Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	122.0	5637.0	46.0	-1.076	0.036	1000.0	-1000.0	-0.113	-1000.0
Syndecan-4-mediated signaling events	104.0	6997.0	67.0	-0.564	0.096	1000.0	-1000.0	-0.124	-1000.0
Ephrin A  reverse signaling	90.0	636.0	7.0	-0.201	-0.0	1000.0	-1000.0	-0.053	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	83.0	2833.0	34.0	-0.249	0.015	1000.0	-1000.0	-0.098	-1000.0
Glypican 2 network	78.0	315.0	4.0	-0.133	-0.054	1000.0	-1000.0	-0.058	-1000.0
PDGFR-alpha signaling pathway	76.0	3354.0	44.0	-0.243	0.03	1000.0	-1000.0	-0.086	-1000.0
IL23-mediated signaling events	69.0	4140.0	60.0	-0.548	0.015	1000.0	-1000.0	-0.192	-1000.0
IL4-mediated signaling events	68.0	6278.0	91.0	-0.783	0.58	1000.0	-1000.0	-0.169	-1000.0
Syndecan-1-mediated signaling events	63.0	2175.0	34.0	-0.297	0.015	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by the Hedgehog family	63.0	3288.0	52.0	-0.424	0.166	1000.0	-1000.0	-0.126	-1000.0
LPA4-mediated signaling events	56.0	680.0	12.0	-0.253	0.021	1000.0	-1000.0	-0.043	-1000.0
amb2 Integrin signaling	53.0	4363.0	82.0	-0.428	0.015	1000.0	-1000.0	-0.131	-1000.0
IL6-mediated signaling events	48.0	3641.0	75.0	-0.651	0.05	1000.0	-1000.0	-0.128	-1000.0
BMP receptor signaling	47.0	3841.0	81.0	-0.373	0.027	1000.0	-1000.0	-0.137	-1000.0
Wnt signaling	47.0	334.0	7.0	-0.143	0.011	1000.0	-1000.0	-0.049	-1000.0
Glypican 1 network	45.0	2191.0	48.0	-0.191	0.027	1000.0	-1000.0	-0.077	-1000.0
Endothelins	45.0	4355.0	96.0	-0.311	0.016	1000.0	-1000.0	-0.113	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	41.0	2808.0	68.0	-0.449	0.112	1000.0	-1000.0	-0.187	-1000.0
HIF-1-alpha transcription factor network	40.0	3078.0	76.0	-0.434	0.048	1000.0	-1000.0	-0.187	-1000.0
TCR signaling in naïve CD8+ T cells	40.0	3756.0	93.0	-0.206	0.04	1000.0	-1000.0	-0.128	-1000.0
IL12-mediated signaling events	38.0	3373.0	87.0	-0.312	0.108	1000.0	-1000.0	-0.164	-1000.0
p75(NTR)-mediated signaling	38.0	4826.0	125.0	-0.552	0.015	1000.0	-1000.0	-0.16	-1000.0
EGFR-dependent Endothelin signaling events	36.0	772.0	21.0	-0.225	0.015	1000.0	-1000.0	-0.108	-1000.0
IL27-mediated signaling events	35.0	1823.0	51.0	-0.232	0.094	1000.0	-1000.0	-0.131	-1000.0
EPO signaling pathway	34.0	1913.0	55.0	-0.41	0.015	1000.0	-1000.0	-0.148	-1000.0
Effects of Botulinum toxin	34.0	903.0	26.0	-0.231	0.015	1000.0	-1000.0	-0.102	-1000.0
Reelin signaling pathway	33.0	1870.0	56.0	-0.359	0.015	1000.0	-1000.0	-0.131	-1000.0
Calcium signaling in the CD4+ TCR pathway	33.0	1037.0	31.0	-0.336	0.015	1000.0	-1000.0	-0.154	-1000.0
Angiopoietin receptor Tie2-mediated signaling	33.0	2935.0	88.0	-0.372	0.076	1000.0	-1000.0	-0.166	-1000.0
Visual signal transduction: Rods	33.0	1740.0	52.0	-0.185	0.015	1000.0	-1000.0	-0.128	-1000.0
Glucocorticoid receptor regulatory network	32.0	3666.0	114.0	-0.479	0.12	1000.0	-1000.0	-0.101	-1000.0
Noncanonical Wnt signaling pathway	30.0	799.0	26.0	-0.167	0.015	1000.0	-1000.0	-0.132	-1000.0
