7Q31.1) MUTATED | 39 | 69.9 (7.6)
DEL PEAK 17(7Q31.1) WILD-TYPE | 403 | 62.9 (11.3)

Figure S100. Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 17(7q31.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.01e-17 (Chi-square test), Q value = 4.7e-15

Table S101. Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 17(7Q31.1) MUTATED | 7 | 0 | 0 | 0 | 1 | 3 | 28
DEL PEAK 17(7Q31.1) WILD-TYPE | 320 | 3 | 8 | 2 | 6 | 15 | 50

Figure S101. Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 18(7q36.3) mutation analysis' versus 'AGE'

P value = 3.53e-08 (t-test), Q value = 1.5e-05

Table S102. Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 18(7Q36.3) MUTATED | 49 | 70.8 (8.4)
DEL PEAK 18(7Q36.3) WILD-TYPE | 393 | 62.6 (11.2)

Figure S102. Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 18(7q36.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.76e-17 (Chi-square test), Q value = 1.3e-14

Table S103. Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 18(7Q36.3) MUTATED | 12 | 0 | 0 | 0 | 1 | 5 | 31
DEL PEAK 18(7Q36.3) WILD-TYPE | 315 | 3 | 8 | 2 | 6 | 13 | 47

Figure S103. Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 19(8p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.72e-25 (Chi-square test), Q value = 1.3e-22

Table S104. Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 19(8P23.2) MUTATED | 25 | 0 | 0 | 0 | 2 | 4 | 48
DEL PEAK 19(8P23.2) WILD-TYPE | 302 | 3 | 8 | 2 | 5 | 14 | 30

Figure S104. Get High-res Image Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 20(9p23) mutation analysis' versus 'AGE'

P value = 0.000379 (t-test), Q value = 0.13

Table S105. Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 20(9P23) MUTATED | 50 | 68.0 (8.5)
DEL PEAK 20(9P23) WILD-TYPE | 392 | 63.0 (11.4)

Figure S105. Get High-res Image Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 20(9p23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.75e-10 (Chi-square test), Q value = 2.9e-07

Table S106. Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 20(9P23) MUTATED | 20 | 0 | 0 | 0 | 0 | 3 | 27
DEL PEAK 20(9P23) WILD-TYPE | 307 | 3 | 8 | 2 | 7 | 15 | 51

Figure S106. Get High-res Image Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 21(9q34.11) mutation analysis' versus 'AGE'

P value = 2.55e-10 (t-test), Q value = 1.1e-07

Table S107. Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 21(9Q34.11) MUTATED | 101 | 69.0 (8.8)
DEL PEAK 21(9Q34.11) WILD-TYPE | 341 | 61.9 (11.4)

Figure S107. Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 21(9q34.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.18e-16 (Chi-square test), Q value = 5.5e-14

Table S108. Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 21(9Q34.11) MUTATED | 44 | 0 | 0 | 0 | 2 | 8 | 47
DEL PEAK 21(9Q34.11) WILD-TYPE | 283 | 3 | 8 | 2 | 5 | 10 | 31

Figure S108. Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 22(10q23.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000137 (Chi-square test), Q value = 0.049

Table S109. Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 22(10Q23.31) MUTATED | 26 | 0 | 0 | 0 | 1 | 3 | 22
DEL PEAK 22(10Q23.31) WILD-TYPE | 301 | 3 | 8 | 2 | 6 | 15 | 56

Figure S109. Get High-res Image Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 23(11p15.5) mutation analysis' versus 'AGE'

P value = 2.81e-08 (t-test), Q value = 1.2e-05

Table S110. Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 23(11P15.5) MUTATED | 76 | 69.2 (8.7)
DEL PEAK 23(11P15.5) WILD-TYPE | 366 | 62.4 (11.4)

Figure S110. Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 23(11p15.5) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.03e-21 (Chi-square test), Q value = 4.9e-19

Table S111. Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 23(11P15.5) MUTATED | 25 | 0 | 0 | 0 | 1 | 6 | 44
DEL PEAK 23(11P15.5) WILD-TYPE | 302 | 3 | 8 | 2 | 6 | 12 | 34

Figure S111. Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 24(11q14.1) mutation analysis' versus 'AGE'

