Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	12.0	1100.0	91.0	-0.541	0.455	1000.0	-1000.0	-0.113	-1000.0
TCGA08_p53	12.0	84.0	7.0	-0.063	0.032	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-alpha and p38-beta	11.0	523.0	44.0	-0.123	0.033	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by the Hedgehog family	7.0	383.0	52.0	-0.078	0.047	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	351.0	46.0	-0.293	0.035	1000.0	-1000.0	-0.116	-1000.0
Endothelins	7.0	764.0	96.0	-0.112	0.033	1000.0	-1000.0	-0.055	-1000.0
Ephrin B reverse signaling	6.0	292.0	48.0	-0.092	0.046	1000.0	-1000.0	-0.035	-1000.0
BCR signaling pathway	6.0	617.0	99.0	-0.131	0.033	1000.0	-1000.0	-0.066	-1000.0
EGFR-dependent Endothelin signaling events	6.0	127.0	21.0	-0.06	0.047	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	6.0	441.0	67.0	-0.085	0.048	1000.0	-1000.0	-0.046	-1000.0
IL23-mediated signaling events	6.0	365.0	60.0	-0.307	0.036	1000.0	-1000.0	-0.121	-1000.0
IL12-mediated signaling events	5.0	511.0	87.0	-0.234	0.042	1000.0	-1000.0	-0.078	-1000.0
HIF-1-alpha transcription factor network	5.0	383.0	76.0	-0.144	0.037	1000.0	-1000.0	-0.098	-1000.0
Glypican 1 network	5.0	249.0	48.0	-0.076	0.051	1000.0	-1000.0	-0.033	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	509.0	97.0	-0.198	0.063	1000.0	-1000.0	-0.071	-1000.0
IL1-mediated signaling events	5.0	338.0	62.0	-0.045	0.131	1000.0	-1000.0	-0.073	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	535.0	93.0	-0.084	0.083	1000.0	-1000.0	-0.053	-1000.0
Plasma membrane estrogen receptor signaling	5.0	464.0	86.0	-0.062	0.08	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	417.0	78.0	-0.245	0.042	1000.0	-1000.0	-0.052	-1000.0
Thromboxane A2 receptor signaling	4.0	517.0	105.0	-0.087	0.034	1000.0	-1000.0	-0.044	-1000.0
Arf6 signaling events	4.0	274.0	62.0	-0.067	0.069	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	4.0	507.0	125.0	-0.097	0.08	1000.0	-1000.0	-0.083	-1000.0
Glucocorticoid receptor regulatory network	4.0	538.0	114.0	-0.233	0.126	1000.0	-1000.0	-0.048	-1000.0
Reelin signaling pathway	4.0	241.0	56.0	-0.056	0.079	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	4.0	28.0	7.0	-0.048	0.028	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	4.0	486.0	102.0	-0.081	0.04	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	322.0	68.0	-0.154	0.065	1000.0	-1000.0	-0.082	-1000.0
VEGFR1 specific signals	4.0	226.0	56.0	-0.024	0.089	1000.0	-1000.0	-0.047	-1000.0
PDGFR-beta signaling pathway	4.0	447.0	97.0	-0.063	0.088	1000.0	-1000.0	-0.068	-1000.0
ErbB2/ErbB3 signaling events	3.0	202.0	65.0	-0.051	0.047	1000.0	-1000.0	-0.049	-1000.0
Osteopontin-mediated events	3.0	115.0	38.0	-0.094	0.049	1000.0	-1000.0	-0.048	-1000.0
Noncanonical Wnt signaling pathway	3.0	83.0	26.0	-0.055	0.039	1000.0	-1000.0	-0.046	-1000.0
Syndecan-2-mediated signaling events	3.0	227.0	69.0	-0.027	0.071	1000.0	-1000.0	-0.052	-1000.0
Cellular roles of Anthrax toxin	3.0	124.0	39.0	-0.032	0.035	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PTP1B	3.0	251.0	76.0	-0.038	0.058	1000.0	-1000.0	-0.039	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	216.0	61.0	-0.062	0.067	1000.0	-1000.0	-0.048	-1000.0
BMP receptor signaling	3.0	312.0	81.0	-0.052	0.056	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	3.0	183.0	53.0	-0.079	0.033	1000.0	-1000.0	-0.043	-1000.0
amb2 Integrin signaling	3.0	264.0	82.0	-0.061	0.057	1000.0	-1000.0	-0.047	-1000.0
FAS signaling pathway (CD95)	3.0	145.0	47.0	-0.109	0.047	1000.0	-1000.0	-0.04	-1000.0
Retinoic acid receptors-mediated signaling	3.0	221.0	58.0	-0.072	0.048	1000.0	-1000.0	-0.048	-1000.0
Syndecan-3-mediated signaling events	3.0	108.0	35.0	-0.027	0.067	1000.0	-1000.0	-0.038	-1000.0
EPHB forward signaling	3.0	295.0	85.0	-0.069	0.115	1000.0	-1000.0	-0.07	-1000.0
