Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.197 -9999.0 0.0 -0.616 9.0 9.0 IHH 0.013 0.099 -9999.0 0.0 -0.531 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.063 0.139 -9999.0 0.0 -0.299 23.0 23.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.062 0.138 0.297 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.045 0.149 -9999.0 0.0 -0.397 8.0 8.0 SMO -0.056 0.148 -9999.0 0.0 -0.385 11.0 11.0 AKT1 -0.03 0.122 -9999.0 0.0 -0.398 6.0 6.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.054 0.147 -9999.0 0.0 -0.38 11.0 11.0 STIL -0.063 0.13 -9999.0 0.0 -0.311 10.0 10.0 DHH N/PTCH2 -0.001 0.118 -9999.0 0.0 -0.365 9.0 9.0 DHH N/PTCH1 -0.015 0.121 -9999.0 0.0 -0.29 14.0 14.0 PIK3CA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.007 0.117 -9999.0 0.0 -0.5 5.0 5.0 PTHLH -0.074 0.301 -9999.0 0.0 -0.971 9.0 9.0 determination of left/right symmetry -0.054 0.147 -9999.0 0.0 -0.38 11.0 11.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.073 0.296 -9999.0 0.0 -0.957 9.0 9.0 IHH N/Hhip -0.022 0.153 -9999.0 0.0 -0.393 13.0 13.0 DHH N/Hhip -0.031 0.157 -9999.0 0.0 -0.385 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.054 0.147 -9999.0 0.0 -0.38 11.0 11.0 pancreas development -0.038 0.168 -9999.0 0.0 -0.499 11.0 11.0 HHAT 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.138 -9999.0 0.0 -0.5 7.0 7.0 somite specification -0.054 0.147 -9999.0 0.0 -0.38 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.058 0.139 -9999.0 0.0 -0.277 25.0 25.0 SHH Np/Cholesterol/PTCH2 -0.046 0.133 -9999.0 0.0 -0.297 20.0 20.0 SHH Np/Cholesterol/Megalin -0.042 0.136 -9999.0 0.0 -0.312 18.0 18.0 SHH -0.078 0.134 -9999.0 0.0 -0.366 17.0 17.0 catabolic process -0.012 0.117 -9999.0 0.0 -0.329 11.0 11.0 SMO/Vitamin D3 -0.071 0.153 -9999.0 0.0 -0.371 12.0 12.0 SHH Np/Cholesterol/Hhip -0.069 0.158 -9999.0 0.0 -0.328 24.0 24.0 LRP2 0.009 0.093 -9999.0 0.0 -0.5 3.0 3.0 receptor-mediated endocytosis -0.08 0.157 -9999.0 0.0 -0.409 10.0 10.0 SHH Np/Cholesterol/BOC -0.031 0.112 -9999.0 0.0 -0.285 15.0 15.0 SHH Np/Cholesterol/CDO -0.04 0.126 -9999.0 0.0 -0.299 17.0 17.0 mesenchymal cell differentiation 0.069 0.157 0.325 24.0 -9999.0 0.0 24.0 mol:Vitamin D3 -0.053 0.146 0.342 1.0 -0.277 25.0 26.0 IHH N/PTCH2 0.009 0.107 -9999.0 0.0 -0.372 6.0 6.0 CDON 0.015 0.076 -9999.0 0.0 -0.5 2.0 2.0 IHH N/PTCH1 -0.002 0.122 -9999.0 0.0 -0.331 11.0 11.0 Megalin/LRPAP1 0.025 0.072 -9999.0 0.0 -0.365 3.0 3.0 PTCH2 0.004 0.106 -9999.0 0.0 -0.5 4.0 4.0 SHH Np/Cholesterol -0.052 0.108 -9999.0 0.0 -0.281 17.0 17.0 PTCH1 -0.012 0.117 -9999.0 0.0 -0.33 11.0 11.0 HHIP -0.038 0.168 -9999.0 0.0 -0.5 11.0 11.0