Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.04 0.169 -9999.0 0.0 -0.538 7.0 7.0 IHH -0.003 0.134 -9999.0 0.0 -0.484 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.017 0.112 0.182 2.0 -0.239 15.0 17.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.017 0.111 0.237 15.0 -0.18 2.0 17.0 SMO/beta Arrestin2 -0.039 0.187 -9999.0 0.0 -0.513 7.0 7.0 SMO -0.059 0.185 -9999.0 0.0 -0.455 11.0 11.0 AKT1 -0.047 0.181 -9999.0 0.0 -0.589 6.0 6.0 ARRB2 0.026 0.014 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.035 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.058 0.182 -9999.0 0.0 -0.448 11.0 11.0 STIL -0.045 0.143 0.197 7.0 -0.353 9.0 16.0 DHH N/PTCH2 0.014 0.107 -9999.0 0.0 -0.302 8.0 8.0 DHH N/PTCH1 -0.025 0.151 -9999.0 0.0 -0.307 16.0 16.0 PIK3CA 0.027 0.05 -9999.0 0.0 -0.416 1.0 1.0 DHH -0.008 0.127 -9999.0 0.0 -0.416 7.0 7.0 PTHLH -0.078 0.268 -9999.0 0.0 -0.892 7.0 7.0 determination of left/right symmetry -0.058 0.182 -9999.0 0.0 -0.448 11.0 11.0 PIK3R1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.077 0.265 -9999.0 0.0 -0.881 7.0 7.0 IHH N/Hhip -0.019 0.164 -9999.0 0.0 -0.388 12.0 12.0 DHH N/Hhip -0.026 0.151 -9999.0 0.0 -0.322 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.058 0.182 -9999.0 0.0 -0.448 11.0 11.0 pancreas development -0.022 0.149 -9999.0 0.0 -0.415 10.0 10.0 HHAT 0.026 0.05 -9999.0 0.0 -0.416 1.0 1.0 PI3K 0.042 0.041 -9999.0 0.0 -0.302 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.011 0.155 -9999.0 0.0 -0.416 10.0 10.0 somite specification -0.058 0.182 -9999.0 0.0 -0.448 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.029 0.14 -9999.0 0.0 -0.342 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.007 0.078 0.171 1.0 -0.273 5.0 6.0 SHH Np/Cholesterol/Megalin -0.018 0.063 -9999.0 0.0 -0.234 5.0 5.0 SHH -0.034 0.069 0.238 1.0 -0.303 4.0 5.0 catabolic process -0.022 0.132 -9999.0 0.0 -0.336 11.0 11.0 SMO/Vitamin D3 -0.053 0.171 -9999.0 0.0 -0.416 12.0 12.0 SHH Np/Cholesterol/Hhip -0.022 0.113 0.171 1.0 -0.266 13.0 14.0 LRP2 0.001 0.036 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.055 0.166 -9999.0 0.0 -0.424 11.0 11.0 SHH Np/Cholesterol/BOC 0.012 0.063 0.171 1.0 -0.24 4.0 5.0 SHH Np/Cholesterol/CDO 0.008 0.066 0.171 1.0 -0.233 5.0 6.0 mesenchymal cell differentiation 0.022 0.113 0.265 13.0 -0.169 1.0 14.0 mol:Vitamin D3 -0.02 0.155 0.28 2.0 -0.343 11.0 13.0 IHH N/PTCH2 0.021 0.106 -9999.0 0.0 -0.344 5.0 5.0 CDON 0.026 0.05 -9999.0 0.0 -0.416 1.0 1.0 IHH N/PTCH1 -0.009 0.138 -9999.0 0.0 -0.339 11.0 11.0 Megalin/LRPAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.029 0.051 -9999.0 0.0 -0.416 1.0 1.0 SHH Np/Cholesterol -0.029 0.051 -9999.0 0.0 -0.225 5.0 5.0 PTCH1 -0.022 0.133 -9999.0 0.0 -0.337 11.0 11.0 HHIP -0.023 0.149 -9999.0 0.0 -0.416 10.0 10.0