Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	17.0	1061.0	60.0	-0.705	0.012	1000.0	-1000.0	-0.184	-1000.0
IL4-mediated signaling events	15.0	1395.0	91.0	-0.807	0.684	1000.0	-1000.0	-0.158	-1000.0
HIF-1-alpha transcription factor network	13.0	1061.0	76.0	-0.615	0.02	1000.0	-1000.0	-0.169	-1000.0
Glypican 2 network	13.0	55.0	4.0	-0.097	-0.077	1000.0	-1000.0	-0.022	-1000.0
p75(NTR)-mediated signaling	12.0	1618.0	125.0	-0.242	0.033	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by the Hedgehog family	10.0	546.0	52.0	-0.28	0.075	1000.0	-1000.0	-0.061	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	942.0	93.0	-0.198	0.108	1000.0	-1000.0	-0.086	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	328.0	34.0	-0.095	0.012	1000.0	-1000.0	-0.049	-1000.0
IL12-mediated signaling events	9.0	812.0	87.0	-0.322	0.1	1000.0	-1000.0	-0.139	-1000.0
Syndecan-1-mediated signaling events	9.0	325.0	34.0	-0.226	0.012	1000.0	-1000.0	-0.066	-1000.0
BMP receptor signaling	9.0	805.0	81.0	-0.253	0.027	1000.0	-1000.0	-0.09	-1000.0
Glucocorticoid receptor regulatory network	9.0	1122.0	114.0	-0.643	0.324	1000.0	-1000.0	-0.071	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	397.0	44.0	-0.24	0.012	1000.0	-1000.0	-0.058	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	286.0	31.0	-0.269	0.012	1000.0	-1000.0	-0.086	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	639.0	68.0	-0.371	0.081	1000.0	-1000.0	-0.125	-1000.0
Class IB PI3K non-lipid kinase events	9.0	27.0	3.0	-0.043	-1000.0	1000.0	-1000.0	-0.022	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	391.0	46.0	-0.393	0.019	1000.0	-1000.0	-0.116	-1000.0
Ephrin B reverse signaling	8.0	409.0	48.0	-0.122	0.085	1000.0	-1000.0	-0.062	-1000.0
Wnt signaling	8.0	60.0	7.0	-0.104	0.012	1000.0	-1000.0	-0.039	-1000.0
BCR signaling pathway	8.0	804.0	99.0	-0.195	0.023	1000.0	-1000.0	-0.1	-1000.0
ErbB4 signaling events	7.0	502.0	69.0	-0.201	0.07	1000.0	-1000.0	-0.087	-1000.0
Glypican 1 network	7.0	345.0	48.0	-0.15	0.021	1000.0	-1000.0	-0.051	-1000.0
amb2 Integrin signaling	7.0	651.0	82.0	-0.141	0.017	1000.0	-1000.0	-0.09	-1000.0
Endothelins	7.0	734.0	96.0	-0.273	0.043	1000.0	-1000.0	-0.097	-1000.0
EPHB forward signaling	7.0	632.0	85.0	-0.128	0.103	1000.0	-1000.0	-0.092	-1000.0
Effects of Botulinum toxin	7.0	195.0	26.0	-0.207	0.012	1000.0	-1000.0	-0.065	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	949.0	120.0	-0.284	0.215	1000.0	-1000.0	-0.077	-1000.0
Syndecan-2-mediated signaling events	6.0	468.0	69.0	-0.13	0.024	1000.0	-1000.0	-0.062	-1000.0
Nectin adhesion pathway	6.0	434.0	63.0	-0.112	0.024	1000.0	-1000.0	-0.089	-1000.0
Signaling events regulated by Ret tyrosine kinase	6.0	526.0	82.0	-0.125	0.012	1000.0	-1000.0	-0.093	-1000.0
IL27-mediated signaling events	6.0	308.0	51.0	-0.152	0.086	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	6.0	129.0	21.0	-0.123	0.019	1000.0	-1000.0	-0.076	-1000.0
Syndecan-4-mediated signaling events	6.0	437.0	67.0	-0.13	0.023	1000.0	-1000.0	-0.079	-1000.0
Plasma membrane estrogen receptor signaling	6.0	577.0	86.0	-0.117	0.079	1000.0	-1000.0	-0.083	-1000.0
LPA4-mediated signaling events	5.0	63.0	12.0	-0.076	0.018	1000.0	-1000.0	-0.031	-1000.0
Caspase cascade in apoptosis	5.0	396.0	74.0	-0.096	0.038	1000.0	-1000.0	-0.043	-1000.0
Coregulation of Androgen receptor activity	5.0	422.0	76.0	-0.19	0.022	1000.0	-1000.0	-0.049	-1000.0
Osteopontin-mediated events	5.0	223.0	38.0	-0.122	0.013	1000.0	-1000.0	-0.102	-1000.0
Ephrin A  reverse signaling	5.0	41.0	7.0	-0.029	0.0	1000.0	-1000.0	-0.031	-1000.0
Noncanonical Wnt signaling pathway	5.0	140.0	26.0	-0.106	0.012	1000.0	-1000.0	-0.066	-1000.0
Thromboxane A2 receptor signaling	5.0	525.0	105.0	-0.123	0.031	1000.0	-1000.0	-0.077	-1000.0
Arf6 signaling events	5.0	327.0	62.0	-0.123	0.016	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by PTP1B	5.0	424.0	76.0	-0.202	0.02	1000.0	-1000.0	-0.084	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	528.0	97.0	-0.125	0.028	1000.0	-1000.0	-0.095	-1000.0
