Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	13.0	1262.0	91.0	-0.499	0.454	1000.0	-1000.0	-0.088	-1000.0
TCGA08_retinoblastoma	13.0	105.0	8.0	-0.069	0.08	1000.0	-1000.0	-0.001	-1000.0
IL23-mediated signaling events	12.0	744.0	60.0	-0.452	0.026	1000.0	-1000.0	-0.096	-1000.0
Syndecan-1-mediated signaling events	11.0	379.0	34.0	-0.113	0.026	1000.0	-1000.0	-0.037	-1000.0
Endothelins	10.0	977.0	96.0	-0.075	0.026	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	989.0	93.0	-0.116	0.04	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by the Hedgehog family	9.0	515.0	52.0	-0.08	0.069	1000.0	-1000.0	-0.03	-1000.0
Glucocorticoid receptor regulatory network	9.0	1074.0	114.0	-0.434	0.223	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	436.0	44.0	-0.078	0.026	1000.0	-1000.0	-0.031	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	638.0	68.0	-0.2	0.091	1000.0	-1000.0	-0.067	-1000.0
IL12-mediated signaling events	8.0	708.0	87.0	-0.259	0.042	1000.0	-1000.0	-0.065	-1000.0
Wnt signaling	8.0	61.0	7.0	-0.082	0.016	1000.0	-1000.0	-0.015	-1000.0
Noncanonical Wnt signaling pathway	7.0	190.0	26.0	-0.083	0.026	1000.0	-1000.0	-0.042	-1000.0
Thromboxane A2 receptor signaling	7.0	824.0	105.0	-0.084	0.033	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	7.0	617.0	82.0	-0.094	0.033	1000.0	-1000.0	-0.04	-1000.0
Reelin signaling pathway	7.0	392.0	56.0	-0.073	0.059	1000.0	-1000.0	-0.041	-1000.0
EPHB forward signaling	7.0	657.0	85.0	-0.075	0.067	1000.0	-1000.0	-0.067	-1000.0
Syndecan-4-mediated signaling events	7.0	489.0	67.0	-0.119	0.039	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	6.0	444.0	74.0	-0.088	0.063	1000.0	-1000.0	-0.035	-1000.0
HIF-1-alpha transcription factor network	6.0	459.0	76.0	-0.17	0.036	1000.0	-1000.0	-0.069	-1000.0
p75(NTR)-mediated signaling	6.0	856.0	125.0	-0.067	0.058	1000.0	-1000.0	-0.063	-1000.0
BMP receptor signaling	6.0	563.0	81.0	-0.13	0.05	1000.0	-1000.0	-0.039	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	583.0	97.0	-0.115	0.04	1000.0	-1000.0	-0.056	-1000.0
S1P5 pathway	6.0	102.0	17.0	-0.037	0.026	1000.0	-1000.0	-0.012	-1000.0
IL27-mediated signaling events	6.0	347.0	51.0	-0.251	0.047	1000.0	-1000.0	-0.048	-1000.0
LPA receptor mediated events	6.0	683.0	102.0	-0.104	0.03	1000.0	-1000.0	-0.062	-1000.0
BCR signaling pathway	6.0	692.0	99.0	-0.129	0.033	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	6.0	368.0	57.0	-0.053	0.044	1000.0	-1000.0	-0.037	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.008	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	476.0	78.0	-0.092	0.045	1000.0	-1000.0	-0.041	-1000.0
Glypican 1 network	5.0	264.0	48.0	-0.086	0.036	1000.0	-1000.0	-0.036	-1000.0
Signaling events regulated by Ret tyrosine kinase	5.0	430.0	82.0	-0.044	0.026	1000.0	-1000.0	-0.043	-1000.0
ceramide signaling pathway	5.0	264.0	49.0	-0.029	0.038	1000.0	-1000.0	-0.037	-1000.0
Ephrin B reverse signaling	5.0	270.0	48.0	-0.03	0.034	1000.0	-1000.0	-0.023	-1000.0
Glypican 2 network	5.0	21.0	4.0	0.001	0.008	1000.0	-1000.0	0.011	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	178.0	31.0	-0.108	0.025	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Rods	5.0	287.0	52.0	-0.109	0.031	1000.0	-1000.0	-0.029	-1000.0
Osteopontin-mediated events	4.0	160.0	38.0	-0.079	0.026	1000.0	-1000.0	-0.05	-1000.0
Ephrin A  reverse signaling	4.0	30.0	7.0	-0.03	0.011	1000.0	-1000.0	-0.021	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	76.0	17.0	-0.034	0.026	1000.0	-1000.0	-0.032	-1000.0
Syndecan-2-mediated signaling events	4.0	293.0	69.0	-0.045	0.041	1000.0	-1000.0	-0.035	-1000.0
Nectin adhesion pathway	4.0	252.0	63.0	-0.052	0.05	1000.0	-1000.0	-0.044	-1000.0
IL1-mediated signaling events	4.0	298.0	62.0	-0.072	0.054	1000.0	-1000.0	-0.036	-1000.0
