Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.091 -9999.0 0.0 -0.256 21.0 21.0 epithelial cell differentiation 0.055 0.064 -9999.0 0.0 -0.266 5.0 5.0 CYFIP2 0.029 0.052 -9999.0 0.0 -0.505 2.0 2.0 ENAH -0.016 0.06 0.282 1.0 -9999.0 0.0 1.0 EGFR 0.021 0.073 -9999.0 0.0 -0.505 4.0 4.0 EPHA2 0.015 0.074 -9999.0 0.0 -0.318 10.0 10.0 MYO6 0.008 0.052 -9999.0 0.0 -0.257 5.0 5.0 CTNNB1 0.024 0.058 -9999.0 0.0 -0.318 6.0 6.0 ABI1/Sra1/Nap1 0.063 0.042 -9999.0 0.0 -0.313 2.0 2.0 AQP5 0.006 0.055 -9999.0 0.0 -0.375 1.0 1.0 CTNND1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.054 -9999.0 0.0 -0.253 5.0 5.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.068 -9999.0 0.0 -0.255 11.0 11.0 EGF -0.092 0.21 -9999.0 0.0 -0.427 59.0 59.0 NCKAP1 0.033 0.024 -9999.0 0.0 -0.318 1.0 1.0 AQP3 0.007 0.052 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.055 0.064 -9999.0 0.0 -0.266 5.0 5.0 GO:0000145 -0.012 0.048 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.066 -9999.0 0.0 -0.268 5.0 5.0 MLLT4 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.024 0.055 -9999.0 0.0 -0.35 2.0 2.0 ARF6 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.059 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.003 0.044 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.024 -9999.0 0.0 -0.318 1.0 1.0 ZYX 0.007 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.064 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.021 0.081 -9999.0 0.0 -0.505 5.0 5.0 EGFR/EGFR/EGF/EGF -0.025 0.13 -9999.0 0.0 -0.383 3.0 3.0 RhoA/GDP 0.057 0.063 -9999.0 0.0 -0.254 5.0 5.0 actin cytoskeleton organization -0.0 0.048 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.274 0.267 -9999.0 0.0 -0.505 124.0 124.0 DIAPH1 0.057 0.108 -9999.0 0.0 -0.684 2.0 2.0 Wnt receptor signaling pathway -0.055 0.064 0.266 5.0 -9999.0 0.0 5.0 RHOA 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.055 -9999.0 0.0 -0.352 2.0 2.0 CTNNA1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.001 0.049 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.013 0.049 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.036 0.079 -9999.0 0.0 -0.319 5.0 5.0 SEC6/SEC8 0.006 0.047 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.002 0.069 -9999.0 0.0 -0.258 11.0 11.0 HGF/MET -0.037 0.111 -9999.0 0.0 -0.33 4.0 4.0 HGF 0.029 0.034 -9999.0 0.0 -0.318 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.092 -9999.0 0.0 -0.258 21.0 21.0 actin cable formation 0.013 0.084 0.318 6.0 -0.307 1.0 7.0 KIAA1543 -0.013 0.049 -9999.0 0.0 -0.245 5.0 5.0 KIFC3 0.005 0.058 -9999.0 0.0 -0.265 7.0 7.0 NCK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.053 -9999.0 0.0 -0.257 5.0 5.0 NCK1/GIT1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.064 -9999.0 0.0 -0.266 5.0 5.0 EXOC4 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.009 0.049 -9999.0 0.0 -0.257 5.0 5.0 PIP5K1C 0.01 0.054 -9999.0 0.0 -0.257 5.0 5.0 LIMA1 -0.011 0.149 -9999.0 0.0 -0.505 18.0 18.0 ABI1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.071 0.303 3.0 -9999.0 0.0 3.0 adherens junction assembly 0.007 0.061 0.285 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer/IGF1 -0.125 0.158 -9999.0 0.0 -0.444 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.021 -9999.0 0.0 -0.218 1.0 1.0 MET -0.112 0.172 -9999.0 0.0 -0.318 89.0 89.0 PLEKHA7 0.01 0.054 -9999.0 0.0 -0.257 5.0 5.0 mol:GTP 0.06 0.058 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.003 0.067 0.331 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization 0.002 0.091 -9999.0 0.0 -0.256 21.0 21.0 regulation of cell-cell adhesion -0.0 0.048 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.092 -9999.0 0.0 -0.258 21.0 21.0