Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.023 0.102 -9999.0 0.0 -0.493 4.0 4.0 IHH 0.035 0.055 -9999.0 0.0 -0.62 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.086 0.165 -9999.0 0.0 -0.298 76.0 76.0 LRPAP1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.085 0.164 0.296 76.0 -9999.0 0.0 76.0 SMO/beta Arrestin2 0.037 0.073 -9999.0 0.0 -0.534 1.0 1.0 SMO 0.025 0.067 -9999.0 0.0 -0.558 1.0 1.0 AKT1 0.012 0.108 -9999.0 0.0 -0.374 2.0 2.0 ARRB2 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.025 0.066 -9999.0 0.0 -0.549 1.0 1.0 STIL -0.014 0.118 0.369 1.0 -0.362 8.0 9.0 DHH N/PTCH2 0.049 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.046 0.066 -9999.0 0.0 -0.492 1.0 1.0 PIK3CA 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.023 0.1 -9999.0 0.0 -0.871 1.0 1.0 determination of left/right symmetry 0.025 0.066 -9999.0 0.0 -0.549 1.0 1.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.023 0.099 -9999.0 0.0 -0.861 1.0 1.0 IHH N/Hhip -0.039 0.186 -9999.0 0.0 -0.409 43.0 43.0 DHH N/Hhip -0.034 0.166 -9999.0 0.0 -0.367 43.0 43.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.025 0.066 -9999.0 0.0 -0.549 1.0 1.0 pancreas development -0.073 0.215 -9999.0 0.0 -0.505 43.0 43.0 HHAT -0.017 0.156 -9999.0 0.0 -0.505 20.0 20.0 PI3K 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.128 0.243 -9999.0 0.0 -0.489 67.0 67.0 somite specification 0.025 0.066 -9999.0 0.0 -0.549 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.008 0.098 -9999.0 0.0 -0.373 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.003 0.093 -9999.0 0.0 -0.291 19.0 19.0 SHH Np/Cholesterol/Megalin 0.003 0.094 -9999.0 0.0 -0.291 19.0 19.0 SHH -0.015 0.113 0.23 1.0 -0.376 19.0 20.0 catabolic process 0.03 0.069 -9999.0 0.0 -0.543 1.0 1.0 SMO/Vitamin D3 0.009 0.098 -9999.0 0.0 -0.494 1.0 1.0 SHH Np/Cholesterol/Hhip -0.056 0.16 -9999.0 0.0 -0.322 53.0 53.0 LRP2 0.032 0.024 -9999.0 0.0 -0.318 1.0 1.0 receptor-mediated endocytosis 0.005 0.097 -9999.0 0.0 -0.457 1.0 1.0 SHH Np/Cholesterol/BOC 0.005 0.091 -9999.0 0.0 -0.291 18.0 18.0 SHH Np/Cholesterol/CDO 0.003 0.093 -9999.0 0.0 -0.291 19.0 19.0 mesenchymal cell differentiation 0.056 0.158 0.319 53.0 -9999.0 0.0 53.0 mol:Vitamin D3 0.014 0.107 0.386 1.0 -0.374 3.0 4.0 IHH N/PTCH2 0.05 0.035 -9999.0 0.0 -0.387 1.0 1.0 CDON 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.039 0.072 -9999.0 0.0 -0.549 1.0 1.0 Megalin/LRPAP1 0.047 0.021 -9999.0 0.0 -0.218 1.0 1.0 PTCH2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.009 0.089 -9999.0 0.0 -0.29 19.0 19.0 PTCH1 0.03 0.069 -9999.0 0.0 -0.545 1.0 1.0 HHIP -0.073 0.215 -9999.0 0.0 -0.505 43.0 43.0