P value = 1.04e-05 (t-test), Q value = 0.004

Table S112. Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 24(11Q14.1) MUTATED | 50 | 69.1 (8.5)
DEL PEAK 24(11Q14.1) WILD-TYPE | 392 | 62.8 (11.4)

Figure S112. Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 24(11q14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.73e-13 (Chi-square test), Q value = 7.7e-11

Table S113. Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 24(11Q14.1) MUTATED | 16 | 0 | 0 | 0 | 0 | 6 | 28
DEL PEAK 24(11Q14.1) WILD-TYPE | 311 | 3 | 8 | 2 | 7 | 12 | 50

Figure S113. Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 25(11q25) mutation analysis' versus 'AGE'

P value = 8.41e-05 (t-test), Q value = 0.031

Table S114. Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 25(11Q25) MUTATED | 68 | 68.1 (9.9)
DEL PEAK 25(11Q25) WILD-TYPE | 374 | 62.7 (11.3)

Figure S114. Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 25(11q25) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.19e-14 (Chi-square test), Q value = 1.4e-11

Table S115. Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 25(11Q25) MUTATED | 27 | 0 | 0 | 0 | 0 | 5 | 36
DEL PEAK 25(11Q25) WILD-TYPE | 300 | 3 | 8 | 2 | 7 | 13 | 42

Figure S115. Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 26(12q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.45e-11 (Chi-square test), Q value = 2.4e-08

Table S116. Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 26(12Q23.1) MUTATED | 10 | 0 | 0 | 0 | 0 | 1 | 22
DEL PEAK 26(12Q23.1) WILD-TYPE | 317 | 3 | 8 | 2 | 7 | 17 | 56

Figure S116. Get High-res Image Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 27(12q24.33) mutation analysis' versus 'AGE'

P value = 0.000113 (t-test), Q value = 0.041

Table S117. Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 27(12Q24.33) MUTATED | 43 | 68.9 (8.7)
DEL PEAK 27(12Q24.33) WILD-TYPE | 399 | 63.0 (11.3)

Figure S117. Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 27(12q24.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.79e-14 (Chi-square test), Q value = 2.1e-11

Table S118. Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 27(12Q24.33) MUTATED | 14 | 0 | 0 | 0 | 0 | 1 | 28
DEL PEAK 27(12Q24.33) WILD-TYPE | 313 | 3 | 8 | 2 | 7 | 17 | 50

Figure S118. Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 28(13q11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.11e-09 (Chi-square test), Q value = 4.7e-07

Table S119. Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 28(13Q11) MUTATED | 30 | 0 | 0 | 0 | 2 | 3 | 32
DEL PEAK 28(13Q11) WILD-TYPE | 297 | 3 | 8 | 2 | 5 | 15 | 46

Figure S119. Get High-res Image Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 29(13q14.2) mutation analysis' versus 'AGE'

P value = 0.000606 (t-test), Q value = 0.2

Table S120. Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 29(13Q14.2) MUTATED | 71 | 67.3 (9.4)
DEL PEAK 29(13Q14.2) WILD-TYPE | 371 | 62.8 (11.4)

Figure S120. Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 29(13q14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000306 (Chi-square test), Q value = 0.1

Table S121. Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 29(13Q14.2) MUTATED | 39 | 0 | 0 | 0 | 2 | 4 | 26
DEL PEAK 29(13Q14.2) WILD-TYPE | 288 | 3 | 8 | 2 | 5 | 14 | 52

Figure S121. Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 30(14q13.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.18e-12 (Chi-square test), Q value = 3.6e-09

Table S122. Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 30(14Q13.1) MUTATED | 20 | 0 | 0 | 0 | 0 | 5 | 29
DEL PEAK 30(14Q13.1) WILD-TYPE | 307 | 3 | 8 | 2 | 7 | 13 | 49

Figure S122. Get High-res Image Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 31(15q15.1) mutation analysis' versus 'AGE'

P value = 1.54e-08 (t-test), Q value = 6.4e-06

Table S123. Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 31(15Q15.1) MUTATED | 102 | 68.6 (9.5)
DEL PEAK 31(15Q15.1) WILD-TYPE | 340 | 62.0 (11.3)

Figure S123. Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 31(15q15.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.67e-20 (Chi-square test), Q value = 1.3e-17

Table S124. Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 31(15Q15.1) MUTATED | 42 | 0 | 0 | 0 | 2 | 7 | 51
DEL PEAK 31(15Q15.1) WILD-TYPE | 285 | 3 | 8 | 2 | 5 | 11 | 27

