Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.126 0.272 -9999.0 0.0 -0.771 11.0 11.0 IHH -0.096 0.193 -9999.0 0.0 -0.465 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.168 0.227 -9999.0 0.0 -0.469 30.0 30.0 LRPAP1 0.008 0.042 -9999.0 0.0 -0.406 1.0 1.0 dorsoventral neural tube patterning 0.166 0.225 0.465 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.107 0.18 -9999.0 0.0 -0.555 6.0 6.0 SMO -0.12 0.189 -9999.0 0.0 -0.518 11.0 11.0 AKT1 -0.038 0.087 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.092 -9999.0 0.0 -0.499 3.0 3.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.118 0.186 -9999.0 0.0 -0.51 11.0 11.0 STIL -0.142 0.194 -9999.0 0.0 -0.477 14.0 14.0 DHH N/PTCH2 -0.038 0.157 -9999.0 0.0 -0.467 11.0 11.0 DHH N/PTCH1 -0.088 0.175 -9999.0 0.0 -0.461 12.0 12.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.03 0.159 -9999.0 0.0 -0.638 6.0 6.0 PTHLH -0.191 0.398 -9999.0 0.0 -1.18 11.0 11.0 determination of left/right symmetry -0.118 0.186 -9999.0 0.0 -0.51 11.0 11.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.187 0.389 -9999.0 0.0 -1.153 11.0 11.0 IHH N/Hhip -0.144 0.222 -9999.0 0.0 -0.449 29.0 29.0 DHH N/Hhip -0.106 0.217 -9999.0 0.0 -0.435 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.118 0.186 -9999.0 0.0 -0.51 11.0 11.0 pancreas development -0.117 0.242 -9999.0 0.0 -0.544 22.0 22.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.113 0.251 -9999.0 0.0 -0.587 20.0 20.0 somite specification -0.118 0.186 -9999.0 0.0 -0.51 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.156 0.203 -9999.0 0.0 -0.473 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.116 0.192 -9999.0 0.0 -0.423 23.0 23.0 SHH Np/Cholesterol/Megalin -0.133 0.199 -9999.0 0.0 -0.453 21.0 21.0 SHH -0.133 0.214 -9999.0 0.0 -0.51 19.0 19.0 catabolic process -0.079 0.167 -9999.0 0.0 -0.482 10.0 10.0 SMO/Vitamin D3 -0.166 0.209 -9999.0 0.0 -0.517 16.0 16.0 SHH Np/Cholesterol/Hhip -0.169 0.232 -9999.0 0.0 -0.469 31.0 31.0 LRP2 -0.054 0.17 -9999.0 0.0 -0.47 13.0 13.0 receptor-mediated endocytosis -0.18 0.209 -9999.0 0.0 -0.52 19.0 19.0 SHH Np/Cholesterol/BOC -0.105 0.18 -9999.0 0.0 -0.417 20.0 20.0 SHH Np/Cholesterol/CDO -0.123 0.193 -9999.0 0.0 -0.432 22.0 22.0 mesenchymal cell differentiation 0.168 0.23 0.465 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.155 0.204 -9999.0 0.0 -0.474 19.0 19.0 IHH N/PTCH2 -0.07 0.158 -9999.0 0.0 -0.412 13.0 13.0 CDON -0.034 0.159 -9999.0 0.0 -0.545 8.0 8.0 IHH N/PTCH1 -0.08 0.169 -9999.0 0.0 -0.488 10.0 10.0 Megalin/LRPAP1 -0.032 0.127 -9999.0 0.0 -0.509 3.0 3.0 PTCH2 -0.021 0.145 -9999.0 0.0 -0.629 5.0 5.0 SHH Np/Cholesterol -0.11 0.164 -9999.0 0.0 -0.404 19.0 19.0 PTCH1 -0.079 0.167 -9999.0 0.0 -0.484 10.0 10.0 HHIP -0.117 0.243 -9999.0 0.0 -0.545 22.0 22.0