Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.108 -9999.0 0.0 -0.257 1.0 1.0 epithelial cell differentiation -0.059 0.113 -9999.0 0.0 -0.29 24.0 24.0 CYFIP2 0.009 0.048 -9999.0 0.0 -0.579 1.0 1.0 ENAH 0.01 0.091 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.223 0.274 -9999.0 0.0 -0.537 66.0 66.0 EPHA2 -0.001 0.084 -9999.0 0.0 -0.516 4.0 4.0 MYO6 -0.027 0.121 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.025 0.03 -9999.0 0.0 -0.349 1.0 1.0 AQP5 -0.15 0.227 -9999.0 0.0 -0.546 33.0 33.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.121 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.134 -9999.0 0.0 -0.555 2.0 2.0 EGF -0.042 0.169 -9999.0 0.0 -0.557 15.0 15.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.069 0.125 -9999.0 0.0 -0.437 9.0 9.0 cortical microtubule organization -0.059 0.113 -9999.0 0.0 -0.29 24.0 24.0 GO:0000145 -0.027 0.115 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.035 0.127 -9999.0 0.0 -0.293 24.0 24.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.05 0.087 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.055 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.115 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.027 0.121 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.028 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.109 0.234 -9999.0 0.0 -0.556 33.0 33.0 EGFR/EGFR/EGF/EGF -0.179 0.174 -9999.0 0.0 -0.53 19.0 19.0 RhoA/GDP -0.054 0.105 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.019 0.117 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.007 0.057 -9999.0 0.0 -0.495 2.0 2.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.058 -9999.0 0.0 -0.495 2.0 2.0 IGF1 -0.03 0.148 -9999.0 0.0 -0.537 12.0 12.0 DIAPH1 -0.001 0.056 -9999.0 0.0 -0.696 1.0 1.0 Wnt receptor signaling pathway 0.059 0.113 0.29 24.0 -9999.0 0.0 24.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.05 0.088 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.119 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.009 0.048 -9999.0 0.0 -0.579 1.0 1.0 LPP -0.022 0.118 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.059 0.104 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.046 0.09 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.036 0.136 -9999.0 0.0 -0.567 2.0 2.0 HGF/MET -0.166 0.196 -9999.0 0.0 -0.554 22.0 22.0 HGF -0.093 0.221 -9999.0 0.0 -0.55 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.109 -9999.0 0.0 -0.259 1.0 1.0 actin cable formation 0.026 0.091 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.122 0.185 -9999.0 0.0 -0.538 13.0 13.0 KIFC3 -0.029 0.122 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.122 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.059 0.113 -9999.0 0.0 -0.29 24.0 24.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.027 0.121 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.029 0.122 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.006 0.067 -9999.0 0.0 -0.579 2.0 2.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.001 0.102 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.1 0.184 -9999.0 0.0 -0.522 13.0 13.0 IGF-1R heterotetramer/IGF1 -0.074 0.129 -9999.0 0.0 -0.503 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.14 0.247 -9999.0 0.0 -0.534 43.0 43.0 PLEKHA7 -0.04 0.141 -9999.0 0.0 -0.549 3.0 3.0 mol:GTP 0.023 0.055 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.002 0.108 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.027 0.108 -9999.0 0.0 -0.257 1.0 1.0 regulation of cell-cell adhesion -0.019 0.117 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.109 -9999.0 0.0 -0.259 1.0 1.0