Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.047 0.228 -9999.0 0.0 -0.587 11.0 11.0 IHH -0.034 0.162 -9999.0 0.0 -0.595 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.083 0.145 -9999.0 0.0 -0.268 30.0 30.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.083 0.144 0.267 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.064 0.225 -9999.0 0.0 -0.604 9.0 9.0 SMO -0.073 0.238 -9999.0 0.0 -0.643 9.0 9.0 AKT1 -0.016 0.108 -9999.0 0.0 -0.347 3.0 3.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.083 -9999.0 0.0 -0.433 3.0 3.0 ADRBK1 0.007 0.049 -9999.0 0.0 -0.433 1.0 1.0 heart looping -0.072 0.233 -9999.0 0.0 -0.629 9.0 9.0 STIL -0.028 0.181 -9999.0 0.0 -0.614 5.0 5.0 DHH N/PTCH2 -0.044 0.146 -9999.0 0.0 -0.378 13.0 13.0 DHH N/PTCH1 -0.059 0.191 -9999.0 0.0 -0.615 5.0 5.0 PIK3CA 0.006 0.059 -9999.0 0.0 -0.528 1.0 1.0 DHH -0.058 0.178 -9999.0 0.0 -0.511 11.0 11.0 PTHLH -0.085 0.323 -9999.0 0.0 -0.88 11.0 11.0 determination of left/right symmetry -0.072 0.233 -9999.0 0.0 -0.629 9.0 9.0 PIK3R1 0.007 0.049 -9999.0 0.0 -0.433 1.0 1.0 skeletal system development -0.084 0.319 -9999.0 0.0 -0.868 11.0 11.0 IHH N/Hhip -0.071 0.2 -9999.0 0.0 -0.474 15.0 15.0 DHH N/Hhip -0.09 0.194 -9999.0 0.0 -0.408 21.0 21.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.072 0.233 -9999.0 0.0 -0.629 9.0 9.0 pancreas development -0.07 0.191 -9999.0 0.0 -0.513 13.0 13.0 HHAT 0.006 0.059 -9999.0 0.0 -0.528 1.0 1.0 PI3K 0.009 0.055 -9999.0 0.0 -0.337 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.128 0.221 -9999.0 0.0 -0.473 24.0 24.0 somite specification -0.072 0.233 -9999.0 0.0 -0.629 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.035 0.191 -9999.0 0.0 -0.596 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.016 0.106 -9999.0 0.0 -0.286 10.0 10.0 SHH Np/Cholesterol/Megalin -0.02 0.093 -9999.0 0.0 -0.257 11.0 11.0 SHH -0.017 0.112 -9999.0 0.0 -0.357 8.0 8.0 catabolic process -0.029 0.176 -9999.0 0.0 -0.567 5.0 5.0 SMO/Vitamin D3 -0.06 0.223 -9999.0 0.0 -0.629 8.0 8.0 SHH Np/Cholesterol/Hhip -0.052 0.149 -9999.0 0.0 -0.316 18.0 18.0 LRP2 -0.011 0.082 -9999.0 0.0 -0.433 3.0 3.0 receptor-mediated endocytosis -0.054 0.213 -9999.0 0.0 -0.638 7.0 7.0 SHH Np/Cholesterol/BOC -0.015 0.102 -9999.0 0.0 -0.28 10.0 10.0 SHH Np/Cholesterol/CDO -0.014 0.103 -9999.0 0.0 -0.301 9.0 9.0 mesenchymal cell differentiation 0.052 0.148 0.314 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.033 0.193 -9999.0 0.0 -0.599 6.0 6.0 IHH N/PTCH2 -0.022 0.132 -9999.0 0.0 -0.417 7.0 7.0 CDON -0.001 0.083 -9999.0 0.0 -0.528 2.0 2.0 IHH N/PTCH1 -0.028 0.179 -9999.0 0.0 -0.574 5.0 5.0 Megalin/LRPAP1 0.002 0.058 -9999.0 0.0 -0.298 3.0 3.0 PTCH2 -0.005 0.089 -9999.0 0.0 -0.465 3.0 3.0 SHH Np/Cholesterol -0.014 0.085 -9999.0 0.0 -0.274 8.0 8.0 PTCH1 -0.029 0.177 -9999.0 0.0 -0.569 5.0 5.0 HHIP -0.07 0.191 -9999.0 0.0 -0.513 13.0 13.0