Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.087 -9999.0 0.0 -0.303 5.0 5.0 epithelial cell differentiation 0.054 0.052 -9999.0 0.0 -0.228 2.0 2.0 CYFIP2 0.021 0.07 -9999.0 0.0 -0.416 2.0 2.0 ENAH -0.039 0.067 0.236 1.0 -0.316 1.0 2.0 EGFR 0.022 0.051 -9999.0 0.0 -0.416 1.0 1.0 EPHA2 0.032 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.033 0.045 -9999.0 0.0 -0.225 2.0 2.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.054 -9999.0 0.0 -0.262 2.0 2.0 AQP5 -0.017 0.053 -9999.0 0.0 -0.33 1.0 1.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.03 0.054 -9999.0 0.0 -0.222 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.077 0.207 1.0 -0.224 8.0 9.0 EGF -0.022 0.161 -9999.0 0.0 -0.416 11.0 11.0 NCKAP1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.025 0.095 -9999.0 0.0 -0.471 3.0 3.0 cortical microtubule organization 0.054 0.052 -9999.0 0.0 -0.228 2.0 2.0 GO:0000145 -0.029 0.049 -9999.0 0.0 -0.212 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.06 0.054 -9999.0 0.0 -0.23 2.0 2.0 MLLT4 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.057 0.039 -9999.0 0.0 -0.226 3.0 3.0 ARF6 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.066 0.049 -9999.0 0.0 -0.245 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.039 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.035 0.04 -9999.0 0.0 -0.225 2.0 2.0 ARF6/GTP 0.064 0.058 -9999.0 0.0 -0.235 1.0 1.0 CDH1 0.02 0.07 -9999.0 0.0 -0.416 2.0 2.0 EGFR/EGFR/EGF/EGF 0.001 0.117 -9999.0 0.0 -0.256 12.0 12.0 RhoA/GDP 0.055 0.053 -9999.0 0.0 -0.223 2.0 2.0 actin cytoskeleton organization -0.035 0.039 -9999.0 0.0 -0.228 2.0 2.0 IGF-1R heterotetramer 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 0.032 0.147 -9999.0 0.0 -0.604 4.0 4.0 Wnt receptor signaling pathway -0.054 0.052 0.228 2.0 -9999.0 0.0 2.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.057 0.039 -9999.0 0.0 -0.227 3.0 3.0 CTNNA1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.035 0.04 -9999.0 0.0 -0.233 2.0 2.0 EFNA1 0.026 0.05 -9999.0 0.0 -0.416 1.0 1.0 LPP -0.033 0.052 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.038 0.063 -9999.0 0.0 -0.226 3.0 3.0 SEC6/SEC8 -0.051 0.034 -9999.0 0.0 -0.227 2.0 2.0 MGAT3 -0.044 0.078 0.208 1.0 -0.227 8.0 9.0 HGF/MET 0.042 0.061 -9999.0 0.0 -0.226 3.0 3.0 HGF 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.087 -9999.0 0.0 -0.305 5.0 5.0 actin cable formation -0.022 0.102 0.387 2.0 -0.274 1.0 3.0 KIAA1543 -0.03 0.05 -9999.0 0.0 -0.215 2.0 2.0 KIFC3 -0.038 0.039 -9999.0 0.0 -0.225 2.0 2.0 NCK1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.028 0.055 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.054 0.052 -9999.0 0.0 -0.228 2.0 2.0 EXOC4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.036 0.039 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.03 0.054 -9999.0 0.0 -0.225 2.0 2.0 LIMA1 0.009 0.098 -9999.0 0.0 -0.416 4.0 4.0 ABI1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.078 0.263 2.0 -0.365 1.0 3.0 adherens junction assembly -0.014 0.07 0.259 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer/IGF1 0.046 0.053 -9999.0 0.0 -0.225 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.045 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.05 -9999.0 0.0 -0.416 1.0 1.0 PLEKHA7 -0.031 0.054 -9999.0 0.0 -0.225 2.0 2.0 mol:GTP 0.064 0.048 -9999.0 0.0 -0.243 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.041 0.07 0.294 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.007 0.087 -9999.0 0.0 -0.303 5.0 5.0 regulation of cell-cell adhesion -0.035 0.039 -9999.0 0.0 -0.228 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.087 -9999.0 0.0 -0.305 5.0 5.0