rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(1), CD33(4), CD5(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(1), IL3(1), ITGAX(6), TLR2(3), TLR4(1), TLR7(3), TLR9(2) 8029007 31 31 31 8 2 20 4 1 4 0 3.92e-07 0.000241 2 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(2), CD19(1), CD1B(1), CD1D(3), CD1E(2), CD2(1), CD22(3), CD33(4), CD37(1), CD38(1), CD3E(2), CD3G(1), CD44(3), CD5(2), CD55(1), CD59(1), CR2(3), CSF1R(1), CSF2(2), DNTT(1), EPO(1), FCER2(1), FLT3(4), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(4), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(3) 34897969 79 70 78 28 18 36 9 2 14 0 0.000110 0.0339 3 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 BRAF(5), CD244(1), CSF2(2), FYN(1), ICAM1(1), ICAM2(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC3(2), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), NCR1(1), NFATC2(2), NFATC4(2), PAK1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PTK2B(2), PTPN11(4), RAF1(1), SH2D1A(1), SH2D1B(1), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(3), VAV2(2), VAV3(1), ZAP70(3) 47276775 102 78 95 34 30 30 19 9 14 0 0.000240 0.0494 4 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1) 3629573 14 14 14 1 1 6 5 0 2 0 0.000434 0.0532 5 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), IL4R(4) 5517896 19 18 19 4 3 8 3 2 3 0 0.000515 0.0532 6 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(2), MAP3K7(2), MAPK8(1), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(3), TLR3(1), TLR4(1), TLR6(5), TLR7(3), TLR9(2), TRAF6(1) 15827389 38 37 38 9 9 16 5 2 6 0 0.000518 0.0532 7 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), C1QC(1), C1S(2), C2(2), C3(3), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(1), C8B(3), C9(2), CD46(2), CD55(1), CD59(1), CFB(1), CFH(2), CFI(1), CR2(3), F10(1), F13A1(3), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), KLKB1(1), KNG1(2), MASP2(1), MBL2(1), PLAT(1), PLG(2), SERPINA5(1), SERPINC1(1), SERPING1(2), VWF(5) 39287991 81 70 81 25 24 29 14 2 12 0 0.000661 0.0546 8 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(4) 312623 4 4 4 0 2 2 0 0 0 0 0.000709 0.0546 9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(1), BRAF(5), CREB1(1), CREBBP(4), CRKL(1), DAG1(2), EGR1(3), EGR2(1), EGR3(1), ELK1(2), MAP1B(2), MAPK1(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), NTRK1(1), PIK3C2G(6), PTPN11(4), RPS6KA3(1), SRC(2), TERF2IP(1) 20692311 46 42 42 14 12 14 6 4 10 0 0.000946 0.0648 10 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 19 ADCY1(3), AKT1(1), BCL2(2), CSF2RB(2), IGF1(2), IGF1R(2), IL3(1), KIT(3), KITLG(1), PRKAR1B(1), PRKAR2B(1), YWHAH(1) 7358109 20 20 20 4 4 7 5 1 3 0 0.00123 0.0684 11 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), LPA(2), PLAT(1), PLG(2), SERPINB2(1), VWF(5) 15208087 37 34 37 8 11 13 7 1 5 0 0.00133 0.0684 12 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2(2), FGA(4), FGB(2), FGG(3), PLAT(1), PLG(2), SERPINB2(1) 5783693 18 18 18 3 5 8 5 0 0 0 0.00136 0.0684 13 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(1), CSF2(2), FCER1A(1), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCG1(6), PLCG2(2), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(3), VAV2(2), VAV3(1) 29587532 66 55 64 19 16 24 12 5 9 0 0.00148 0.0684 14 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(1), EZR(3), F11R(1), GRLF1(1), ICAM1(1), ITGA4(3), ITGAM(4), ITGB1(1), ITGB2(4), MAPK13(1), MLLT4(4), MMP9(2), MSN(1), NCF1(1), NOX3(3), OCLN(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PRKCA(1), PRKCG(2), PTK2B(2), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), ROCK1(1), ROCK2(1), SIPA1(2), TXK(1), VASP(1), VAV1(3), VAV2(2), VAV3(1), VCAM1(1) 52588430 98 83 97 39 21 39 15 9 14 0 0.00159 0.0684 15 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 230 ADCYAP1R1(1), ADRA2C(2), AGTR1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), C5AR1(3), CALCRL(1), CCKAR(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), DRD2(1), DRD3(1), F2(2), F2RL3(1), GABBR2(2), GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), GABRB3(4), GABRD(1), GABRE(2), GABRG1(1), GABRG2(3), GABRP(1), GALR1(1), GLP1R(1), GLP2R(2), GLRA1(1), GPR156(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(1), GRIK1(1), GRIK2(1), GRIK3(4), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRIN3A(1), GRIN3B(1), GRM1(4), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), HRH2(2), HRH3(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), LEPR(1), LHCGR(2), MC2R(3), MC3R(3), MC4R(2), MC5R(2), MCHR1(1), MCHR2(1), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), P2RX2(1), P2RX5(1), P2RY2(1), P2RY4(1), PPYR1(1), PRLHR(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(2), RXFP2(1), SSTR4(2), TAAR1(1), TAAR5(1), TACR3(3), TRPV1(2) 93125688 176 127 176 79 50 80 19 16 11 0 0.00167 0.0684 16 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AMD1(1), AOC2(2), CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), DAO(4), GAMT(1), GATM(2), MAOB(2), NOS1(5), NOS3(4), OTC(2), RARS(1) 18918444 43 39 42 9 11 21 7 4 0 0 0.00204 0.0784 17 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ASS1(1), CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), DAO(4), EPRS(2), GAMT(1), GATM(2), GLUD2(1), NOS1(5), NOS3(4), OTC(2), PARS2(1), RARS(1) 15394114 34 33 33 9 11 13 6 4 0 0 0.00330 0.119 18 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(1), BCL10(1), CARD11(5), CD19(1), CD22(3), CHUK(1), CR2(3), FOS(1), GSK3B(1), IFITM1(2), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(2), PPP3CB(1), PPP3R2(1), VAV1(3), VAV2(2), VAV3(1) 30550804 65 54 64 22 19 25 8 4 9 0 0.00356 0.122 19 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(1), CCR1(1), CCR3(1), CD28(1), CSF2(2), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), IL4R(4) 8171462 21 20 21 5 3 7 4 2 5 0 0.00523 0.170 20 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), GPX1(1), PRKCE(1) 2594780 9 9 9 4 0 5 2 2 0 0 0.00827 0.252 21 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCKAR(1), CCR1(1), CCR3(1), CX3CR1(1), GALR1(1), GALT(1), LHCGR(2), MC2R(3), MC3R(3), MC4R(2), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), PPYR1(1), SSTR4(2), TACR3(3) 21986223 42 42 42 16 18 15 4 2 3 0 0.00860 0.252 22 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(2), F5(4), FGA(4), FGB(2), FGG(3), SERPINC1(1) 7052009 17 17 17 5 4 8 3 0 2 0 0.00955 0.253 23 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK3(3), MAP2K3(3), MAP3K1(2), MAP3K7(2), MAPK8(1), NFKB1(1), NFKBIA(1), TRAF6(1) 12838756 27 27 27 6 8 10 2 1 6 0 0.0100 0.253 24 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(2) 2922983 10 9 10 3 3 3 1 1 2 0 0.0104 0.253 25 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(1), FYN(1), LRP8(1), RELN(12) 6075714 15 15 15 7 2 6 3 1 3 0 0.0105 0.253 26 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2B(2), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(1), NEK3(2), OCRL(2), PAK4(3), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(2), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), RAF1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(1) 48209435 88 71 86 23 16 29 17 11 15 0 0.0107 0.253 27 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(3) 3923657 12 11 12 3 1 5 1 2 3 0 0.0111 0.253 28 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2), F10(1), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), KLKB1(1), SERPINC1(1), SERPING1(2) 19392242 41 37 41 10 13 15 8 0 5 0 0.0119 0.254 29 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 ELK1(2), FOS(1), IGF1(2), IGF1R(2), IRS1(2), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 9066593 21 19 21 4 5 4 7 1 4 0 0.0136 0.254 30 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD2(1), DRD3(1), HRH2(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2) 10640936 25 24 25 5 6 15 2 2 0 0 0.0141 0.254 31 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(4), IFNA21(1), IFNB1(1), IKBKB(1), IL12B(1), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(1), TLR1(2), TLR2(3), TLR3(1), TLR4(1), TLR5(1), TLR6(5), TLR7(3), TLR8(1), TLR9(2), TRAF6(1) 37242543 75 61 73 22 17 32 10 4 12 0 0.0142 0.254 32 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(1), CASP9(1), KDR(6), KRAS(2), MAP2K1(1), MAPK1(1), MAPK13(1), MAPK3(1), NFATC2(2), NFATC4(2), NOS3(4), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCG1(6), PLCG2(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), SRC(2), VEGFA(2) 29608070 62 50 61 17 13 26 8 6 9 0 0.0146 0.254 33 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 494731 3 3 3 0 0 1 1 0 1 0 0.0146 0.254 34 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4), PTPRC(2) 4641027 12 12 12 4 3 5 1 0 3 0 0.0147 0.254 35 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR109B(2), GPR161(1), GPR34(2), GPR45(2), GPR65(1), GPR68(1), GPR75(1), GPR81(1) 4252744 11 11 11 3 4 3 2 1 1 0 0.0148 0.254 36 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(1), NR0B2(1), NR1H3(1), NR1H4(2), RXRA(2) 2351195 8 8 8 1 3 4 0 0 1 0 0.0158 0.254 37 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), OCRL(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(2) 18590778 41 33 40 15 7 12 7 5 10 0 0.0159 0.254 38 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(1), ITGA4(3), ITGAM(4), ITGB1(1), ITGB2(4), SELE(1), SELP(1) 7503073 18 17 18 10 5 8 1 1 3 0 0.0159 0.254 39 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PTPN11(4) 3910560 11 11 11 3 1 6 2 1 1 0 0.0161 0.254 40 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3E(2), CD3G(1), CD58(1), IL3(1), IL6(1), KITLG(1) 2720165 8 8 8 1 1 3 2 0 2 0 0.0173 0.267 41 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), CSF2(2), HLA-DRA(1), IL3(1) 1320343 5 5 5 0 1 2 1 0 1 0 0.0195 0.293 42 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 29 ACPT(2), ALPP(2), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(3), CYP2C19(1), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(1), CYP4B1(2), CYP4F8(2), PON1(2) 11847904 26 24 25 8 7 11 5 0 3 0 0.0206 0.293 43 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 AKT1(1), CHRM1(1), FLT1(5), FLT4(1), KDR(6), NOS3(4), PDE2A(1), PDE3A(1), PRKAR1B(1), PRKAR2B(1), PRKG2(4) 13462312 26 26 26 6 3 13 1 5 4 0 0.0209 0.293 44 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4), PTPRC(2) 4882248 12 12 12 4 3 5 1 0 3 0 0.0211 0.293 45 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 66 ADH1A(2), ADH1B(2), ADH1C(1), AKR1C1(1), AKR1C4(2), ALDH3A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(3), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(1), GSTA1(1), GSTA4(2), GSTK1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1) 22434757 41 40 41 17 16 14 8 0 3 0 0.0231 0.293 46 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(1), ITGAM(4), ITGB2(4), SELE(1) 5097909 13 12 13 7 4 5 0 1 3 0 0.0232 0.293 47 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(1), BCL10(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CHUK(1), CSF2(2), FOS(1), FYN(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PPP3R2(1), PRKCQ(1), PTPRC(2), SOS1(3), TEC(1), VAV1(3), VAV2(2), VAV3(1), ZAP70(3) 42346108 79 64 78 22 17 29 17 4 12 0 0.0233 0.293 48 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(6), PLCG1(6), PRKCA(1), PTK2B(2), PXN(1), RAF1(1) 10472944 21 20 21 3 3 6 4 4 4 0 0.0237 0.293 49 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2) 12364217 26 24 26 5 6 7 5 3 5 0 0.0238 0.293 50 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SOS1(3) 6659731 16 15 16 1 4 4 5 1 2 0 0.0239 0.293 51 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(1), BRAF(5), EIF4B(1), FIGF(2), IGF1(2), MAPK1(1), MAPK3(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(2), ULK2(1), VEGFA(2), VEGFB(1) 21325577 42 37 38 11 11 16 6 4 5 0 0.0242 0.293 52 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 244 AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CD70(1), CSF1R(1), CSF2(2), CSF2RB(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL6(1), EDA(1), EGF(3), EPO(1), FLT1(5), FLT3(4), FLT4(1), HGF(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18R1(2), IL18RAP(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(1), IL28B(1), IL28RA(1), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), INHBE(1), KDR(6), KIT(3), KITLG(1), LEPR(1), MET(1), MPL(2), OSM(1), OSMR(1), PDGFRB(2), PPBP(1), RELT(1), TGFBR1(1), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF4(2), TNFRSF8(1), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(1), TNFSF8(1), TNFSF9(3), TPO(3), VEGFA(2), VEGFB(1), XCL1(1) 73129927 131 100 127 55 31 57 18 8 17 0 0.0248 0.294 53 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(4), SELE(1) 5828922 13 13 13 7 4 4 1 1 3 0 0.0287 0.331 54 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(2), CES1(2) 2603156 8 8 8 0 1 6 1 0 0 0 0.0294 0.331 55 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(4), DLD(1), GAMT(1), GATM(2), GLDC(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(2), TARS(1) 18066774 36 32 36 8 8 15 5 4 4 0 0.0301 0.331 56 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT3(2), FUT5(3), FUT6(1) 2183771 6 6 6 3 3 1 1 1 0 0 0.0303 0.331 57 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR2(3), JAK1(2), JAK2(1), STAT1(1) 3554721 9 9 9 0 0 2 2 2 3 0 0.0306 0.331 58 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADRA2C(2), AGTR1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CHML(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(1), DRD2(1), DRD3(1), F2RL3(1), GALR1(1), GALT(1), GPR17(1), GPR27(1), GPR4(1), GPR50(1), GPR83(2), GPR85(2), HRH2(2), HRH3(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), LHCGR(2), MC3R(3), MC4R(2), MC5R(2), NMBR(1), NMUR1(1), NMUR2(3), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), OR1F1(1), OR1Q1(1), OR2H1(2), OR7C1(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR4(2) 51577921 88 78 87 44 28 43 7 5 5 0 0.0316 0.335 59 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4) 