Figure S124. Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 32(15q23) mutation analysis' versus 'AGE'

P value = 8.73e-06 (t-test), Q value = 0.0034

Table S125. Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 32(15Q23) MUTATED | 82 | 68.1 (9.4)
DEL PEAK 32(15Q23) WILD-TYPE | 360 | 62.5 (11.4)

Figure S125. Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 32(15q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.75e-20 (Chi-square test), Q value = 3.2e-17

Table S126. Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 32(15Q23) MUTATED | 30 | 0 | 0 | 0 | 2 | 5 | 45
DEL PEAK 32(15Q23) WILD-TYPE | 297 | 3 | 8 | 2 | 5 | 13 | 33

Figure S126. Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 33(16p13.3) mutation analysis' versus 'AGE'

P value = 2.74e-08 (t-test), Q value = 1.1e-05

Table S127. Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 33(16P13.3) MUTATED | 61 | 69.5 (7.8)
DEL PEAK 33(16P13.3) WILD-TYPE | 381 | 62.6 (11.4)

Figure S127. Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 33(16p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.77e-15 (Chi-square test), Q value = 8.1e-13

Table S128. Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 33(16P13.3) MUTATED | 22 | 0 | 0 | 0 | 0 | 4 | 35
DEL PEAK 33(16P13.3) WILD-TYPE | 305 | 3 | 8 | 2 | 7 | 14 | 43

Figure S128. Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 34(16q21) mutation analysis' versus 'AGE'

P value = 1.51e-08 (t-test), Q value = 6.3e-06

Table S129. Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 34(16Q21) MUTATED | 116 | 68.1 (9.1)
DEL PEAK 34(16Q21) WILD-TYPE | 326 | 61.9 (11.5)

Figure S129. Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 34(16q21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.27e-21 (Chi-square test), Q value = 2e-18

Table S130. Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 34(16Q21) MUTATED | 52 | 0 | 0 | 0 | 1 | 7 | 56
DEL PEAK 34(16Q21) WILD-TYPE | 275 | 3 | 8 | 2 | 6 | 11 | 22

Figure S130. Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q23.1) mutation analysis' versus 'AGE'

P value = 1e-07 (t-test), Q value = 4.1e-05

Table S131. Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 35(16Q23.1) MUTATED | 126 | 67.7 (9.3)
DEL PEAK 35(16Q23.1) WILD-TYPE | 316 | 61.9 (11.5)

Figure S131. Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 35(16q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.19e-24 (Chi-square test), Q value = 5.8e-22

Table S132. Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 35(16Q23.1) MUTATED | 57 | 0 | 0 | 0 | 1 | 6 | 62
DEL PEAK 35(16Q23.1) WILD-TYPE | 270 | 3 | 8 | 2 | 6 | 12 | 16

Figure S132. Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q23.1) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 3e-04 (Fisher's exact test), Q value = 0.1

Table S133. Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
DEL PEAK 35(16Q23.1) MUTATED | 81 | 45
DEL PEAK 35(16Q23.1) WILD-TYPE | 257 | 60

Figure S133. Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 36(17p13.3) mutation analysis' versus 'AGE'

P value = 4.09e-05 (t-test), Q value = 0.015

Table S134. Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 36(17P13.3) MUTATED | 84 | 67.5 (9.2)
DEL PEAK 36(17P13.3) WILD-TYPE | 358 | 62.6 (11.5)

Figure S134. Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 36(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.11e-16 (Chi-square test), Q value = 1.4e-13

Table S135. Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 36(17P13.3) MUTATED | 33 | 0 | 0 | 0 | 2 | 8 | 41
DEL PEAK 36(17P13.3) WILD-TYPE | 294 | 3 | 8 | 2 | 5 | 10 | 37

Figure S135. Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17p12) mutation analysis' versus 'AGE'

P value = 3.09e-07 (t-test), Q value = 0.00012

Table S136. Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 37(17P12) MUTATED | 96 | 68.1 (8.9)
DEL PEAK 37(17P12) WILD-TYPE | 346 | 62.3 (11.5)

Figure S136. Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 37(17p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.12e-24 (Chi-square test), Q value = 5.5e-22

