Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.108 0.242 -9999.0 0.0 -0.577 11.0 11.0 IHH -0.126 0.233 -9999.0 0.0 -0.508 17.0 17.0 SHH Np/Cholesterol/GAS1 -0.053 0.123 -9999.0 0.0 -0.245 18.0 18.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.123 0.243 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.1 0.217 -9999.0 0.0 -0.513 10.0 10.0 SMO -0.108 0.224 -9999.0 0.0 -0.537 10.0 10.0 AKT1 -0.032 0.102 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.004 0.063 -9999.0 0.0 -0.504 1.0 1.0 BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.106 0.22 -9999.0 0.0 -0.528 10.0 10.0 STIL -0.107 0.187 -9999.0 0.0 -0.463 9.0 9.0 DHH N/PTCH2 -0.014 0.102 -9999.0 0.0 -0.332 6.0 6.0 DHH N/PTCH1 -0.091 0.204 -9999.0 0.0 -0.569 7.0 7.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.026 0.133 -9999.0 0.0 -0.485 5.0 5.0 PTHLH -0.166 0.364 -9999.0 0.0 -0.955 10.0 10.0 determination of left/right symmetry -0.106 0.22 -9999.0 0.0 -0.528 10.0 10.0 PIK3R1 -0.001 0.073 -9999.0 0.0 -0.411 2.0 2.0 skeletal system development -0.164 0.359 -9999.0 0.0 -0.942 10.0 10.0 IHH N/Hhip -0.093 0.181 -9999.0 0.0 -0.381 16.0 16.0 DHH N/Hhip -0.038 0.132 -9999.0 0.0 -0.335 10.0 10.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.106 0.22 -9999.0 0.0 -0.528 10.0 10.0 pancreas development -0.03 0.121 -9999.0 0.0 -0.411 6.0 6.0 HHAT -0.042 0.156 -9999.0 0.0 -0.49 7.0 7.0 PI3K 0.009 0.052 -9999.0 0.0 -0.281 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.01 0.102 -9999.0 0.0 -0.473 3.0 3.0 somite specification -0.106 0.22 -9999.0 0.0 -0.528 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.112 0.198 -9999.0 0.0 -0.475 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.045 0.118 -9999.0 0.0 -0.29 7.0 7.0 SHH Np/Cholesterol/Megalin -0.101 0.147 -9999.0 0.0 -0.26 28.0 28.0 SHH -0.064 0.143 -9999.0 0.0 -0.311 16.0 16.0 catabolic process -0.087 0.196 -9999.0 0.0 -0.497 8.0 8.0 SMO/Vitamin D3 -0.12 0.217 -9999.0 0.0 -0.495 12.0 12.0 SHH Np/Cholesterol/Hhip -0.063 0.143 -9999.0 0.0 -0.29 17.0 17.0 LRP2 -0.1 0.195 -9999.0 0.0 -0.44 16.0 16.0 receptor-mediated endocytosis -0.149 0.223 -9999.0 0.0 -0.532 12.0 12.0 SHH Np/Cholesterol/BOC -0.041 0.108 -9999.0 0.0 -0.229 16.0 16.0 SHH Np/Cholesterol/CDO -0.044 0.118 -9999.0 0.0 -0.242 16.0 16.0 mesenchymal cell differentiation 0.065 0.141 0.288 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.111 0.2 -9999.0 0.0 -0.477 10.0 10.0 IHH N/PTCH2 -0.068 0.154 -9999.0 0.0 -0.341 13.0 13.0 CDON 0.006 0.052 -9999.0 0.0 -0.411 1.0 1.0 IHH N/PTCH1 -0.087 0.198 -9999.0 0.0 -0.503 8.0 8.0 Megalin/LRPAP1 -0.062 0.139 -9999.0 0.0 -0.304 16.0 16.0 PTCH2 0.006 0.052 -9999.0 0.0 -0.411 1.0 1.0 SHH Np/Cholesterol -0.049 0.108 -9999.0 0.0 -0.236 16.0 16.0 PTCH1 -0.087 0.197 -9999.0 0.0 -0.499 8.0 8.0 HHIP -0.03 0.122 -9999.0 0.0 -0.411 6.0 6.0