Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.068 0.207 -9999.0 0.0 -0.553 9.0 9.0 IHH -0.041 0.184 -9999.0 0.0 -0.397 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.012 0.072 -9999.0 0.0 -0.223 6.0 6.0 LRPAP1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.072 0.222 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.064 0.184 -9999.0 0.0 -0.383 13.0 13.0 SMO -0.077 0.186 -9999.0 0.0 -0.386 15.0 15.0 AKT1 -0.021 0.106 -9999.0 0.0 -0.534 1.0 1.0 ARRB2 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.076 0.184 -9999.0 0.0 -0.38 15.0 15.0 STIL -0.059 0.137 -9999.0 0.0 -0.355 8.0 8.0 DHH N/PTCH2 0.017 0.078 -9999.0 0.0 -0.282 4.0 4.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.309 16.0 16.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.0 0.102 -9999.0 0.0 -0.396 4.0 4.0 PTHLH -0.126 0.308 -9999.0 0.0 -0.844 9.0 9.0 determination of left/right symmetry -0.076 0.184 -9999.0 0.0 -0.38 15.0 15.0 PIK3R1 0.029 0.019 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.124 0.305 -9999.0 0.0 -0.834 9.0 9.0 IHH N/Hhip -0.011 0.123 0.212 1.0 -0.259 11.0 12.0 DHH N/Hhip 0.019 0.084 -9999.0 0.0 -0.294 4.0 4.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.076 0.184 -9999.0 0.0 -0.38 15.0 15.0 pancreas development 0.021 0.037 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.007 0.113 -9999.0 0.0 -0.396 5.0 5.0 PI3K 0.038 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.074 -9999.0 0.0 -0.396 2.0 2.0 somite specification -0.076 0.184 -9999.0 0.0 -0.38 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.059 0.145 -9999.0 0.0 -0.351 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.005 0.063 -9999.0 0.0 -0.226 4.0 4.0 SHH Np/Cholesterol/Megalin -0.015 0.096 0.24 1.0 -0.22 9.0 10.0 SHH -0.021 0.079 0.243 1.0 -0.284 4.0 5.0 catabolic process -0.055 0.159 -9999.0 0.0 -0.329 15.0 15.0 SMO/Vitamin D3 -0.069 0.172 -9999.0 0.0 -0.375 12.0 12.0 SHH Np/Cholesterol/Hhip -0.012 0.065 -9999.0 0.0 -0.226 4.0 4.0 LRP2 0.007 0.125 0.134 11.0 -0.396 5.0 16.0 receptor-mediated endocytosis -0.083 0.17 -9999.0 0.0 -0.379 12.0 12.0 SHH Np/Cholesterol/BOC -0.003 0.06 -9999.0 0.0 -0.216 4.0 4.0 SHH Np/Cholesterol/CDO -0.004 0.062 -9999.0 0.0 -0.226 4.0 4.0 mesenchymal cell differentiation 0.012 0.064 0.225 4.0 -9999.0 0.0 4.0 mol:Vitamin D3 -0.055 0.149 -9999.0 0.0 -0.352 9.0 9.0 IHH N/PTCH2 -0.008 0.118 -9999.0 0.0 -0.273 9.0 9.0 CDON 0.025 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.039 0.17 -9999.0 0.0 -0.331 15.0 15.0 Megalin/LRPAP1 0.022 0.093 -9999.0 0.0 -0.281 5.0 5.0 PTCH2 0.025 0.015 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.009 0.057 -9999.0 0.0 -0.214 4.0 4.0 PTCH1 -0.055 0.16 -9999.0 0.0 -0.33 15.0 15.0 HHIP 0.021 0.038 -9999.0 0.0 -9999.0 0.0 0.0