Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Class IB PI3K non-lipid kinase events	22.0	66.0	3.0	-0.029	-1000.0	1000.0	-1000.0	-0.018	-1000.0
Ephrin B reverse signaling	8.0	398.0	48.0	-0.18	0.032	1000.0	-1000.0	-0.02	-1000.0
Syndecan-1-mediated signaling events	7.0	270.0	34.0	-0.085	0.026	1000.0	-1000.0	-0.023	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	730.0	93.0	-0.115	0.035	1000.0	-1000.0	-0.04	-1000.0
Wnt signaling	7.0	50.0	7.0	-0.067	0.011	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by the Hedgehog family	6.0	351.0	52.0	-0.126	0.038	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	318.0	46.0	-0.356	0.027	1000.0	-1000.0	-0.084	-1000.0
Glypican 1 network	6.0	290.0	48.0	-0.074	0.044	1000.0	-1000.0	-0.018	-1000.0
PDGFR-alpha signaling pathway	6.0	305.0	44.0	-0.068	0.029	1000.0	-1000.0	-0.028	-1000.0
Endothelins	6.0	662.0	96.0	-0.107	0.051	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	268.0	44.0	-0.059	0.025	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	6.0	390.0	60.0	-0.252	0.029	1000.0	-1000.0	-0.082	-1000.0
ErbB2/ErbB3 signaling events	5.0	361.0	65.0	-0.073	0.035	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	173.0	34.0	-0.029	0.039	1000.0	-1000.0	-0.021	-1000.0
IL12-mediated signaling events	5.0	488.0	87.0	-0.225	0.047	1000.0	-1000.0	-0.065	-1000.0
Noncanonical Wnt signaling pathway	5.0	146.0	26.0	-0.079	0.025	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	5.0	447.0	76.0	-0.123	0.037	1000.0	-1000.0	-0.072	-1000.0
IL4-mediated signaling events	5.0	463.0	91.0	-0.254	0.156	1000.0	-1000.0	-0.095	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	573.0	97.0	-0.102	0.046	1000.0	-1000.0	-0.048	-1000.0
amb2 Integrin signaling	5.0	428.0	82.0	-0.102	0.032	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	5.0	306.0	56.0	-0.067	0.061	1000.0	-1000.0	-0.028	-1000.0
Nongenotropic Androgen signaling	5.0	309.0	52.0	-0.082	0.045	1000.0	-1000.0	-0.022	-1000.0
LPA receptor mediated events	5.0	601.0	102.0	-0.113	0.029	1000.0	-1000.0	-0.037	-1000.0
TCGA08_retinoblastoma	5.0	44.0	8.0	-0.015	0.031	1000.0	-1000.0	-0.002	-1000.0
Visual signal transduction: Rods	5.0	261.0	52.0	-0.069	0.025	1000.0	-1000.0	-0.015	-1000.0
Coregulation of Androgen receptor activity	4.0	313.0	76.0	-0.133	0.051	1000.0	-1000.0	-0.021	-1000.0
Osteopontin-mediated events	4.0	172.0	38.0	-0.061	0.025	1000.0	-1000.0	-0.038	-1000.0
Thromboxane A2 receptor signaling	4.0	514.0	105.0	-0.047	0.031	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	4.0	308.0	69.0	-0.061	0.035	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	4.0	261.0	62.0	-0.033	0.051	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	4.0	621.0	125.0	-0.059	0.064	1000.0	-1000.0	-0.049	-1000.0
BMP receptor signaling	4.0	326.0	81.0	-0.074	0.05	1000.0	-1000.0	-0.03	-1000.0
Glucocorticoid receptor regulatory network	4.0	492.0	114.0	-0.166	0.113	1000.0	-1000.0	-0.039	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	211.0	52.0	-0.06	0.055	1000.0	-1000.0	-0.031	-1000.0
Effects of Botulinum toxin	4.0	118.0	26.0	-0.065	0.031	1000.0	-1000.0	-0.004	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	145.0	31.0	-0.098	0.038	1000.0	-1000.0	-0.032	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	332.0	68.0	-0.225	0.074	1000.0	-1000.0	-0.068	-1000.0
BCR signaling pathway	4.0	434.0	99.0	-0.07	0.039	1000.0	-1000.0	-0.039	-1000.0
EGFR-dependent Endothelin signaling events	4.0	96.0	21.0	-0.041	0.035	1000.0	-1000.0	-0.031	-1000.0
IGF1 pathway	4.0	257.0	57.0	-0.053	0.048	1000.0	-1000.0	-0.036	-1000.0
