Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.134 0.261 -9999.0 0.0 -0.632 17.0 17.0 IHH -0.031 0.101 -9999.0 0.0 -0.317 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.035 0.118 -9999.0 0.0 -0.363 9.0 9.0 LRPAP1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.034 0.117 0.361 9.0 -9999.0 0.0 9.0 SMO/beta Arrestin2 -0.119 0.212 -9999.0 0.0 -0.548 10.0 10.0 SMO -0.128 0.214 -9999.0 0.0 -0.546 12.0 12.0 AKT1 -0.069 0.162 -9999.0 0.0 -0.591 6.0 6.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.093 -9999.0 0.0 -0.393 4.0 4.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.125 0.212 -9999.0 0.0 -0.537 12.0 12.0 STIL -0.076 0.152 -9999.0 0.0 -0.429 8.0 8.0 DHH N/PTCH2 0.014 0.099 -9999.0 0.0 -0.424 4.0 4.0 DHH N/PTCH1 -0.067 0.157 -9999.0 0.0 -0.391 11.0 11.0 PIK3CA 0.018 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.071 -9999.0 0.0 -0.333 3.0 3.0 PTHLH -0.199 0.378 -9999.0 0.0 -0.904 19.0 19.0 determination of left/right symmetry -0.125 0.212 -9999.0 0.0 -0.537 12.0 12.0 PIK3R1 0.008 0.093 -9999.0 0.0 -0.393 4.0 4.0 skeletal system development -0.197 0.372 -9999.0 0.0 -0.892 19.0 19.0 IHH N/Hhip -0.025 0.093 -9999.0 0.0 -0.248 6.0 6.0 DHH N/Hhip 0.006 0.083 -9999.0 0.0 -0.319 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.125 0.212 -9999.0 0.0 -0.537 12.0 12.0 pancreas development -0.016 0.075 -9999.0 0.0 -0.212 11.0 11.0 HHAT 0.007 0.106 -9999.0 0.0 -0.574 3.0 3.0 PI3K 0.012 0.07 -9999.0 0.0 -0.424 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.021 0.144 -9999.0 0.0 -0.377 11.0 11.0 somite specification -0.125 0.212 -9999.0 0.0 -0.537 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.081 0.155 -9999.0 0.0 -0.413 11.0 11.0 SHH Np/Cholesterol/PTCH2 -0.02 0.097 -9999.0 0.0 -0.315 7.0 7.0 SHH Np/Cholesterol/Megalin -0.026 0.09 -9999.0 0.0 -0.269 8.0 8.0 SHH -0.034 0.095 -9999.0 0.0 -0.426 4.0 4.0 catabolic process -0.078 0.16 -9999.0 0.0 -0.402 12.0 12.0 SMO/Vitamin D3 -0.105 0.186 -9999.0 0.0 -0.493 12.0 12.0 SHH Np/Cholesterol/Hhip -0.031 0.092 -9999.0 0.0 -0.253 10.0 10.0 LRP2 -0.009 0.076 -9999.0 0.0 -0.212 11.0 11.0 receptor-mediated endocytosis -0.106 0.18 -9999.0 0.0 -0.473 13.0 13.0 SHH Np/Cholesterol/BOC -0.021 0.093 -9999.0 0.0 -0.334 6.0 6.0 SHH Np/Cholesterol/CDO -0.02 0.094 -9999.0 0.0 -0.334 6.0 6.0 mesenchymal cell differentiation 0.031 0.091 0.252 10.0 -9999.0 0.0 10.0 mol:Vitamin D3 -0.074 0.161 -9999.0 0.0 -0.414 11.0 11.0 IHH N/PTCH2 -0.018 0.109 -9999.0 0.0 -0.385 5.0 5.0 CDON 0.01 0.087 -9999.0 0.0 -0.574 2.0 2.0 IHH N/PTCH1 -0.071 0.165 -9999.0 0.0 -0.377 17.0 17.0 Megalin/LRPAP1 0.015 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.005 0.109 -9999.0 0.0 -0.484 4.0 4.0 SHH Np/Cholesterol -0.016 0.079 -9999.0 0.0 -0.332 4.0 4.0 PTCH1 -0.078 0.16 -9999.0 0.0 -0.403 12.0 12.0 HHIP -0.016 0.075 -9999.0 0.0 -0.212 11.0 11.0