TCGA08_p53	4.0	28.0	7.0	-0.014	0.026	1000.0	-1000.0	-0.011	-1000.0
Integrins in angiogenesis	4.0	353.0	84.0	-0.097	0.056	1000.0	-1000.0	-0.049	-1000.0
Nongenotropic Androgen signaling	4.0	235.0	52.0	-0.048	0.042	1000.0	-1000.0	-0.029	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	364.0	74.0	-0.088	0.044	1000.0	-1000.0	-0.061	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	592.0	120.0	-0.129	0.095	1000.0	-1000.0	-0.045	-1000.0
S1P4 pathway	4.0	109.0	25.0	-0.037	0.036	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling events	4.0	21.0	5.0	-0.007	0.024	1000.0	-1000.0	0.008	-1000.0
LPA4-mediated signaling events	3.0	41.0	12.0	-0.053	0.0	1000.0	-1000.0	-0.022	-1000.0
ErbB2/ErbB3 signaling events	3.0	245.0	65.0	-0.045	0.036	1000.0	-1000.0	-0.059	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	415.0	136.0	-0.389	0.07	1000.0	-1000.0	-0.05	-1000.0
Coregulation of Androgen receptor activity	3.0	285.0	76.0	-0.261	0.045	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	87.0	28.0	-0.032	0.035	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	3.0	226.0	62.0	-0.022	0.04	1000.0	-1000.0	-0.033	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	293.0	85.0	-0.033	0.034	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PTP1B	3.0	254.0	76.0	-0.033	0.032	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	202.0	61.0	-0.06	0.058	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	160.0	46.0	-0.186	0.068	1000.0	-1000.0	-0.087	-1000.0
PDGFR-alpha signaling pathway	3.0	137.0	44.0	-0.054	0.041	1000.0	-1000.0	-0.047	-1000.0
IFN-gamma pathway	3.0	246.0	68.0	-0.071	0.043	1000.0	-1000.0	-0.058	-1000.0
Ceramide signaling pathway	3.0	241.0	76.0	-0.02	0.058	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	3.0	162.0	43.0	-0.031	0.041	1000.0	-1000.0	-0.039	-1000.0
S1P1 pathway	3.0	111.0	36.0	-0.038	0.025	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	56.0	15.0	-0.018	0.024	1000.0	-1000.0	-0.031	-1000.0
Canonical Wnt signaling pathway	3.0	171.0	51.0	-0.057	0.061	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	3.0	284.0	75.0	-0.059	0.052	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	286.0	76.0	-0.069	0.047	1000.0	-1000.0	-0.058	-1000.0
Plasma membrane estrogen receptor signaling	3.0	284.0	86.0	-0.04	0.047	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	272.0	88.0	-0.045	0.031	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling in keratinocytes	3.0	129.0	43.0	-0.037	0.026	1000.0	-1000.0	-0.035	-1000.0
Regulation of Androgen receptor activity	3.0	232.0	70.0	-0.322	0.036	1000.0	-1000.0	-0.047	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	56.0	17.0	-0.01	0.045	1000.0	-1000.0	-0.026	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	86.0	34.0	-0.018	0.05	1000.0	-1000.0	-0.035	-1000.0
ErbB4 signaling events	2.0	167.0	69.0	-0.062	0.042	1000.0	-1000.0	-0.051	-1000.0
Visual signal transduction: Cones	2.0	97.0	38.0	-0.012	0.038	1000.0	-1000.0	-0.017	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	131.0	54.0	-0.053	0.038	1000.0	-1000.0	-0.039	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	14.0	5.0	0.004	0.027	1000.0	-1000.0	0.007	-1000.0
Cellular roles of Anthrax toxin	2.0	90.0	39.0	-0.032	0.026	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	181.0	65.0	-0.084	0.062	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	2.0	99.0	48.0	-0.022	0.042	1000.0	-1000.0	-0.032	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	151.0	52.0	-0.084	0.062	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	2.0	128.0	47.0	-0.123	0.037	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	2.0	148.0	58.0	-0.059	0.04	1000.0	-1000.0	-0.037	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	109.0	45.0	-0.012	0.045	1000.0	-1000.0	-0.045	-1000.0
