E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.032 0.128 -9999.0 0.0 -0.455 18.0 18.0 KLHL20 0.011 0.076 0.181 7.0 -0.289 4.0 11.0 CYFIP2 0.016 0.069 -9999.0 0.0 -0.529 7.0 7.0 Rac1/GDP 0.007 0.09 0.292 5.0 -0.327 4.0 9.0 ENAH -0.029 0.126 -9999.0 0.0 -0.464 18.0 18.0 AP1M1 0.03 0.028 -9999.0 0.0 -0.559 1.0 1.0 RAP1B 0.03 0.018 -9999.0 0.0 -0.345 1.0 1.0 RAP1A 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.022 0.058 -9999.0 0.0 -0.318 1.0 1.0 ABI1/Sra1/Nap1 -0.015 0.038 -9999.0 0.0 -0.195 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.033 0.104 -9999.0 0.0 -0.389 20.0 20.0 RAPGEF1 -0.029 0.124 0.259 2.0 -0.419 14.0 16.0 CTNND1 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.134 -9999.0 0.0 -0.469 19.0 19.0 CRK -0.037 0.129 -9999.0 0.0 -0.44 16.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.03 0.086 -9999.0 0.0 -0.381 15.0 15.0 alphaE/beta7 Integrin 0.036 0.062 -9999.0 0.0 -0.39 9.0 9.0 IQGAP1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.053 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.029 0.124 -9999.0 0.0 -0.461 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.003 0.037 -9999.0 0.0 -0.246 2.0 2.0 MLLT4 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.052 0.03 -9999.0 0.0 -0.32 1.0 1.0 PI3K -0.001 0.049 -9999.0 0.0 -0.323 2.0 2.0 ARF6 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.103 -9999.0 0.0 -0.406 23.0 23.0 TIAM1 0.028 0.039 -9999.0 0.0 -0.559 2.0 2.0 E-cadherin(dimer)/Ca2+ 0.032 0.071 -9999.0 0.0 -0.3 12.0 12.0 AKT1 0.007 0.04 0.128 1.0 -0.33 2.0 3.0 PIK3R1 0.023 0.052 -9999.0 0.0 -0.416 6.0 6.0 CDH1 0.005 0.115 -9999.0 0.0 -0.501 22.0 22.0 RhoA/GDP 0.025 0.087 0.316 8.0 -0.312 5.0 13.0 actin cytoskeleton organization 0.012 0.062 0.177 13.0 -0.206 4.0 17.0 CDC42/GDP 0.013 0.108 0.347 12.0 -0.321 4.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.062 -9999.0 0.0 -0.288 15.0 15.0 ITGB7 0.022 0.072 -9999.0 0.0 -0.559 7.0 7.0 RAC1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.076 -9999.0 0.0 -0.318 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.021 0.065 -9999.0 0.0 -0.299 12.0 12.0 mol:GDP -0.002 0.114 0.378 10.0 -0.35 12.0 22.0 CDC42/GTP/IQGAP1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.061 -9999.0 0.0 -0.559 5.0 5.0 p120 catenin/RhoA/GDP 0.005 0.086 0.298 3.0 -0.321 4.0 7.0 RAC1/GTP/IQGAP1 0.038 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.048 -9999.0 0.0 -0.521 3.0 3.0 RHOA 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.013 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.056 0.172 9.0 -0.216 11.0 20.0 NME1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.032 0.128 -9999.0 0.0 -0.468 17.0 17.0 regulation of cell-cell adhesion 0.006 0.046 -9999.0 0.0 -0.278 1.0 1.0 WASF2 0.013 0.035 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.027 0.069 0.243 3.0 -0.359 1.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.108 -9999.0 0.0 -0.38 20.0 20.0 CCND1 0.012 0.067 0.195 9.0 -0.27 11.0 20.0 VAV2 -0.036 0.175 -9999.0 0.0 -0.58 21.0 21.0 RAP1/GDP 0.029 0.083 0.311 5.0 -0.349 1.0 6.0 adherens junction assembly -0.031 0.124 -9999.0 0.0 -0.452 17.0 17.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.048 -9999.0 0.0 -0.559 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.041 0.109 -9999.0 0.0 -0.545 6.0 6.0 E-cadherin/beta catenin -0.005 0.079 -9999.0 0.0 -0.363 20.0 20.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.127 -9999.0 0.0 -0.46 17.0 17.0 PIK3CA 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.038 0.085 -9999.0 0.0 -0.381 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.024 0.075 -9999.0 0.0 -0.348 12.0 12.0 ITGAE 0.028 0.031 -9999.0 0.0 -0.345 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.137 -9999.0 0.0 -0.479 19.0 19.0