Table S137. Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 37(17P12) MUTATED | 35 | 0 | 0 | 0 | 1 | 8 | 52
DEL PEAK 37(17P12) WILD-TYPE | 292 | 3 | 8 | 2 | 6 | 10 | 26

Figure S137. Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17p12) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.000622 (Fisher's exact test), Q value = 0.21

Table S138. Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
DEL PEAK 37(17P12) MUTATED | 60 | 36
DEL PEAK 37(17P12) WILD-TYPE | 278 | 69

Figure S138. Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 38(17p11.2) mutation analysis' versus 'AGE'

P value = 3.63e-06 (t-test), Q value = 0.0014

Table S139. Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 38(17P11.2) MUTATED | 87 | 68.0 (9.1)
DEL PEAK 38(17P11.2) WILD-TYPE | 355 | 62.5 (11.5)

Figure S139. Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 38(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.97e-17 (Chi-square test), Q value = 9.2e-15

Table S140. Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 38(17P11.2) MUTATED | 35 | 0 | 0 | 0 | 1 | 7 | 44
DEL PEAK 38(17P11.2) WILD-TYPE | 292 | 3 | 8 | 2 | 6 | 11 | 34

Figure S140. Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 39(17q11.2) mutation analysis' versus 'AGE'

P value = 1.6e-05 (t-test), Q value = 0.0061

Table S141. Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 39(17Q11.2) MUTATED | 77 | 68.0 (9.1)
DEL PEAK 39(17Q11.2) WILD-TYPE | 365 | 62.6 (11.4)

Figure S141. Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 39(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.05e-10 (Chi-square test), Q value = 1.3e-07

Table S142. Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 39(17Q11.2) MUTATED | 35 | 0 | 0 | 0 | 2 | 5 | 35
DEL PEAK 39(17Q11.2) WILD-TYPE | 292 | 3 | 8 | 2 | 5 | 13 | 43

Figure S142. Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 40(17q21.2) mutation analysis' versus 'AGE'

P value = 2.13e-05 (t-test), Q value = 0.008

Table S143. Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 40(17Q21.2) MUTATED | 82 | 67.9 (9.5)
DEL PEAK 40(17Q21.2) WILD-TYPE | 360 | 62.6 (11.4)

Figure S143. Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 40(17q21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.08e-14 (Chi-square test), Q value = 2.3e-11

Table S144. Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 40(17Q21.2) MUTATED | 35 | 0 | 0 | 0 | 1 | 6 | 40
DEL PEAK 40(17Q21.2) WILD-TYPE | 292 | 3 | 8 | 2 | 6 | 12 | 38

Figure S144. Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 41(18q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.41e-15 (Chi-square test), Q value = 2.9e-12

Table S145. Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 41(18Q23) MUTATED | 28 | 0 | 0 | 0 | 2 | 5 | 38
DEL PEAK 41(18Q23) WILD-TYPE | 299 | 3 | 8 | 2 | 5 | 13 | 40

Figure S145. Get High-res Image Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'AGE'

P value = 5.3e-12 (t-test), Q value = 2.3e-09

Table S146. Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 42(19P13.3) MUTATED | 115 | 69.0 (8.7)
DEL PEAK 42(19P13.3) WILD-TYPE | 327 | 61.6 (11.4)

Figure S146. Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 42(19p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.23e-44 (Chi-square test), Q value = 6e-42

Table S147. Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 42(19P13.3) MUTATED | 35 | 0 | 0 | 0 | 1 | 8 | 71
DEL PEAK 42(19P13.3) WILD-TYPE | 292 | 3 | 8 | 2 | 6 | 10 | 7

Figure S147. Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'NEOADJUVANT.THERAPY'

P value = 0.00032 (Fisher's exact test), Q value = 0.11

Table S148. Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

nPatients | NO | YES
--- | --- | ---
ALL | 338 | 105
DEL PEAK 42(19P13.3) MUTATED | 73 | 42
DEL PEAK 42(19P13.3) WILD-TYPE | 265 | 63

Figure S148. Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #5: 'NEOADJUVANT.THERAPY'

'Del Peak 43(19p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.16e-07 (Chi-square test), Q value = 0.00021

Table S149. Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 43(19P12) MUTATED | 13 | 0 | 0 | 0 | 2 | 4 | 18
DEL PEAK 43(19P12) WILD-TYPE | 314 | 3 | 8 | 2 | 5 | 14 | 60