3748418 9 9 9 2 2 3 1 0 3 0 0.0330 0.344 60 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2) 4741790 11 11 11 5 1 3 1 1 5 0 0.0339 0.347 61 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), GAMT(1), GATM(2), OTC(2) 7395785 15 15 14 4 4 4 3 4 0 0 0.0344 0.347 62 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3) 3946713 10 10 10 4 3 4 2 0 1 0 0.0357 0.353 63 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(1) 3837211 9 9 9 3 4 2 0 1 2 0 0.0372 0.353 64 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(1) 3837211 9 9 9 3 4 2 0 1 2 0 0.0372 0.353 65 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(2), CHUK(1), DAXX(2), EGF(3), ETS1(1), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K5(1), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), RAF1(1), RIPK1(1), TNFRSF1A(1) 20197054 35 34 34 9 9 11 5 3 7 0 0.0383 0.353 66 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PLCG1(6) 6611974 15 14 15 4 2 6 2 2 3 0 0.0385 0.353 67 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(1), UGDH(1), UXS1(1) 1710073 5 5 5 0 0 1 2 0 2 0 0.0391 0.353 68 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 EGF(3), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1) 13456839 27 25 27 7 7 9 5 2 4 0 0.0396 0.353 69 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), JAK2(1), MAPK8(1), STAT4(2), TYK2(1) 7809070 17 17 17 3 3 7 4 0 3 0 0.0401 0.353 70 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(1), CD3E(2), CD3G(1), IFNG(2), IL12B(1), IL12RB1(2), IL12RB2(1), JAK2(1), STAT4(2), TYK2(1) 6105492 14 14 14 2 1 7 3 0 3 0 0.0408 0.353 71 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), VAV1(3), ZAP70(3) 19055455 36 32 36 10 9 11 8 3 5 0 0.0409 0.353 72 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD28(1), CD3E(2), CD3G(1) 1094328 4 4 4 0 0 2 1 0 1 0 0.0412 0.353 73 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), AOC2(2), AOX1(4), DDC(1), MAOB(2), TAT(2), TPO(3), TYR(1) 13320935 26 26 24 6 7 14 5 0 0 0 0.0444 0.371 74 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(2), IRS1(2), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), YWHAH(1) 6524169 13 13 13 2 2 2 4 1 4 0 0.0445 0.371 75 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), NOS1(5), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1) 10895283 22 21 22 9 11 8 2 1 0 0 0.0500 0.411 76 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(1), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1) 10418574 21 20 21 2 3 10 5 1 2 0 0.0510 0.414 77 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 ELK1(2), FOS(1), INSR(2), IRS1(2), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 9385676 19 18 19 6 4 6 5 1 3 0 0.0525 0.419 78 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), ELK1(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PIK3C2G(6), PLCB1(1), PPP3CB(1), RAF1(1) 16695470 28 28 28 11 5 9 4 3 7 0 0.0531 0.419 79 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CREBBP(4), CSK(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9801015 19 19 19 6 7 6 2 1 3 0 0.0558 0.424 80 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CREBBP(4), CSK(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9801015 19 19 19 6 7 6 2 1 3 0 0.0558 0.424 81 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 12 CASR(3), GRM1(4), GRM4(2), GRM5(2), GRM7(2), GRM8(5) 8259379 18 17 18 16 8 6 2 1 1 0 0.0563 0.424 82 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(3), KARS(2) 3018145 7 7 5 3 2 1 1 0 3 0 0.0566 0.424 83 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(2), EPO(1), FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SOS1(3), STAT5B(1) 9325827 19 18 19 1 4 6 5 1 3 0 0.0572 0.424 84 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(5), CREB1(1), MAPK1(1), RAF1(1), SRC(2), TERF2IP(1) 4945446 11 10 7 1 6 0 2 1 2 0 0.0582 0.427 85 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), NTRK1(1), PLCG1(6), PRKCA(1), SOS1(3) 5114208 12 11 12 3 1 5 3 1 2 0 0.0589 0.427 86 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(2), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(1), ST8SIA1(1) 6945818 13 13 13 4 3 4 1 3 2 0 0.0613 0.439 87 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(2) 2047473 5 5 4 2 1 1 1 0 2 0 0.0631 0.447 88 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 AKT1(1), CAMK1(1), CAMK4(1), CREBBP(4), ELSPBP1(2), F2(2), GATA4(1), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(8), NFATC2(2), NFATC4(2), NPPA(1), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1) 20114719 36 32 36 9 6 11 10 2 7 0 0.0658 0.460 89 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1) 12377790 24 22 24 4 6 7 5 2 4 0 0.0666 0.460 90 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(1), ABL2(1), AKT1(1), BRAF(5), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CRKL(1), EGF(3), ELK1(2), ERBB2(1), ERBB4(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYC(1), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2), STAT5B(1) 41779710 68 60 63 20 23 21 12 4 8 0 0.0672 0.460 91 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS1(1) 2294427 6 6 6 2 1 2 1 0 2 0 0.0679 0.460 92 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(1), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), CEL(3), CYP27A1(1), SRD5A1(1), SRD5A2(1) 10112870 19 19 19 6 7 8 3 0 1 0 0.0704 0.464 93 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(2) 3027399 7 7 7 2 3 2 0 1 1 0 0.0704 0.464 94 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH3A1(2), AOC2(2), DDC(1), EPX(2), MAOB(2), MPO(1), TAT(2), TPO(3) 9515278 19 19 18 2 5 11 3 0 0 0 0.0724 0.464 95 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1) 3482875 8 8 8 3 2 3 2 0 1 0 0.0729 0.464 96 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(2), IL12B(1) 1296081 4 4 4 1 0 2 1 0 1 0 0.0741 0.464 97 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 EIF2S2(1), EIF2S3(1), FLT1(5), FLT4(1), KDR(6), NOS3(4), PLCG1(6), PRKCA(1), PXN(1) 13064588 26 23 26 7 2 12 3 4 5 0 0.0748 0.464 98 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 23 RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1), XYLB(1) 9836171 19 19 19 11 7 5 4 1 2 0 0.0755 0.464 99 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(2), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1) 4809744 10 10 10 4 5 2 0 1 2 0 0.0758 0.464 100 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MPL(2), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(1), STAT3(1), STAT5B(1), THPO(1) 11315088 21 20 21 2 4 7 5 1 4 0 0.0763 0.464 101 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN3(1), DES(2), DMD(9), FAM48A(1), MYBPC3(1), MYH3(2), MYH6(1), MYH7(3), MYH8(7), MYL3(1), MYOM1(2), NEB(5), TMOD1(1), TNNC2(1), TNNT1(1), TNNT2(1), TPM3(1), TTN(70) 59498363 111 82 110 23 26 44 18 8 15 0 0.0764 0.464 102 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(4), SELP(1), SELPLG(2), VCAM1(1) 10775962 20 19 20 8 4 7 3 1 5 0 0.0768 0.464 103 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(2), BMP6(1), BTRC(1), CSNK1G1(1), CSNK1G3(1), DHH(1), GLI1(4), GLI2(3), GSK3B(1), IHH(1), LRP2(13), PRKX(1), PTCH1(1), PTCH2(1), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1) 26092930 45 42 45 7 10 17 8 2 8 0 0.0800 0.467 104 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 131 COL11A1(1), COL11A2(5), COL17A1(2), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), DES(2), DSC1(2), DSC2(4), DSC3(4), DSG1(2), DSG2(1), DSG4(4), FN1(2), GJA10(1), GJA9(1), GJB3(2), GJC1(1), GJC3(1), GJD2(2), INA(1), ITGB4(2), KRT1(1), KRT12(1), KRT13(2), KRT14(1), KRT15(2), KRT16(2), KRT2(1), KRT20(1), KRT23(2), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33B(1), KRT34(1), KRT35(1), KRT36(1), KRT37(4), KRT4(1), KRT6B(1), KRT74(1), KRT75(1), KRT76(1), KRT79(2), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(2), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), NES(1), RELN(12), THBS3(1), THBS4(1), TNC(1), TNN(2), TNXB(2), VWF(5) 102098059 161 123 160 70 44 70 16 10 21 0 0.0801 0.467 105 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(4), DLD(1), GAMT(1), GATM(2), GLDC(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(1), SARS2(1), TARS(1), TARS2(1) 18397073 30 30 30 5 7 12 6 2 3 0 0.0805 0.467 106 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(1), ITGB1(1), KLRC3(2), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PTK2B(2), VAV1(3) 6448362 13 13 13 4 4 2 1 1 5 0 0.0807 0.467 107 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(1), AKT1(1), ATM(4), BCL2(2), BIRC3(1), CAPN1(2), CASP9(1), CHUK(1), CSF2RB(2), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IRAK1(2), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PPP3R2(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2) 33892408 55 51 55 16 11 24 7 4 9 0 0.0811 0.467 108 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 ELK1(2), FCER1A(1), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PLA2G4A(2), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), VAV1(3) 16964832 32 28 32 9 7 9 8 4 4 0 0.0820 0.467 109 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 CRKL(1), DOCK1(1), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MET(1), PAK1(1), PTK2B(2), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1) 17291107 31 29 31 5 7 11 7 3 3 0 0.0827 0.467 110 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 7 ACE(2), AGTR1(1), KNG1(2), NOS3(4) 3943899 9 9 9 2 2 5 0 0 2 0 0.0844 0.472 111 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(1), TGFBR2(2), TGFBR3(1) 4618304 10 10 10 1 1 4 3 0 2 0 0.0855 0.475 112 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 52 ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), AOX1(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(3), CYP2C19(1), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(1), CYP4B1(2), CYP4F8(2), DDC(1), ECHS1(1), EHHADH(1), KYNU(1), MAOB(2), TPH1(2), WARS(1) 23144414 45 37 43 10 9 25 8 0 3 0 0.0874 0.476 113 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(3), APOBEC2(1), APOBEC3F(2), APOBEC3G(1) 3167649 7 7 7 2 3 2 1 1 0 0 0.0874 0.476 114 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CD28(1), CSK(1), DAG1(2), EPHB2(1), FBXW7(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PAK1(1), PAK3(1), PAK4(3), PLCG1(6), PTPRC(2), RAF1(1), RASGRP2(1), RASGRP4(1), SOS1(3), VAV1(3), ZAP70(3) 24105165 40 37 40 8 6 15 9 3 7 0 0.0901 0.487 115 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PSAT1(1) 2095452 5 5 4 0 1 4 0 0 0 0 0.0910 0.488 116 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(1), UGDH(1), UXS1(1) 2164996 5 5 5 0 0 1 2 0 2 0 0.0923 0.490 117 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITPR1(4), ITPR2(2), ITPR3(3), OCRL(2), PI4KB(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), PRKCA(1), PRKCG(2), SYNJ2(2) 52366293 90 69 89 24 25 31 12 7 15 0 0.0945 0.494 118 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 39 ALAS1(1), COX10(1), CP(3), EPRS(2), FECH(1), FTMT(2), HMBS(1), HMOX1(1), MMAB(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1) 16350877 29 28 29 12 10 9 7 2 1 0 0.0945 0.494 119 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(2), CAMK2A(1), CLCA1(2), CLCA4(1), CNGA4(1), CNGB1(2), GUCA1C(1), PDC(1), PDE1C(4), PRKG2(4), PRKX(1) 13206146 23 23 23 2 4 10 4 2 3 0 0.104 0.538 120 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(1), RAF1(1), SOS1(3), STAT1(1), STAT5B(1) 10452283 18 18 18 3 3 4 4 1 6 0 0.106 0.541 121 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CCL2(1), FOS(1), MAPK8(1), PLCG1(6), PRKCA(1), PTK2B(2) 5668328 12 11 12 3 4 3 2 1 2 0 0.106 0.541 122 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 45 ACCN1(2), ADCY6(2), ADCY8(2), CACNA1A(1), GRM4(2), ITPR3(3), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(2), SCNN1G(4), TAS1R1(3), TAS1R2(2), TAS2R1(1), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R4(1), TAS2R5(1), TAS2R60(1), TRPM5(1) 23709506 40 39 39 17 8 20 5 1 6 0 0.109 0.548 123 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(2), SOS1(3), SRC(2) 3819577 8 8 8 1 2 1 3 0 2 0 0.110 0.548 124 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(3), ADCY9(3), AK1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), PLCG1(6), PLCG2(2), PRKCA(1), TRIM23(1) 16036713 28 26 28 10 6 12 3 2 5 0 0.111 0.548 125 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGTR1(1), ELK1(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2) 13455157 22 22 22 4 10 2 5 2 3 0 0.111 0.548 126 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(3), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1) 3569181 7 7 7 0 2 1 1 1 2 0 0.114 0.559 127 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNG(2), IFNGR2(3), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(1), TNFRSF1A(1), USH1C(1), WT1(1) 6865497 12 12 12 1 1 4 3 2 2 0 0.117 0.568 128 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2892500 6 6 6 1 2 1 1 2 0 0 0.120 0.574 129 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2892500 6 6 6 1 2 1 1 2 0 0 0.120 0.574 130 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(1), CHAT(2), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(2), PISD(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(2) 21750113 38 34 38 11 9 15 4 5 5 0 0.122 0.578 131 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1) 6040819 11 11 11 3 2 4 0 2 3 0 0.123 0.578 132 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(3), ADCY8(2), BRAF(5), CACNA1C(5), CAMK2A(1), CAMK4(1), CREBBP(4), GRIA1(2), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRM1(4), GRM5(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2) 43570236 73 62 68 26 32 23 8 3 7 0 0.124 0.578 133 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1) 2676018 6 6 6 2 1 3 1 0 1 0 0.127 0.585 134 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1) 14936666 25 24 25 3 7 7 5 2 4 0 0.128 0.585 135 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(1), IL1A(1), IL3(1), IL6(1), IL7(1) 5663359 11 11 11 5 2 5 2 0 