Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Class IB PI3K non-lipid kinase events	22.0	66.0	3.0	-0.147	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Glypican 1 network	11.0	559.0	48.0	-0.205	0.02	1000.0	-1000.0	-0.031	-1000.0
PDGFR-alpha signaling pathway	11.0	518.0	44.0	-0.148	0.022	1000.0	-1000.0	-0.058	-1000.0
Glypican 2 network	11.0	45.0	4.0	-0.06	-0.03	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by the Hedgehog family	9.0	472.0	52.0	-0.166	0.065	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	9.0	437.0	48.0	-0.215	0.064	1000.0	-1000.0	-0.051	-1000.0
Wnt signaling	9.0	65.0	7.0	-0.11	-0.038	1000.0	-1000.0	-0.02	-1000.0
IL23-mediated signaling events	9.0	553.0	60.0	-0.408	0.013	1000.0	-1000.0	-0.146	-1000.0
Syndecan-1-mediated signaling events	8.0	292.0	34.0	-0.165	0.012	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Cones	8.0	308.0	38.0	-0.157	0.012	1000.0	-1000.0	-0.026	-1000.0
amb2 Integrin signaling	8.0	711.0	82.0	-0.195	0.017	1000.0	-1000.0	-0.07	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	756.0	93.0	-0.143	0.044	1000.0	-1000.0	-0.064	-1000.0
TCGA08_retinoblastoma	8.0	66.0	8.0	-0.105	0.038	1000.0	-1000.0	-0.013	-1000.0
IL4-mediated signaling events	7.0	680.0	91.0	-0.351	0.258	1000.0	-1000.0	-0.128	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	346.0	46.0	-0.476	0.037	1000.0	-1000.0	-0.076	-1000.0
Endothelins	7.0	681.0	96.0	-0.171	0.012	1000.0	-1000.0	-0.06	-1000.0
Effects of Botulinum toxin	7.0	182.0	26.0	-0.215	0.012	1000.0	-1000.0	-0.058	-1000.0
LPA receptor mediated events	7.0	749.0	102.0	-0.204	0.012	1000.0	-1000.0	-0.071	-1000.0
IL12-mediated signaling events	6.0	567.0	87.0	-0.251	0.051	1000.0	-1000.0	-0.129	-1000.0
Reelin signaling pathway	6.0	346.0	56.0	-0.17	0.022	1000.0	-1000.0	-0.066	-1000.0
Nongenotropic Androgen signaling	6.0	318.0	52.0	-0.193	0.041	1000.0	-1000.0	-0.046	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	446.0	68.0	-0.344	0.147	1000.0	-1000.0	-0.094	-1000.0
Visual signal transduction: Rods	6.0	351.0	52.0	-0.187	0.012	1000.0	-1000.0	-0.054	-1000.0
Coregulation of Androgen receptor activity	5.0	414.0	76.0	-0.209	0.029	1000.0	-1000.0	-0.025	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	190.0	34.0	-0.067	0.012	1000.0	-1000.0	-0.028	-1000.0
Noncanonical Wnt signaling pathway	5.0	148.0	26.0	-0.11	0.012	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	5.0	599.0	105.0	-0.129	0.033	1000.0	-1000.0	-0.055	-1000.0
Syndecan-2-mediated signaling events	5.0	396.0	69.0	-0.195	0.023	1000.0	-1000.0	-0.025	-1000.0
Glucocorticoid receptor regulatory network	5.0	664.0	114.0	-0.352	0.225	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	262.0	44.0	-0.1	0.012	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	174.0	31.0	-0.138	0.012	1000.0	-1000.0	-0.032	-1000.0
Syndecan-4-mediated signaling events	5.0	370.0	67.0	-0.152	0.013	1000.0	-1000.0	-0.055	-1000.0
FOXM1 transcription factor network	5.0	293.0	51.0	-0.223	0.024	1000.0	-1000.0	-0.169	-1000.0
HIF-1-alpha transcription factor network	4.0	311.0	76.0	-0.221	0.036	1000.0	-1000.0	-0.14	-1000.0
p75(NTR)-mediated signaling	4.0	516.0	125.0	-0.159	0.037	1000.0	-1000.0	-0.081	-1000.0
BMP receptor signaling	4.0	384.0	81.0	-0.208	0.041	1000.0	-1000.0	-0.074	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	456.0	97.0	-0.162	0.033	1000.0	-1000.0	-0.073	-1000.0
IL1-mediated signaling events	4.0	276.0	62.0	-0.141	0.048	1000.0	-1000.0	-0.074	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	360.0	82.0	-0.069	0.012	1000.0	-1000.0	-0.066	-1000.0
Rapid glucocorticoid signaling	4.0	94.0	20.0	-0.206	0.017	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	3.0	46.0	12.0	-0.079	0.017	1000.0	-1000.0	-0.014	-1000.0
ErbB2/ErbB3 signaling events	3.0	227.0	65.0	-0.134	0.018	1000.0	-1000.0	-0.054	-1000.0