Figure S149. Get High-res Image Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 44(19q13.43) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.63e-14 (Chi-square test), Q value = 7.4e-12

Table S150. Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 44(19Q13.43) MUTATED | 14 | 0 | 0 | 0 | 0 | 4 | 29
DEL PEAK 44(19Q13.43) WILD-TYPE | 313 | 3 | 8 | 2 | 7 | 14 | 49

Figure S150. Get High-res Image Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 46(22q11.1) mutation analysis' versus 'AGE'

P value = 4.63e-05 (t-test), Q value = 0.017

Table S151. Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 46(22Q11.1) MUTATED | 65 | 68.0 (8.8)
DEL PEAK 46(22Q11.1) WILD-TYPE | 377 | 62.8 (11.4)

Figure S151. Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 46(22q11.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000195 (Chi-square test), Q value = 0.068

Table S152. Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 46(22Q11.1) MUTATED | 35 | 0 | 0 | 0 | 2 | 3 | 25
DEL PEAK 46(22Q11.1) WILD-TYPE | 292 | 3 | 8 | 2 | 5 | 15 | 53

Figure S152. Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 47(22q12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.78e-05 (Chi-square test), Q value = 0.014

Table S153. Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 47(22Q12.1) MUTATED | 37 | 0 | 0 | 0 | 1 | 7 | 25
DEL PEAK 47(22Q12.1) WILD-TYPE | 290 | 3 | 8 | 2 | 6 | 11 | 53

Figure S153. Get High-res Image Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 48(22q13.31) mutation analysis' versus 'AGE'

P value = 1.78e-08 (t-test), Q value = 7.4e-06

Table S154. Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 48(22Q13.31) MUTATED | 99 | 68.7 (9.4)
DEL PEAK 48(22Q13.31) WILD-TYPE | 343 | 62.1 (11.3)

Figure S154. Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 48(22q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.75e-16 (Chi-square test), Q value = 8.1e-14

Table S155. Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 48(22Q13.31) MUTATED | 44 | 0 | 0 | 0 | 1 | 7 | 47
DEL PEAK 48(22Q13.31) WILD-TYPE | 283 | 3 | 8 | 2 | 6 | 11 | 31

Figure S155. Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 49(22q13.32) mutation analysis' versus 'AGE'

P value = 4.1e-07 (t-test), Q value = 0.00016

Table S156. Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 49(22Q13.32) MUTATED | 105 | 68.2 (10.1)
DEL PEAK 49(22Q13.32) WILD-TYPE | 337 | 62.1 (11.2)

Figure S156. Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 49(22q13.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.5e-17 (Chi-square test), Q value = 1.2e-14

Table S157. Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 49(22Q13.32) MUTATED | 47 | 0 | 0 | 0 | 1 | 8 | 49
DEL PEAK 49(22Q13.32) WILD-TYPE | 280 | 3 | 8 | 2 | 6 | 10 | 29

Figure S157. Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'AGE'

P value = 0.000137 (t-test), Q value = 0.049

Table S158. Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

| nPatients | Mean (Std.Dev)
--- | --- | ---
ALL | 442 | 63.5 (11.2)
DEL PEAK 50(XP21.1) MUTATED | 62 | 67.8 (8.8)
DEL PEAK 50(XP21.1) WILD-TYPE | 380 | 62.8 (11.5)

Figure S158. Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.19e-13 (Chi-square test), Q value = 1.9e-10

Table S159. Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA
--- | --- | --- | --- | --- | --- | --- | ---
ALL | 327 | 3 | 8 | 2 | 7 | 18 | 78
DEL PEAK 50(XP21.1) MUTATED | 25 | 0 | 0 | 0 | 1 | 2 | 34
DEL PEAK 50(XP21.1) WILD-TYPE | 302 | 3 | 8 | 2 | 6 | 16 | 44

Figure S159. Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data
Input

- Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.

- Clinical data file = UCEC.clin.merged.picked.txt

- Number of patients = 443

- Number of copy number variation regions = 98

- Number of selected clinical features = 5

- Exclude regions that fewer than K tumors have alterations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene cnvs were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene cnvs using 't.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

- Analysis Results (MD5 checksum)

- Auxiliary Data (MD5 checksum)

- MAGE-TAB File (MD5 checksum)

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[4] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
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[6] GISTIC_version2
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