Effects of Botulinum toxin	2.0	62.0	26.0	-0.012	0.044	1000.0	-1000.0	-0.014	-1000.0
IL2 signaling events mediated by STAT5	2.0	49.0	22.0	-0.074	0.032	1000.0	-1000.0	-0.037	-1000.0
EGFR-dependent Endothelin signaling events	2.0	56.0	21.0	-0.029	0.039	1000.0	-1000.0	-0.04	-1000.0
S1P3 pathway	2.0	118.0	42.0	-0.029	0.036	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	2.0	49.0	20.0	-0.062	0.035	1000.0	-1000.0	-0.012	-1000.0
PDGFR-beta signaling pathway	2.0	194.0	97.0	-0.035	0.056	1000.0	-1000.0	-0.057	-1000.0
FOXM1 transcription factor network	2.0	133.0	51.0	-0.075	0.05	1000.0	-1000.0	-0.128	-1000.0
Aurora B signaling	2.0	148.0	67.0	-0.172	0.061	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	1.0	85.0	57.0	-0.032	0.05	1000.0	-1000.0	-0.031	-1000.0
EPO signaling pathway	1.0	85.0	55.0	-0.002	0.065	1000.0	-1000.0	-0.04	-1000.0
PLK1 signaling events	1.0	105.0	85.0	-0.007	0.053	1000.0	-1000.0	-0.035	-1000.0
Insulin-mediated glucose transport	1.0	34.0	32.0	-0.026	0.044	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	1.0	78.0	53.0	-0.036	0.026	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	67.0	37.0	-0.026	0.048	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class III	1.0	42.0	40.0	-0.049	0.05	1000.0	-1000.0	-0.028	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	106.0	83.0	-0.013	0.045	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	45.0	36.0	-0.038	0.043	1000.0	-1000.0	-0.036	-1000.0
Syndecan-3-mediated signaling events	1.0	41.0	35.0	-0.088	0.058	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	1.0	98.0	54.0	-0.038	0.054	1000.0	-1000.0	-0.045	-1000.0
TCGA08_rtk_signaling	1.0	45.0	26.0	-0.028	0.056	1000.0	-1000.0	-0.01	-1000.0
Class I PI3K signaling events	1.0	138.0	73.0	-0.039	0.046	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	1.0	192.0	102.0	-0.094	0.056	1000.0	-1000.0	-0.046	-1000.0
Insulin Pathway	1.0	118.0	74.0	-0.032	0.057	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	1.0	68.0	56.0	-0.032	0.053	1000.0	-1000.0	-0.038	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	61.0	33.0	-0.057	0.056	1000.0	-1000.0	-0.037	-1000.0
p38 MAPK signaling pathway	1.0	59.0	44.0	-0.012	0.046	1000.0	-1000.0	-0.023	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	0.002	0.048	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.007	0.062	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	0.0	50.0	75.0	-0.025	0.069	1000.0	-1000.0	-0.031	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.011	0.026	1000.0	-1000.0	-0.026	-1000.0
Circadian rhythm pathway	0.0	9.0	22.0	-0.008	0.042	1000.0	-1000.0	-0.033	-1000.0
Aurora A signaling	0.0	27.0	60.0	-0.01	0.055	1000.0	-1000.0	-0.029	-1000.0
Arf6 downstream pathway	0.0	22.0	43.0	-0.041	0.045	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.035	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	62.0	68.0	-0.034	0.054	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class I	0.0	86.0	104.0	-0.067	0.063	1000.0	-1000.0	-0.031	-1000.0
FoxO family signaling	0.0	50.0	64.0	-0.041	0.069	1000.0	-1000.0	-0.052	-1000.0
Retinoic acid receptors-mediated signaling	0.0	39.0	58.0	-0.0	0.062	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	0.0	26.0	31.0	-0.01	0.034	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	79.0	125.0	-0.017	0.062	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.011	0.053	1000.0	-1000.0	-0.037	-1000.0
Arf6 trafficking events	0.0	52.0	71.0	-0.035	0.047	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PRL	0.0	31.0	34.0	-0.057	0.038	1000.0	-1000.0	-0.037	-1000.0
Arf1 pathway	0.0	15.0	54.0	-0.005	0.044	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Total	452	30308	7203	-9.42216095937	-993.684276865	131000	-131000	-4.97977961108	-131000