2 0 0.128 0.585 136 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(2), ARSD(1), ARSE(3), CARM1(3), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(1), HSD17B3(1), LCMT1(1), LCMT2(1), SRD5A1(1), SRD5A2(1), SULT2B1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1) 19848364 37 32 36 16 14 11 8 1 3 0 0.135 0.612 137 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 144 AKT1(1), CBL(1), CBLB(1), CCND2(1), CCND3(1), CREBBP(4), CSF2(2), CSF2RB(2), EPO(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(1), IL28B(1), IL28RA(1), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), IRF9(1), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MPL(2), MYC(1), OSM(1), OSMR(1), PIAS1(1), PIAS3(1), PIAS4(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), SOCS4(1), SOS1(3), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT4(2), STAT5B(1), STAT6(1), TPO(3), TYK2(1) 59745234 100 78 98 36 15 46 18 7 14 0 0.137 0.614 138 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), BCL2(2), GSK3B(1), IL4R(4), IRS1(2), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), STAT6(1) 14212254 23 23 23 8 2 9 5 1 6 0 0.138 0.615 139 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), BRAF(5), DAG1(2), DRD2(1), EPHB2(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PIK3CB(4), PITX2(2), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1), TERF2IP(1) 24344853 41 35 37 7 15 11 7 4 4 0 0.143 0.633 140 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(1), APC(1), AXIN1(3), DACT1(1), DKK1(1), DKK2(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(8), MVP(3), NKD1(1), PTPRA(3), WIF1(1) 17248503 29 27 29 3 4 12 8 0 5 0 0.146 0.642 141 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(4), IRS1(2), JAK1(2), JAK3(2), STAT6(1) 6458330 12 12 12 4 1 6 1 0 4 0 0.147 0.642 142 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(1), CYP11B2(2), HSD11B1(1) 2988112 6 6 6 2 4 1 0 0 1 0 0.150 0.645 143 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), ARSD(1), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B3(1), SRD5A1(1), SRD5A2(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2) 11290052 20 19 20 11 9 5 3 1 2 0 0.150 0.645 144 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 AKT1(1), DAG1(2), GCA(1), ITGA9(1), ITPR1(4), ITPR2(2), ITPR3(3), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(1), PIK3C2G(6), RIPK3(1), RPS4X(1), VASP(1) 19665955 30 29 30 9 8 9 3 4 6 0 0.153 0.654 145 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(2), CREB3L4(1), CREBBP(4), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(2), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1) 45676254 68 60 66 20 19 22 13 3 11 0 0.158 0.667 146 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 797225 2 2 2 0 1 1 0 0 0 0 0.158 0.667 147 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ADC(2), ALDH3A1(2), AMD1(1), AOC2(2), ASS1(1), CPS1(4), GATM(2), MAOB(2), OTC(2) 12828348 22 21 22 6 1 12 6 2 1 0 0.160 0.667 148 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C8B(3), C9(2) 9123223 15 15 15 6 5 3 2 1 4 0 0.160 0.667 149 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(2), IGF1R(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), PTPRR(3), RAF1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1) 12278977 20 20 20 3 6 6 4 1 3 0 0.166 0.687 150 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), SRC(2) 4323960 9 8 9 5 1 5 1 2 0 0 0.172 0.707 151 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(2), PAPPA(2), RPS6KA3(1), SOS1(3), VAV1(3), VAV2(2), VAV3(1) 13848746 24 22 24 7 6 8 4 4 2 0 0.178 0.726 152 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), IARS(3), IL4R(4), INPP5D(3), JAK1(2), JAK2(1), JAK3(2), NR0B2(1), SOS1(3), SRC(2), STAT6(1), TYK2(1) 15087822 24 24 24 6 6 11 4 1 2 0 0.179 0.726 153 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), VAV1(3) 16543052 29 25 29 9 8 7 7 3 4 0 0.180 0.726 154 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), EGF(3), FOS(1), MYC(1), NFKB1(1), PLCG1(6), PRKCA(1) 7755400 14 13 14 5 2 6 3 1 2 0 0.182 0.727 155 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 88 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), DRD2(1), EGF(3), GJD2(2), GRM1(4), GRM5(2), GUCY1B3(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(1), PDGFD(1), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG2(4), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(2), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3) 54163383 84 72 82 33 25 33 11 4 11 0 0.183 0.728 156 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(1), CTH(1), MUT(1) 2115066 4 4 4 1 1 1 1 1 0 0 0.184 0.728 157 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH1C(1) 2442402 5 5 5 1 2 2 1 0 0 0 0.187 0.734 158 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1) 8949940 14 14 14 4 3 4 1 2 4 0 0.189 0.734 159 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(2), ACE2(2), AGTR1(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(2), LNPEP(1), MME(1) 8795293 15 15 15 3 3 7 1 0 4 0 0.190 0.734 160 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(1), EGF(3), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(2), RAF1(1), SOS1(3), SRC(2) 9427019 15 15 15 7 3 3 5 2 2 0 0.191 0.734 161 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(2), MAP3K7(2), NFKB1(1), NFKBIA(1), RIPK1(1), TLR4(1), TNFRSF1A(1), TRAF6(1) 10617620 17 17 17 4 4 7 2 1 3 0 0.193 0.734 162 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(4), CAMK2A(1), ELK1(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K4(3), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2) 53575404 82 71 80 23 26 30 12 4 10 0 0.194 0.734 163 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(5), CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(1), GRM1(4), GRM5(2), GUCY1B3(1), GUCY2F(1), IGF1(2), IGF1R(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), LYN(2), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(5), NOS3(4), NPR1(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(2), PRKCA(1), PRKCG(2), PRKG2(4), RAF1(1), RYR1(3) 48108928 74 63 69 30 30 20 11 5 8 0 0.194 0.734 164 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RALBP1(1), RALGDS(1) 6663873 11 11 11 0 3 4 2 0 2 0 0.198 0.742 165 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(1), CETP(2), LCAT(2), LDLR(1), LRP1(8), SOAT1(3) 10855118 17 16 17 5 4 3 4 1 5 0 0.200 0.746 166 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(2), IL12B(1), IL16(1), IL1A(1), IL3(1), IL6(1) 4271934 8 8 8 4 1 4 2 0 1 0 0.205 0.761 167 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1) 2327308 5 5 5 1 2 2 0 0 1 0 0.206 0.761 168 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(1), CDKN2A(2), MDM2(2), PRB1(1) 3109345 6 6 6 0 1 2 0 0 3 0 0.210 0.767 169 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(4), ATR(3), CHEK1(2), CHEK2(1), YWHAH(1) 6596845 11 11 11 3 0 4 4 1 2 0 0.214 0.767 170 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(1), ATM(4), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(1), MAPK8(1), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1) 12573760 20 20 20 6 2 10 3 1 4 0 0.214 0.767 171 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), BCL2(2), CD19(1), CD22(3), CR2(3), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(4), ITPR2(2), ITPR3(3), LYN(2), MAP4K1(2), MAPK1(1), MAPK3(1), NFATC2(2), NR0B2(1), PLCG2(2), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(3) 30479385 48 43 48 17 16 13 7 2 10 0 0.216 0.767 172 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(4), DAXX(2), PAX3(3), SP100(2), TNFRSF1A(1) 7175492 12 12 12 4 2 5 1 1 3 0 0.216 0.767 173 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 INSR(2), IRS1(2), JAK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT5B(1) 12659046 21 19 21 5 2 8 4 2 5 0 0.218 0.767 174 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 164 ADCY1(3), ADCY2(2), ADCY3(3), ADCY7(1), ADCY8(2), ADCY9(3), AGTR1(1), ATP2A1(1), ATP2A3(1), ATP2B2(3), ATP2B3(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(3), CACNA1S(4), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), ERBB2(1), ERBB4(1), GRIN2A(8), GRIN2C(1), GRIN2D(1), GRM1(4), GRM5(2), HRH2(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), ITPR1(4), ITPR2(2), ITPR3(3), LHCGR(2), MYLK(2), NOS1(5), NOS3(4), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRB(2), PHKA1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(2), RYR1(3), RYR3(10), TACR3(3), TNNC2(1), TRPC1(1), VDAC1(1) 111310760 171 125 170 68 55 72 17 5 22 0 0.218 0.767 175 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C9(2) 7696465 12 12 12 6 4 2 2 1 3 0 0.218 0.767 176 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDK7(1), CDKN1A(1), CHEK1(2), NEK1(1), WEE1(1) 3107501 6 6 6 0 2 2 1 0 1 0 0.222 0.771 177 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(1), FYN(1), ITGA1(2), ITGB1(1), L1CAM(4), LYN(2), SELP(1) 6822621 12 12 12 4 2 6 4 0 0 0 0.222 0.771 178 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(1), MST1R(2) 2802594 5 5 5 3 3 0 0 0 2 0 0.225 0.775 179 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1) 6704191 10 10 10 2 2 2 2 1 3 0 0.226 0.775 180 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2A1L(1), GTF2H1(2), TAF1(3), TAF1L(8), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(2), TBPL2(1) 15528835 24 23 24 9 8 3 6 3 4 0 0.227 0.775 181 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), CNDP1(1), DDC(1), HAL(2), HARS(1), HDC(1), MAOB(2) 10596263 19 18 19 3 2 14 3 0 0 0 0.228 0.775 182 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNB1(1), MAPK8(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1) 4821422 8 8 8 4 3 3 1 0 1 0 0.231 0.781 183 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(3), ECHS1(1) 2334095 4 5 5 1 1 2 1 0 0 0 0.232 0.781 184 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(2), FOS(1), IL3(1), JAK2(1), MAP2K1(1), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1) 7290038 12 12 12 0 1 5 4 0 2 0 0.235 0.784 185 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CSK(1), PRKCA(1), PTPRA(3), SRC(2) 3993959 7 7 7 0 4 2 1 0 0 0 0.235 0.784 186 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(3), CAMK1(1), IGF1(2), IGF1R(2), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PPP3CB(1), YWHAH(1) 13399152 20 20 20 7 4 7 6 0 3 0 0.238 0.788 187 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(2), CREBBP(4), FYN(1), IL7(1), IL7R(1), JAK1(2), JAK3(2), PTK2B(2), STAT5B(1) 10547775 16 16 16 9 3 4 2 0 7 0 0.247 0.810 188 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(1), RETN(1), RXRA(2) 2505472 5 5 5 0 1 2 0 0 2 0 0.247 0.810 189 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF2S2(1), EIF2S3(1), GSK3B(1), IGF1(2), IGF1R(2), INPPL1(3) 6556075 11 10 11 2 1 2 4 0 4 0 0.254 0.821 190 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(4), JAK1(2), JAK2(1), TYK2(1) 4517951 8 8 8 4 0 5 1 0 2 0 0.255 0.821 191 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(4), JAK1(2), JAK2(1), TYK2(1) 4517951 8 8 8 4 0 5 1 0 2 0 0.255 0.821 192 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR2(1), EGR3(1), MAP3K1(2), MYC(1), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1) 11875443 19 17 19 4 2 7 3 3 4 0 0.257 0.825 193 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IFNG(2), IKBKB(1), MAP3K1(2), MAP3K5(1), MAPK8(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3) 8475412 14 13 13 5 5 4 2 1 2 0 0.259 0.828 194 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2RL3(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(2), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1) 10574431 18 16 18 1 4 7 4 1 2 0 0.263 0.836 195 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C9(2), MASP2(1), MBL2(1) 9336561 14 14 14 7 4 4 2 1 3 0 0.264 0.836 196 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(5), MCAT(1), OXSM(1) 6773157 11 11 11 2 4 4 1 1 1 0 0.266 0.837 197 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(2), ARHGEF12(1), ARHGEF6(2), ARHGEF7(1), ARPC2(1), BDKRB1(1), BRAF(5), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(2), DIAPH3(1), DOCK1(1), EGF(3), EZR(3), F2(2), FGD1(1), FGD3(2), FGF14(2), FGF18(1), FGF7(1), FGFR1(1), FGFR3(4), FGFR4(1), FN1(2), GRLF1(1), GSN(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(1), ITGAE(1), ITGAM(4), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), KRAS(2), LIMK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), MSN(1), MYH14(2), MYH9(3), MYLK(2), NCKAP1L(1), PAK1(1), PAK3(1), PAK4(3), PDGFRB(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(1), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(4), VAV1(3), VAV2(2), VAV3(1), WAS(1) 116362947 168 124 160 60 41 68 27 9 23 0 0.272 0.852 198 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(1), ACTN1(2), AKT1(1), ARHGEF6(2), ARHGEF7(1), BRAF(5), CDKN2A(2), CSE1L(1), DOCK1(1), EPHB2(1), FYN(1), GRB7(2), GRLF1(1), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PLCG1(6), PLCG2(2), RAF1(1), ROCK1(1), ROCK2(1), SOS1(3), SRC(2), TERF2IP(1), TLN2(2), VASP(1), WAS(1), ZYX(2) 51677514 77 63 73 20 17 22 15 8 15 0 0.279 0.858 199 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE2(1), CDKN2A(2), E2F4(1), PRB1(1) 3714191 6 6 6 0 1 1 1 1 2 0 0.280 0.858 200 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), MPO(1), MTHFR(2), TPO(3) 5036457 8 8 8 1 3 3 0 1 1 0 0.281 0.858 201 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(1), CBR1(2), CYP4F2(1), CYP4F3(2), EPX(2), GGT1(1), MPO(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1), TPO(3) 12059434 20 19 20 3 7 10 2 0 1 0 0.283 0.858 202 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNG(1), MUSK(1), PTK2B(2), SRC(2), TERT(1), YWHAH(1) 5482973 9 9 9 1 3 3 2 0 1 0 0.283 0.858 203 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), TLR4(1), WNT1(1) 11360005 18 17 18 5 3 7 5 1 2 0 0.285 0.858 204 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(1), CDKN2A(2), MDM2(2), MYC(1), POLR1A(2), POLR1B(1) 5927298 9 9 9 0 1 2 1 