Effects of Botulinum toxin	3.0	90.0	26.0	-0.079	0.052	1000.0	-1000.0	-0.02	-1000.0
Nongenotropic Androgen signaling	3.0	188.0	52.0	-0.03	0.065	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	265.0	76.0	-0.038	0.072	1000.0	-1000.0	-0.059	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	3.0	86.0	27.0	-0.056	0.039	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	3.0	248.0	73.0	-0.062	0.035	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	283.0	88.0	-0.094	0.085	1000.0	-1000.0	-0.07	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	387.0	120.0	-0.079	0.087	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PRL	3.0	104.0	34.0	-0.037	0.081	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.016	0.016	1000.0	-1000.0	-0.017	-1000.0
S1P4 pathway	3.0	82.0	25.0	-0.03	0.043	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	2.0	218.0	74.0	-0.074	0.052	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	72.0	34.0	-0.035	0.083	1000.0	-1000.0	-0.033	-1000.0
Syndecan-1-mediated signaling events	2.0	91.0	34.0	-0.029	0.042	1000.0	-1000.0	-0.041	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	118.0	54.0	-0.063	0.049	1000.0	-1000.0	-0.057	-1000.0
Ephrin A  reverse signaling	2.0	18.0	7.0	-0.041	0.036	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	37.0	17.0	-0.029	0.053	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	215.0	85.0	-0.052	0.071	1000.0	-1000.0	-0.044	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	156.0	65.0	-0.056	0.049	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	2.0	160.0	55.0	-0.059	0.057	1000.0	-1000.0	-0.06	-1000.0
PLK1 signaling events	2.0	219.0	85.0	-0.021	0.063	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	2.0	171.0	68.0	-0.063	0.048	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	158.0	68.0	-0.048	0.076	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	2.0	131.0	63.0	-0.02	0.065	1000.0	-1000.0	-0.042	-1000.0
Ceramide signaling pathway	2.0	219.0	76.0	-0.057	0.077	1000.0	-1000.0	-0.037	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	213.0	82.0	-0.056	0.062	1000.0	-1000.0	-0.061	-1000.0
ceramide signaling pathway	2.0	99.0	49.0	-0.009	0.055	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	2.0	100.0	36.0	-0.037	0.055	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by PI3K	2.0	143.0	58.0	-0.059	0.044	1000.0	-1000.0	-0.051	-1000.0
Integrins in angiogenesis	2.0	182.0	84.0	-0.086	0.077	1000.0	-1000.0	-0.072	-1000.0
Canonical Wnt signaling pathway	2.0	150.0	51.0	-0.064	0.113	1000.0	-1000.0	-0.045	-1000.0
Regulation of p38-alpha and p38-beta	2.0	151.0	54.0	-0.074	0.054	1000.0	-1000.0	-0.049	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	82.0	31.0	-0.031	0.033	1000.0	-1000.0	-0.048	-1000.0
IL27-mediated signaling events	2.0	123.0	51.0	-0.134	0.067	1000.0	-1000.0	-0.051	-1000.0
TCGA08_rtk_signaling	2.0	53.0	26.0	-0.031	0.07	1000.0	-1000.0	-0.011	-1000.0
IL2 signaling events mediated by STAT5	2.0	45.0	22.0	-0.07	0.033	1000.0	-1000.0	-0.041	-1000.0
TCGA08_retinoblastoma	2.0	23.0	8.0	-0.005	0.027	1000.0	-1000.0	-0.003	-1000.0
Insulin Pathway	2.0	152.0	74.0	-0.069	0.086	1000.0	-1000.0	-0.059	-1000.0
S1P3 pathway	2.0	112.0	42.0	-0.03	0.049	1000.0	-1000.0	-0.029	-1000.0
FOXM1 transcription factor network	2.0	107.0	51.0	-0.157	0.04	1000.0	-1000.0	-0.117	-1000.0
Regulation of Androgen receptor activity	2.0	158.0	70.0	-0.139	0.07	1000.0	-1000.0	-0.054	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	34.0	17.0	-0.008	0.035	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	2.0	162.0	67.0	-0.201	0.069	1000.0	-1000.0	-0.039	-1000.0
