Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.262 0.35 -9999.0 0.0 -0.871 67.0 67.0 IHH -0.221 0.362 -9999.0 0.0 -0.83 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.071 0.183 -9999.0 0.0 -0.497 67.0 67.0 LRPAP1 0.009 0.069 -9999.0 0.0 -0.85 3.0 3.0 dorsoventral neural tube patterning 0.07 0.182 0.493 67.0 -9999.0 0.0 67.0 SMO/beta Arrestin2 -0.173 0.266 -9999.0 0.0 -0.74 46.0 46.0 SMO -0.19 0.282 -9999.0 0.0 -0.764 53.0 53.0 AKT1 -0.068 0.151 -9999.0 0.0 -0.908 5.0 5.0 ARRB2 0.013 0.033 -9999.0 0.0 -0.694 1.0 1.0 BOC 0.0 0.112 -9999.0 0.0 -0.85 8.0 8.0 ADRBK1 0.009 0.069 -9999.0 0.0 -0.85 3.0 3.0 heart looping -0.186 0.276 -9999.0 0.0 -0.746 53.0 53.0 STIL -0.17 0.26 -9999.0 0.0 -0.684 55.0 55.0 DHH N/PTCH2 -0.102 0.237 -9999.0 0.0 -0.622 77.0 77.0 DHH N/PTCH1 -0.211 0.29 -9999.0 0.0 -0.748 66.0 66.0 PIK3CA 0.013 0.04 -9999.0 0.0 -0.85 1.0 1.0 DHH -0.063 0.239 -9999.0 0.0 -0.791 45.0 45.0 PTHLH -0.424 0.536 -9999.0 0.0 -1.226 114.0 114.0 determination of left/right symmetry -0.186 0.276 -9999.0 0.0 -0.746 53.0 53.0 PIK3R1 0.005 0.086 -9999.0 0.0 -0.746 6.0 6.0 skeletal system development -0.415 0.522 -9999.0 0.0 -1.197 114.0 114.0 IHH N/Hhip -0.286 0.358 -9999.0 0.0 -0.683 192.0 192.0 DHH N/Hhip -0.202 0.303 -9999.0 0.0 -0.618 153.0 153.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.186 0.276 -9999.0 0.0 -0.746 53.0 53.0 pancreas development -0.185 0.336 -9999.0 0.0 -0.748 122.0 122.0 HHAT 0.008 0.073 -9999.0 0.0 -0.772 4.0 4.0 PI3K -0.009 0.07 -9999.0 0.0 -0.575 7.0 7.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.018 0.155 -9999.0 0.0 -0.749 20.0 20.0 somite specification -0.186 0.276 -9999.0 0.0 -0.746 53.0 53.0 SHH Np/Cholesterol/PTCH1 -0.186 0.274 -9999.0 0.0 -0.692 67.0 67.0 SHH Np/Cholesterol/PTCH2 -0.088 0.198 -9999.0 0.0 -0.57 45.0 45.0 SHH Np/Cholesterol/Megalin -0.132 0.256 -9999.0 0.0 -0.567 109.0 109.0 SHH -0.042 0.202 -9999.0 0.0 -0.607 51.0 51.0 catabolic process -0.192 0.268 -9999.0 0.0 -0.622 95.0 95.0 SMO/Vitamin D3 -0.192 0.287 -9999.0 0.0 -0.758 57.0 57.0 SHH Np/Cholesterol/Hhip -0.167 0.259 -9999.0 0.0 -0.519 141.0 141.0 LRP2 -0.118 0.309 -9999.0 0.0 -0.837 73.0 73.0 receptor-mediated endocytosis -0.253 0.291 -9999.0 0.0 -0.821 68.0 68.0 SHH Np/Cholesterol/BOC -0.061 0.169 -9999.0 0.0 -0.495 58.0 58.0 SHH Np/Cholesterol/CDO -0.072 0.196 -9999.0 0.0 -0.534 63.0 63.0 mesenchymal cell differentiation 0.166 0.256 0.506 152.0 -9999.0 0.0 152.0 mol:Vitamin D3 -0.186 0.277 -9999.0 0.0 -0.697 67.0 67.0 IHH N/PTCH2 -0.177 0.302 -9999.0 0.0 -0.643 122.0 122.0 CDON -0.018 0.165 -9999.0 0.0 -0.842 18.0 18.0 IHH N/PTCH1 -0.194 0.272 -9999.0 0.0 -0.632 95.0 95.0 Megalin/LRPAP1 -0.104 0.238 -9999.0 0.0 -0.644 76.0 76.0 PTCH2 -0.046 0.212 -9999.0 0.0 -0.777 36.0 36.0 SHH Np/Cholesterol -0.053 0.157 -9999.0 0.0 -0.49 51.0 51.0 PTCH1 -0.192 0.269 -9999.0 0.0 -0.625 95.0 95.0 HHIP -0.185 0.337 -9999.0 0.0 -0.749 122.0 122.0