1 4 0 0.286 0.858 205 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(2), JAK1(2), JAK3(2), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), SOS1(3), STAT5B(1) 14053905 20 20 20 4 1 6 5 1 7 0 0.287 0.858 206 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), TAT(2), TYR(1) 2029685 4 4 3 0 2 1 1 0 0 0 0.289 0.858 207 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ESR1(1), ESR2(2), HNF4A(3), NR1H2(2), NR1H3(1), NR1I2(1), NR1I3(2), NR2C2(1), NR2F2(1), NR4A1(2), NR5A2(1), PGR(4), PPARA(1), PPARG(1), RORC(2), RXRA(2) 18263674 27 26 27 8 7 10 4 1 5 0 0.290 0.858 208 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CSDA(1), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(2), EPB41(1), EPB41L2(2), EPB41L3(3), F11R(1), HCLS1(2), INADL(1), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MLLT4(4), MPDZ(1), MYH1(5), MYH11(5), MYH13(6), MYH14(2), MYH15(3), MYH2(8), MYH3(2), MYH4(4), MYH6(1), MYH7(3), MYH7B(2), MYH8(7), MYH9(3), OCLN(1), PARD6B(1), PPM1J(2), PPP2R1B(2), PPP2R3A(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), SPTAN1(2), SRC(2), SYMPK(2), TJAP1(1), TJP1(2), TJP3(4), ZAK(2) 83504294 125 97 123 29 32 48 22 5 18 0 0.290 0.858 209 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(1), BCL2(2), IGF1R(2), MYC(1), POLR2A(2), PRKCA(1), TEP1(3), TERT(1), TNKS(1) 9943915 14 14 14 4 4 3 1 1 5 0 0.293 0.862 210 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), MAPK8(1), RAF1(1), SOS1(3), STAT5B(1) 10205977 15 15 15 7 4 4 4 0 3 0 0.299 0.872 211 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(1), CCND2(1), CCND3(1), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), RBL1(1) 5938841 9 9 9 1 4 1 1 0 3 0 0.299 0.872 212 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), PDHA1(1), PDHA2(2) 11166277 16 17 17 5 4 8 2 0 2 0 0.303 0.881 213 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR2(3), HLA-DRA(1), ICAM1(1), ITGB2(4), PTPRC(2) 6562480 11 10 11 4 4 5 0 0 2 0 0.306 0.885 214 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(1), YWHAH(1) 14271876 21 20 21 5 5 8 4 1 3 0 0.311 0.891 215 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(1), TPO(3), TYR(1) 4181447 7 7 7 1 3 3 1 0 0 0 0.314 0.891 216 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1) 5405096 8 8 8 2 1 2 1 1 3 0 0.316 0.891 217 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(1), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(1) 5134220 9 8 9 1 1 6 0 1 1 0 0.317 0.891 218 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(2), CPS1(4), CTH(1), GLS(1), GLUL(1), HAL(2) 8104493 13 12 13 1 3 6 1 1 2 0 0.317 0.891 219 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(1), C6(1), C8A(1), C9(2) 5491892 8 8 8 5 2 0 2 1 3 0 0.318 0.891 220 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(1), GAPDH(1), INSR(2), MAGI1(2), MAGI2(2), RERE(4), WWP2(1) 10309672 16 15 16 3 4 6 2 1 3 0 0.318 0.891 221 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2) 6319162 10 10 9 3 2 5 3 0 0 0 0.329 0.914 222 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(5), ERBB2(1), ERBB4(1), ETS1(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH2(2), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1) 21475254 29 28 24 6 12 7 6 1 3 0 0.329 0.914 223 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(3), CYP2C19(1), CYP2E1(1), CYP2U1(1), CYP4A11(2), CYP4F2(1), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), GPX5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1) 16890082 28 24 28 11 6 15 5 0 2 0 0.336 0.926 224 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1681503 3 3 3 1 1 2 0 0 0 0 0.338 0.926 225 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF8(1), TNFSF8(1) 5867714 9 9 9 1 1 3 0 1 4 0 0.338 0.926 226 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3C2G(6), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1) 10997841 15 15 15 3 3 4 3 2 3 0 0.340 0.926 227 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1) 3485438 5 5 5 1 0 3 0 2 0 0 0.341 0.926 228 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), MPO(1), TPO(3) 3645859 6 6 6 1 3 3 0 0 0 0 0.344 0.929 229 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), SOS1(3) 6082268 9 9 9 4 3 2 2 0 2 0 0.346 0.929 230 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(2), GSTA1(1), GSTA4(2) 7456527 11 11 11 1 3 4 3 0 1 0 0.347 0.929 231 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BCL2(2), CABIN1(3), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CREBBP(4), CSF2(2), CSNK2B(2), EGR2(1), EGR3(1), FCER1A(1), FOS(1), GATA4(1), GRLF1(1), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MAPK8(1), MEF2A(2), MEF2D(1), MYF5(1), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), PAK1(1), PPP3CB(1), PTPRC(2), SFN(1), VAV1(3), VAV2(2), VAV3(1) 38711362 57 51 57 19 11 18 12 1 15 0 0.352 0.937 232 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(4), ITPR2(2), ITPR3(3), LYN(2), NR0B2(1), PITX2(2), PLCG2(2), PREX1(5), PTPRC(2), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(3) 22774055 35 33 35 14 12 12 2 2 7 0 0.353 0.937 233 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5C1B(2), NT5E(2), NUDT12(1) 9349270 14 14 13 7 2 7 5 0 0 0 0.356 0.938 234 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(1) 2094895 3 3 3 0 1 1 0 0 1 0 0.357 0.938 235 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(4), CRY1(1), PER1(1) 3693114 6 6 5 1 1 2 0 0 3 0 0.359 0.938 236 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), PAH(2), TAT(2) 3582283 6 6 5 1 2 3 1 0 0 0 0.359 0.938 237 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MAPK8(1), MET(1), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(2), PTPN11(4), PTPRZ1(1), SRC(2), TJP1(2) 29302667 45 39 45 14 8 18 8 3 8 0 0.365 0.941 238 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL10(1), BCL2(2), CASP8AP2(1), CASP9(1), CES1(2) 4830646 7 7 7 0 2 2 0 0 3 0 0.366 0.941 239 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 CADM3(1), CD2(1), CD22(3), CD276(1), CD28(1), CD58(1), CD6(2), CD86(2), CDH4(1), CDH5(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(1), F11R(1), HLA-DMB(1), HLA-DRA(1), HLA-F(1), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(1), ITGAM(4), ITGAV(1), ITGB1(1), ITGB2(4), ITGB7(1), ITGB8(1), L1CAM(4), MAG(3), MPZL1(2), NCAM1(2), NEGR1(1), NLGN1(1), NLGN3(1), NRCAM(1), NRXN1(4), NRXN3(1), OCLN(1), PTPRC(2), PTPRF(4), PTPRM(1), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(1), SELP(1), SELPLG(2), SIGLEC1(1), VCAM1(1), VCAN(2) 63571232 92 78 92 44 20 42 11 7 12 0 0.366 0.941 240 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 875338 1 1 1 0 1 0 0 0 0 0 0.369 0.941 241 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 ATM(4), BCL2(2), CDKN1A(1), MDM2(2), TIMP3(1) 6768332 10 10 10 1 1 1 3 0 5 0 0.369 0.941 242 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(2), CPS1(4), CTH(1), GLS(1), GLUD2(1), GLUL(1), HAL(2) 9080446 14 13 14 2 3 7 1 1 2 0 0.371 0.941 243 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPK13(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1) 14505443 21 20 21 3 5 7 3 2 4 0 0.374 0.941 244 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(2), ADH1B(2), ADH1C(1), AGPAT1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), CEL(3), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), LCT(1), LIPG(1), PNLIP(1) 20637665 29 29 29 7 9 15 2 1 2 0 0.375 0.941 245 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(2), GSTA1(1), GSTA4(2), GSTK1(1), OPLAH(1) 9087561 13 13 13 1 5 4 3 0 1 0 0.375 0.941 246 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(5), CHUK(1), CREB1(1), DAXX(2), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAP4K1(2), MAP4K2(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), STAT1(1), TGFBR1(1) 41666357 57 52 53 12 19 18 7 4 9 0 0.376 0.941 247 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(1), CREBBP(4), NCOA3(1), PRKAR1B(1), PRKAR2B(1), RXRA(2) 8768662 13 13 12 5 5 3 0 1 4 0 0.377 0.941 248 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(1), MAPK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA5(1), SOS1(3) 10800918 15 15 15 1 4 5 3 2 1 0 0.380 0.944 249 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1) 1044718 2 2 2 0 0 2 0 0 0 0 0.387 0.958 250 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2) 1395548 2 2 2 0 0 1 1 0 0 0 0.394 0.966 251 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 1135454 2 2 1 0 2 0 0 0 0 0 0.396 0.966 252 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(2), NFKB1(1), NFKBIA(1), TGFBR1(1), TGFBR2(2), TLR2(3) 12862646 20 18 20 5 3 8 3 0 6 0 0.396 0.966 253 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(2), AKT1(1), CFL2(1), FLNC(3), GDI1(1), MYH2(8), MYLK(2), PAK1(1), PAK3(1), PAK4(3), ROCK1(1), ROCK2(1), RPS4X(1), VASP(1) 20634189 27 26 27 8 6 10 4 3 4 0 0.400 0.966 254 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), EPHB2(1), F2(2), F2RL3(1), MAPK1(1), MAPK7(1), MAPK8(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(3) 11931253 17 16 17 5 4 4 5 2 2 0 0.400 0.966 255 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(3), PDHA1(1), PDHA2(2) 4346650 6 6 6 2 2 3 0 1 0 0 0.401 0.966 256 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), SOAT1(3) 6058462 10 9 10 2 1 6 1 0 2 0 0.402 0.966 257 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CCND2(1), EGR1(3), ESR2(2), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(1), PGR(4), ZP2(1) 15205801 21 21 21 1 5 9 3 1 3 0 0.406 0.966 258 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), CAPN1(2), CAPN11(2), CAPN6(1), CAPNS1(1), CAV3(1), CSK(1), DOCK1(1), FYN(1), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(1), ITGAE(1), ITGAM(4), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK3(1), PAK4(3), PIK3R2(3), PXN(1), ROCK1(1), ROCK2(1), SDCCAG8(1), SORBS1(1), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2) 58279953 82 71 82 25 18 39 12 4 9 0 0.406 0.966 259 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(2), ELK1(2), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), PLA2G4A(2), RIPK1(1), RPS6KA5(1), STAT1(1), TGFBR1(1) 15962681 23 21 23 3 7 5 5 2 4 0 0.410 0.966 260 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CUL1(2), SKP2(1) 2965398 4 4 4 0 2 1 0 0 1 0 0.410 0.966 261 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CIITA(3), CREB1(1), CTSS(1), HLA-DMB(1), HLA-DRA(1), HLA-F(1), IFNA10(4), IFNA21(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC3(2), KLRD1(1), NFYB(1), PDIA3(1), TAP2(3) 20142880 30 26 28 14 11 9 5 2 3 0 0.414 0.966 262 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1) 5071437 7 7 7 3 0 3 1 1 2 0 0.416 0.966 263 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(3), MAP2K1(1), MAP3K1(2), NCOR2(1), RXRA(2) 6304698 9 9 9 5 2 3 0 1 3 0 0.417 0.966 264 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(2), CD44(3), COL11A1(1), COL11A2(5), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), DAG1(2), FN1(2), FNDC1(1), FNDC4(1), HSPG2(5), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), RELN(12), SDC1(1), SDC2(1), SDC4(1), SV2B(1), SV2C(2), THBS3(1), THBS4(1), TNC(1), TNN(2), TNXB(2), VWF(5) 93965669 131 105 132 52 30 56 20 7 18 0 0.419 0.966 265 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 700226 1 1 1 0 0 0 1 0 0 0 0.420 0.966 266 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), PAH(2), TAT(2), YARS2(1) 3781985 6 6 5 1 2 3 1 0 0 0 0.420 0.966 267 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), CTTN(2), EZR(3), FYN(1), HCLS1(2), ITGB1(1), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3), WAS(1) 22781844 32 31 32 14 6 15 7 2 2 0 0.421 0.966 268 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), CTTN(2), EZR(3), FYN(1), HCLS1(2), ITGB1(1), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3), WAS(1) 22781844 32 31 32 14 6 15 7 2 2 0 0.421 0.966 269 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(2), JAK2(1), JAK3(2), PIAS3(1), SRC(2), STAT3(1) 6697196 10 10 10 2 1 7 1 0 1 0 0.423 0.966 270 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), FOS(1), MAPK1(1), MAPK8(1), PRKCA(1) 3774772 5 5 5 3 2 0 1 1 1 0 0.424 0.966 271 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(2), MYC(1), WT1(1) 2683688 4 4 4 2 2 0 0 0 2 0 0.426 0.966 272 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1) 5350897 8 7 8 2 4 2 0 1 1 0 0.428 0.966 273 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(4), CCNA1(1), CCND2(1), CCND3(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), CREB3L1(1), CREB3L3(2), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MYC(1), NACA(1), POLA2(1), POLE(1), PRIM1(1), RBL1(1), TNXB(2), WEE1(1) 31839469 42 40 42 5 6 10 10 5 11 0 0.431 0.966 274 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CUL1(2), SKP2(1), UBE2M(1) 2963093 4 4 4 0 1 1 0 0 2 0 0.431 0.966 275 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), ESR1(1), MAPK1(1), MAPK3(1), SRC(2) 6408309 9 9 9 5 4 1 1 1 2 0 0.432 0.966 276 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1) 5384302 8 8 8 1 2 4 1 0 1 0 0.433 0.966 277 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 ABP1(4), ACMSD(1), ALDH3A1(2), AOC2(2), AOX1(4), CARM1(3), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOB(2), NFX1(1), OGDH(3), TPH1(2), WARS(1) 25973660 35 35 31 8 8 16 4 0 7 0 0.436 0.966 278 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), TRAF6(1) 12758072 17 17 17 4 3 8 0 2 4 0 0.437 0.966 279 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), YWHAH(1) 4497505 6 6 6 0 0 4 1 0 1 0 0.445 0.966 280 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH3A1(2) 3464219 5 5 5 2 1 4 0 0 0 0 0.445 0.966 281 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH3A1(2) 3464219 5 5 5 2 1 4 0 0 0 0 0.445 0.966 282 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), CNDP1(1), DPYD(2), ECHS1(1), EHHADH(1), MLYCD(1) 12583512 17 17 17 5 4 9 2 1 1 0 0.446 0.966 283 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 18 ADCY1(3), AKT1(1), ITGAV(1), ITGB3(1), MAPK1(1), MAPK3(1), PLCB1(1), PRKCA(1), SRC(2) 