Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	32.0	260.0	8.0	-0.306	0.155	1000.0	-1000.0	-0.021	-1000.0
IL23-mediated signaling events	18.0	1088.0	60.0	-0.602	0.012	1000.0	-1000.0	-0.152	-1000.0
Syndecan-1-mediated signaling events	17.0	580.0	34.0	-0.225	0.012	1000.0	-1000.0	-0.057	-1000.0
IL4-mediated signaling events	15.0	1439.0	91.0	-0.639	0.576	1000.0	-1000.0	-0.138	-1000.0
TCGA08_p53	13.0	96.0	7.0	-0.231	0.12	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by the Hedgehog family	12.0	670.0	52.0	-0.191	0.168	1000.0	-1000.0	-0.061	-1000.0
Wnt signaling	12.0	87.0	7.0	-0.146	0.005	1000.0	-1000.0	-0.029	-1000.0
IL12-mediated signaling events	11.0	1008.0	87.0	-0.349	0.077	1000.0	-1000.0	-0.128	-1000.0
Glucocorticoid receptor regulatory network	11.0	1361.0	114.0	-0.62	0.359	1000.0	-1000.0	-0.062	-1000.0
Glypican 2 network	11.0	46.0	4.0	-0.054	-0.049	1000.0	-1000.0	-0.014	-1000.0
BMP receptor signaling	10.0	851.0	81.0	-0.272	0.028	1000.0	-1000.0	-0.096	-1000.0
amb2 Integrin signaling	10.0	868.0	82.0	-0.188	0.014	1000.0	-1000.0	-0.082	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	1017.0	93.0	-0.195	0.106	1000.0	-1000.0	-0.082	-1000.0
Syndecan-4-mediated signaling events	10.0	677.0	67.0	-0.25	0.034	1000.0	-1000.0	-0.075	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	663.0	68.0	-0.312	0.108	1000.0	-1000.0	-0.133	-1000.0
Noncanonical Wnt signaling pathway	8.0	230.0	26.0	-0.146	0.012	1000.0	-1000.0	-0.061	-1000.0
Glypican 1 network	8.0	395.0	48.0	-0.223	0.014	1000.0	-1000.0	-0.046	-1000.0
Reelin signaling pathway	8.0	449.0	56.0	-0.172	0.028	1000.0	-1000.0	-0.079	-1000.0
BCR signaling pathway	8.0	816.0	99.0	-0.221	0.018	1000.0	-1000.0	-0.093	-1000.0
HIF-1-alpha transcription factor network	7.0	564.0	76.0	-0.443	0.02	1000.0	-1000.0	-0.163	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	597.0	82.0	-0.11	0.012	1000.0	-1000.0	-0.082	-1000.0
Endothelins	7.0	754.0	96.0	-0.172	0.022	1000.0	-1000.0	-0.087	-1000.0
EPHB forward signaling	7.0	597.0	85.0	-0.108	0.093	1000.0	-1000.0	-0.087	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	239.0	31.0	-0.216	0.012	1000.0	-1000.0	-0.093	-1000.0
Visual signal transduction: Rods	7.0	395.0	52.0	-0.194	0.012	1000.0	-1000.0	-0.067	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.038	-1000.0	1000.0	-1000.0	-0.016	-1000.0
Caspase cascade in apoptosis	6.0	483.0	74.0	-0.129	0.066	1000.0	-1000.0	-0.046	-1000.0
Thromboxane A2 receptor signaling	6.0	684.0	105.0	-0.111	0.033	1000.0	-1000.0	-0.07	-1000.0
p75(NTR)-mediated signaling	6.0	861.0	125.0	-0.206	0.037	1000.0	-1000.0	-0.11	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	648.0	97.0	-0.131	0.028	1000.0	-1000.0	-0.084	-1000.0
IL27-mediated signaling events	6.0	331.0	51.0	-0.326	0.059	1000.0	-1000.0	-0.081	-1000.0
IGF1 pathway	6.0	347.0	57.0	-0.109	0.023	1000.0	-1000.0	-0.092	-1000.0
Coregulation of Androgen receptor activity	5.0	414.0	76.0	-0.335	0.023	1000.0	-1000.0	-0.04	-1000.0
Ephrin A  reverse signaling	5.0	36.0	7.0	-0.042	0.0	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	5.0	349.0	69.0	-0.156	0.033	1000.0	-1000.0	-0.049	-1000.0
IL1-mediated signaling events	5.0	366.0	62.0	-0.17	0.057	1000.0	-1000.0	-0.097	-1000.0
Ephrin B reverse signaling	5.0	250.0	48.0	-0.087	0.055	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	254.0	44.0	-0.128	0.012	1000.0	-1000.0	-0.058	-1000.0
Integrins in angiogenesis	5.0	420.0	84.0	-0.177	0.018	1000.0	-1000.0	-0.092	-1000.0
Nongenotropic Androgen signaling	5.0	287.0	52.0	-0.151	0.018	1000.0	-1000.0	-0.057	-1000.0
LPA receptor mediated events	5.0	557.0	102.0	-0.143	0.029	1000.0	-1000.0	-0.094	-1000.0
IL6-mediated signaling events	5.0	396.0	75.0	-0.125	0.057	1000.0	-1000.0	-0.079	-1000.0
EGFR-dependent Endothelin signaling events	5.0	119.0	21.0	-0.086	0.018	1000.0	-1000.0	-0.068	-1000.0