S1P5 pathway	5.0	96.0	17.0	-0.076	0.071	1000.0	-1000.0	-0.037	-1000.0
Integrins in angiogenesis	5.0	474.0	84.0	-0.188	0.019	1000.0	-1000.0	-0.099	-1000.0
Nongenotropic Androgen signaling	5.0	293.0	52.0	-0.123	0.019	1000.0	-1000.0	-0.065	-1000.0
LPA receptor mediated events	5.0	595.0	102.0	-0.127	0.018	1000.0	-1000.0	-0.096	-1000.0
IL6-mediated signaling events	5.0	378.0	75.0	-0.128	0.045	1000.0	-1000.0	-0.097	-1000.0
IGF1 pathway	5.0	331.0	57.0	-0.122	0.025	1000.0	-1000.0	-0.103	-1000.0
Visual signal transduction: Rods	5.0	281.0	52.0	-0.188	0.012	1000.0	-1000.0	-0.075	-1000.0
Visual signal transduction: Cones	4.0	177.0	38.0	-0.095	0.012	1000.0	-1000.0	-0.045	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	69.0	17.0	-0.032	0.012	1000.0	-1000.0	-0.045	-1000.0
Cellular roles of Anthrax toxin	4.0	190.0	39.0	-0.09	0.012	1000.0	-1000.0	-0.022	-1000.0
Reelin signaling pathway	4.0	278.0	56.0	-0.17	0.019	1000.0	-1000.0	-0.088	-1000.0
IL1-mediated signaling events	4.0	291.0	62.0	-0.159	0.058	1000.0	-1000.0	-0.11	-1000.0
Syndecan-3-mediated signaling events	4.0	155.0	35.0	-0.187	0.033	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	4.0	210.0	51.0	-0.157	0.067	1000.0	-1000.0	-0.077	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	393.0	88.0	-0.158	0.03	1000.0	-1000.0	-0.121	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	95.0	28.0	-0.076	0.03	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	231.0	65.0	-0.303	0.037	1000.0	-1000.0	-0.069	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	240.0	61.0	-0.157	0.029	1000.0	-1000.0	-0.083	-1000.0
PDGFR-alpha signaling pathway	3.0	162.0	44.0	-0.071	0.021	1000.0	-1000.0	-0.067	-1000.0
IFN-gamma pathway	3.0	206.0	68.0	-0.155	0.021	1000.0	-1000.0	-0.11	-1000.0
TRAIL signaling pathway	3.0	181.0	48.0	-0.044	0.015	1000.0	-1000.0	-0.075	-1000.0
IL2 signaling events mediated by PI3K	3.0	181.0	58.0	-0.072	0.024	1000.0	-1000.0	-0.086	-1000.0
IL2 signaling events mediated by STAT5	3.0	69.0	22.0	-0.043	0.028	1000.0	-1000.0	-0.057	-1000.0
TCGA08_retinoblastoma	3.0	25.0	8.0	-0.012	0.012	1000.0	-1000.0	-0.022	-1000.0
Regulation of Telomerase	3.0	315.0	102.0	-0.177	0.037	1000.0	-1000.0	-0.123	-1000.0
S1P4 pathway	3.0	84.0	25.0	-0.076	0.019	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	264.0	78.0	-0.054	0.032	1000.0	-1000.0	-0.089	-1000.0
Regulation of Androgen receptor activity	3.0	259.0	70.0	-0.246	0.028	1000.0	-1000.0	-0.077	-1000.0
ErbB2/ErbB3 signaling events	2.0	160.0	65.0	-0.117	0.022	1000.0	-1000.0	-0.07	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	308.0	136.0	-0.176	0.065	1000.0	-1000.0	-0.078	-1000.0
BARD1 signaling events	2.0	152.0	57.0	-0.042	0.034	1000.0	-1000.0	-0.074	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	-0.005	0.012	1000.0	-1000.0	-0.02	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	134.0	54.0	-0.074	0.025	1000.0	-1000.0	-0.112	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	12.0	5.0	-0.013	0.012	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	177.0	85.0	-0.046	0.021	1000.0	-1000.0	-0.089	-1000.0
Ceramide signaling pathway	2.0	193.0	76.0	-0.123	0.036	1000.0	-1000.0	-0.055	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	75.0	37.0	-0.043	0.019	1000.0	-1000.0	-0.062	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	147.0	52.0	-0.096	0.04	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	2.0	105.0	36.0	-0.1	0.012	1000.0	-1000.0	-0.06	-1000.0
FAS signaling pathway (CD95)	2.0	95.0	47.0	-0.056	0.015	1000.0	-1000.0	-0.056	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	39.0	15.0	-0.028	0.023	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	2.0	135.0	58.0	-0.094	0.025	1000.0	-1000.0	-0.078	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	155.0	74.0	-0.193	0.059	1000.0	-1000.0	-0.104	-1000.0