9135969 12 12 12 2 6 2 2 1 1 0 0.448 0.966 284 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(2), JAK1(2), JAK2(1), JAK3(2), STAT1(1), STAT3(1), STAT5B(1), TYK2(1) 8004687 11 11 11 4 1 6 1 0 3 0 0.450 0.966 285 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1) 6548929 9 9 9 4 1 5 2 0 1 0 0.451 0.966 286 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1) 6548929 9 9 9 4 1 5 2 0 1 0 0.451 0.966 287 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1) 6548929 9 9 9 4 1 5 2 0 1 0 0.451 0.966 288 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(1), ACSL3(1), ACSL4(1), AKT1(1), CAMKK1(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(2), IRS4(2), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(2), PPARA(1), PRKAG3(1), PRKCQ(1), PTPN11(4), RXRA(2), SLC2A1(2), STAT3(1), TNFRSF1A(1), TYK2(1) 35985449 48 46 48 14 8 24 4 4 8 0 0.452 0.966 289 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(3), F2(2), F2RL3(1), MAP3K7(2), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1) 9586464 14 13 14 2 4 4 3 0 3 0 0.458 0.976 290 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(3), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1) 7078064 10 9 10 2 2 4 1 1 2 0 0.462 0.978 291 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2) 1671061 2 2 2 0 0 0 0 0 2 0 0.464 0.978 292 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), AXIN1(3), BMP2(1), BMP5(2), BMPR2(1), CHRD(1), DVL1(1), FZD1(1), GATA4(1), GSK3B(1), MAP3K7(2), NPPA(1), RFC1(1), TGFBR1(1), TGFBR2(2), TGFBR3(1), WNT1(1) 15530159 22 20 22 4 4 6 6 2 4 0 0.467 0.978 293 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHST13(1), DSE(2), UST(1), XYLT1(1), XYLT2(2) 6116235 8 8 8 1 4 2 0 1 1 0 0.469 0.978 294 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(1) 6214183 8 8 8 0 2 3 1 1 1 0 0.470 0.978 295 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1) 5021695 7 7 7 0 1 3 1 0 2 0 0.473 0.978 296 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 NDUFA12(1), NDUFA13(1) 1770413 2 2 2 1 0 2 0 0 0 0 0.476 0.978 297 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(1), CDKN1A(1), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1) 6376034 8 8 8 0 2 3 1 1 1 0 0.477 0.978 298 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ECHS1(1), EHHADH(1) 5266679 7 7 7 2 2 4 0 0 1 0 0.478 0.978 299 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(1), AKR1C4(2), ALDH3A1(2), CEL(3), CYP27A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1) 13835603 19 18 19 6 7 6 4 0 2 0 0.479 0.978 300 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(1), CREBBP(4), CTBP2(1), DLL1(1), DTX1(1), DTX2(1), DTX3L(1), DTX4(1), DVL1(1), DVL2(1), DVL3(1), HDAC2(3), HES1(1), JAG1(1), JAG2(4), LFNG(1), MAML1(2), MAML3(1), MFNG(1), NCOR2(1), NCSTN(1), NOTCH2(2), NOTCH3(1), NOTCH4(2), RBPJL(3) 29747800 38 36 38 15 6 10 9 4 9 0 0.479 0.978 301 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 CCR3(1), CELSR1(3), CELSR2(2), CELSR3(2), CHRM2(3), CHRM3(1), EMR2(1), EMR3(2), GPR116(4), GPR132(1), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GRM1(4), LGR6(1), LPHN3(2), NTSR1(3), OR8G2(1), PTGFR(1), SMO(1), TAAR5(1) 28437488 41 37 41 28 14 17 6 1 3 0 0.479 0.978 302 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(5), AKT1(1), BRAF(5), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INSR(2), IRS1(2), IRS4(2), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PCK1(2), PDE3A(1), PFKL(1), PFKP(1), PHKA1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP1R3A(3), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(4), PYGB(1), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS4(1), SORBS1(1), SOS1(3), SREBF1(1), TSC2(2) 67613158 91 75 86 33 30 30 14 7 10 0 0.481 0.978 303 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(3), BTRC(1), CREBBP(4), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(2), MYC(1), WIF1(1), WNT1(1) 12459981 17 16 17 8 3 3 4 1 6 0 0.482 0.978 304 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), HEXA(1), LCT(1), MAN2B1(4), MAN2B2(2), NEU2(2) 8859893 11 11 11 2 6 1 0 2 2 0 0.483 0.978 305 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(4), GLS(1) 3244649 5 4 5 2 1 2 1 1 0 0 0.486 0.981 306 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), PRKCA(1), TGM2(1) 2180493 3 3 3 2 2 1 0 0 0 0 0.495 0.996 307 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1) 9030959 13 12 13 3 3 5 2 1 2 0 0.499 1.000 308 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1) 5485227 7 7 7 0 2 2 2 1 0 0 0.501 1.000 309 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 4672441 6 6 6 1 1 2 0 1 2 0 0.502 1.000 310 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), IGF1(2), IGF1R(2) 4112083 5 5 5 1 1 1 2 0 1 0 0.506 1.000 311 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA2(1), ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), ATP2A3(1), CACNB3(2), CALCA(1), CAMK2A(1), CNN2(1), CORIN(2), DGKZ(1), FOS(1), GNB4(1), GNG2(1), GNG5(1), IL1B(1), IL6(1), ITPR1(4), ITPR2(2), ITPR3(3), MIB1(4), NFKB1(1), NOS1(5), NOS3(4), PLCD1(1), PLCG1(6), PLCG2(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(1), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(1), RGS6(1), RGS9(2), RYR1(3), RYR3(10), SFN(1), TNXB(2), YWHAH(1) 70349080 99 82 98 32 25 41 14 4 15 0 0.508 1.000 312 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CHEK1(2), WEE1(1), YWHAH(1) 5967043 8 8 8 0 0 2 4 0 2 0 0.510 1.000 313 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(3), EPRS(2), FECH(1), HMBS(1), HMOX1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2) 11255326 15 15 15 7 6 4 2 2 1 0 0.517 1.000 314 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1) 6947927 9 9 9 4 1 5 2 0 1 0 0.521 1.000 315 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), IL6(1), LDLR(1) 2308315 3 3 3 1 1 2 0 0 0 0 0.522 1.000 316 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(4), ALDH3A1(2), AOC2(2), CNDP1(1), DPYD(2), ECHS1(1), EHHADH(1), HIBCH(1), MLYCD(1) 11705168 15 15 15 2 4 7 2 1 1 0 0.522 1.000 317 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(3), PDHA1(1), PDHA2(2), VARS(2), VARS2(2) 8057520 10 10 10 2 2 4 2 1 1 0 0.526 1.000 318 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP19(1), SRP54(1), SRPR(2) 3246608 4 4 4 0 0 1 2 0 1 0 0.528 1.000 319 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 18 ADCYAP1R1(1), CALCRL(1), CD97(1), CRHR2(2), EMR1(1), EMR2(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN3(2) 10665444 14 14 14 10 1 7 4 0 2 0 0.529 1.000 320 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 AKT1(1), ATM(4), CDKN1A(1), MAPK8(1), MDM2(2), NQO1(1) 7527351 10 10 10 2 2 2 2 0 4 0 0.530 1.000 321 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), OCRL(2), PI4KB(2), PIK3CB(4), PIK3CG(5), PIP4K2C(3), PIP5K1B(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), SYNJ2(2) 30853830 45 36 45 16 10 14 8 5 8 0 0.533 1.000 322 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 ATM(4), ATR(3), CASP9(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(1), GADD45B(1), GTSE1(1), IGF1(2), MDM2(2), RPRM(1), RRM2(1), SERPINB5(1), SESN3(1), SFN(1), TSC2(2) 27392242 34 34 34 15 3 11 9 3 8 0 0.533 1.000 323 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(1), ATM(4), ATR(3), CCNA1(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), GSK3B(1), SKP2(1) 11859498 15 15 15 1 3 4 4 0 4 0 0.533 1.000 324 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2A(1), F2(2), FYN(1), JAK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), STAT1(1), STAT3(1) 18075630 26 22 26 4 4 8 6 3 5 0 0.534 1.000 325 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1) 3576946 4 4 4 1 1 2 0 0 1 0 0.534 1.000 326 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPN1(2), CAPNS1(1), EGF(3), ITGA1(2), ITGB1(1), MAPK1(1), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1) 12929929 16 16 16 4 2 8 0 5 1 0 0.534 1.000 327 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1) 7278128 10 10 11 2 1 4 2 1 2 0 0.537 1.000 328 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(2), RECK(1), TIMP3(1) 3246505 4 4 4 2 1 1 2 0 0 0 0.538 1.000 329 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 20 ACP6(2), ACPT(2), ALPP(2), CYP3A4(1), PON1(2) 6720707 9 9 9 3 3 5 0 0 1 0 0.540 1.000 330 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 AKT1(1), APC(1), BRAF(5), CCL13(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PITX2(2), RAF1(1), SRC(2) 20500987 27 25 23 6 11 7 4 3 2 0 0.542 1.000 331 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(1), STAT3(1) 5287209 7 7 7 2 0 5 0 0 2 0 0.547 1.000 332 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), MCCC1(1), MUT(1), PCCA(1), PCCB(1) 15591919 21 21 21 7 5 10 5 0 1 0 0.547 1.000 333 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1) 4820236 6 6 6 0 0 3 1 1 1 0 0.548 1.000 334 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 DCN(1) 1264406 1 1 1 1 0 0 0 0 1 0 0.557 1.000 335 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CHUK(1), IKBKB(1), MAP2K3(3), MAP3K1(2), MAP4K2(1), MAPK8(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1) 10545229 13 13 13 7 3 6 0 1 3 0 0.559 1.000 336 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2) 1862679 2 2 2 0 0 1 1 0 0 0 0.559 1.000 337 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(2), HARS(1), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1) 13885906 17 17 17 2 1 7 6 1 2 0 0.561 1.000 338 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS1(1), GSK3B(1) 4038731 5 5 5 0 1 2 1 1 0 0 0.562 1.000 339 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB11(1), ABCB4(3), ABCC1(1), ABCC3(1) 5098956 6 6 6 4 2 1 1 0 2 0 0.565 1.000 340 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(1), ABLIM3(1), ARHGEF12(1), CFL2(1), DCC(3), DPYSL5(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(2), EPHA5(3), EPHA6(3), EPHA7(3), EPHA8(2), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(2), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(4), LIMK2(2), LRRC4C(2), MAPK1(1), MAPK3(1), MET(1), NFATC2(2), NFATC4(2), NRP1(1), NTN1(2), NTN4(3), NTNG1(1), PAK1(1), PAK3(1), PAK4(3), PLXNA1(1), PLXNA2(1), PLXNB1(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), PPP3R2(1), RGS3(2), ROBO1(3), ROBO2(1), ROCK1(1), ROCK2(1), SEMA3E(5), SEMA3F(1), SEMA4A(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(1), SLIT3(6), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5C(2), UNC5D(1) 84573453 110 91 108 37 30 34 25 6 15 0 0.565 1.000 341 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), CYP11A1(1), HPGD(1), HSD11B1(1), PLA2G4A(2), PTGER4(1), PTGFR(1), PTGIS(1), PTGS1(1), TBXAS1(1) 8953293 11 11 11 4 2 5 1 0 3 0 0.581 1.000 342 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), BRD4(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(2), IRS4(2), LNPEP(1), MAPK1(1), MAPK3(1), PPYR1(1), RAF1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(1), SOS1(3), YWHAE(1), YWHAH(1) 23610685 29 28 29 8 1 9 9 1 9 0 0.583 1.000 343 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), AOC2(2), AOX1(4), CARM1(3), DDC(1), LCMT1(1), LCMT2(1), MAOB(2), TAT(2), TPO(3), TYR(1), TYRP1(2) 25333463 33 33 29 7 10 15 5 0 3 0 0.586 1.000 344 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT6(1), ENPP2(4), PAFAH2(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLD1(1) 10079499 13 13 13 3 0 9 3 1 0 0 0.586 1.000 345 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), MLYCD(1), MUT(1), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(2) 14306801 19 18 19 6 7 7 2 1 2 0 0.591 1.000 346 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CUL1(2), FBXW7(1) 2855656 3 3 3 0 1 0 0 0 2 0 0.595 1.000 347 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(5), DGKI(2), FAU(2), RPL10(1), RPL11(2), RPL15(1), RPL22(1), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBA52(1) 22512366 29 27 29 6 4 8 5 4 8 0 0.595 1.000 348 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(4), PLCB1(1), PRKAR1B(1), PRKAR2B(1) 6763814 8 8 8 5 2 3 0 1 2 0 0.597 1.000 349 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(1), ATM(4), BUB1(1), CCNA1(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CDAN1(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(1), DTX4(1), E2F4(1), E2F6(1), ESPL1(2), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(2), PRKDC(4), PTPRA(3), RBL1(1), SKP2(1), TBC1D8(2), WEE1(1) 46948406 60 56 60 15 10 21 12 5 12 0 0.598 1.000 350 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2) 5782852 7 7 7 2 2 4 1 0 0 0 0.599 1.000 351 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2) 7004695 9 9 9 8 5 2 0 0 2 0 0.600 1.000 352 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(4), CHEK1(2), WEE1(1), YWHAH(1) 6505232 8 8 8 0 0 2 4 0 2 0 0.606 1.000 353 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(1), CD19(1), CSK(1), DAG1(2), EPHB2(1), LYN(2), MAP2K1(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PLCG2(2), RAF1(1), SOS1(3), VAV1(3) 21037651 26 25 26 11 4 11 5 2 4 0 0.610 1.000 354 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1) 9436432 12 12 12 8 3 5 2 0 2 0 0.613 1.000 355 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(5), CREB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3) 12858357 16 15 12 4 6 5 2 1 2 0 0.616 1.000 356 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1C(1), AKT1(1), BRAF(5), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(3), CACNA1S(4), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNB3(2), CACNG3(1), CHUK(1), CRKL(1), DAXX(2), DUSP5(1), DUSP8(1), EGF(3), ELK1(2), ELK4(1), FGF14(2), FGF18(1), FGF7(1), FGFR1(1), FGFR3(4), FGFR4(1), FLNB(1), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(2), MAP4K2(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MAX(2), MYC(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NTF3(1), NTRK1(1), PAK1(1), PDGFRB(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PPM1B(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RASGRF1(2), RASGRP2(1), RASGRP4(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(1), TGFBR2(2), TNFRSF1A(1), TRAF6(1), ZAK(2) 