Osteopontin-mediated events	3.0	147.0	38.0	-0.098	0.012	1000.0	-1000.0	-0.078	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	179.0	54.0	-0.17	0.024	1000.0	-1000.0	-0.077	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	57.0	17.0	-0.063	0.012	1000.0	-1000.0	-0.029	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	19.0	5.0	-0.02	-0.001	1000.0	-1000.0	-0.014	-1000.0
Cellular roles of Anthrax toxin	3.0	122.0	39.0	-0.062	0.013	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	3.0	197.0	62.0	-0.067	0.016	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PTP1B	3.0	246.0	76.0	-0.091	0.019	1000.0	-1000.0	-0.057	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	196.0	52.0	-0.134	0.026	1000.0	-1000.0	-0.044	-1000.0
TCGA08_p53	3.0	23.0	7.0	-0.075	0.048	1000.0	-1000.0	-0.009	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	57.0	15.0	-0.071	0.012	1000.0	-1000.0	-0.02	-1000.0
Syndecan-3-mediated signaling events	3.0	123.0	35.0	-0.186	0.037	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	3.0	306.0	84.0	-0.119	0.02	1000.0	-1000.0	-0.073	-1000.0
EPHB forward signaling	3.0	285.0	85.0	-0.084	0.058	1000.0	-1000.0	-0.067	-1000.0
IL27-mediated signaling events	3.0	157.0	51.0	-0.127	0.037	1000.0	-1000.0	-0.089	-1000.0
IL6-mediated signaling events	3.0	285.0	75.0	-0.139	0.049	1000.0	-1000.0	-0.062	-1000.0
BCR signaling pathway	3.0	311.0	99.0	-0.128	0.021	1000.0	-1000.0	-0.071	-1000.0
IGF1 pathway	3.0	217.0	57.0	-0.113	0.025	1000.0	-1000.0	-0.075	-1000.0
Plasma membrane estrogen receptor signaling	3.0	310.0	86.0	-0.113	0.028	1000.0	-1000.0	-0.066	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	331.0	88.0	-0.081	0.015	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	264.0	78.0	-0.051	0.026	1000.0	-1000.0	-0.075	-1000.0
Aurora B signaling	3.0	239.0	67.0	-0.071	0.012	1000.0	-1000.0	-0.067	-1000.0
ErbB4 signaling events	2.0	172.0	69.0	-0.129	0.102	1000.0	-1000.0	-0.071	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	-0.012	0.002	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	153.0	61.0	-0.116	0.041	1000.0	-1000.0	-0.064	-1000.0
Aurora C signaling	2.0	19.0	7.0	-0.049	0.0	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	78.0	37.0	-0.044	0.027	1000.0	-1000.0	-0.048	-1000.0
TRAIL signaling pathway	2.0	111.0	48.0	-0.064	0.037	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	2.0	35.0	17.0	-0.057	0.012	1000.0	-1000.0	-0.024	-1000.0
HIF-2-alpha transcription factor network	2.0	92.0	43.0	-0.063	0.051	1000.0	-1000.0	-0.06	-1000.0
S1P1 pathway	2.0	96.0	36.0	-0.084	0.012	1000.0	-1000.0	-0.047	-1000.0
FAS signaling pathway (CD95)	2.0	129.0	47.0	-0.153	0.02	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	2.0	137.0	51.0	-0.116	0.04	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	2.0	59.0	26.0	-0.147	0.025	1000.0	-1000.0	-0.018	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	160.0	74.0	-0.113	0.044	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	2.0	60.0	22.0	-0.107	0.013	1000.0	-1000.0	-0.04	-1000.0
EGFR-dependent Endothelin signaling events	2.0	60.0	21.0	-0.062	0.018	1000.0	-1000.0	-0.053	-1000.0
VEGFR1 specific signals	2.0	125.0	56.0	-0.022	0.019	1000.0	-1000.0	-0.048	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	290.0	120.0	-0.098	0.076	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling events	2.0	14.0	5.0	-0.019	0.012	1000.0	-1000.0	-0.018	-1000.0
Regulation of Androgen receptor activity	2.0	183.0	70.0	-0.136	0.026	1000.0	-1000.0	-0.056	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	46.0	17.0	-0.041	0.023	1000.0	-1000.0	-0.032	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	249.0	136.0	-0.193	0.109	1000.0	-1000.0	-0.049	-1000.0
