Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.002 0.122 -9999.0 0.0 -0.497 8.0 8.0 IHH 0.023 0.052 -9999.0 0.0 -0.164 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.01 0.072 -9999.0 0.0 -0.225 13.0 13.0 LRPAP1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.072 0.224 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.045 0.115 -9999.0 0.0 -0.51 3.0 3.0 SMO -0.004 0.09 -9999.0 0.0 -0.471 4.0 4.0 AKT1 -0.003 0.102 -9999.0 0.0 -0.375 8.0 8.0 ARRB2 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.036 -9999.0 0.0 -0.383 1.0 1.0 ADRBK1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.089 -9999.0 0.0 -0.465 4.0 4.0 STIL 0.021 0.122 0.183 29.0 -0.307 7.0 36.0 DHH N/PTCH2 0.023 0.076 -9999.0 0.0 -0.275 8.0 8.0 DHH N/PTCH1 0.009 0.105 -9999.0 0.0 -0.312 12.0 12.0 PIK3CA 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.015 0.071 -9999.0 0.0 -0.383 4.0 4.0 PTHLH -0.012 0.15 -9999.0 0.0 -0.599 8.0 8.0 determination of left/right symmetry -0.004 0.089 -9999.0 0.0 -0.465 4.0 4.0 PIK3R1 0.03 0.036 -9999.0 0.0 -0.383 1.0 1.0 skeletal system development -0.012 0.149 -9999.0 0.0 -0.594 8.0 8.0 IHH N/Hhip -0.011 0.12 -9999.0 0.0 -0.312 18.0 18.0 DHH N/Hhip -0.012 0.115 -9999.0 0.0 -0.285 20.0 20.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.089 -9999.0 0.0 -0.465 4.0 4.0 pancreas development -0.029 0.135 -9999.0 0.0 -0.382 18.0 18.0 HHAT 0.027 0.048 -9999.0 0.0 -0.383 2.0 2.0 PI3K 0.045 0.03 -9999.0 0.0 -0.272 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.072 -9999.0 0.0 -0.383 4.0 4.0 somite specification -0.004 0.089 -9999.0 0.0 -0.465 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.018 0.088 -9999.0 0.0 -0.317 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.006 0.068 -9999.0 0.0 -0.226 11.0 11.0 SHH Np/Cholesterol/Megalin -0.034 0.097 -9999.0 0.0 -0.236 25.0 25.0 SHH -0.031 0.066 -9999.0 0.0 -0.273 10.0 10.0 catabolic process 0.001 0.098 -9999.0 0.0 -0.359 9.0 9.0 SMO/Vitamin D3 -0.014 0.102 -9999.0 0.0 -0.46 4.0 4.0 SHH Np/Cholesterol/Hhip -0.023 0.079 -9999.0 0.0 -0.214 20.0 20.0 LRP2 -0.066 0.166 -9999.0 0.0 -0.383 31.0 31.0 receptor-mediated endocytosis -0.039 0.124 -9999.0 0.0 -0.423 9.0 9.0 SHH Np/Cholesterol/BOC -0.003 0.06 -9999.0 0.0 -0.209 10.0 10.0 SHH Np/Cholesterol/CDO -0.004 0.062 -9999.0 0.0 -0.209 11.0 11.0 mesenchymal cell differentiation 0.023 0.079 0.213 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.028 0.128 0.197 30.0 -0.318 7.0 37.0 IHH N/PTCH2 0.031 0.068 -9999.0 0.0 -0.316 4.0 4.0 CDON 0.024 0.06 -9999.0 0.0 -0.383 3.0 3.0 IHH N/PTCH1 0.011 0.102 -9999.0 0.0 -0.361 9.0 9.0 Megalin/LRPAP1 -0.03 0.129 -9999.0 0.0 -0.272 31.0 31.0 PTCH2 0.022 0.068 -9999.0 0.0 -0.383 4.0 4.0 SHH Np/Cholesterol -0.008 0.055 -9999.0 0.0 -0.204 10.0 10.0 PTCH1 0.001 0.098 -9999.0 0.0 -0.36 9.0 9.0 HHIP -0.029 0.135 -9999.0 0.0 -0.383 18.0 18.0