LPA4-mediated signaling events	3.0	36.0	12.0	-0.064	0.006	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	3.0	134.0	38.0	-0.056	0.047	1000.0	-1000.0	-0.017	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	58.0	17.0	-0.067	0.043	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	3.0	285.0	76.0	-0.092	0.033	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	3.0	188.0	62.0	-0.053	0.051	1000.0	-1000.0	-0.029	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	286.0	82.0	-0.036	0.031	1000.0	-1000.0	-0.041	-1000.0
ceramide signaling pathway	3.0	157.0	49.0	-0.015	0.036	1000.0	-1000.0	-0.043	-1000.0
HIF-2-alpha transcription factor network	3.0	134.0	43.0	-0.042	0.045	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	51.0	15.0	-0.087	0.025	1000.0	-1000.0	-0.026	-1000.0
TCGA08_rtk_signaling	3.0	80.0	26.0	-0.03	0.051	1000.0	-1000.0	-0.004	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	255.0	74.0	-0.055	0.053	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	3.0	234.0	67.0	-0.086	0.044	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	3.0	284.0	86.0	-0.063	0.058	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	343.0	88.0	-0.086	0.044	1000.0	-1000.0	-0.06	-1000.0
E-cadherin signaling in keratinocytes	3.0	152.0	43.0	-0.059	0.029	1000.0	-1000.0	-0.023	-1000.0
FOXM1 transcription factor network	3.0	153.0	51.0	-0.073	0.051	1000.0	-1000.0	-0.103	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	305.0	78.0	-0.055	0.032	1000.0	-1000.0	-0.035	-1000.0
Caspase cascade in apoptosis	2.0	170.0	74.0	-0.056	0.054	1000.0	-1000.0	-0.031	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	155.0	54.0	-0.052	0.034	1000.0	-1000.0	-0.028	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	0.0	0.006	1000.0	-1000.0	-0.0	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	11.0	5.0	-0.002	0.033	1000.0	-1000.0	0.012	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	192.0	85.0	-0.038	0.054	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	147.0	61.0	-0.024	0.064	1000.0	-1000.0	-0.038	-1000.0
PLK1 signaling events	2.0	215.0	85.0	-0.008	0.041	1000.0	-1000.0	-0.024	-1000.0
Nectin adhesion pathway	2.0	137.0	63.0	-0.019	0.06	1000.0	-1000.0	-0.041	-1000.0
S1P1 pathway	2.0	106.0	36.0	-0.047	0.025	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	2.0	15.0	7.0	-0.027	0.024	1000.0	-1000.0	-0.004	-1000.0
FAS signaling pathway (CD95)	2.0	132.0	47.0	-0.083	0.035	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	2.0	137.0	58.0	-0.036	0.048	1000.0	-1000.0	-0.034	-1000.0
Syndecan-3-mediated signaling events	2.0	86.0	35.0	-0.045	0.064	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	2.0	139.0	58.0	-0.065	0.049	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	2.0	246.0	84.0	-0.049	0.054	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	105.0	45.0	-0.028	0.059	1000.0	-1000.0	-0.039	-1000.0
Canonical Wnt signaling pathway	2.0	123.0	51.0	-0.061	0.056	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	2.0	209.0	85.0	-0.052	0.068	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	2.0	10.0	4.0	0.016	0.037	1000.0	-1000.0	0.012	-1000.0
IL6-mediated signaling events	2.0	162.0	75.0	-0.066	0.042	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	167.0	76.0	-0.018	0.043	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	2.0	137.0	56.0	-0.046	0.03	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	89.0	33.0	-0.031	0.063	1000.0	-1000.0	-0.026	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	331.0	120.0	-0.088	0.066	1000.0	-1000.0	-0.033	-1000.0
E-cadherin signaling events	2.0	14.0	5.0	-0.003	0.024	1000.0	-1000.0	0.015	-1000.0
Regulation of Androgen receptor activity	2.0	191.0	70.0	-0.114	0.032	1000.0	-1000.0	-0.038	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	48.0	17.0	-0.029	0.042	1000.0	-1000.0	-0.022	-1000.0
Aurora B signaling	2.0	189.0	67.0	-0.081	0.062	1000.0	-1000.0	-0.034	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	187.0	136.0	-0.059	0.081	1000.0	-1000.0	-0.038	-1000.0
