Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.028 0.209 -9999.0 0.0 -0.658 11.0 11.0 IHH -0.013 0.097 -9999.0 0.0 -0.463 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.099 0.171 -9999.0 0.0 -0.375 27.0 27.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.099 0.17 0.372 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.02 0.146 -9999.0 0.0 -0.624 4.0 4.0 SMO -0.028 0.154 -9999.0 0.0 -0.663 4.0 4.0 AKT1 0.002 0.098 -9999.0 0.0 -0.601 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.074 -9999.0 0.0 -0.523 3.0 3.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.027 0.152 -9999.0 0.0 -0.65 4.0 4.0 STIL -0.076 0.175 -9999.0 0.0 -0.6 6.0 6.0 DHH N/PTCH2 -0.032 0.14 -9999.0 0.0 -0.396 19.0 19.0 DHH N/PTCH1 -0.042 0.177 -9999.0 0.0 -0.478 15.0 15.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.039 0.159 -9999.0 0.0 -0.523 15.0 15.0 PTHLH -0.029 0.223 -9999.0 0.0 -0.709 11.0 11.0 determination of left/right symmetry -0.027 0.152 -9999.0 0.0 -0.65 4.0 4.0 PIK3R1 0.002 0.078 -9999.0 0.0 -0.551 3.0 3.0 skeletal system development -0.028 0.221 -9999.0 0.0 -0.701 11.0 11.0 IHH N/Hhip -0.102 0.205 -9999.0 0.0 -0.435 41.0 41.0 DHH N/Hhip -0.116 0.209 -9999.0 0.0 -0.415 48.0 48.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.027 0.152 -9999.0 0.0 -0.65 4.0 4.0 pancreas development -0.123 0.239 -9999.0 0.0 -0.539 38.0 38.0 HHAT -0.005 0.102 -9999.0 0.0 -0.562 5.0 5.0 PI3K 0.012 0.057 -9999.0 0.0 -0.395 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.045 0.166 -9999.0 0.0 -0.515 17.0 17.0 somite specification -0.027 0.152 -9999.0 0.0 -0.65 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.087 0.184 -9999.0 0.0 -0.639 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.078 0.157 -9999.0 0.0 -0.303 47.0 47.0 SHH Np/Cholesterol/Megalin -0.176 0.215 -9999.0 0.0 -0.363 79.0 79.0 SHH -0.097 0.184 -9999.0 0.0 -0.384 44.0 44.0 catabolic process -0.021 0.165 -9999.0 0.0 -0.509 11.0 11.0 SMO/Vitamin D3 -0.076 0.184 -9999.0 0.0 -0.621 7.0 7.0 SHH Np/Cholesterol/Hhip -0.143 0.196 -9999.0 0.0 -0.335 71.0 71.0 LRP2 -0.183 0.268 -9999.0 0.0 -0.547 54.0 54.0 receptor-mediated endocytosis -0.142 0.215 -9999.0 0.0 -0.542 21.0 21.0 SHH Np/Cholesterol/BOC -0.073 0.145 -9999.0 0.0 -0.288 47.0 47.0 SHH Np/Cholesterol/CDO -0.081 0.152 -9999.0 0.0 -0.294 50.0 50.0 mesenchymal cell differentiation 0.142 0.194 0.333 71.0 -9999.0 0.0 71.0 mol:Vitamin D3 -0.084 0.186 -9999.0 0.0 -0.639 6.0 6.0 IHH N/PTCH2 -0.009 0.1 -9999.0 0.0 -0.462 5.0 5.0 CDON -0.012 0.114 -9999.0 0.0 -0.531 7.0 7.0 IHH N/PTCH1 -0.021 0.167 -9999.0 0.0 -0.511 11.0 11.0 Megalin/LRPAP1 -0.124 0.197 -9999.0 0.0 -0.391 54.0 54.0 PTCH2 -0.005 0.102 -9999.0 0.0 -0.562 5.0 5.0 SHH Np/Cholesterol -0.082 0.138 -9999.0 0.0 -0.296 44.0 44.0 PTCH1 -0.021 0.166 -9999.0 0.0 -0.511 11.0 11.0 HHIP -0.123 0.239 -9999.0 0.0 -0.54 38.0 38.0