S1P3 pathway	2.0	119.0	42.0	-0.066	0.024	1000.0	-1000.0	-0.039	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	66.0	33.0	-0.113	0.03	1000.0	-1000.0	-0.064	-1000.0
Rapid glucocorticoid signaling	2.0	53.0	20.0	-0.057	0.014	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	2.0	89.0	44.0	-0.114	0.024	1000.0	-1000.0	-0.072	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	47.0	17.0	-0.02	0.02	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	1.0	48.0	39.0	-0.049	0.062	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by HDAC Class II	1.0	82.0	75.0	-0.084	0.033	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	1.0	108.0	60.0	-0.17	0.037	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class III	1.0	71.0	40.0	-0.171	0.021	1000.0	-1000.0	-0.044	-1000.0
ceramide signaling pathway	1.0	50.0	49.0	-0.049	0.027	1000.0	-1000.0	-0.057	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	91.0	83.0	-0.042	0.053	1000.0	-1000.0	-0.078	-1000.0
TCGA08_p53	1.0	7.0	7.0	-0.007	0.012	1000.0	-1000.0	-0.019	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	42.0	36.0	-0.043	0.025	1000.0	-1000.0	-0.083	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	-0.02	0.04	1000.0	-1000.0	-0.052	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	75.0	45.0	-0.069	0.037	1000.0	-1000.0	-0.1	-1000.0
Regulation of p38-alpha and p38-beta	1.0	88.0	54.0	-0.11	0.032	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	142.0	125.0	-0.081	0.051	1000.0	-1000.0	-0.106	-1000.0
TCGA08_rtk_signaling	1.0	44.0	26.0	-0.034	0.033	1000.0	-1000.0	-0.026	-1000.0
Class I PI3K signaling events	1.0	142.0	73.0	-0.11	0.023	1000.0	-1000.0	-0.073	-1000.0
Insulin Pathway	1.0	131.0	74.0	-0.158	0.034	1000.0	-1000.0	-0.098	-1000.0
PDGFR-beta signaling pathway	1.0	142.0	97.0	-0.071	0.038	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by PRL	1.0	51.0	34.0	-0.087	0.034	1000.0	-1000.0	-0.047	-1000.0
FOXM1 transcription factor network	1.0	73.0	51.0	-0.088	0.128	1000.0	-1000.0	-0.198	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	18.0	23.0	-0.035	0.04	1000.0	-1000.0	-0.056	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.019	0.041	1000.0	-1000.0	-0.043	-1000.0
Arf6 downstream pathway	0.0	38.0	43.0	-0.034	0.025	1000.0	-1000.0	-0.04	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.002	0.016	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	0.0	34.0	55.0	-0.022	0.057	1000.0	-1000.0	-0.102	-1000.0
PLK1 signaling events	0.0	24.0	85.0	-0.011	0.035	1000.0	-1000.0	-0.051	-1000.0
Insulin-mediated glucose transport	0.0	27.0	32.0	-0.042	0.044	1000.0	-1000.0	-0.07	-1000.0
mTOR signaling pathway	0.0	51.0	53.0	-0.024	0.019	1000.0	-1000.0	-0.069	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.042	0.045	1000.0	-1000.0	-0.064	-1000.0
HIF-2-alpha transcription factor network	0.0	35.0	43.0	-0.091	0.093	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by HDAC Class I	0.0	64.0	104.0	-0.049	0.05	1000.0	-1000.0	-0.075	-1000.0
FoxO family signaling	0.0	27.0	64.0	-0.058	0.131	1000.0	-1000.0	-0.083	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	58.0	76.0	-0.046	0.051	1000.0	-1000.0	-0.088	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.032	1000.0	-1000.0	-0.058	-1000.0
Arf6 trafficking events	0.0	43.0	71.0	-0.034	0.041	1000.0	-1000.0	-0.083	-1000.0
VEGFR1 specific signals	0.0	25.0	56.0	-0.028	0.045	1000.0	-1000.0	-0.087	-1000.0
E-cadherin signaling in keratinocytes	0.0	25.0	43.0	-0.034	0.033	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.025	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	0.0	10.0	54.0	-0.026	0.026	1000.0	-1000.0	-0.04	-1000.0
Alternative NF-kappaB pathway	0.0	9.0	13.0	-0.003	0.032	1000.0	-1000.0	-0.047	-1000.0
Aurora B signaling	0.0	44.0	67.0	-0.064	0.034	1000.0	-1000.0	-0.076	-1000.0
Total	508	33848	7203	-16.837833004	-994.520957088	131000	-131000	-9.62827962174	-131000