ErbB4 signaling events	1.0	129.0	69.0	-0.087	0.076	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	1.0	63.0	57.0	-0.052	0.057	1000.0	-1000.0	-0.033	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	29.0	28.0	-0.007	0.045	1000.0	-1000.0	-0.015	-1000.0
Cellular roles of Anthrax toxin	1.0	76.0	39.0	-0.046	0.032	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	94.0	65.0	-0.017	0.053	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	1.0	9.0	7.0	-0.002	0.033	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	1.0	63.0	55.0	-0.008	0.063	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	1.0	40.0	32.0	-0.046	0.046	1000.0	-1000.0	-0.019	-1000.0
IFN-gamma pathway	1.0	73.0	68.0	-0.073	0.066	1000.0	-1000.0	-0.044	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	70.0	68.0	-0.024	0.047	1000.0	-1000.0	-0.031	-1000.0
Ceramide signaling pathway	1.0	150.0	76.0	-0.032	0.055	1000.0	-1000.0	-0.032	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	40.0	37.0	-0.027	0.051	1000.0	-1000.0	-0.027	-1000.0
TRAIL signaling pathway	1.0	95.0	48.0	-0.015	0.063	1000.0	-1000.0	-0.028	-1000.0
S1P5 pathway	1.0	18.0	17.0	-0.008	0.03	1000.0	-1000.0	-0.011	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	128.0	83.0	-0.042	0.048	1000.0	-1000.0	-0.026	-1000.0
FoxO family signaling	1.0	97.0	64.0	-0.081	0.041	1000.0	-1000.0	-0.053	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	41.0	36.0	-0.042	0.045	1000.0	-1000.0	-0.023	-1000.0
Regulation of p38-alpha and p38-beta	1.0	91.0	54.0	-0.065	0.057	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	178.0	125.0	-0.025	0.054	1000.0	-1000.0	-0.035	-1000.0
IL27-mediated signaling events	1.0	100.0	51.0	-0.106	0.027	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by STAT5	1.0	40.0	22.0	-0.087	0.035	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events	1.0	111.0	73.0	-0.042	0.047	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	1.0	82.0	74.0	-0.058	0.058	1000.0	-1000.0	-0.038	-1000.0
S1P3 pathway	1.0	74.0	42.0	-0.038	0.038	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	1.0	29.0	20.0	-0.05	0.03	1000.0	-1000.0	-0.003	-1000.0
PDGFR-beta signaling pathway	1.0	118.0	97.0	-0.02	0.07	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PRL	1.0	46.0	34.0	-0.032	0.035	1000.0	-1000.0	-0.035	-1000.0
S1P4 pathway	1.0	34.0	25.0	-0.011	0.04	1000.0	-1000.0	-0.02	-1000.0
p38 MAPK signaling pathway	1.0	71.0	44.0	-0.073	0.044	1000.0	-1000.0	-0.016	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.002	0.052	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	0.0	28.0	39.0	-0.005	0.053	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class II	0.0	45.0	75.0	-0.028	0.07	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.008	-1000.0	1000.0	-1000.0	-0.007	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.007	0.063	1000.0	-1000.0	-0.033	-1000.0
Aurora A signaling	0.0	53.0	60.0	-0.039	0.052	1000.0	-1000.0	-0.015	-1000.0
Arf6 downstream pathway	0.0	2.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.027	-1000.0
mTOR signaling pathway	0.0	38.0	53.0	-0.034	0.038	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	0.0	36.0	40.0	-0.045	0.048	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class I	0.0	60.0	104.0	-0.048	0.06	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	0.0	29.0	31.0	-0.006	0.038	1000.0	-1000.0	-0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.008	0.059	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	0.0	32.0	71.0	-0.04	0.041	1000.0	-1000.0	-0.029	-1000.0
Regulation of Telomerase	0.0	98.0	102.0	-0.013	0.064	1000.0	-1000.0	-0.026	-1000.0
Arf1 pathway	0.0	26.0	54.0	-0.009	0.045	1000.0	-1000.0	-0.013	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.063	1000.0	-1000.0	0.0	-1000.0
Total	355	22946	7203	-7.85280875708	-1994.10194568	131000	-131000	-4.08654481304	-131000