119654185 167 121 160 60 45 68 20 9 25 0 0.619 1.000 357 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(1), ABCA10(3), ABCA12(1), ABCA13(3), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(2), ABCA7(2), ABCA9(2), ABCB11(1), ABCB4(3), ABCB5(4), ABCB6(1), ABCB9(2), ABCC1(1), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(2), ABCC6(1), ABCC9(8), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(1), ABCG2(2), ABCG4(1), ABCG8(1), CFTR(2), TAP2(3) 50296436 67 57 67 27 12 26 17 6 6 0 0.621 1.000 358 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(4), CRY1(1), PER1(1), PER2(1), PER3(2) 7381198 9 9 8 3 2 4 0 0 3 0 0.623 1.000 359 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(2), HK3(1), PGM1(1), TGDS(1) 4414679 5 5 5 0 2 2 1 0 0 0 0.625 1.000 360 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(2), JAK1(2), JAK2(1), STAT1(1) 4981759 6 6 6 1 0 2 1 0 3 0 0.626 1.000 361 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(3), CREBBP(4), DVL1(1), FZD1(1), GSK3B(1), PITX2(2), TRRAP(4), WNT1(1) 14069169 18 17 18 10 4 4 4 1 5 0 0.626 1.000 362 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3) 2836232 3 3 3 0 2 0 1 0 0 0 0.627 1.000 363 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), UQCRC1(1) 2856490 3 3 3 3 1 1 1 0 0 0 0.628 1.000 364 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(2), DDC(1), HDC(1), PAH(2), TPH1(2) 6222077 8 8 8 5 1 6 0 1 0 0 0.629 1.000 365 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), XDH(1) 3453068 4 4 4 4 0 3 0 0 1 0 0.633 1.000 366 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(1), ANAPC1(2), ANAPC4(1), ATM(4), ATR(3), BUB1(1), CCNA1(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CDC23(2), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), CHEK1(2), CHEK2(1), CREBBP(4), CUL1(2), DBF4(1), ESPL1(2), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), PRKDC(4), RBL1(1), SFN(1), SKP2(1), SMC1A(3), SMC1B(1), WEE1(1), YWHAE(1), YWHAH(1) 57179681 72 65 72 20 10 23 15 6 18 0 0.633 1.000 367 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1) 3951151 4 4 4 0 0 2 1 0 1 0 0.634 1.000 368 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(4), ACACB(5), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HIBCH(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(2) 17173704 23 21 23 4 10 7 2 2 2 0 0.634 1.000 369 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH3A1(2), AOC2(2), DDC(1), EPX(2), MAOB(2), MPO(1), TAT(2), TPO(3) 14811012 19 19 18 2 5 11 3 0 0 0 0.637 1.000 370 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(1), AXIN1(3), CCND2(1), CCND3(1), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GSK3B(1), LDLR(1), MYC(1), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1) 25336482 34 30 33 8 8 10 8 1 7 0 0.641 1.000 371 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), GSK3B(1), LYN(2), PFKL(1), PFKP(1), PLCG1(6), PRKCE(1), VAV2(2) 10854584 15 14 15 3 2 7 4 1 1 0 0.643 1.000 372 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(1), LDHAL6B(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2), PFKL(1), PFKP(1), PGK1(1), PGK2(1), TNFAIP1(1) 18038642 22 22 22 9 6 9 5 1 1 0 0.646 1.000 373 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(1) 1835508 2 2 2 2 0 2 0 0 0 0 0.647 1.000 374 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), HLA-DRA(1) 1737727 2 2 2 2 0 2 0 0 0 0 0.650 1.000 375 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(1), RPL10L(1), RPL11(2), RPL22L1(1), RPL36A(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1) 9819049 12 11 12 5 0 2 2 1 7 0 0.651 1.000 376 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 5425466 6 6 6 2 1 2 0 1 2 0 0.654 1.000 377 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(3), CREBBP(4), ESR1(1), GRIP1(4), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(1), NRIP1(1), POLR2A(2), TBP(2) 20145177 26 25 25 8 9 9 1 1 6 0 0.658 1.000 378 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(2), MPO(1), TPO(3) 5114310 6 6 6 1 3 3 0 0 0 0 0.661 1.000 379 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 BCL2(2), CASP9(1), DAXX(2), IL1A(1) 4916710 6 5 6 1 1 2 0 1 2 0 0.663 1.000 380 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), FECH(1), HMBS(1) 3303571 3 3 3 0 0 1 0 2 0 0 0.664 1.000 381 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), HK2(2), HK3(1), PDHA1(1), PDHA2(2), PFKP(1), PGK1(1), PGM1(1) 20869210 26 25 26 10 8 13 4 1 0 0 0.664 1.000 382 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), HK2(2), HK3(1), PDHA1(1), PDHA2(2), PFKP(1), PGK1(1), PGM1(1) 20869210 26 25 26 10 8 13 4 1 0 0 0.664 1.000 383 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2), TAT(2) 8997083 10 10 9 3 4 3 0 1 2 0 0.665 1.000 384 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 HDC(1), TPH1(2) 2594436 3 3 3 4 0 3 0 0 0 0 0.668 1.000 385 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(1), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1) 23535454 27 27 27 4 3 9 9 1 5 0 0.672 1.000 386 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(2), PCYT1A(2), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLD1(1), PTDSS1(3) 28558842 34 34 34 7 9 13 7 2 3 0 0.673 1.000 387 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 OGDH(3), SUCLA2(1) 4061458 4 4 2 3 0 1 0 0 3 0 0.676 1.000 388 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1) 4410361 5 5 5 1 0 3 2 0 0 0 0.677 1.000 389 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CAPNS1(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1) 10486855 12 12 12 4 4 3 2 1 2 0 0.678 1.000 390 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(1), CSF1R(1), EGF(3), MET(1), PRKCA(1), SRC(2) 6299925 9 7 9 3 3 2 3 0 1 0 0.680 1.000 391 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), HTR2C(1), PLCB1(1) 3097302 3 3 3 1 1 1 0 0 1 0 0.681 1.000 392 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), NCOA1(1), NCOA2(2), PPARG(1), RXRA(2) 7987657 10 10 10 5 1 4 1 0 4 0 0.682 1.000 393 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACO1(1), CLYBL(3), DLD(1), OGDH(3), PC(1), PCK1(2), SUCLA2(1), SUCLG1(2) 12505438 14 14 12 5 3 3 4 1 3 0 0.684 1.000 394 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACADS(3), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(1), PCCB(1) 18711401 23 23 23 4 8 8 5 0 2 0 0.687 1.000 395 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GNT3(2), B4GALNT1(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1) 21090210 23 23 23 11 4 9 3 3 4 0 0.691 1.000 396 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(1), EIF2S2(1), EIF2S3(1), GSK3B(1) 5018662 5 5 5 1 1 0 3 0 1 0 0.691 1.000 397 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), ATP1A4(1), ATP2A3(1), ATP2B2(3), ATP2B3(2), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1S(4), CACNB3(2), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GNAO1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNB1(2), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(1), RGS6(1), RGS9(2), RYR1(3), RYR3(10), SFN(1), YWHAH(1) 77086666 114 86 112 33 32 47 19 2 14 0 0.693 1.000 398 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ALDH3A1(2), AMDHD1(1), AOC2(2), CARM1(3), CNDP1(1), DDC(1), HAL(2), HARS(1), HDC(1), LCMT1(1), LCMT2(1), MAOB(2), UROC1(1) 17141810 23 22 22 4 4 14 4 0 1 0 0.697 1.000 399 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2), SLC23A2(1), SLC2A1(2), SLC2A3(2) 10956610 16 13 16 5 6 5 3 0 2 0 0.700 1.000 400 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR2(1), DNMT1(1), PTAFR(1), PTGER4(1), PTGFR(1) 4875591 5 5 5 6 1 2 0 0 2 0 0.704 1.000 401 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1406013 1 1 1 0 1 0 0 0 0 0 0.707 1.000 402 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 AKT1(1), NFKB1(1), NOS3(4), NPPA(1) 6143104 7 7 7 1 0 6 1 0 0 0 0.709 1.000 403 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPT(2), ENPP1(1), TYR(1) 4168656 4 4 4 0 2 0 2 0 0 0 0.710 1.000 404 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(2), ADH1B(2), ADH1C(1), AGPAT1(1), AGPAT6(1), AKR1A1(1), ALDH3A1(2), CEL(3), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), GK2(1), LCT(1), LIPG(1), PNLIP(1) 25212158 30 30 30 6 9 15 2 1 3 0 0.710 1.000 405 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2) 2624105 2 2 2 0 0 1 1 0 0 0 0.710 1.000 406 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(4), ATR(3), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(1), MDM2(2), PRKDC(4), WEE1(1), YWHAH(1) 18116856 22 22 22 8 1 10 5 1 5 0 0.712 1.000 407 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(2), SRC(2) 12353114 15 14 15 1 3 7 2 2 1 0 0.712 1.000 408 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), MAPK1(1), MAPK3(1), PTK2B(2), SOS1(3) 7493428 8 8 8 3 2 2 2 1 1 0 0.712 1.000 409 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 918711 1 1 1 0 0 1 0 0 0 0 0.713 1.000 410 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), ITGB1(1), MAPK1(1), MAPK3(1), SOS1(3) 6401037 7 7 7 0 1 3 2 1 0 0 0.715 1.000 411 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1) 5027368 5 5 5 4 0 2 1 0 2 0 0.719 1.000 412 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(3), MAPK1(1), MAPK3(1), PRKAR1B(1), PRKAR2B(1), SRC(2) 8709763 9 9 9 1 4 1 2 2 0 0 0.719 1.000 413 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(2), PXN(1), RAF1(1), ROCK1(1), SRC(2) 14630761 18 16 17 4 2 7 3 3 3 0 0.724 1.000 414 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(2), CYP8B1(2), EHHADH(1), FABP6(1), GK2(1), MMP1(1), NR1H3(1), OLR1(1), PCK1(2), PLTP(1), PPARA(1), PPARG(1), RXRA(2), SLC27A1(1), SLC27A2(5), SLC27A6(4), SORBS1(1) 28043610 37 34 37 12 8 18 7 1 3 0 0.729 1.000 415 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PITX2(2), PLD1(1) 19446730 26 22 26 5 6 11 4 2 3 0 0.729 1.000 416 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC3(1), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1) 11770465 14 13 14 3 0 8 4 0 2 0 0.729 1.000 417 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ACADS(3), ACSM1(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(2), PLA1A(1), PPME1(1) 17670570 19 20 20 6 4 8 3 1 3 0 0.729 1.000 418 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), CREB1(1), DAG1(2), EPHB2(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2) 12287538 13 13 13 3 2 3 3 2 3 0 0.730 1.000 419 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 1653145 1 1 1 2 0 1 0 0 0 0 0.732 1.000 420 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), LCMT1(1), LCMT2(1), PCYT1A(2) 6106044 7 7 6 2 3 2 0 0 2 0 0.733 1.000 421 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(2), HK3(1), PGM1(1), TGDS(1) 5030266 5 5 5 0 2 2 1 0 0 0 0.734 1.000 422 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(3), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), SCLY(1) 10769216 13 12 12 3 7 3 0 1 2 0 0.735 1.000 423 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), WNT1(1) 8898061 10 9 10 4 1 2 3 1 3 0 0.739 1.000 424 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(2), ACPT(2), ENPP1(1), MTMR1(1), TYR(1) 6473556 7 7 7 2 2 3 2 0 0 0 0.739 1.000 425 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFA10(1), NDUFA4(1), NDUFS2(1) 2906509 3 3 3 1 0 1 1 0 1 0 0.740 1.000 426 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(1), HEXA(1), HGSNAT(1), HPSE(2), HPSE2(2), LCT(1), MAN2B1(4), MAN2B2(2), NEU2(2) 14983233 16 16 16 4 7 4 1 2 2 0 0.741 1.000 427 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HSD17B4(1), MECR(1) 3691784 3 3 3 0 1 0 1 0 1 0 0.743 1.000 428 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(1), SOS1(3), SRC(2), ZYX(2) 20389003 27 22 27 3 4 11 6 4 2 0 0.746 1.000 429 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1830718 1 1 1 0 1 0 0 0 0 0 0.746 1.000 430 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 BCL2(2), BIRC3(1), CASP9(1), MAP3K1(2), MCL1(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(2), RIPK1(1), TNFRSF1A(1), TNFSF10(2) 15939922 18 18 18 6 3 7 2 1 5 0 0.749 1.000 431 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BNIP1(1), STX6(1), STX7(1), TSNARE1(1), USE1(1), VAMP3(1), VAMP5(1) 7025832 7 7 7 2 2 1 1 1 2 0 0.751 1.000 432 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(1), APC2(2), AXIN1(3), BTRC(1), CAMK2A(1), CCND2(1), CCND3(1), CHD8(8), CREBBP(4), CSNK2B(2), CTBP2(1), CUL1(2), DAAM2(1), DKK1(1), DKK2(2), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GSK3B(1), LRP6(2), MAP3K7(2), MAPK8(1), MMP7(1), MYC(1), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), ROCK1(1), ROCK2(1), RUVBL1(2), SOX17(1), TCF7L2(2), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1) 69283541 85 72 85 22 23 19 16 5 22 0 0.753 1.000 433 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN3(1), CSK(1), CTNNA1(1), CTNNA2(2), PXN(1), SRC(2) 8896833 10 9 10 2 2 2 4 1 1 0 0.754 1.000 434 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), YWHAH(1) 8787673 9 9 9 3 3 2 3 0 1 0 0.755 1.000 435 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ECHS1(1), EHHADH(1) 3609859 3 3 3 0 2 0 0 0 1 0 0.757 1.000 436 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 GCNT2(1), ST8SIA1(1) 2681439 2 2 2 2 0 1 0 0 1 0 0.768 1.000 437 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 1675708 1 1 1 1 0 0 1 0 0 0 0.770 1.000 438 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST6GALNAC4(1), ST8SIA1(1) 2424967 2 2 2 1 0 1 0 0 1 0 0.772 1.000 439 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TRAF6(1) 9740577 11 10 11 4 2 5 0 0 4 0 0.774 1.000 440 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXTL1(1), HS3ST1(1), HS3ST3A1(2), NDST3(1), NDST4(5) 9054855 10 9 10 2 2 3 4 1 0 0 0.779 1.000 441 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(2), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2) 10751025 15 12 15 6 7 5 3 0 0 0 0.782 1.000 442 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA5(1), PSMB8(1) 3765853 3 3 3 0 0 2 0 1 0 0 0.782 1.000 443 