Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	18.0	127.0	7.0	-0.128	0.0	1000.0	-1000.0	-0.014	-1000.0
IL4-mediated signaling events	13.0	1241.0	91.0	-0.587	0.52	1000.0	-1000.0	-0.157	-1000.0
Signaling mediated by p38-alpha and p38-beta	12.0	530.0	44.0	-0.173	0.012	1000.0	-1000.0	-0.034	-1000.0
Syndecan-4-mediated signaling events	10.0	736.0	67.0	-0.194	0.026	1000.0	-1000.0	-0.081	-1000.0
IL23-mediated signaling events	10.0	639.0	60.0	-0.415	0.012	1000.0	-1000.0	-0.163	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	454.0	46.0	-0.499	0.028	1000.0	-1000.0	-0.111	-1000.0
Signaling events mediated by the Hedgehog family	8.0	437.0	52.0	-0.128	0.083	1000.0	-1000.0	-0.038	-1000.0
HIF-1-alpha transcription factor network	8.0	610.0	76.0	-0.378	0.019	1000.0	-1000.0	-0.145	-1000.0
Endothelins	8.0	852.0	96.0	-0.155	0.013	1000.0	-1000.0	-0.072	-1000.0
TCGA08_p53	8.0	57.0	7.0	-0.057	0.026	1000.0	-1000.0	-0.016	-1000.0
Wnt signaling	8.0	56.0	7.0	-0.08	0.006	1000.0	-1000.0	-0.024	-1000.0
EGFR-dependent Endothelin signaling events	8.0	180.0	21.0	-0.174	0.013	1000.0	-1000.0	-0.054	-1000.0
IL12-mediated signaling events	7.0	686.0	87.0	-0.308	0.083	1000.0	-1000.0	-0.132	-1000.0
Syndecan-1-mediated signaling events	7.0	246.0	34.0	-0.139	0.012	1000.0	-1000.0	-0.055	-1000.0
BMP receptor signaling	7.0	580.0	81.0	-0.174	0.031	1000.0	-1000.0	-0.077	-1000.0
Glypican 1 network	7.0	369.0	48.0	-0.177	0.014	1000.0	-1000.0	-0.038	-1000.0
amb2 Integrin signaling	7.0	638.0	82.0	-0.137	0.012	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	7.0	481.0	68.0	-0.3	0.088	1000.0	-1000.0	-0.103	-1000.0
BCR signaling pathway	7.0	767.0	99.0	-0.16	0.016	1000.0	-1000.0	-0.076	-1000.0
p75(NTR)-mediated signaling	6.0	773.0	125.0	-0.142	0.031	1000.0	-1000.0	-0.087	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	588.0	97.0	-0.112	0.03	1000.0	-1000.0	-0.067	-1000.0
Glucocorticoid receptor regulatory network	6.0	768.0	114.0	-0.373	0.23	1000.0	-1000.0	-0.061	-1000.0
Ephrin B reverse signaling	6.0	295.0	48.0	-0.149	0.065	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	602.0	93.0	-0.127	0.017	1000.0	-1000.0	-0.066	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	197.0	31.0	-0.146	0.012	1000.0	-1000.0	-0.033	-1000.0
TCGA08_retinoblastoma	6.0	55.0	8.0	-0.071	0.03	1000.0	-1000.0	-0.018	-1000.0
Thromboxane A2 receptor signaling	5.0	589.0	105.0	-0.174	0.043	1000.0	-1000.0	-0.059	-1000.0
Syndecan-2-mediated signaling events	5.0	381.0	69.0	-0.131	0.025	1000.0	-1000.0	-0.028	-1000.0
Reelin signaling pathway	5.0	286.0	56.0	-0.077	0.024	1000.0	-1000.0	-0.067	-1000.0
Effects of Botulinum toxin	5.0	136.0	26.0	-0.123	0.012	1000.0	-1000.0	-0.05	-1000.0
LPA receptor mediated events	5.0	518.0	102.0	-0.147	0.012	1000.0	-1000.0	-0.073	-1000.0
Plasma membrane estrogen receptor signaling	5.0	464.0	86.0	-0.064	0.049	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	397.0	78.0	-0.11	0.07	1000.0	-1000.0	-0.085	-1000.0
Caspase cascade in apoptosis	4.0	329.0	74.0	-0.08	0.061	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	4.0	168.0	38.0	-0.137	0.012	1000.0	-1000.0	-0.091	-1000.0
Noncanonical Wnt signaling pathway	4.0	120.0	26.0	-0.08	0.012	1000.0	-1000.0	-0.04	-1000.0
Arf6 signaling events	4.0	253.0	62.0	-0.174	0.022	1000.0	-1000.0	-0.042	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	256.0	61.0	-0.162	0.055	1000.0	-1000.0	-0.071	-1000.0
FAS signaling pathway (CD95)	4.0	220.0	47.0	-0.144	0.013	1000.0	-1000.0	-0.043	-1000.0
Retinoic acid receptors-mediated signaling	4.0	255.0	58.0	-0.162	0.012	1000.0	-1000.0	-0.068	-1000.0
Canonical Wnt signaling pathway	4.0	204.0	51.0	-0.162	0.083	1000.0	-1000.0	-0.064	-1000.0
EPHB forward signaling	4.0	390.0	85.0	-0.149	0.073	1000.0	-1000.0	-0.079	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	588.0	120.0	-0.185	0.119	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by PRL	4.0	153.0	34.0	-0.057	0.045	1000.0	-1000.0	-0.03	-1000.0
