E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.017 0.136 -9999.0 0.0 -0.601 20.0 20.0 KLHL20 -0.017 0.059 -9999.0 0.0 -0.356 7.0 7.0 CYFIP2 0.001 0.107 -9999.0 0.0 -0.811 8.0 8.0 Rac1/GDP 0.049 0.097 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.017 0.136 -9999.0 0.0 -0.601 20.0 20.0 AP1M1 0.013 0.04 -9999.0 0.0 -0.85 1.0 1.0 RAP1B 0.013 0.033 -9999.0 0.0 -0.694 1.0 1.0 RAP1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.018 0.07 -9999.0 0.0 -0.535 1.0 1.0 ABI1/Sra1/Nap1 -0.013 0.045 -9999.0 0.0 -0.245 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.038 0.157 -9999.0 0.0 -0.651 23.0 23.0 RAPGEF1 0.033 0.124 -9999.0 0.0 -0.5 21.0 21.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.13 -9999.0 0.0 -0.627 20.0 20.0 CRK 0.026 0.131 -9999.0 0.0 -0.554 20.0 20.0 E-cadherin/gamma catenin/alpha catenin -0.037 0.145 -9999.0 0.0 -0.612 23.0 23.0 alphaE/beta7 Integrin -0.013 0.094 -9999.0 0.0 -0.67 9.0 9.0 IQGAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.001 0.018 -9999.0 0.0 -0.4 1.0 1.0 DLG1 0.017 0.136 -9999.0 0.0 -0.601 20.0 20.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.055 -9999.0 0.0 -0.397 1.0 1.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.01 0.07 -9999.0 0.0 -0.512 9.0 9.0 PI3K -0.02 0.072 -9999.0 0.0 -0.563 1.0 1.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.042 0.166 -9999.0 0.0 -0.658 30.0 30.0 TIAM1 0.0 0.112 -9999.0 0.0 -0.851 8.0 8.0 E-cadherin(dimer)/Ca2+ -0.026 0.108 -9999.0 0.0 -0.49 20.0 20.0 AKT1 -0.012 0.047 -9999.0 0.0 -0.468 2.0 2.0 PIK3R1 0.005 0.086 -9999.0 0.0 -0.746 6.0 6.0 CDH1 -0.033 0.193 -9999.0 0.0 -0.81 27.0 27.0 RhoA/GDP 0.048 0.096 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.012 0.043 -9999.0 0.0 -0.248 7.0 7.0 CDC42/GDP 0.048 0.096 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.006 0.096 -9999.0 0.0 -0.383 23.0 23.0 ITGB7 0.002 0.105 -9999.0 0.0 -0.85 7.0 7.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.028 0.113 -9999.0 0.0 -0.516 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.027 0.11 -9999.0 0.0 -0.499 20.0 20.0 mol:GDP 0.043 0.111 -9999.0 0.0 -0.551 1.0 1.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.006 0.089 -9999.0 0.0 -0.85 5.0 5.0 p120 catenin/RhoA/GDP -0.02 0.08 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 -0.005 0.069 -9999.0 0.0 -0.833 3.0 3.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.029 0.06 -9999.0 0.0 -0.284 13.0 13.0 NME1 0.013 0.033 -9999.0 0.0 -0.694 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.017 0.136 -9999.0 0.0 -0.601 20.0 20.0 regulation of cell-cell adhesion -0.016 0.061 -9999.0 0.0 -0.449 1.0 1.0 WASF2 -0.007 0.025 -9999.0 0.0 -0.268 1.0 1.0 Rap1/GTP -0.021 0.081 -9999.0 0.0 -0.642 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.04 0.167 -9999.0 0.0 -1.03 8.0 8.0 CCND1 0.033 0.074 -9999.0 0.0 -0.364 13.0 13.0 VAV2 0.031 0.128 -9999.0 0.0 -0.577 2.0 2.0 RAP1/GDP -0.019 0.081 -9999.0 0.0 -0.629 1.0 1.0 adherens junction assembly 0.019 0.131 -9999.0 0.0 -0.578 20.0 20.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.009 0.069 -9999.0 0.0 -0.85 3.0 3.0 regulation of heterotypic cell-cell adhesion -0.038 0.159 -9999.0 0.0 -0.985 8.0 8.0 E-cadherin/beta catenin -0.029 0.113 -9999.0 0.0 -0.453 30.0 30.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.015 0.14 -9999.0 0.0 -0.602 20.0 20.0 PIK3CA 0.013 0.04 -9999.0 0.0 -0.85 1.0 1.0 Rac1/GTP -0.028 0.106 -9999.0 0.0 -0.65 8.0 8.0 E-cadherin/beta catenin/alpha catenin -0.031 0.125 -9999.0 0.0 -0.567 20.0 20.0 ITGAE 0.01 0.057 -9999.0 0.0 -0.694 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.032 0.134 -9999.0 0.0 -0.645 20.0 20.0