Rapid glucocorticoid signaling	5.0	112.0	20.0	-0.186	0.012	1000.0	-1000.0	-0.021	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	618.0	120.0	-0.181	0.134	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	428.0	78.0	-0.089	0.058	1000.0	-1000.0	-0.086	-1000.0
LPA4-mediated signaling events	4.0	58.0	12.0	-0.084	0.018	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	4.0	270.0	65.0	-0.156	0.021	1000.0	-1000.0	-0.076	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	143.0	34.0	-0.048	0.012	1000.0	-1000.0	-0.058	-1000.0
ErbB4 signaling events	4.0	336.0	69.0	-0.229	0.052	1000.0	-1000.0	-0.088	-1000.0
Osteopontin-mediated events	4.0	181.0	38.0	-0.085	0.012	1000.0	-1000.0	-0.098	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	83.0	17.0	-0.053	0.012	1000.0	-1000.0	-0.04	-1000.0
Arf6 signaling events	4.0	290.0	62.0	-0.092	0.012	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	4.0	314.0	76.0	-0.118	0.015	1000.0	-1000.0	-0.071	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	194.0	46.0	-0.318	0.018	1000.0	-1000.0	-0.096	-1000.0
Nectin adhesion pathway	4.0	267.0	63.0	-0.085	0.022	1000.0	-1000.0	-0.073	-1000.0
S1P5 pathway	4.0	76.0	17.0	-0.082	0.066	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	4.0	143.0	35.0	-0.191	0.037	1000.0	-1000.0	-0.051	-1000.0
Effects of Botulinum toxin	4.0	110.0	26.0	-0.059	0.012	1000.0	-1000.0	-0.06	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	323.0	74.0	-0.103	0.04	1000.0	-1000.0	-0.096	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	149.0	33.0	-0.313	0.037	1000.0	-1000.0	-0.06	-1000.0
E-cadherin signaling events	4.0	21.0	5.0	-0.031	0.012	1000.0	-1000.0	-0.024	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	537.0	136.0	-0.247	0.087	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	105.0	28.0	-0.082	0.016	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Cones	3.0	134.0	38.0	-0.059	0.012	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	185.0	54.0	-0.172	0.025	1000.0	-1000.0	-0.096	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	16.0	5.0	-0.021	0.001	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	3.0	166.0	44.0	-0.056	0.02	1000.0	-1000.0	-0.065	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	178.0	52.0	-0.173	0.035	1000.0	-1000.0	-0.05	-1000.0
S1P1 pathway	3.0	122.0	36.0	-0.083	0.012	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	3.0	166.0	51.0	-0.13	0.047	1000.0	-1000.0	-0.062	-1000.0
Plasma membrane estrogen receptor signaling	3.0	322.0	86.0	-0.102	0.022	1000.0	-1000.0	-0.088	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	341.0	88.0	-0.103	0.042	1000.0	-1000.0	-0.109	-1000.0
E-cadherin signaling in keratinocytes	3.0	152.0	43.0	-0.057	0.022	1000.0	-1000.0	-0.065	-1000.0
FOXM1 transcription factor network	3.0	164.0	51.0	-0.317	0.13	1000.0	-1000.0	-0.201	-1000.0
S1P4 pathway	3.0	87.0	25.0	-0.082	0.015	1000.0	-1000.0	-0.062	-1000.0
Regulation of Androgen receptor activity	3.0	271.0	70.0	-0.389	0.022	1000.0	-1000.0	-0.073	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.052	0.022	1000.0	-1000.0	-0.041	-1000.0
Cellular roles of Anthrax toxin	2.0	110.0	39.0	-0.064	0.015	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	183.0	85.0	-0.092	0.02	1000.0	-1000.0	-0.083	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	155.0	65.0	-0.145	0.052	1000.0	-1000.0	-0.062	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	168.0	61.0	-0.118	0.033	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	2.0	145.0	68.0	-0.076	0.025	1000.0	-1000.0	-0.098	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	77.0	37.0	-0.038	0.018	1000.0	-1000.0	-0.054	-1000.0
TRAIL signaling pathway	2.0	124.0	48.0	-0.044	0.033	1000.0	-1000.0	-0.07	-1000.0
HIF-2-alpha transcription factor network	2.0	123.0	43.0	-0.048	0.044	1000.0	-1000.0	-0.092	-1000.0
