Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	53.0	424.0	8.0	-0.183	0.115	1000.0	-1000.0	-0.016	-1000.0
Syndecan-1-mediated signaling events	30.0	1027.0	34.0	-0.314	0.013	1000.0	-1000.0	-0.046	-1000.0
IL23-mediated signaling events	28.0	1703.0	60.0	-0.548	0.013	1000.0	-1000.0	-0.163	-1000.0
Ephrin A  reverse signaling	25.0	175.0	7.0	-0.067	-0.0	1000.0	-1000.0	-0.02	-1000.0
Signaling events regulated by Ret tyrosine kinase	21.0	1794.0	82.0	-0.239	0.013	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling events	20.0	101.0	5.0	-0.109	0.013	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by the Hedgehog family	19.0	1020.0	52.0	-0.183	0.142	1000.0	-1000.0	-0.052	-1000.0
IL4-mediated signaling events	19.0	1801.0	91.0	-0.55	0.412	1000.0	-1000.0	-0.135	-1000.0
Glypican 2 network	19.0	78.0	4.0	-0.064	-0.048	1000.0	-1000.0	-0.022	-1000.0
IL12-mediated signaling events	17.0	1549.0	87.0	-0.423	0.067	1000.0	-1000.0	-0.14	-1000.0
Glypican 1 network	17.0	838.0	48.0	-0.256	0.028	1000.0	-1000.0	-0.038	-1000.0
PDGFR-alpha signaling pathway	17.0	781.0	44.0	-0.102	0.023	1000.0	-1000.0	-0.068	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	768.0	44.0	-0.179	0.013	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1595.0	93.0	-0.189	0.037	1000.0	-1000.0	-0.077	-1000.0
Reelin signaling pathway	16.0	942.0	56.0	-0.253	0.029	1000.0	-1000.0	-0.082	-1000.0
Effects of Botulinum toxin	16.0	439.0	26.0	-0.172	0.013	1000.0	-1000.0	-0.062	-1000.0
EGFR-dependent Endothelin signaling events	16.0	356.0	21.0	-0.223	0.02	1000.0	-1000.0	-0.062	-1000.0
Syndecan-4-mediated signaling events	16.0	1116.0	67.0	-0.19	0.023	1000.0	-1000.0	-0.063	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1423.0	88.0	-0.195	0.029	1000.0	-1000.0	-0.121	-1000.0
Visual signal transduction: Cones	14.0	539.0	38.0	-0.134	0.013	1000.0	-1000.0	-0.057	-1000.0
Arf6 signaling events	14.0	901.0	62.0	-0.223	0.024	1000.0	-1000.0	-0.057	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1209.0	85.0	-0.161	0.013	1000.0	-1000.0	-0.079	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	612.0	46.0	-0.417	0.016	1000.0	-1000.0	-0.107	-1000.0
Glucocorticoid receptor regulatory network	13.0	1548.0	114.0	-0.451	0.27	1000.0	-1000.0	-0.064	-1000.0
Endothelins	13.0	1319.0	96.0	-0.233	0.038	1000.0	-1000.0	-0.077	-1000.0
TCGA08_p53	13.0	92.0	7.0	-0.131	0.044	1000.0	-1000.0	-0.011	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	404.0	31.0	-0.229	0.013	1000.0	-1000.0	-0.067	-1000.0
HIF-1-alpha transcription factor network	12.0	948.0	76.0	-0.253	0.045	1000.0	-1000.0	-0.131	-1000.0
p75(NTR)-mediated signaling	12.0	1581.0	125.0	-0.21	0.04	1000.0	-1000.0	-0.097	-1000.0
amb2 Integrin signaling	12.0	1014.0	82.0	-0.214	0.014	1000.0	-1000.0	-0.076	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	827.0	68.0	-0.367	0.028	1000.0	-1000.0	-0.114	-1000.0
Visual signal transduction: Rods	12.0	636.0	52.0	-0.145	0.013	1000.0	-1000.0	-0.077	-1000.0
ErbB2/ErbB3 signaling events	11.0	717.0	65.0	-0.178	0.019	1000.0	-1000.0	-0.067	-1000.0
Caspase cascade in apoptosis	10.0	757.0	74.0	-0.18	0.052	1000.0	-1000.0	-0.047	-1000.0
Thromboxane A2 receptor signaling	10.0	1074.0	105.0	-0.223	0.024	1000.0	-1000.0	-0.071	-1000.0
IL1-mediated signaling events	10.0	634.0	62.0	-0.152	0.042	1000.0	-1000.0	-0.092	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	493.0	54.0	-0.181	0.026	1000.0	-1000.0	-0.099	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	-0.03	-0.005	1000.0	-1000.0	-0.019	-1000.0
Syndecan-3-mediated signaling events	9.0	342.0	35.0	-0.223	0.04	1000.0	-1000.0	-0.044	-1000.0
Wnt signaling	9.0	66.0	7.0	-0.071	0.002	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	9.0	243.0	26.0	-0.223	0.017	1000.0	-1000.0	-0.019	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	285.0	34.0	-0.044	0.013	1000.0	-1000.0	-0.047	-1000.0
Noncanonical Wnt signaling pathway	8.0	218.0	26.0	-0.088	0.013	1000.0	-1000.0	-0.052	-1000.0