LPA receptor mediated events	30.0	3122.0	102.0	-0.176	0.015	1000.0	-1000.0	-0.132	-1000.0
VEGFR1 specific signals	30.0	1735.0	56.0	-0.165	0.015	1000.0	-1000.0	-0.121	-1000.0
Arf6 signaling events	29.0	1852.0	62.0	-0.225	0.015	1000.0	-1000.0	-0.097	-1000.0
Signaling events regulated by Ret tyrosine kinase	27.0	2236.0	82.0	-0.213	0.015	1000.0	-1000.0	-0.134	-1000.0
Nongenotropic Androgen signaling	26.0	1373.0	52.0	-0.096	0.019	1000.0	-1000.0	-0.103	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	26.0	3336.0	125.0	-0.159	0.027	1000.0	-1000.0	-0.162	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	26.0	3213.0	120.0	-0.254	0.16	1000.0	-1000.0	-0.123	-1000.0
Integrins in angiogenesis	25.0	2109.0	84.0	-0.353	0.019	1000.0	-1000.0	-0.141	-1000.0
Visual signal transduction: Cones	24.0	914.0	38.0	-0.157	0.015	1000.0	-1000.0	-0.102	-1000.0
Thromboxane A2 receptor signaling	24.0	2603.0	105.0	-0.225	0.028	1000.0	-1000.0	-0.114	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	23.0	855.0	37.0	-0.415	0.015	1000.0	-1000.0	-0.088	-1000.0
EPHB forward signaling	23.0	1987.0	85.0	-0.201	0.095	1000.0	-1000.0	-0.148	-1000.0
FOXM1 transcription factor network	23.0	1184.0	51.0	-0.122	0.189	1000.0	-1000.0	-0.21	-1000.0
HIF-2-alpha transcription factor network	22.0	971.0	43.0	-0.292	0.09	1000.0	-1000.0	-0.126	-1000.0
BCR signaling pathway	22.0	2196.0	99.0	-0.191	0.035	1000.0	-1000.0	-0.135	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	22.0	1723.0	78.0	-0.414	0.04	1000.0	-1000.0	-0.111	-1000.0
Syndecan-2-mediated signaling events	21.0	1488.0	69.0	-0.232	0.04	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by PTP1B	21.0	1617.0	76.0	-0.226	0.023	1000.0	-1000.0	-0.108	-1000.0
S1P1 pathway	21.0	789.0	36.0	-0.092	0.015	1000.0	-1000.0	-0.081	-1000.0
JNK signaling in the CD4+ TCR pathway	20.0	355.0	17.0	-0.1	0.015	1000.0	-1000.0	-0.093	-1000.0
Canonical Wnt signaling pathway	20.0	1040.0	51.0	-0.175	0.052	1000.0	-1000.0	-0.089	-1000.0
Aurora B signaling	20.0	1358.0	67.0	-0.255	0.015	1000.0	-1000.0	-0.107	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	19.0	1035.0	54.0	-0.204	0.031	1000.0	-1000.0	-0.146	-1000.0
Fc-epsilon receptor I signaling in mast cells	19.0	1858.0	97.0	-0.159	0.032	1000.0	-1000.0	-0.137	-1000.0
Presenilin action in Notch and Wnt signaling	18.0	1158.0	61.0	-0.175	0.047	1000.0	-1000.0	-0.103	-1000.0
TCGA08_retinoblastoma	18.0	145.0	8.0	-0.03	0.019	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.015	-1000.0	1000.0	-1000.0	-0.018	-1000.0
IL1-mediated signaling events	17.0	1114.0	62.0	-0.222	0.067	1000.0	-1000.0	-0.151	-1000.0
E-cadherin signaling events	17.0	89.0	5.0	-0.037	0.015	1000.0	-1000.0	-0.07	-1000.0
Ras signaling in the CD4+ TCR pathway	17.0	291.0	17.0	-0.049	0.015	1000.0	-1000.0	-0.074	-1000.0
Ephrin B reverse signaling	16.0	784.0	48.0	-0.107	0.103	1000.0	-1000.0	-0.11	-1000.0
Signaling mediated by p38-gamma and p38-delta	16.0	246.0	15.0	-0.05	0.02	1000.0	-1000.0	-0.05	-1000.0
