E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.049 0.18 -9999.0 0.0 -0.456 24.0 24.0 KLHL20 -0.031 0.06 -9999.0 0.0 -0.242 3.0 3.0 CYFIP2 0.009 0.048 -9999.0 0.0 -0.579 1.0 1.0 Rac1/GDP -0.007 0.124 -9999.0 0.0 -0.492 1.0 1.0 ENAH -0.049 0.18 -9999.0 0.0 -0.456 24.0 24.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.007 0.058 -9999.0 0.0 -0.495 2.0 2.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.04 0.077 -9999.0 0.0 -0.389 1.0 1.0 ABI1/Sra1/Nap1 -0.021 0.041 -9999.0 0.0 -0.175 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.05 0.151 -9999.0 0.0 -0.33 27.0 27.0 RAPGEF1 -0.031 0.164 -9999.0 0.0 -0.396 24.0 24.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.058 0.185 -9999.0 0.0 -0.475 24.0 24.0 CRK -0.04 0.171 -9999.0 0.0 -0.423 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.053 0.158 -9999.0 0.0 -0.348 33.0 33.0 alphaE/beta7 Integrin 0.002 0.083 -9999.0 0.0 -0.378 7.0 7.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.032 -9999.0 0.0 -0.259 2.0 2.0 DLG1 -0.049 0.18 -9999.0 0.0 -0.456 24.0 24.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.264 1.0 1.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.024 0.023 -9999.0 0.0 -0.259 1.0 1.0 PI3K -0.039 0.071 -9999.0 0.0 -0.35 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.074 0.183 -9999.0 0.0 -0.417 33.0 33.0 TIAM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.035 0.127 -9999.0 0.0 -0.293 24.0 24.0 AKT1 -0.023 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.002 0.078 -9999.0 0.0 -0.551 3.0 3.0 CDH1 -0.109 0.234 -9999.0 0.0 -0.556 33.0 33.0 RhoA/GDP -0.007 0.124 -9999.0 0.0 -0.492 1.0 1.0 actin cytoskeleton organization 0.01 0.062 -9999.0 0.0 -0.186 2.0 2.0 CDC42/GDP -0.007 0.124 -9999.0 0.0 -0.492 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.032 0.112 -9999.0 0.0 -0.272 24.0 24.0 ITGB7 -0.005 0.099 -9999.0 0.0 -0.546 5.0 5.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.037 0.135 -9999.0 0.0 -0.311 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.043 0.127 -9999.0 0.0 -0.3 24.0 24.0 mol:GDP -0.019 0.142 -9999.0 0.0 -0.475 2.0 2.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.007 0.058 -9999.0 0.0 -0.495 2.0 2.0 p120 catenin/RhoA/GDP -0.05 0.104 -9999.0 0.0 -0.498 1.0 1.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.017 0.035 -9999.0 0.0 -0.418 1.0 1.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.007 0.053 -9999.0 0.0 -0.185 5.0 5.0 NME1 0.01 0.041 -9999.0 0.0 -0.495 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.049 0.18 -9999.0 0.0 -0.456 24.0 24.0 regulation of cell-cell adhesion -0.036 0.068 -9999.0 0.0 -0.335 1.0 1.0 WASF2 -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.046 0.088 -9999.0 0.0 -0.452 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.043 0.151 -9999.0 0.0 -0.535 4.0 4.0 CCND1 0.008 0.064 -9999.0 0.0 -0.229 5.0 5.0 VAV2 -0.047 0.201 -9999.0 0.0 -0.461 26.0 26.0 RAP1/GDP -0.007 0.116 -9999.0 0.0 -0.49 1.0 1.0 adherens junction assembly -0.046 0.175 -9999.0 0.0 -0.441 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.009 0.048 -9999.0 0.0 -0.579 1.0 1.0 regulation of heterotypic cell-cell adhesion -0.034 0.145 -9999.0 0.0 -0.509 4.0 4.0 E-cadherin/beta catenin -0.073 0.142 -9999.0 0.0 -0.329 34.0 34.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.051 0.181 -9999.0 0.0 -0.455 24.0 24.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.049 0.094 -9999.0 0.0 -0.382 4.0 4.0 E-cadherin/beta catenin/alpha catenin -0.051 0.148 -9999.0 0.0 -0.349 24.0 24.0 ITGAE 0.007 0.058 -9999.0 0.0 -0.495 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.06 0.189 -9999.0 0.0 -0.486 24.0 24.0