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 8 ALPP(2) 2458837 2 2 2 1 0 1 0 0 1 0 0.784 1.000 444 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(1), CDKN2A(2), CREB1(1), ERBB4(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(2), IRS4(2), MET(1), MYC(1), PAK1(1), PAK3(1), PAK4(3), PREX1(5), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(2), YWHAE(1), YWHAH(1) 31947625 38 34 38 13 3 11 11 0 13 0 0.788 1.000 445 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP7B(1), COX10(1), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1) 15099459 17 17 17 5 3 8 4 0 2 0 0.790 1.000 446 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2) 7572774 7 7 7 3 2 2 0 1 2 0 0.790 1.000 447 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(3), B4GALT6(1), ENPP7(3), GAL3ST1(1), LCT(1), NEU2(2), SGMS2(1), SGPP2(2), UGT8(1) 15464050 16 16 16 8 4 6 4 1 1 0 0.791 1.000 448 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLD(1), OGDH(3), PC(1), PDHA1(1), PDHA2(2), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2) 12299117 13 13 11 5 7 2 1 0 3 0 0.792 1.000 449 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), HAGH(1), ME2(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2) 15964138 18 17 18 6 6 8 3 0 1 0 0.793 1.000 450 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(5), ACOT12(1), ALDH3A1(2), DLD(1), HAGH(1), LDHAL6B(1), ME2(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2) 20213396 22 22 22 7 8 8 4 1 1 0 0.795 1.000 451 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3) 3309105 3 3 3 3 1 2 0 0 0 0 0.795 1.000 452 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 PRKAR1B(1), PRKAR2B(1), PRKCA(1) 3991372 3 3 3 0 1 1 0 1 0 0 0.796 1.000 453 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CREBBP(4), MAP2K1(1), MAP3K7(2), MAPK3(1), TGFBR1(1), TGFBR2(2) 11120508 12 12 12 6 2 3 3 0 4 0 0.798 1.000 454 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), CAV3(1), DAG1(2), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PITX2(2), RYR1(3) 20087401 24 22 24 10 6 9 5 2 2 0 0.801 1.000 455 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT3(2) 3127275 2 2 2 3 2 0 0 0 0 0 0.802 1.000 456 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1) 7888460 8 7 8 0 1 0 2 2 3 0 0.805 1.000 457 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPO(1), JAK2(1), NFKB1(1), NFKBIA(1) 5463708 5 5 5 0 1 4 0 0 0 0 0.806 1.000 458 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), NCL(1) 3838650 3 3 3 2 0 1 1 0 1 0 0.806 1.000 459 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH3A1(2), UGDH(1) 3702096 3 3 3 1 0 2 0 0 1 0 0.810 1.000 460 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(1), TRAF6(1) 7896627 7 7 7 2 2 2 0 1 2 0 0.812 1.000 461 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1) 5866088 5 5 5 2 0 2 1 0 2 0 0.814 1.000 462 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1) 2111057 1 1 1 1 0 0 1 0 0 0 0.814 1.000 463 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(1) 8958488 9 9 8 4 1 5 0 1 2 0 0.816 1.000 464 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 184 ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC3(1), BRAF(5), CAV3(1), CCND2(1), CCND3(1), COL11A1(1), COL11A2(5), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), CRKL(1), DOCK1(1), EGF(3), ELK1(2), ERBB2(1), FIGF(2), FLNB(1), FLNC(3), FLT1(5), FN1(2), FYN(1), GRLF1(1), GSK3B(1), HGF(1), IGF1(2), IGF1R(2), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), KDR(6), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(1), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PDGFD(1), PDGFRB(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), RELN(12), ROCK1(1), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS3(1), THBS4(1), TLN2(2), TNC(1), TNN(2), TNXB(2), VASP(1), VAV1(3), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VWF(5), ZYX(2) 152617397 220 134 214 80 51 85 36 16 32 0 0.819 1.000 465 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), RIPK1(1), TNFRSF1A(1) 3681763 3 3 3 1 0 2 1 0 0 0 0.822 1.000 466 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 NCOA1(1), NCOA2(2), NCOA3(1), NCOR2(1), POLR2A(2), RXRA(2), TBP(2) 10808010 11 11 11 3 1 4 1 0 5 0 0.822 1.000 467 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1) 8386484 8 8 8 1 2 3 1 1 1 0 0.826 1.000 468 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), MVD(1), MVK(1) 5738835 5 5 5 0 0 3 1 1 0 0 0.826 1.000 469 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4) 4564721 4 4 4 3 1 1 0 0 2 0 0.832 1.000 470 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 MAP3K1(2), MYLK(2), PAK1(1), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(1), VAV1(3) 12576719 12 12 12 6 1 2 3 3 3 0 0.832 1.000 471 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(2), ECHS1(1), EHHADH(1), HSD17B4(1) 21183820 23 23 24 7 5 11 3 1 3 0 0.834 1.000 472 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), DLD(1), DUSP8(1), IL1R1(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAPK7(1), MAPK8(1), NR2C2(1), PAPPA(2), TRAF6(1), ZAK(2) 21494760 24 23 24 7 6 9 3 3 3 0 0.835 1.000 473 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 ALOX5(1), CYP1A2(2), CYP2C19(1), CYP2E1(1), CYP3A4(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1) 9896968 11 10 11 3 1 6 3 0 1 0 0.837 1.000 474 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FOS(1), FYN(1) 3191336 2 2 2 4 0 0 2 0 0 0 0.838 1.000 475 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), BCL2(2), DLG4(1), LPA(2), MAP3K1(2), MAP3K5(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PLD1(1), ROCK1(1), ROCK2(1), SRF(1) 21240204 25 22 25 7 4 10 5 2 4 0 0.842 1.000 476 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(1), ALOX5(1), GGT1(1), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1) 6496871 7 6 7 2 2 3 1 0 1 0 0.842 1.000 477 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 BCL2(2), BIRC3(1), CASP9(1), CHUK(1), DAXX(2), GSN(1), MAP3K1(2), MAP3K5(1), MAPK8(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(4), PRKCD(3), PRKDC(4), RIPK1(1), SPTAN1(2), TNFRSF1A(1) 29561943 31 31 30 7 5 12 3 2 9 0 0.843 1.000 478 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(1) 6282362 6 6 6 2 3 1 0 0 2 0 0.845 1.000 479 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 BCL2(2), BIRC3(1), CASP1(1), CASP9(1), CHUK(1), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(2), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2) 24469895 28 26 28 9 5 14 3 1 5 0 0.847 1.000 480 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 GALNT11(1), GALNT13(1), GALNT14(3), GALNT2(1), GALNT5(2), GALNT7(1), GALNT8(1), GALNTL4(1), GCNT1(1), GCNT3(1), GCNT4(1) 13461424 14 14 14 6 2 6 2 0 4 0 0.847 1.000 481 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKAR2B(1) 4383485 3 3 3 2 0 1 0 2 0 0 0.848 1.000 482 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(1), EHHADH(1) 3378177 2 2 2 0 1 0 0 0 1 0 0.856 1.000 483 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(1) 11575098 11 11 11 1 1 2 2 1 5 0 0.856 1.000 484 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(1), RANGAP1(2) 3591517 3 3 3 0 1 1 0 0 1 0 0.859 1.000 485 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ARPC2(1), PAK1(1) 3198906 2 2 2 0 0 0 0 0 2 0 0.860 1.000 486 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), IFNA10(4), IFNA21(1), IFNG(2), ULK2(1) 9033130 10 8 8 1 0 3 4 0 3 0 0.862 1.000 487 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(1) 2438357 1 1 1 0 1 0 0 0 0 0 0.865 1.000 488 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 GLS(1) 2279345 1 1 1 1 0 1 0 0 0 0 0.865 1.000 489 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 CAD(1), CASP8AP2(1), DAXX(2), DEDD(1), DEDD2(1), EPHB2(1), FAF1(1), IL1A(1), MAP3K1(2), MAP3K5(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MET(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(1), TPX2(2) 30285124 34 30 34 8 10 12 4 4 4 0 0.867 1.000 490 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(2), CES1(2), PLA1A(1), PPME1(1) 10997423 11 11 11 1 1 8 1 1 0 0 0.869 1.000 491 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), NFKB1(1), XDH(1) 4343866 3 3 3 0 0 2 1 0 0 0 0.869 1.000 492 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), DLD(1), PC(1), PCK1(2), SUCLA2(1), SUCLG1(2) 8524040 8 8 8 1 3 3 2 0 0 0 0.869 1.000 493 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 AKT1(1), ARHGAP4(2), CFL2(1), GDI1(1), INPPL1(3), ITPR1(4), ITPR2(2), ITPR3(3), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PIK3CG(5), PITX2(2), RACGAP1(1), ROCK1(1), ROCK2(1), RPS4X(1) 28581287 35 29 35 10 10 13 2 3 7 0 0.870 1.000 494 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(4), ATR(3), BRCA1(3), BRCA2(3), CHEK1(2), CHEK2(1), FANCD2(2), MRE11A(1), RAD50(1) 18776862 20 20 20 4 2 9 6 1 2 0 0.871 1.000 495 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(1), PGM1(1), PYGL(1), PYGM(1), TREH(1) 5801878 5 5 5 2 1 3 1 0 0 0 0.874 1.000 496 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GGT1(1) 2495650 1 1 1 0 1 0 0 0 0 0 0.874 1.000 497 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(3), CASP1(1), CASP9(1) 5579595 5 5 4 5 0 5 0 0 0 0 0.875 1.000 498 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3) 4123399 3 3 3 0 2 0 1 0 0 0 0.876 1.000 499 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), PRKAR1B(1), PRKAR2B(1) 6482689 5 5 5 0 2 1 1 1 0 0 0.882 1.000 500 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(1), LDHAL6B(1), PDHA1(1), PDHA2(2), PFKL(1), PFKP(1), PGK1(1), PGK2(1), PGM1(1) 24693634 27 26 27 11 8 13 4 1 1 0 0.884 1.000 501 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2718651 1 1 1 2 0 0 0 1 0 0 0.887 1.000 502 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(1) 2569191 1 1 1 2 1 0 0 0 0 0 0.887 1.000 503 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTN1(2), ACTN3(1), ACVR1C(1), CREBBP(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(2), INSR(2), LMO7(2), MAP3K7(2), MAPK1(1), MAPK3(1), MET(1), MLLT4(4), PTPRB(2), PTPRF(4), PTPRJ(1), PTPRM(1), PVRL1(2), PVRL2(1), PVRL4(2), SNAI2(2), SORBS1(1), SRC(2), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(2), WAS(1), WASF3(1) 50530225 59 52 59 19 10 17 14 2 16 0 0.887 1.000 504 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B3(1), HSD17B4(1) 3512366 2 2 2 1 0 1 0 0 1 0 0.888 1.000 505 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP4A(2), ATP5A1(1), ATP5B(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), COX10(1), COX7C(1), CYC1(1), NDUFA10(1), NDUFA12(1), NDUFA13(1), NDUFA4(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1) 24103551 26 25 26 9 5 13 4 1 3 0 0.888 1.000 506 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 DAXX(2), FAF1(1), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PRKDC(4), PTPN13(1), SPTAN1(2) 17386857 16 16 16 4 4 4 1 2 5 0 0.893 1.000 507 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(1), SRC(2) 19878432 21 20 20 7 3 9 5 1 3 0 0.895 1.000 508 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HEXA(1), HK2(2), HK3(1) 7314515 6 6 6 0 3 1 1 0 1 0 0.898 1.000 509 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 DIAPH2(2), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), POLA2(1), POLE(1), PRIM1(1), RFC1(1), RFC4(1), RPA4(1), UBA52(1) 22029075 22 22 22 4 2 8 4 4 4 0 0.899 1.000 510 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT2(1), GALNT7(1), GALNT8(1), GCNT1(1) 5692565 4 4 4 4 1 0 1 0 2 0 0.901 1.000 511 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXA(1), LCT(1), SLC33A1(1), ST6GALNAC4(1), ST8SIA1(1) 7137043 6 6 6 7 2 3 0 0 1 0 0.902 1.000 512 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), MTA1(1), MTA3(1) 4699944 3 3 3 3 2 0 0 0 1 0 0.905 1.000 513 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2) 16023513 15 15 13 7 4 7 0 0 4 0 0.908 1.000 514 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST13(1), SULT2B1(1), SUOX(1) 4021001 3 3 3 0 0 2 1 0 0 0 0.909 1.000 515 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDK7(1), SHH(2) 3786821 3 2 3 0 2 1 0 0 0 0 0.911 1.000 516 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), HAO1(2), HYI(1) 5530124 4 4 4 2 1 1 1 1 0 0 0.912 1.000 517 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2(2), BCL2A1(1), BOK(1), CASP1(1), CASP9(1), DAXX(2), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), SFRS2IP(2), TNFRSF1A(1), TRAF6(1) 19143112 18 17 17 8 2 7 0 1 8 0 0.915 1.000 518 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 FBP1(1), HK2(2), HK3(1), PFKFB1(2), PFKFB4(1), PFKP(1), PMM1(1) 10368529 9 9 9 5 2 5 0 1 1 0 0.915 1.000 519 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1) 2938769 1 1 1 0 1 0 0 0 0 0 0.917 1.000 520 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 PC(1), PDHA1(1) 3983137 2 2 2 1 0 1 1 0 0 0 0.918 1.000 521 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(1), CPS1(4), EPRS(2), GFPT1(1), GLS(1), GLUL(1), NADSYN1(1), QARS(2) 14251932 14 13 14 2 4 4 5 1 0 0 0.918 1.000 522 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EGF(3) 4409665 3 3 3 3 1 2 0 0 0 0 0.922 1.000 523 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1C(1), ACVRL1(1), AMHR2(1), BMP2(1), BMP5(2), BMP6(1), BMPR2(1), CDKN2B(1), CHRD(1), CREBBP(4), CUL1(2), DCN(1), E2F4(1), FST(1), GDF6(1), ID1(1), IFNG(2), INHBE(1), LEFTY2(2), MAPK1(1), MAPK3(1), MYC(1), PITX2(2), PPP2R1B(2), RBL1(1), ROCK1(1), ROCK2(1), SMAD7(1), SMURF1(1), TGFBR1(1), TGFBR2(2), THBS3(1), THBS4(1), ZFYVE9(1) 43016841 44 43 44 12 7 13 7 7 10 0 0.922 1.000 524 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(2), MAPK1(1), MAPK3(1), PRKCA(1) 10199792 9 8 9 2 3 1 2 1 2 0 0.924 1.000 525 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), PRKCA(1) 3876603 2 2 2 0 1 1 0 0 0 0 0.925 1.000 526 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 MADD(1), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PRKDC(4), RIPK1(1), SPTAN1(2), TNFRSF1A(1) 16359141 15 15 15 5 3 6 1 1 4 0 0.926 1.000 527 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), LCMT1(1), LCMT2(1) 