BARD1 signaling events	1.0	91.0	57.0	-0.015	0.038	1000.0	-1000.0	-0.042	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	52.0	28.0	-0.057	0.025	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.006	0.011	1000.0	-1000.0	-0.01	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	138.0	85.0	-0.049	0.023	1000.0	-1000.0	-0.059	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	87.0	65.0	-0.057	0.058	1000.0	-1000.0	-0.056	-1000.0
Aurora A signaling	1.0	80.0	60.0	-0.145	0.038	1000.0	-1000.0	-0.031	-1000.0
EPO signaling pathway	1.0	63.0	55.0	-0.07	0.054	1000.0	-1000.0	-0.072	-1000.0
PLK1 signaling events	1.0	150.0	85.0	-0.047	0.026	1000.0	-1000.0	-0.034	-1000.0
Insulin-mediated glucose transport	1.0	53.0	32.0	-0.115	0.027	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	1.0	125.0	63.0	-0.033	0.024	1000.0	-1000.0	-0.065	-1000.0
Ceramide signaling pathway	1.0	115.0	76.0	-0.113	0.025	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	119.0	83.0	-0.115	0.041	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	1.0	80.0	58.0	-0.064	0.034	1000.0	-1000.0	-0.062	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	41.0	36.0	-0.044	0.021	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by PI3K	1.0	97.0	58.0	-0.087	0.025	1000.0	-1000.0	-0.069	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	77.0	45.0	-0.051	0.029	1000.0	-1000.0	-0.066	-1000.0
Regulation of p38-alpha and p38-beta	1.0	54.0	54.0	-0.034	0.032	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	180.0	125.0	-0.039	0.053	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	115.0	76.0	-0.021	0.035	1000.0	-1000.0	-0.067	-1000.0
Class I PI3K signaling events	1.0	76.0	73.0	-0.033	0.029	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	1.0	83.0	42.0	-0.057	0.018	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	45.0	33.0	-0.107	0.037	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PRL	1.0	49.0	34.0	-0.047	0.018	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in keratinocytes	1.0	82.0	43.0	-0.1	0.019	1000.0	-1000.0	-0.049	-1000.0
S1P4 pathway	1.0	44.0	25.0	-0.057	0.023	1000.0	-1000.0	-0.025	-1000.0
p38 MAPK signaling pathway	1.0	71.0	44.0	-0.121	0.024	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	0.0	56.0	74.0	-0.044	0.034	1000.0	-1000.0	-0.034	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.001	0.039	1000.0	-1000.0	-0.039	-1000.0
Canonical NF-kappaB pathway	0.0	34.0	39.0	-0.04	0.053	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class II	0.0	56.0	75.0	-0.052	0.037	1000.0	-1000.0	-0.038	-1000.0
Circadian rhythm pathway	0.0	9.0	22.0	-0.03	0.04	1000.0	-1000.0	-0.04	-1000.0
Arf6 downstream pathway	0.0	14.0	43.0	-0.018	0.019	1000.0	-1000.0	-0.04	-1000.0
mTOR signaling pathway	0.0	4.0	53.0	-0.006	0.028	1000.0	-1000.0	-0.052	-1000.0
IFN-gamma pathway	0.0	57.0	68.0	-0.121	0.054	1000.0	-1000.0	-0.074	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	37.0	68.0	-0.115	0.044	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	0.0	37.0	40.0	-0.038	0.026	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	0.0	38.0	49.0	-0.038	0.027	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class I	0.0	54.0	104.0	-0.043	0.049	1000.0	-1000.0	-0.057	-1000.0
FoxO family signaling	0.0	57.0	64.0	-0.115	0.085	1000.0	-1000.0	-0.079	-1000.0
Atypical NF-kappaB pathway	0.0	29.0	31.0	-0.019	0.024	1000.0	-1000.0	-0.03	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.032	1000.0	-1000.0	-0.043	-1000.0
Arf6 trafficking events	0.0	25.0	71.0	-0.051	0.038	1000.0	-1000.0	-0.065	-1000.0
Regulation of Telomerase	0.0	99.0	102.0	-0.052	0.041	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	0.0	65.0	74.0	-0.044	0.035	1000.0	-1000.0	-0.068	-1000.0
PDGFR-beta signaling pathway	0.0	81.0	97.0	-0.024	0.043	1000.0	-1000.0	-0.067	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.002	0.026	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.001	0.026	1000.0	-1000.0	-0.023	-1000.0
Total	410	24984	7203	-14.2607251928	-995.693066464	131000	-131000	-6.84750097143	-131000