Syndecan-2-mediated signaling events	8.0	553.0	69.0	-0.173	0.026	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	8.0	704.0	81.0	-0.181	0.029	1000.0	-1000.0	-0.095	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	856.0	97.0	-0.181	0.039	1000.0	-1000.0	-0.08	-1000.0
Retinoic acid receptors-mediated signaling	8.0	501.0	58.0	-0.151	0.025	1000.0	-1000.0	-0.069	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	616.0	76.0	-0.109	0.024	1000.0	-1000.0	-0.085	-1000.0
IL2 signaling events mediated by STAT5	8.0	197.0	22.0	-0.195	0.014	1000.0	-1000.0	-0.046	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	1077.0	120.0	-0.199	0.074	1000.0	-1000.0	-0.077	-1000.0
LPA4-mediated signaling events	7.0	89.0	12.0	-0.038	0.017	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by PTP1B	7.0	588.0	76.0	-0.224	0.02	1000.0	-1000.0	-0.071	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	428.0	61.0	-0.221	0.04	1000.0	-1000.0	-0.074	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	7.0	370.0	52.0	-0.141	0.029	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	7.0	258.0	36.0	-0.092	0.013	1000.0	-1000.0	-0.054	-1000.0
Integrins in angiogenesis	7.0	657.0	84.0	-0.158	0.03	1000.0	-1000.0	-0.091	-1000.0
LPA receptor mediated events	7.0	762.0	102.0	-0.223	0.025	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	7.0	575.0	75.0	-0.167	0.046	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	603.0	78.0	-0.061	0.034	1000.0	-1000.0	-0.066	-1000.0
Coregulation of Androgen receptor activity	6.0	472.0	76.0	-0.183	0.027	1000.0	-1000.0	-0.037	-1000.0
ErbB4 signaling events	6.0	458.0	69.0	-0.223	0.076	1000.0	-1000.0	-0.08	-1000.0
Osteopontin-mediated events	6.0	250.0	38.0	-0.06	0.016	1000.0	-1000.0	-0.097	-1000.0
Nectin adhesion pathway	6.0	418.0	63.0	-0.109	0.022	1000.0	-1000.0	-0.073	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	236.0	37.0	-0.059	0.02	1000.0	-1000.0	-0.055	-1000.0
S1P5 pathway	6.0	104.0	17.0	-0.057	0.013	1000.0	-1000.0	-0.03	-1000.0
FAS signaling pathway (CD95)	6.0	299.0	47.0	-0.201	0.015	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by PI3K	6.0	362.0	58.0	-0.184	0.024	1000.0	-1000.0	-0.085	-1000.0
Canonical Wnt signaling pathway	6.0	345.0	51.0	-0.221	0.084	1000.0	-1000.0	-0.062	-1000.0
EPHB forward signaling	6.0	534.0	85.0	-0.128	0.072	1000.0	-1000.0	-0.087	-1000.0
Nongenotropic Androgen signaling	6.0	352.0	52.0	-0.055	0.013	1000.0	-1000.0	-0.062	-1000.0
IL27-mediated signaling events	6.0	353.0	51.0	-0.149	0.014	1000.0	-1000.0	-0.086	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	457.0	74.0	-0.223	0.059	1000.0	-1000.0	-0.094	-1000.0
BCR signaling pathway	6.0	644.0	99.0	-0.138	0.033	1000.0	-1000.0	-0.093	-1000.0
Rapid glucocorticoid signaling	6.0	134.0	20.0	-0.086	0.014	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling in keratinocytes	6.0	260.0	43.0	-0.223	0.015	1000.0	-1000.0	-0.071	-1000.0
FOXM1 transcription factor network	6.0	342.0	51.0	-0.189	0.109	1000.0	-1000.0	-0.196	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.05	0.013	1000.0	-1000.0	-0.038	-1000.0
Ceramide signaling pathway	5.0	423.0	76.0	-0.108	0.022	1000.0	-1000.0	-0.048	-1000.0
TRAIL signaling pathway	5.0	249.0	48.0	-0.041	0.026	1000.0	-1000.0	-0.066	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	232.0	45.0	-0.084	0.022	1000.0	-1000.0	-0.093	-1000.0
Plasma membrane estrogen receptor signaling	5.0	473.0	86.0	-0.094	0.036	1000.0	-1000.0	-0.086	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	172.0	33.0	-0.183	0.036	1000.0	-1000.0	-0.038	-1000.0
Aurora B signaling	5.0	364.0	67.0	-0.148	0.014	1000.0	-1000.0	-0.069	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	654.0	136.0	-0.153	0.148	1000.0	-1000.0	-0.064	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.001	0.006	1000.0	-1000.0	-0.012	-1000.0
