E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.046 0.159 -9999.0 0.0 -0.396 24.0 24.0 KLHL20 0.021 0.098 0.182 11.0 -0.228 4.0 15.0 CYFIP2 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.017 0.103 0.22 1.0 -0.255 19.0 20.0 ENAH -0.044 0.156 -9999.0 0.0 -0.395 23.0 23.0 AP1M1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.005 0.083 -9999.0 0.0 -0.298 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.044 -9999.0 0.0 -0.157 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.024 0.112 -9999.0 0.0 -0.215 24.0 24.0 RAPGEF1 -0.039 0.148 0.221 1.0 -0.372 21.0 22.0 CTNND1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.166 -9999.0 0.0 -0.397 25.0 25.0 CRK -0.043 0.152 -9999.0 0.0 -0.389 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.11 -9999.0 0.0 -0.234 23.0 23.0 alphaE/beta7 Integrin 0.042 0.04 -9999.0 0.0 -0.262 2.0 2.0 IQGAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.054 0.026 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.046 0.159 -9999.0 0.0 -0.396 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.046 -9999.0 0.0 -0.216 1.0 1.0 MLLT4 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.059 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.044 0.058 -9999.0 0.0 -0.28 1.0 1.0 ARF6 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.006 0.117 -9999.0 0.0 -0.274 23.0 23.0 TIAM1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.027 0.103 -9999.0 0.0 -0.2 23.0 23.0 AKT1 -0.017 0.052 0.149 1.0 -0.164 1.0 2.0 PIK3R1 0.03 0.036 -9999.0 0.0 -0.383 1.0 1.0 CDH1 -0.037 0.15 -9999.0 0.0 -0.383 23.0 23.0 RhoA/GDP -0.012 0.116 0.221 1.0 -0.254 21.0 22.0 actin cytoskeleton organization 0.019 0.077 0.15 11.0 -0.166 4.0 15.0 CDC42/GDP -0.012 0.116 0.221 1.0 -0.254 21.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.017 0.085 -9999.0 0.0 -0.206 24.0 24.0 ITGB7 0.026 0.05 -9999.0 0.0 -0.383 2.0 2.0 RAC1 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.11 -9999.0 0.0 -0.213 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.013 0.093 -9999.0 0.0 -0.195 23.0 23.0 mol:GDP -0.03 0.123 0.219 1.0 -0.288 21.0 22.0 CDC42/GTP/IQGAP1 0.045 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.003 0.123 0.232 1.0 -0.261 21.0 22.0 RAC1/GTP/IQGAP1 0.031 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.029 -9999.0 0.0 -0.272 1.0 1.0 RHOA 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.054 0.114 10.0 -0.119 2.0 12.0 NME1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.044 0.158 -9999.0 0.0 -0.396 24.0 24.0 regulation of cell-cell adhesion -0.014 0.066 -9999.0 0.0 -0.261 1.0 1.0 WASF2 0.008 0.042 0.097 4.0 -9999.0 0.0 4.0 Rap1/GTP -0.004 0.092 -9999.0 0.0 -0.332 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.113 -9999.0 0.0 -0.207 24.0 24.0 CCND1 0.017 0.063 0.131 10.0 -0.145 2.0 12.0 VAV2 -0.048 0.213 -9999.0 0.0 -0.673 8.0 8.0 RAP1/GDP -0.003 0.1 -9999.0 0.0 -0.375 1.0 1.0 adherens junction assembly -0.042 0.153 -9999.0 0.0 -0.384 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.035 -9999.0 0.0 -0.383 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.016 0.102 -9999.0 0.0 -0.203 23.0 23.0 E-cadherin/beta catenin -0.042 0.111 -9999.0 0.0 -0.296 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.155 -9999.0 0.0 -0.408 21.0 21.0 PIK3CA 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.034 0.1 -9999.0 0.0 -0.348 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.014 0.109 -9999.0 0.0 -0.232 23.0 23.0 ITGAE 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.039 0.169 -9999.0 0.0 -0.405 25.0 25.0