FAS signaling pathway (CD95)	2.0	137.0	47.0	-0.185	0.013	1000.0	-1000.0	-0.039	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	43.0	15.0	-0.02	0.017	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	2.0	152.0	58.0	-0.094	0.03	1000.0	-1000.0	-0.086	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	98.0	45.0	-0.06	0.026	1000.0	-1000.0	-0.096	-1000.0
TCGA08_rtk_signaling	2.0	53.0	26.0	-0.057	0.032	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	202.0	76.0	-0.052	0.029	1000.0	-1000.0	-0.087	-1000.0
IL2 signaling events mediated by STAT5	2.0	60.0	22.0	-0.107	0.015	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events	2.0	149.0	73.0	-0.072	0.025	1000.0	-1000.0	-0.068	-1000.0
Regulation of Telomerase	2.0	259.0	102.0	-0.139	0.042	1000.0	-1000.0	-0.118	-1000.0
S1P3 pathway	2.0	105.0	42.0	-0.081	0.02	1000.0	-1000.0	-0.038	-1000.0
Aurora B signaling	2.0	146.0	67.0	-0.172	0.023	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class II	1.0	96.0	75.0	-0.057	0.033	1000.0	-1000.0	-0.048	-1000.0
BARD1 signaling events	1.0	76.0	57.0	-0.013	0.058	1000.0	-1000.0	-0.065	-1000.0
EPO signaling pathway	1.0	60.0	55.0	-0.034	0.043	1000.0	-1000.0	-0.098	-1000.0
Ceramide signaling pathway	1.0	128.0	76.0	-0.102	0.021	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class III	1.0	61.0	40.0	-0.113	0.018	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	111.0	83.0	-0.069	0.038	1000.0	-1000.0	-0.076	-1000.0
Retinoic acid receptors-mediated signaling	1.0	73.0	58.0	-0.05	0.038	1000.0	-1000.0	-0.079	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	47.0	36.0	-0.03	0.025	1000.0	-1000.0	-0.073	-1000.0
Regulation of p38-alpha and p38-beta	1.0	103.0	54.0	-0.072	0.03	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	139.0	125.0	-0.021	0.064	1000.0	-1000.0	-0.098	-1000.0
Insulin Pathway	1.0	110.0	74.0	-0.072	0.033	1000.0	-1000.0	-0.082	-1000.0
VEGFR1 specific signals	1.0	58.0	56.0	-0.021	0.046	1000.0	-1000.0	-0.079	-1000.0
PDGFR-beta signaling pathway	1.0	161.0	97.0	-0.046	0.051	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by PRL	1.0	54.0	34.0	-0.113	0.032	1000.0	-1000.0	-0.043	-1000.0
p38 MAPK signaling pathway	1.0	55.0	44.0	-0.076	0.024	1000.0	-1000.0	-0.069	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.012	0.043	1000.0	-1000.0	-0.053	-1000.0
Canonical NF-kappaB pathway	0.0	29.0	39.0	-0.056	0.07	1000.0	-1000.0	-0.094	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.012	0.021	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.021	0.04	1000.0	-1000.0	-0.054	-1000.0
Aurora A signaling	0.0	40.0	60.0	-0.035	0.034	1000.0	-1000.0	-0.06	-1000.0
Arf6 downstream pathway	0.0	17.0	43.0	-0.023	0.026	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.009	0.012	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	0.0	19.0	85.0	-0.005	0.034	1000.0	-1000.0	-0.047	-1000.0
Insulin-mediated glucose transport	0.0	31.0	32.0	-0.04	0.029	1000.0	-1000.0	-0.068	-1000.0
mTOR signaling pathway	0.0	24.0	53.0	-0.007	0.032	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	33.0	68.0	-0.04	0.045	1000.0	-1000.0	-0.056	-1000.0
ceramide signaling pathway	0.0	48.0	49.0	-0.056	0.026	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by HDAC Class I	0.0	83.0	104.0	-0.081	0.052	1000.0	-1000.0	-0.075	-1000.0
FoxO family signaling	0.0	31.0	64.0	-0.062	0.13	1000.0	-1000.0	-0.07	-1000.0
Atypical NF-kappaB pathway	0.0	21.0	31.0	-0.014	0.033	1000.0	-1000.0	-0.044	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.005	0.031	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	0.0	55.0	71.0	-0.052	0.04	1000.0	-1000.0	-0.075	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.004	0.028	1000.0	-1000.0	-0.036	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.037	1000.0	-1000.0	-0.042	-1000.0
Total	553	33976	7203	-16.9016516368	-994.500092297	131000	-131000	-8.90805299744	-131000