Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.004 0.09 -9999.0 0.0 -0.298 5.0 5.0 epithelial cell differentiation 0.034 0.061 -9999.0 0.0 -0.194 4.0 4.0 CYFIP2 0.006 0.088 -9999.0 0.0 -0.396 3.0 3.0 ENAH -0.021 0.069 0.267 2.0 -0.274 2.0 4.0 EGFR -0.013 0.123 0.134 1.0 -0.396 6.0 7.0 EPHA2 0.027 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.001 0.118 0.345 5.0 -0.285 2.0 7.0 CTNNB1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.061 -9999.0 0.0 -0.238 3.0 3.0 AQP5 -0.039 0.135 -9999.0 0.0 -0.424 6.0 6.0 CTNND1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.09 0.298 4.0 -0.193 2.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.01 0.079 0.284 3.0 -0.193 2.0 5.0 EGF -0.002 0.101 -9999.0 0.0 -0.396 4.0 4.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.055 0.174 -9999.0 0.0 -0.482 9.0 9.0 cortical microtubule organization 0.034 0.061 -9999.0 0.0 -0.194 4.0 4.0 GO:0000145 -0.005 0.087 0.287 4.0 -0.185 2.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.063 -9999.0 0.0 -0.196 4.0 4.0 MLLT4 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.061 -9999.0 0.0 -0.355 2.0 2.0 ARF6 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.051 0.056 -9999.0 0.0 -0.237 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.05 -9999.0 0.0 -0.215 1.0 1.0 PVRL2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.022 0.053 0.172 1.0 -0.233 2.0 3.0 ARF6/GTP 0.053 0.056 -9999.0 0.0 -0.223 2.0 2.0 CDH1 -0.003 0.101 -9999.0 0.0 -0.396 4.0 4.0 EGFR/EGFR/EGF/EGF -0.005 0.107 -9999.0 0.0 -0.22 12.0 12.0 RhoA/GDP 0.036 0.058 -9999.0 0.0 -0.18 4.0 4.0 actin cytoskeleton organization 0.003 0.112 0.33 5.0 -0.278 2.0 7.0 IGF-1R heterotetramer 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.031 0.159 -9999.0 0.0 -0.396 10.0 10.0 DIAPH1 -0.028 0.199 -9999.0 0.0 -0.612 4.0 4.0 Wnt receptor signaling pathway -0.034 0.061 0.194 4.0 -9999.0 0.0 4.0 RHOA 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.061 -9999.0 0.0 -0.355 2.0 2.0 CTNNA1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.113 0.332 5.0 -0.285 2.0 7.0 EFNA1 0.011 0.073 -9999.0 0.0 -0.396 2.0 2.0 LPP -0.024 0.052 0.163 1.0 -0.218 3.0 4.0 Ephrin A1/EPHA2 0.024 0.083 -9999.0 0.0 -0.314 3.0 3.0 SEC6/SEC8 -0.027 0.038 -9999.0 0.0 -0.187 2.0 2.0 MGAT3 -0.01 0.08 0.286 3.0 -0.196 2.0 5.0 HGF/MET 0.023 0.089 -9999.0 0.0 -0.263 5.0 5.0 HGF 0.022 0.082 -9999.0 0.0 -0.396 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.004 0.091 -9999.0 0.0 -0.3 5.0 5.0 actin cable formation 0.026 0.181 0.548 5.0 -0.301 2.0 7.0 KIAA1543 -0.012 0.105 0.335 3.0 -0.357 2.0 5.0 KIFC3 -0.012 0.063 0.172 1.0 -0.217 4.0 5.0 NCK1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.022 0.053 0.172 1.0 -0.233 2.0 3.0 NCK1/GIT1 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.034 0.061 -9999.0 0.0 -0.194 4.0 4.0 EXOC4 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.049 0.172 1.0 -0.189 4.0 5.0 PIP5K1C -0.005 0.091 0.3 4.0 -0.196 2.0 6.0 LIMA1 0.011 0.073 -9999.0 0.0 -0.396 2.0 2.0 ABI1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.023 0.078 0.287 2.0 -0.317 2.0 4.0 adherens junction assembly 0.02 0.162 0.561 4.0 -0.41 2.0 6.0 IGF-1R heterotetramer/IGF1 -0.003 0.101 -9999.0 0.0 -0.193 14.0 14.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.017 0.052 -9999.0 0.0 -0.396 1.0 1.0 PLEKHA7 -0.013 0.108 0.346 3.0 -0.374 2.0 5.0 mol:GTP 0.049 0.055 -9999.0 0.0 -0.236 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.024 0.049 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.004 0.09 -9999.0 0.0 -0.298 5.0 5.0 regulation of cell-cell adhesion 0.003 0.112 0.33 5.0 -0.278 2.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.004 0.091 -9999.0 0.0 -0.3 5.0 5.0