Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.034 -9999.0 0.0 -0.247 4.0 4.0 epithelial cell differentiation 0.047 0.046 -9999.0 0.0 -0.286 4.0 4.0 CYFIP2 0.006 0.099 -9999.0 0.0 -0.53 9.0 9.0 ENAH 0.011 0.072 0.216 9.0 -9999.0 0.0 9.0 EGFR 0.017 0.065 -9999.0 0.0 -0.53 4.0 4.0 EPHA2 0.023 0.046 -9999.0 0.0 -0.53 2.0 2.0 MYO6 -0.008 0.049 0.181 8.0 -0.277 5.0 13.0 CTNNB1 0.023 0.033 -9999.0 0.0 -0.53 1.0 1.0 ABI1/Sra1/Nap1 0.036 0.072 -9999.0 0.0 -0.334 9.0 9.0 AQP5 -0.073 0.174 -9999.0 0.0 -0.473 44.0 44.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.007 0.047 0.18 9.0 -0.273 4.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.07 0.177 6.0 -0.291 14.0 20.0 EGF -0.064 0.189 -9999.0 0.0 -0.384 66.0 66.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.047 0.152 -9999.0 0.0 -0.452 34.0 34.0 cortical microtubule organization 0.047 0.046 -9999.0 0.0 -0.286 4.0 4.0 GO:0000145 -0.007 0.044 0.168 9.0 -0.261 4.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.048 -9999.0 0.0 -0.288 4.0 4.0 MLLT4 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.033 -9999.0 0.0 -0.255 5.0 5.0 ARF6 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.043 -9999.0 0.0 -0.306 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.002 0.04 0.207 1.0 -0.252 3.0 4.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.046 0.181 8.0 -0.277 4.0 12.0 ARF6/GTP 0.059 0.046 -9999.0 0.0 -0.288 2.0 2.0 CDH1 0.021 0.056 -9999.0 0.0 -0.53 3.0 3.0 EGFR/EGFR/EGF/EGF -0.018 0.115 -9999.0 0.0 -0.279 42.0 42.0 RhoA/GDP 0.048 0.045 -9999.0 0.0 -0.274 4.0 4.0 actin cytoskeleton organization -0.01 0.045 0.191 1.0 -0.268 5.0 6.0 IGF-1R heterotetramer 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.02 0.137 -9999.0 0.0 -0.53 17.0 17.0 DIAPH1 0.015 0.153 -9999.0 0.0 -0.618 6.0 6.0 Wnt receptor signaling pathway -0.047 0.046 0.286 4.0 -9999.0 0.0 4.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.033 -9999.0 0.0 -0.256 5.0 5.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.01 0.046 0.192 1.0 -0.274 5.0 6.0 EFNA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.01 0.044 0.195 2.0 -0.268 4.0 6.0 Ephrin A1/EPHA2 0.038 0.051 -9999.0 0.0 -0.272 6.0 6.0 SEC6/SEC8 -0.017 0.03 -9999.0 0.0 -0.262 4.0 4.0 MGAT3 -0.027 0.071 0.179 6.0 -0.296 14.0 20.0 HGF/MET 0.009 0.095 -9999.0 0.0 -0.272 27.0 27.0 HGF -0.015 0.134 -9999.0 0.0 -0.369 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.034 -9999.0 0.0 -0.249 4.0 4.0 actin cable formation 0.041 0.092 0.224 38.0 -9999.0 0.0 38.0 KIAA1543 -0.012 0.057 0.17 8.0 -0.289 8.0 16.0 KIFC3 -0.012 0.047 0.179 5.0 -0.278 6.0 11.0 NCK1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.053 0.182 8.0 -0.273 7.0 15.0 NCK1/GIT1 0.035 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.047 0.046 -9999.0 0.0 -0.286 4.0 4.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.007 0.047 0.182 9.0 -0.277 4.0 13.0 PIP5K1C -0.007 0.047 0.182 9.0 -0.277 4.0 13.0 LIMA1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.082 0.26 7.0 -9999.0 0.0 7.0 adherens junction assembly -0.013 0.096 0.257 4.0 -0.455 7.0 11.0 IGF-1R heterotetramer/IGF1 0.015 0.086 -9999.0 0.0 -0.269 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.014 0.085 -9999.0 0.0 -0.53 7.0 7.0 PLEKHA7 -0.012 0.061 0.182 8.0 -0.303 8.0 16.0 mol:GTP 0.053 0.042 -9999.0 0.0 -0.305 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.018 0.087 0.306 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.018 0.034 -9999.0 0.0 -0.247 4.0 4.0 regulation of cell-cell adhesion -0.01 0.045 0.191 1.0 -0.268 5.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.034 -9999.0 0.0 -0.249 4.0 4.0