LPA4-mediated signaling events	3.0	42.0	12.0	-0.026	0.016	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.004	-0.001	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	3.0	122.0	38.0	-0.022	0.008	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	3.0	153.0	39.0	-0.037	0.012	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by PTP1B	3.0	260.0	76.0	-0.174	0.018	1000.0	-1000.0	-0.067	-1000.0
IL1-mediated signaling events	3.0	216.0	62.0	-0.101	0.051	1000.0	-1000.0	-0.087	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	286.0	82.0	-0.094	0.012	1000.0	-1000.0	-0.077	-1000.0
S1P1 pathway	3.0	118.0	36.0	-0.097	0.012	1000.0	-1000.0	-0.053	-1000.0
Integrins in angiogenesis	3.0	315.0	84.0	-0.153	0.025	1000.0	-1000.0	-0.087	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.004	0.001	1000.0	-1000.0	-0.015	-1000.0
Nongenotropic Androgen signaling	3.0	189.0	52.0	-0.054	0.015	1000.0	-1000.0	-0.047	-1000.0
IL27-mediated signaling events	3.0	192.0	51.0	-0.256	0.017	1000.0	-1000.0	-0.077	-1000.0
Class I PI3K signaling events	3.0	225.0	73.0	-0.066	0.021	1000.0	-1000.0	-0.054	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	298.0	88.0	-0.143	0.075	1000.0	-1000.0	-0.102	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.007	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	53.0	17.0	-0.048	0.012	1000.0	-1000.0	-0.043	-1000.0
ErbB2/ErbB3 signaling events	2.0	146.0	65.0	-0.034	0.038	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	274.0	136.0	-0.056	0.053	1000.0	-1000.0	-0.045	-1000.0
Coregulation of Androgen receptor activity	2.0	214.0	76.0	-0.114	0.039	1000.0	-1000.0	-0.031	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	95.0	34.0	-0.04	0.012	1000.0	-1000.0	-0.035	-1000.0
ErbB4 signaling events	2.0	198.0	69.0	-0.117	0.032	1000.0	-1000.0	-0.077	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	83.0	28.0	-0.054	0.02	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	114.0	54.0	-0.074	0.023	1000.0	-1000.0	-0.086	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	42.0	17.0	-0.014	0.012	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	186.0	65.0	-0.09	0.034	1000.0	-1000.0	-0.059	-1000.0
EPO signaling pathway	2.0	111.0	55.0	-0.033	0.031	1000.0	-1000.0	-0.076	-1000.0
PDGFR-alpha signaling pathway	2.0	95.0	44.0	-0.076	0.024	1000.0	-1000.0	-0.046	-1000.0
Nectin adhesion pathway	2.0	184.0	63.0	-0.042	0.017	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class III	2.0	103.0	40.0	-0.073	0.022	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	2.0	130.0	48.0	-0.037	0.025	1000.0	-1000.0	-0.066	-1000.0
S1P5 pathway	2.0	41.0	17.0	-0.054	0.022	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	30.0	15.0	-0.025	0.015	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	2.0	155.0	58.0	-0.057	0.023	1000.0	-1000.0	-0.071	-1000.0
TCGA08_rtk_signaling	2.0	55.0	26.0	-0.045	0.024	1000.0	-1000.0	-0.02	-1000.0
IL6-mediated signaling events	2.0	177.0	75.0	-0.106	0.041	1000.0	-1000.0	-0.061	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	78.0	27.0	-0.033	0.012	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by STAT5	2.0	55.0	22.0	-0.04	0.022	1000.0	-1000.0	-0.036	-1000.0
Regulation of Telomerase	2.0	269.0	102.0	-0.174	0.032	1000.0	-1000.0	-0.092	-1000.0
S1P3 pathway	2.0	120.0	42.0	-0.064	0.018	1000.0	-1000.0	-0.035	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	78.0	33.0	-0.074	0.036	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	2.0	142.0	52.0	-0.061	0.018	1000.0	-1000.0	-0.059	-1000.0
S1P4 pathway	2.0	69.0	25.0	-0.054	0.018	1000.0	-1000.0	-0.031	-1000.0
Regulation of Androgen receptor activity	2.0	142.0	70.0	-0.186	0.037	1000.0	-1000.0	-0.076	-1000.0
Canonical NF-kappaB pathway	1.0	46.0	39.0	-0.019	0.051	1000.0	-1000.0	-0.078	-1000.0