LPA4-mediated signaling events	1.0	20.0	12.0	-0.035	0.006	1000.0	-1000.0	-0.03	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	215.0	136.0	-0.097	0.056	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	1.0	147.0	76.0	-0.064	0.059	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class II	1.0	84.0	75.0	-0.049	0.085	1000.0	-1000.0	-0.037	-1000.0
ErbB4 signaling events	1.0	109.0	69.0	-0.044	0.056	1000.0	-1000.0	-0.045	-1000.0
BARD1 signaling events	1.0	69.0	57.0	-0.03	0.071	1000.0	-1000.0	-0.052	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	34.0	28.0	-0.031	0.048	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.033	-1000.0	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Cones	1.0	42.0	38.0	-0.02	0.051	1000.0	-1000.0	-0.02	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.016	0.048	1000.0	-1000.0	0.017	-1000.0
Arf6 downstream pathway	1.0	57.0	43.0	-0.043	0.044	1000.0	-1000.0	-0.036	-1000.0
Insulin-mediated glucose transport	1.0	61.0	32.0	-0.167	0.046	1000.0	-1000.0	-0.034	-1000.0
PDGFR-alpha signaling pathway	1.0	60.0	44.0	-0.019	0.076	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	1.0	66.0	40.0	-0.055	0.058	1000.0	-1000.0	-0.036	-1000.0
TRAIL signaling pathway	1.0	89.0	48.0	-0.036	0.048	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	1.0	21.0	17.0	-0.016	0.033	1000.0	-1000.0	-0.019	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	60.0	52.0	-0.031	0.1	1000.0	-1000.0	-0.042	-1000.0
HIF-2-alpha transcription factor network	1.0	54.0	43.0	-0.062	0.064	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	134.0	83.0	-0.059	0.051	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	1.0	130.0	104.0	-0.063	0.071	1000.0	-1000.0	-0.038	-1000.0
FoxO family signaling	1.0	119.0	64.0	-0.066	0.067	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.03	0.034	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	86.0	45.0	-0.051	0.077	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	134.0	125.0	-0.047	0.116	1000.0	-1000.0	-0.067	-1000.0
IL6-mediated signaling events	1.0	128.0	75.0	-0.038	0.079	1000.0	-1000.0	-0.062	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	147.0	74.0	-0.057	0.066	1000.0	-1000.0	-0.068	-1000.0
Arf6 trafficking events	1.0	104.0	71.0	-0.052	0.054	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	1.0	173.0	102.0	-0.056	0.054	1000.0	-1000.0	-0.057	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	57.0	33.0	-0.02	0.068	1000.0	-1000.0	-0.031	-1000.0
Visual signal transduction: Rods	1.0	76.0	52.0	-0.046	0.065	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in keratinocytes	1.0	66.0	43.0	-0.033	0.089	1000.0	-1000.0	-0.033	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	0.02	0.048	1000.0	-1000.0	0.019	-1000.0
Arf1 pathway	1.0	75.0	54.0	-0.014	0.066	1000.0	-1000.0	-0.023	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	-0.003	0.034	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	0.0	29.0	39.0	-0.024	0.066	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	0.0	1.0	22.0	-0.007	0.072	1000.0	-1000.0	-0.037	-1000.0
Aurora A signaling	0.0	55.0	60.0	-0.033	0.085	1000.0	-1000.0	-0.034	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.04	1000.0	-1000.0	-0.02	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	36.0	37.0	-0.02	0.079	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.063	0.065	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	0.0	19.0	31.0	-0.022	0.051	1000.0	-1000.0	-0.034	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.032	0.048	1000.0	-1000.0	0.023	-1000.0
IGF1 pathway	0.0	32.0	57.0	-0.052	0.08	1000.0	-1000.0	-0.06	-1000.0
Rapid glucocorticoid signaling	0.0	2.0	20.0	-0.0	0.039	1000.0	-1000.0	-0.002	-1000.0
p38 MAPK signaling pathway	0.0	36.0	44.0	-0.02	0.069	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.086	1000.0	-1000.0	-0.0	-1000.0
Total	335	23502	7203	-8.7787488066	-991.931707814	131000	-131000	-5.75420210402	-131000