6219972 5 5 4 3 3 1 0 0 1 0 0.928 1.000 528 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), PDE6A(1), PDE6B(1), SLC6A13(1) 15594423 15 16 16 2 6 6 1 0 2 0 0.928 1.000 529 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(2), ALDH5A1(1), CAD(1), CPS1(4), EPRS(2), GFPT1(1), GLS(1), GLUD2(1), GLUL(1), NADSYN1(1), QARS(2) 16998280 17 16 17 5 4 6 5 1 1 0 0.929 1.000 530 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), HAO1(2), HYI(1) 5793778 4 4 4 2 1 1 1 1 0 0 0.929 1.000 531 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HEXA(1), HGSNAT(1), HPSE(2), HPSE2(2), LCT(1) 8889791 7 7 7 3 3 3 1 0 0 0 0.930 1.000 532 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 45 CREBBP(4), EHHADH(1), HSD17B4(1), MAPK1(1), MAPK3(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(1), NFKBIA(1), NR0B2(1), NR1H3(1), NRIP1(1), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RXRA(2), STAT5B(1) 24443033 23 23 23 10 6 7 0 2 8 0 0.932 1.000 533 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(1), NFKB1(1), TRAF6(1) 6319389 4 4 4 1 1 1 0 0 2 0 0.932 1.000 534 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 CREB1(1), EPO(1), NOS3(4) 7272071 6 6 6 5 0 5 0 0 1 0 0.932 1.000 535 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), GTF2H1(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2) 15281636 14 13 14 5 3 5 2 1 3 0 0.932 1.000 536 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BCL2(2), BIRC3(1), CASP9(1) 5911694 4 4 4 2 0 1 1 0 2 0 0.933 1.000 537 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), HEXA(1), ST8SIA1(1) 4630736 3 3 3 5 2 1 0 0 0 0 0.934 1.000 538 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), E2F4(1), ETS1(1), FOS(1), HDAC2(3), NCOR2(1), RBL1(1), SIN3A(1) 11303779 10 10 10 2 1 2 3 1 3 0 0.935 1.000 539 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), AGXT(1), ASNS(2), ASS1(1), CAD(1), CRAT(1), DARS(1), DLD(1), PC(1), PDHA1(1), PDHA2(2) 16351681 14 14 14 6 4 4 1 1 4 0 0.936 1.000 540 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 G6PC(1), GAA(1), GALE(1), GALK1(1), GALT(1), HK2(2), HK3(1), LCT(1), MGAM(1), PFKP(1), PGM1(1) 14127094 12 12 12 7 6 4 0 1 1 0 0.937 1.000 541 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 PON1(2) 3645123 2 2 2 3 1 1 0 0 0 0 0.937 1.000 542 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 FBP1(1), G6PD(1), PFKP(1), PGM1(1), PRPS1L1(2), RPE(1) 8840705 7 7 7 5 2 3 2 0 0 0 0.941 1.000 543 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(1), ARSE(3), GAL3ST1(1), LCT(1), NEU2(2) 10513889 8 8 8 6 3 1 2 1 1 0 0.941 1.000 544 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), HEXA(1), LCT(1), NEU2(2) 7198546 5 5 5 1 3 1 0 0 1 0 0.943 1.000 545 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(1), RIPK1(1) 9744649 7 7 7 4 2 3 0 1 1 0 0.944 1.000 546 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), SREBF1(1), SREBF2(1) 5171459 3 3 3 1 2 1 0 0 0 0 0.944 1.000 547 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 FBP1(1), G6PD(1), PFKL(1), PFKP(1), PGM1(1), PRPS1L1(2), RPE(1), TKTL1(1) 10516203 9 9 9 6 3 4 2 0 0 0 0.948 1.000 548 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SUOX(1) 2630256 1 1 1 0 0 0 1 0 0 0 0.949 1.000 549 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(2), ANAPC4(1), BTRC(1), CDC23(2), CUL1(2), CUL2(1), FBXW7(1), FZR1(1), SKP2(1), SMURF1(1), WWP2(1) 16708759 14 14 14 4 2 3 2 3 4 0 0.950 1.000 550 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), SUCLA2(1) 3479091 2 2 2 0 0 2 0 0 0 0 0.951 1.000 551 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), AGXT(1), ASNS(2), CAD(1), CRAT(1), DARS(1), PC(1) 11242522 8 8 8 3 1 2 1 1 3 0 0.953 1.000 552 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLOCK(4), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), PER1(1), PER2(1), PIGF(1), SF3A3(1), ZFR(2) 15822553 14 13 13 2 3 4 2 0 5 0 0.954 1.000 553 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BCL2(2), BIRC3(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TNFSF10(2) 14559545 12 12 12 2 2 5 2 0 3 0 0.957 1.000 554 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1) 10155087 7 7 7 1 1 3 1 1 1 0 0.959 1.000 555 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 OXCT2(1) 3144223 1 1 1 1 1 0 0 0 0 0 0.962 1.000 556 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 PFKL(1), PGK1(1) 3744744 2 2 2 3 0 1 1 0 0 0 0.963 1.000 557 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC2(1) 3519011 1 1 1 0 0 0 0 0 1 0 0.964 1.000 558 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA5(1), PSMC3(1) 5599282 3 3 3 0 0 1 0 1 1 0 0.964 1.000 559 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), GNAO1(1), GNG5(1), GNGT2(1), ITPR1(4), KRAS(2), PDE1A(2), PDE1C(4), PDE4A(1), PDE8A(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), PRKD3(2) 49787108 56 46 54 9 15 18 9 4 10 0 0.965 1.000 560 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(1) 3417266 1 1 1 0 0 0 0 0 1 0 0.967 1.000 561 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 TAX1BP3(1), UBE2M(1) 4519048 2 2 2 0 0 1 0 0 1 0 0.967 1.000 562 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), FUT8(1), MGAT2(1), MGAT5(1), ST6GAL1(1) 8538402 6 6 6 0 1 2 1 0 2 0 0.970 1.000 563 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), EPS15(1), PICALM(1), PPP3CB(1), SYNJ2(2) 9479391 7 7 7 3 4 1 1 0 1 0 0.970 1.000 564 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1) 2763819 1 1 1 2 0 1 0 0 0 0 0.972 1.000 565 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), TSC2(2) 9944634 7 7 7 2 2 2 2 0 1 0 0.972 1.000 566 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 HEXA(1), ST8SIA1(1) 4360620 2 2 2 5 1 1 0 0 0 0 0.973 1.000 567 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(2), ENPP1(1) 6013633 3 3 3 1 1 0 2 0 0 0 0.973 1.000 568 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(1), POLQ(3) 7257528 4 4 4 3 0 0 3 0 1 0 0.973 1.000 569 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CTH(1), LDHAL6B(1) 5156554 2 2 2 1 2 0 0 0 0 0 0.974 1.000 570 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AMY2B(2), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(1), MGAM(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), SI(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2), UXS1(1) 24202080 23 21 23 15 10 6 3 1 3 0 0.979 1.000 571 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 AMT(2), MTHFR(2) 7772610 4 4 4 2 0 1 0 1 2 0 0.979 1.000 572 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1) 3910906 1 1 1 1 0 0 0 0 1 0 0.979 1.000 573 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CAD(1), CDA(1), CTPS(1), DCK(1), DPYD(2), NT5E(2), NUDT2(1), POLE(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1), RRM2(1), TXNRD1(1), UCK1(1), UPP1(1) 24819937 22 20 22 11 3 6 8 1 4 0 0.980 1.000 574 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC(1), GAA(1), GALE(1), GALK1(1), GALT(1), HK2(2), HK3(1), LCT(1), MGAM(1), PFKL(1), PFKP(1), PGM1(1) 16735817 13 13 13 7 6 5 0 1 1 0 0.982 1.000 575 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC2(1), NTRK1(1), WASF3(1) 6631473 3 3 3 4 0 0 0 0 3 0 0.982 1.000 576 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 CARM1(3), DOT1L(1), EHMT2(2), EZH2(2), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(1), MEN1(2), MLL(2), MLL2(4), MLL3(8), MLL4(5), MLL5(1), NSD1(1), PRDM9(7), RBBP5(1), SETD1A(3), SETD2(5), SETDB1(1), SMYD3(1), SUV420H1(1), SUZ12(1), WHSC1(1) 51869131 56 47 55 17 14 19 11 4 8 0 0.985 1.000 577 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 AMT(2), MTHFR(2) 8213716 4 4 4 2 0 1 0 1 2 0 0.986 1.000 578 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HSD17B4(1), NSD1(1), OGDH(3), PIPOX(1), SETD1A(3), SETDB1(1) 25200424 20 20 17 11 3 8 2 0 7 0 0.987 1.000 579 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 FBP1(1), ME2(1), PGK1(1), RPE(1) 7555983 4 4 4 7 1 1 2 0 0 0 0.988 1.000 580 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 FBP1(1), PGK1(1), PGK2(1), RPE(1), TKTL1(1) 8472464 5 5 5 9 2 2 1 0 0 0 0.990 1.000 581 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA5(1), PSMC3(1) 6907793 3 3 3 0 0 1 0 1 1 0 0.990 1.000 582 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC3(1), CASP9(1), SREBF1(1), SREBF2(1) 7911849 4 4 4 1 2 1 1 0 0 0 0.991 1.000 583 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), GFPT1(1), GNPDA1(1), HEXA(1), HK2(2), HK3(1), MTMR1(1) 12377105 8 8 8 4 3 3 1 0 1 0 0.991 1.000 584 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(1), CAD(1), CDA(1), CTPS(1), DCK(1), DPYD(2), NME7(2), NT5C1B(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLE(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(1), UCK1(1), UPP1(1), UPP2(1) 35181438 33 29 33 13 9 10 8 3 3 0 0.992 1.000 585 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 HEXA(1), LCT(1) 6230061 2 2 2 3 2 0 0 0 0 0 0.992 1.000 586 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), EXTL1(1), FUT8(1), GALNT11(1), GALNT13(1), GALNT14(3), GALNT2(1), GALNT5(2), GALNT7(1), GALNT8(1), GALNTL4(1), GCNT1(1), GCNT3(1), GCNT4(1), HS3ST1(1), HS3ST3A1(2), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(5), ST6GAL1(1), UST(1), XYLT1(1), XYLT2(2) 47350665 45 43 45 14 11 18 8 2 6 0 0.993 1.000 587 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1) 10429646 6 6 6 1 0 4 1 0 1 0 0.993 1.000 588 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYD(2), ENPP1(1) 7479435 3 3 3 1 1 0 2 0 0 0 0.993 1.000 589 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), COL2A1(1), CPSF1(2), CSTF1(1), DHX38(1), DICER1(4), NONO(1), NUDT21(1), NXF1(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(1), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SFRS16(1), SFRS2(1), SFRS5(1), SFRS8(2), SNRPB(1), SRPK1(1), SRPK2(1), SRRM1(1) 45588206 41 38 41 13 5 13 7 3 13 0 0.994 1.000 590 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3) 6984155 3 3 3 4 1 2 0 0 0 0 0.995 1.000 591 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACO1(1), SUCLA2(1) 5376107 2 2 2 0 0 2 0 0 0 0 0.995 1.000 592 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLE(1), POLI(2), POLQ(3), PRIM1(1), PRIM2(1), REV1(2) 17870575 12 12 12 4 2 2 5 1 2 0 0.995 1.000 593 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2S2(1), EIF2S3(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(1), PABPC3(3) 19033205 13 13 13 5 4 2 4 0 3 0 0.996 1.000 594 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), AK1(1), AK5(1), AK7(2), ALLC(3), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP1(1), GDA(1), GMPR2(1), GUCY1B3(1), GUCY2F(1), IMPDH1(1), NME7(2), NPR1(1), NT5C1B(2), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(1), PDE1A(2), PDE1C(4), PDE2A(1), PDE4A(1), PDE8A(1), PFAS(1), PNPT1(1), POLA1(1), POLA2(1), POLE(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), PRIM1(1), PRIM2(1), PRPS1L1(2), RRM2(1), XDH(1) 70238886 71 60 71 25 15 29 14 4 9 0 0.996 1.000 595 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 FBP1(1), HK2(2), HK3(1), MTMR1(1), PFKFB1(2), PFKFB4(1), PFKL(1), PFKP(1), PMM1(1) 16092721 11 11 11 9 2 7 0 1 1 0 0.996 1.000 596 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(1), ALDH3A1(2), CYP2C19(1), ECHS1(1), EHHADH(1), YOD1(1) 13145214 7 7 7 3 3 3 0 0 1 0 0.997 1.000 597 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 78 AMY2B(2), ASCC3(2), DDX41(2), DDX56(1), DHX58(1), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(1), MGAM(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(1), SMARCA2(3), SMARCA5(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1), UXS1(1) 51865018 49 44 49 21 18 14 11 2 4 0 0.997 1.000 598 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ADH1A(2), ADH1B(2), ADH1C(1) 10571449 5 5 5 3 2 2 1 0 0 0 0.997 1.000 599 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC3(1), CASP1(1), CASP9(1) 8373601 3 3 3 2 0 2 1 0 0 0 0.999 1.000 600 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1) 6133522 1 1 1 1 1 0 0 0 0 0 0.999 1.000 601 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(3), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), DCK(1), ENPP1(1), GDA(1), GUCY1B3(1), GUCY2F(1), IMPDH1(1), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(1), PDE6B(1), PDE8A(1), PFAS(1), POLE(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1), PRPS1L1(2), RRM2(1) 54908023 52 44 52 21 9 22 12 0 9 0 0.999 1.000 602 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 IMPDH1(1) 5466162 1 1 1 2 0 1 0 0 0 0 0.999 1.000 603 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACOT11(1), ECHS1(1), EHHADH(1), YOD1(1) 10976719 4 4 4 2 2 1 0 0 1 0 0.999 1.000 604 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPP(2), ASCC3(2), DDX41(2), DDX56(1), DHX58(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1) 26890754 18 17 18 5 6 6 3 1 2 0 1.000 1.000 605 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG3(2), FUT8(1), MGAT2(1), MGAT5(1), MGAT5B(1), ST6GAL1(1) 18394661 9 9 9 4 2 4 1 0 2 0 1.000 1.000 606 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 4181979 0 0 0 1 0 0 0 0 0 0 1.000 1.000 607 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 2089940 0 0 0 2 0 0 0 0 0 0 1.000 1.000 608 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 219401 0 0 0 0 0 0 0 0 0 0 1.000 1.000 609 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 6904772 0 0 0 2 0 0 0 0 0 0 1.000 1.000 610 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 565329 0 0 0 0 0 0 0 0 0 0 1.000 1.000 611 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1351174 0 0 0 0 0 0 0 0 0 0 1.000 1.000 612 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 659071 0 0 0 1 0 0 0 0 0 0 1.000 1.000 613 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 2768111 0 0 0 0 0 0 0 0 0 0 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 732168 0 0 0 0 0 0 0 0 0 0 1.000 1.000 615 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 1860397 0 0 0 0 0 0 0 0 0 0 1.000 1.000 616 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 1462857 0 0 0 0 0 0 0 0 0 0 1.000 1.000