Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.199 0.325 -9999.0 0.0 -0.694 22.0 22.0 IHH -0.083 0.182 -9999.0 0.0 -0.563 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.076 0.171 -9999.0 0.0 -0.445 11.0 11.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.075 0.17 0.442 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.142 0.235 -9999.0 0.0 -0.615 13.0 13.0 SMO -0.156 0.247 -9999.0 0.0 -0.654 13.0 13.0 AKT1 -0.065 0.137 -9999.0 0.0 -0.663 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.023 0.138 -9999.0 0.0 -0.558 6.0 6.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.154 0.243 -9999.0 0.0 -0.641 13.0 13.0 STIL -0.119 0.219 -9999.0 0.0 -0.586 12.0 12.0 DHH N/PTCH2 -0.015 0.117 -9999.0 0.0 -0.431 7.0 7.0 DHH N/PTCH1 -0.11 0.206 -9999.0 0.0 -0.54 12.0 12.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.099 -9999.0 0.0 -0.558 3.0 3.0 PTHLH -0.28 0.441 -9999.0 0.0 -1.008 22.0 22.0 determination of left/right symmetry -0.154 0.243 -9999.0 0.0 -0.641 13.0 13.0 PIK3R1 -0.017 0.129 -9999.0 0.0 -0.567 5.0 5.0 skeletal system development -0.276 0.434 -9999.0 0.0 -0.991 22.0 22.0 IHH N/Hhip -0.087 0.186 -9999.0 0.0 -0.444 19.0 19.0 DHH N/Hhip -0.044 0.153 -9999.0 0.0 -0.419 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.154 0.243 -9999.0 0.0 -0.641 13.0 13.0 pancreas development -0.056 0.171 -9999.0 0.0 -0.511 12.0 12.0 HHAT -0.008 0.115 -9999.0 0.0 -0.65 3.0 3.0 PI3K -0.003 0.095 -9999.0 0.0 -0.409 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.06 0.193 -9999.0 0.0 -0.569 12.0 12.0 somite specification -0.154 0.243 -9999.0 0.0 -0.641 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.132 0.231 -9999.0 0.0 -0.575 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.05 0.143 -9999.0 0.0 -0.39 10.0 10.0 SHH Np/Cholesterol/Megalin -0.073 0.163 -9999.0 0.0 -0.457 9.0 9.0 SHH -0.054 0.158 -9999.0 0.0 -0.407 16.0 16.0 catabolic process -0.12 0.215 -9999.0 0.0 -0.592 10.0 10.0 SMO/Vitamin D3 -0.153 0.245 -9999.0 0.0 -0.603 17.0 17.0 SHH Np/Cholesterol/Hhip -0.075 0.17 -9999.0 0.0 -0.413 16.0 16.0 LRP2 -0.055 0.172 -9999.0 0.0 -0.511 12.0 12.0 receptor-mediated endocytosis -0.165 0.233 -9999.0 0.0 -0.589 17.0 17.0 SHH Np/Cholesterol/BOC -0.055 0.138 -9999.0 0.0 -0.307 22.0 22.0 SHH Np/Cholesterol/CDO -0.043 0.132 -9999.0 0.0 -0.373 8.0 8.0 mesenchymal cell differentiation 0.075 0.169 0.41 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.131 0.233 -9999.0 0.0 -0.577 15.0 15.0 IHH N/PTCH2 -0.055 0.153 -9999.0 0.0 -0.471 9.0 9.0 CDON -0.001 0.094 -9999.0 0.0 -0.65 2.0 2.0 IHH N/PTCH1 -0.121 0.217 -9999.0 0.0 -0.599 10.0 10.0 Megalin/LRPAP1 -0.03 0.124 -9999.0 0.0 -0.361 12.0 12.0 PTCH2 -0.014 0.125 -9999.0 0.0 -0.616 4.0 4.0 SHH Np/Cholesterol -0.048 0.121 -9999.0 0.0 -0.316 16.0 16.0 PTCH1 -0.12 0.216 -9999.0 0.0 -0.595 10.0 10.0 HHIP -0.056 0.171 -9999.0 0.0 -0.511 12.0 12.0