Coregulation of Androgen receptor activity	15.0	1144.0	76.0	-0.294	0.024	1000.0	-1000.0	-0.076	-1000.0
IL2 signaling events mediated by PI3K	15.0	873.0	58.0	-0.097	0.03	1000.0	-1000.0	-0.124	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	664.0	44.0	-0.223	0.015	1000.0	-1000.0	-0.079	-1000.0
Regulation of Telomerase	15.0	1550.0	102.0	-0.395	0.046	1000.0	-1000.0	-0.154	-1000.0
ErbB2/ErbB3 signaling events	14.0	953.0	65.0	-0.135	0.027	1000.0	-1000.0	-0.107	-1000.0
ErbB4 signaling events	14.0	1028.0	69.0	-0.159	0.07	1000.0	-1000.0	-0.137	-1000.0
Osteopontin-mediated events	14.0	534.0	38.0	-0.105	0.021	1000.0	-1000.0	-0.157	-1000.0
Cellular roles of Anthrax toxin	14.0	551.0	39.0	-0.08	0.018	1000.0	-1000.0	-0.049	-1000.0
PDGFR-beta signaling pathway	14.0	1408.0	97.0	-0.114	0.034	1000.0	-1000.0	-0.13	-1000.0
Caspase cascade in apoptosis	13.0	1013.0	74.0	-0.135	0.022	1000.0	-1000.0	-0.084	-1000.0
FAS signaling pathway (CD95)	13.0	629.0	47.0	-0.276	0.016	1000.0	-1000.0	-0.074	-1000.0
Syndecan-3-mediated signaling events	12.0	421.0	35.0	-0.137	0.015	1000.0	-1000.0	-0.113	-1000.0
IL2 signaling events mediated by STAT5	12.0	283.0	22.0	-0.086	0.016	1000.0	-1000.0	-0.072	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1090.0	86.0	-0.071	0.043	1000.0	-1000.0	-0.125	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1618.0	136.0	-0.144	0.14	1000.0	-1000.0	-0.107	-1000.0
Aurora A signaling	11.0	696.0	60.0	-0.214	0.033	1000.0	-1000.0	-0.09	-1000.0
IFN-gamma pathway	11.0	768.0	68.0	-0.238	0.027	1000.0	-1000.0	-0.141	-1000.0
Ceramide signaling pathway	11.0	841.0	76.0	-0.225	0.065	1000.0	-1000.0	-0.109	-1000.0
S1P3 pathway	11.0	481.0	42.0	-0.055	0.02	1000.0	-1000.0	-0.082	-1000.0
Regulation of Androgen receptor activity	11.0	770.0	70.0	-0.285	0.035	1000.0	-1000.0	-0.104	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	295.0	28.0	-0.045	0.015	1000.0	-1000.0	-0.084	-1000.0
PLK2 and PLK4 events	10.0	30.0	3.0	-0.004	0.007	1000.0	-1000.0	-0.027	-1000.0
a4b1 and a4b7 Integrin signaling	10.0	54.0	5.0	-0.029	0.002	1000.0	-1000.0	-0.054	-1000.0
Regulation of p38-alpha and p38-beta	10.0	545.0	54.0	-0.161	0.015	1000.0	-1000.0	-0.096	-1000.0
TCGA08_rtk_signaling	10.0	267.0	26.0	-0.223	0.036	1000.0	-1000.0	-0.032	-1000.0
p38 MAPK signaling pathway	10.0	447.0	44.0	-0.185	0.021	1000.0	-1000.0	-0.093	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	9.0	821.0	85.0	-0.096	0.043	1000.0	-1000.0	-0.106	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	636.0	65.0	-0.326	0.062	1000.0	-1000.0	-0.086	-1000.0
Aurora C signaling	9.0	67.0	7.0	-0.047	-0.0	1000.0	-1000.0	-0.069	-1000.0
PLK1 signaling events	9.0	834.0	85.0	-0.044	0.019	1000.0	-1000.0	-0.081	-1000.0
Insulin-mediated glucose transport	9.0	311.0	32.0	-0.187	0.032	1000.0	-1000.0	-0.104	-1000.0
Nectin adhesion pathway	9.0	614.0	63.0	-0.055	0.05	1000.0	-1000.0	-0.106	-1000.0
S1P5 pathway	9.0	168.0	17.0	-0.035	0.034	1000.0	-1000.0	-0.074	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	504.0	52.0	-0.109	0.03	1000.0	-1000.0	-0.098	-1000.0
