Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.015 0.087 -9999.0 0.0 -0.451 2.0 2.0 epithelial cell differentiation -0.026 0.106 -9999.0 0.0 -0.484 20.0 20.0 CYFIP2 0.001 0.107 -9999.0 0.0 -0.811 8.0 8.0 ENAH 0.047 0.113 -9999.0 0.0 -0.507 8.0 8.0 EGFR -0.023 0.173 -9999.0 0.0 -0.801 22.0 22.0 EPHA2 -0.001 0.114 -9999.0 0.0 -0.816 9.0 9.0 MYO6 0.015 0.125 -9999.0 0.0 -0.932 2.0 2.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.07 -9999.0 0.0 -0.534 8.0 8.0 AQP5 -0.043 0.132 -9999.0 0.0 -0.703 9.0 9.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.015 0.116 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.204 -9999.0 0.0 -0.858 14.0 14.0 EGF -0.225 0.365 -9999.0 0.0 -0.773 143.0 143.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.063 0.192 -9999.0 0.0 -0.722 29.0 29.0 cortical microtubule organization -0.026 0.106 -9999.0 0.0 -0.484 20.0 20.0 GO:0000145 0.015 0.11 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.108 -9999.0 0.0 -0.49 20.0 20.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.136 -9999.0 0.0 -0.769 10.0 10.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.022 0.117 -9999.0 0.0 -0.576 16.0 16.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.028 0.117 -9999.0 0.0 -0.57 4.0 4.0 PVRL2 0.011 0.056 -9999.0 0.0 -0.85 2.0 2.0 ZYX 0.015 0.118 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.02 0.106 -9999.0 0.0 -1.323 1.0 1.0 CDH1 -0.033 0.193 -9999.0 0.0 -0.81 27.0 27.0 EGFR/EGFR/EGF/EGF -0.161 0.237 -9999.0 0.0 -0.906 17.0 17.0 RhoA/GDP -0.024 0.099 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.024 0.118 -9999.0 0.0 -0.845 2.0 2.0 IGF-1R heterotetramer 0.009 0.069 -9999.0 0.0 -0.848 3.0 3.0 GIT1 0.011 0.056 -9999.0 0.0 -0.85 2.0 2.0 IGF1R 0.009 0.069 -9999.0 0.0 -0.85 3.0 3.0 IGF1 -0.033 0.185 -9999.0 0.0 -0.736 30.0 30.0 DIAPH1 -0.013 0.094 -9999.0 0.0 -0.821 6.0 6.0 Wnt receptor signaling pathway 0.026 0.106 0.484 20.0 -9999.0 0.0 20.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.036 0.136 -9999.0 0.0 -0.768 10.0 10.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.023 0.122 -9999.0 0.0 -0.886 2.0 2.0 EFNA1 -0.003 0.123 -9999.0 0.0 -0.835 10.0 10.0 LPP 0.022 0.132 -9999.0 0.0 -0.795 5.0 5.0 Ephrin A1/EPHA2 -0.041 0.154 -9999.0 0.0 -0.875 10.0 10.0 SEC6/SEC8 -0.026 0.103 -9999.0 0.0 -0.818 2.0 2.0 MGAT3 -0.032 0.209 -9999.0 0.0 -0.886 14.0 14.0 HGF/MET -0.066 0.177 -9999.0 0.0 -0.827 12.0 12.0 HGF -0.059 0.23 -9999.0 0.0 -0.769 44.0 44.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.015 0.088 -9999.0 0.0 -0.455 2.0 2.0 actin cable formation 0.068 0.109 -9999.0 0.0 -0.478 6.0 6.0 KIAA1543 0.007 0.179 -9999.0 0.0 -1.097 7.0 7.0 KIFC3 0.01 0.139 -9999.0 0.0 -0.826 4.0 4.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.008 0.073 -9999.0 0.0 -0.772 4.0 4.0 ACTN1 0.013 0.132 -9999.0 0.0 -0.825 4.0 4.0 NCK1/GIT1 -0.003 0.043 -9999.0 0.0 -0.655 2.0 2.0 mol:GDP -0.026 0.106 -9999.0 0.0 -0.484 20.0 20.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.016 0.115 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.015 0.118 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.009 0.065 -9999.0 0.0 -0.694 4.0 4.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.114 -9999.0 0.0 -0.625 10.0 10.0 adherens junction assembly 0.018 0.201 -9999.0 0.0 -0.953 14.0 14.0 IGF-1R heterotetramer/IGF1 -0.05 0.146 -9999.0 0.0 -0.746 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.003 0.043 -9999.0 0.0 -0.655 2.0 2.0 MET 0.002 0.1 -9999.0 0.0 -0.753 8.0 8.0 PLEKHA7 0.008 0.151 -9999.0 0.0 -0.932 6.0 6.0 mol:GTP -0.022 0.115 -9999.0 0.0 -0.569 16.0 16.0 establishment of epithelial cell apical/basal polarity 0.044 0.124 -9999.0 0.0 -1.034 2.0 2.0 cortical actin cytoskeleton stabilization 0.015 0.087 -9999.0 0.0 -0.451 2.0 2.0 regulation of cell-cell adhesion 0.024 0.118 -9999.0 0.0 -0.845 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.015 0.088 -9999.0 0.0 -0.455 2.0 2.0