Aurora C signaling	4.0	32.0	7.0	-0.018	0.0	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	4.0	202.0	49.0	-0.108	0.017	1000.0	-1000.0	-0.05	-1000.0
HIF-2-alpha transcription factor network	4.0	176.0	43.0	-0.063	0.028	1000.0	-1000.0	-0.073	-1000.0
Ephrin B reverse signaling	4.0	225.0	48.0	-0.128	0.065	1000.0	-1000.0	-0.063	-1000.0
Regulation of Telomerase	4.0	471.0	102.0	-0.224	0.044	1000.0	-1000.0	-0.108	-1000.0
S1P4 pathway	4.0	109.0	25.0	-0.057	0.023	1000.0	-1000.0	-0.037	-1000.0
Regulation of Androgen receptor activity	4.0	346.0	70.0	-0.27	0.037	1000.0	-1000.0	-0.07	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	76.0	17.0	-0.033	0.025	1000.0	-1000.0	-0.03	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	106.0	28.0	-0.057	0.027	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	3.0	132.0	39.0	-0.081	0.018	1000.0	-1000.0	-0.024	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	233.0	65.0	-0.07	0.053	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	3.0	206.0	55.0	-0.074	0.043	1000.0	-1000.0	-0.084	-1000.0
Insulin-mediated glucose transport	3.0	113.0	32.0	-0.078	0.029	1000.0	-1000.0	-0.07	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	266.0	83.0	-0.151	0.032	1000.0	-1000.0	-0.071	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	116.0	36.0	-0.03	0.027	1000.0	-1000.0	-0.069	-1000.0
Regulation of p38-alpha and p38-beta	3.0	194.0	54.0	-0.157	0.034	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	472.0	125.0	-0.065	0.023	1000.0	-1000.0	-0.085	-1000.0
IGF1 pathway	3.0	224.0	57.0	-0.032	0.026	1000.0	-1000.0	-0.084	-1000.0
Insulin Pathway	3.0	246.0	74.0	-0.084	0.034	1000.0	-1000.0	-0.081	-1000.0
VEGFR1 specific signals	3.0	174.0	56.0	-0.065	0.034	1000.0	-1000.0	-0.058	-1000.0
S1P3 pathway	3.0	162.0	42.0	-0.062	0.02	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.012	-1000.0
Canonical NF-kappaB pathway	2.0	81.0	39.0	-0.081	0.072	1000.0	-1000.0	-0.083	-1000.0
Circadian rhythm pathway	2.0	45.0	22.0	-0.011	0.04	1000.0	-1000.0	-0.05	-1000.0
PLK1 signaling events	2.0	254.0	85.0	-0.041	0.028	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class III	2.0	116.0	40.0	-0.071	0.024	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	33.0	15.0	-0.001	0.029	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	2.0	81.0	31.0	-0.068	0.026	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	2.0	161.0	73.0	-0.068	0.037	1000.0	-1000.0	-0.062	-1000.0
p38 MAPK signaling pathway	2.0	124.0	44.0	-0.062	0.026	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class II	1.0	90.0	75.0	-0.038	0.037	1000.0	-1000.0	-0.045	-1000.0
BARD1 signaling events	1.0	60.0	57.0	-0.024	0.055	1000.0	-1000.0	-0.062	-1000.0
Aurora A signaling	1.0	81.0	60.0	-0.023	0.035	1000.0	-1000.0	-0.032	-1000.0
Arf6 downstream pathway	1.0	52.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.037	-1000.0
mTOR signaling pathway	1.0	81.0	53.0	-0.015	0.026	1000.0	-1000.0	-0.059	-1000.0
IFN-gamma pathway	1.0	133.0	68.0	-0.139	0.07	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class I	1.0	126.0	104.0	-0.081	0.05	1000.0	-1000.0	-0.061	-1000.0
FoxO family signaling	1.0	85.0	64.0	-0.078	0.098	1000.0	-1000.0	-0.076	-1000.0
Arf6 trafficking events	1.0	87.0	71.0	-0.099	0.04	1000.0	-1000.0	-0.073	-1000.0
PDGFR-beta signaling pathway	1.0	187.0	97.0	-0.06	0.052	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by PRL	1.0	54.0	34.0	-0.012	0.024	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	-0.026	0.04	1000.0	-1000.0	-0.06	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	39.0	68.0	-0.078	0.047	1000.0	-1000.0	-0.062	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	13.0	27.0	-0.023	0.032	1000.0	-1000.0	-0.055	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.003	0.031	1000.0	-1000.0	-0.035	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.04	1000.0	-1000.0	-0.031	-1000.0
Total	1033	58265	7203	-18.0949078606	4.83084846071	131000	-131000	-8.40327417639	-131000