FoxO family signaling	9.0	577.0	64.0	-0.468	0.116	1000.0	-1000.0	-0.108	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	9.0	421.0	45.0	-0.089	0.046	1000.0	-1000.0	-0.141	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	690.0	74.0	-0.225	0.068	1000.0	-1000.0	-0.142	-1000.0
Insulin Pathway	9.0	717.0	74.0	-0.084	0.032	1000.0	-1000.0	-0.126	-1000.0
TRAIL signaling pathway	8.0	421.0	48.0	-0.038	0.042	1000.0	-1000.0	-0.105	-1000.0
TCGA08_p53	8.0	62.0	7.0	-0.022	0.018	1000.0	-1000.0	-0.021	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	272.0	33.0	-0.095	0.035	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by PRL	8.0	301.0	34.0	-0.073	0.019	1000.0	-1000.0	-0.07	-1000.0
BARD1 signaling events	7.0	411.0	57.0	-0.031	0.05	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by HDAC Class III	7.0	299.0	40.0	-0.087	0.027	1000.0	-1000.0	-0.068	-1000.0
ceramide signaling pathway	7.0	372.0	49.0	-0.08	0.033	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	7.0	589.0	76.0	-0.042	0.049	1000.0	-1000.0	-0.128	-1000.0
Class I PI3K signaling events	7.0	566.0	73.0	-0.138	0.034	1000.0	-1000.0	-0.114	-1000.0
IGF1 pathway	7.0	428.0	57.0	-0.053	0.03	1000.0	-1000.0	-0.143	-1000.0
E-cadherin signaling in keratinocytes	7.0	322.0	43.0	-0.144	0.034	1000.0	-1000.0	-0.104	-1000.0
S1P4 pathway	7.0	198.0	25.0	-0.031	0.022	1000.0	-1000.0	-0.08	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	570.0	83.0	-0.187	0.056	1000.0	-1000.0	-0.118	-1000.0
Canonical NF-kappaB pathway	5.0	204.0	39.0	-0.08	0.085	1000.0	-1000.0	-0.138	-1000.0
Atypical NF-kappaB pathway	5.0	158.0	31.0	-0.041	0.036	1000.0	-1000.0	-0.111	-1000.0
Signaling events mediated by HDAC Class II	4.0	343.0	75.0	-0.035	0.033	1000.0	-1000.0	-0.104	-1000.0
Circadian rhythm pathway	4.0	88.0	22.0	-0.015	0.041	1000.0	-1000.0	-0.097	-1000.0
mTOR signaling pathway	4.0	262.0	53.0	-0.018	0.03	1000.0	-1000.0	-0.086	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	276.0	68.0	-0.187	0.054	1000.0	-1000.0	-0.096	-1000.0
Retinoic acid receptors-mediated signaling	4.0	252.0	58.0	-0.032	0.041	1000.0	-1000.0	-0.117	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	174.0	36.0	-0.064	0.026	1000.0	-1000.0	-0.104	-1000.0
Arf6 trafficking events	4.0	328.0	71.0	-0.055	0.047	1000.0	-1000.0	-0.116	-1000.0
Alternative NF-kappaB pathway	4.0	56.0	13.0	-0.022	0.015	1000.0	-1000.0	-0.099	-1000.0
Arf6 downstream pathway	3.0	168.0	43.0	-0.025	0.025	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class I	3.0	412.0	104.0	-0.08	0.062	1000.0	-1000.0	-0.106	-1000.0
Rapid glucocorticoid signaling	3.0	78.0	20.0	-0.019	0.015	1000.0	-1000.0	-0.065	-1000.0
Arf1 pathway	2.0	126.0	54.0	-0.014	0.032	1000.0	-1000.0	-0.075	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	36.0	23.0	-0.01	0.051	1000.0	-1000.0	-0.108	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.002	0.033	1000.0	-1000.0	-0.088	-1000.0
Total	2961	168283	7203	-25.2000530441	-994.496564936	131000	-131000	-13.9521708321	-131000