Signaling events mediated by HDAC Class II	1.0	122.0	75.0	-0.058	0.033	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	1.0	67.0	57.0	-0.059	0.051	1000.0	-1000.0	-0.049	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.013	0.018	1000.0	-1000.0	-0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	131.0	85.0	-0.051	0.037	1000.0	-1000.0	-0.061	-1000.0
Aurora C signaling	1.0	7.0	7.0	-0.007	0.012	1000.0	-1000.0	-0.024	-1000.0
mTOR signaling pathway	1.0	62.0	53.0	-0.015	0.02	1000.0	-1000.0	-0.054	-1000.0
IFN-gamma pathway	1.0	111.0	68.0	-0.056	0.028	1000.0	-1000.0	-0.086	-1000.0
Ceramide signaling pathway	1.0	137.0	76.0	-0.174	0.057	1000.0	-1000.0	-0.049	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	63.0	37.0	-0.071	0.036	1000.0	-1000.0	-0.043	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	93.0	52.0	-0.068	0.033	1000.0	-1000.0	-0.046	-1000.0
HIF-2-alpha transcription factor network	1.0	58.0	43.0	-0.055	0.061	1000.0	-1000.0	-0.067	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	152.0	83.0	-0.162	0.047	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class I	1.0	120.0	104.0	-0.033	0.036	1000.0	-1000.0	-0.064	-1000.0
Syndecan-3-mediated signaling events	1.0	65.0	35.0	-0.131	0.026	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	60.0	45.0	-0.048	0.047	1000.0	-1000.0	-0.084	-1000.0
Regulation of p38-alpha and p38-beta	1.0	90.0	54.0	-0.066	0.031	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	171.0	125.0	-0.053	0.055	1000.0	-1000.0	-0.08	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	90.0	74.0	-0.174	0.046	1000.0	-1000.0	-0.079	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	127.0	76.0	-0.039	0.031	1000.0	-1000.0	-0.074	-1000.0
Insulin Pathway	1.0	146.0	74.0	-0.135	0.029	1000.0	-1000.0	-0.075	-1000.0
VEGFR1 specific signals	1.0	98.0	56.0	-0.04	0.018	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	1.0	152.0	97.0	-0.06	0.033	1000.0	-1000.0	-0.071	-1000.0
FOXM1 transcription factor network	1.0	83.0	51.0	-0.127	0.048	1000.0	-1000.0	-0.176	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.001	0.013	1000.0	-1000.0	-0.019	-1000.0
p38 MAPK signaling pathway	1.0	58.0	44.0	-0.022	0.024	1000.0	-1000.0	-0.058	-1000.0
Aurora B signaling	1.0	98.0	67.0	-0.105	0.029	1000.0	-1000.0	-0.058	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	-0.001	0.036	1000.0	-1000.0	-0.041	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.012	0.041	1000.0	-1000.0	-0.043	-1000.0
Aurora A signaling	0.0	59.0	60.0	-0.044	0.03	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	0.0	24.0	43.0	-0.02	0.02	1000.0	-1000.0	-0.034	-1000.0
PLK1 signaling events	0.0	77.0	85.0	-0.02	0.031	1000.0	-1000.0	-0.04	-1000.0
Insulin-mediated glucose transport	0.0	20.0	32.0	-0.014	0.029	1000.0	-1000.0	-0.039	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	34.0	68.0	-0.029	0.039	1000.0	-1000.0	-0.042	-1000.0
ceramide signaling pathway	0.0	38.0	49.0	-0.026	0.03	1000.0	-1000.0	-0.052	-1000.0
FoxO family signaling	0.0	32.0	64.0	-0.076	0.107	1000.0	-1000.0	-0.085	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.035	0.036	1000.0	-1000.0	-0.062	-1000.0
Atypical NF-kappaB pathway	0.0	23.0	31.0	-0.031	0.026	1000.0	-1000.0	-0.038	-1000.0
Arf6 trafficking events	0.0	36.0	71.0	-0.033	0.03	1000.0	-1000.0	-0.071	-1000.0
IGF1 pathway	0.0	37.0	57.0	-0.025	0.032	1000.0	-1000.0	-0.081	-1000.0
Rapid glucocorticoid signaling	0.0	19.0	20.0	-0.009	0.013	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in keratinocytes	0.0	19.0	43.0	-0.027	0.033	1000.0	-1000.0	-0.045	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.019	0.028	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.036	1000.0	-1000.0	-0.032	-1000.0
Total	419	27445	7203	-13.1824403974	-995.287313954	131000	-131000	-7.51052917542	-131000