Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.243 -9999.0 0.0 -0.652 40.0 40.0 IHH 0.006 0.064 -9999.0 0.0 -0.288 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.0 0.07 -9999.0 0.0 -0.325 10.0 10.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.0 0.07 0.323 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.03 0.172 -9999.0 0.0 -0.513 16.0 16.0 SMO -0.05 0.166 -9999.0 0.0 -0.519 18.0 18.0 AKT1 -0.026 0.138 -9999.0 0.0 -0.552 13.0 13.0 ARRB2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.011 0.086 -9999.0 0.0 -0.451 9.0 9.0 ADRBK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.049 0.164 -9999.0 0.0 -0.511 18.0 18.0 STIL -0.031 0.113 -9999.0 0.0 -0.358 13.0 13.0 DHH N/PTCH2 -0.001 0.118 -9999.0 0.0 -0.395 21.0 21.0 DHH N/PTCH1 -0.033 0.15 -9999.0 0.0 -0.385 27.0 27.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.012 0.131 -9999.0 0.0 -0.53 17.0 17.0 PTHLH -0.112 0.348 -9999.0 0.0 -0.955 41.0 41.0 determination of left/right symmetry -0.049 0.164 -9999.0 0.0 -0.511 18.0 18.0 PIK3R1 0.024 0.035 -9999.0 0.0 -0.351 2.0 2.0 skeletal system development -0.11 0.342 -9999.0 0.0 -0.941 41.0 41.0 IHH N/Hhip -0.03 0.135 -9999.0 0.0 -0.43 24.0 24.0 DHH N/Hhip -0.04 0.154 -9999.0 0.0 -0.407 39.0 39.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.049 0.164 -9999.0 0.0 -0.511 18.0 18.0 pancreas development -0.046 0.153 -9999.0 0.0 -0.529 23.0 23.0 HHAT 0.025 0.034 -9999.0 0.0 -0.53 1.0 1.0 PI3K 0.028 0.024 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.01 0.097 -9999.0 0.0 -0.465 11.0 11.0 somite specification -0.049 0.164 -9999.0 0.0 -0.511 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.03 0.114 -9999.0 0.0 -0.37 13.0 13.0 SHH Np/Cholesterol/PTCH2 0.0 0.064 -9999.0 0.0 -0.307 6.0 6.0 SHH Np/Cholesterol/Megalin -0.003 0.064 -9999.0 0.0 -0.315 7.0 7.0 SHH -0.012 0.046 -9999.0 0.0 -0.303 2.0 2.0 catabolic process -0.028 0.137 -9999.0 0.0 -0.363 38.0 38.0 SMO/Vitamin D3 -0.044 0.134 -9999.0 0.0 -0.427 16.0 16.0 SHH Np/Cholesterol/Hhip -0.031 0.096 -9999.0 0.0 -0.305 24.0 24.0 LRP2 0.001 0.087 -9999.0 0.0 -0.53 6.0 6.0 receptor-mediated endocytosis -0.045 0.133 -9999.0 0.0 -0.437 11.0 11.0 SHH Np/Cholesterol/BOC 0.003 0.059 -9999.0 0.0 -0.301 7.0 7.0 SHH Np/Cholesterol/CDO 0.002 0.056 -9999.0 0.0 -0.306 5.0 5.0 mesenchymal cell differentiation 0.031 0.095 0.303 24.0 -9999.0 0.0 24.0 mol:Vitamin D3 -0.027 0.12 0.368 1.0 -0.371 13.0 14.0 IHH N/PTCH2 0.008 0.08 -9999.0 0.0 -0.362 7.0 7.0 CDON 0.016 0.068 -9999.0 0.0 -0.53 4.0 4.0 IHH N/PTCH1 -0.02 0.141 -9999.0 0.0 -0.365 38.0 38.0 Megalin/LRPAP1 0.024 0.066 -9999.0 0.0 -0.389 6.0 6.0 PTCH2 0.008 0.084 -9999.0 0.0 -0.257 21.0 21.0 SHH Np/Cholesterol 0.003 0.037 -9999.0 0.0 -0.305 1.0 1.0 PTCH1 -0.028 0.137 -9999.0 0.0 -0.364 38.0 38.0 HHIP -0.046 0.153 -9999.0 0.0 -0.53 23.0 23.0