Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.164 0.247 -9999.0 0.0 -0.596 84.0 84.0 IHH -0.125 0.233 -9999.0 0.0 -0.514 111.0 111.0 SHH Np/Cholesterol/GAS1 -0.007 0.096 -9999.0 0.0 -0.331 27.0 27.0 LRPAP1 0.027 0.048 -9999.0 0.0 -0.559 3.0 3.0 dorsoventral neural tube patterning 0.007 0.096 0.329 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.103 0.198 -9999.0 0.0 -0.528 42.0 42.0 SMO -0.114 0.2 -9999.0 0.0 -0.538 47.0 47.0 AKT1 -0.053 0.162 -9999.0 0.0 -0.627 23.0 23.0 ARRB2 0.03 0.018 -9999.0 0.0 -0.352 1.0 1.0 BOC 0.02 0.072 -9999.0 0.0 -0.559 7.0 7.0 ADRBK1 0.027 0.048 -9999.0 0.0 -0.559 3.0 3.0 heart looping -0.112 0.197 -9999.0 0.0 -0.529 47.0 47.0 STIL -0.09 0.164 -9999.0 0.0 -0.424 46.0 46.0 DHH N/PTCH2 -0.018 0.149 -9999.0 0.0 -0.348 72.0 72.0 DHH N/PTCH1 -0.12 0.194 -9999.0 0.0 -0.487 59.0 59.0 PIK3CA 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.017 0.151 -9999.0 0.0 -0.48 43.0 43.0 PTHLH -0.264 0.389 -9999.0 0.0 -0.957 92.0 92.0 determination of left/right symmetry -0.112 0.197 -9999.0 0.0 -0.529 47.0 47.0 PIK3R1 0.023 0.052 -9999.0 0.0 -0.416 6.0 6.0 skeletal system development -0.261 0.382 -9999.0 0.0 -0.942 92.0 92.0 IHH N/Hhip -0.146 0.208 -9999.0 0.0 -0.392 168.0 168.0 DHH N/Hhip -0.074 0.187 -9999.0 0.0 -0.334 143.0 143.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.112 0.197 -9999.0 0.0 -0.529 47.0 47.0 pancreas development -0.084 0.202 -9999.0 0.0 -0.419 118.0 118.0 HHAT 0.027 0.037 -9999.0 0.0 -0.416 3.0 3.0 PI3K 0.037 0.042 -9999.0 0.0 -0.296 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.085 -9999.0 0.0 -0.408 17.0 17.0 somite specification -0.112 0.197 -9999.0 0.0 -0.529 47.0 47.0 SHH Np/Cholesterol/PTCH1 -0.101 0.164 -9999.0 0.0 -0.435 51.0 51.0 SHH Np/Cholesterol/PTCH2 -0.016 0.109 -9999.0 0.0 -0.329 38.0 38.0 SHH Np/Cholesterol/Megalin -0.038 0.143 -9999.0 0.0 -0.361 65.0 65.0 SHH -0.016 0.104 -9999.0 0.0 -0.337 41.0 41.0 catabolic process -0.119 0.184 -9999.0 0.0 -0.425 76.0 76.0 SMO/Vitamin D3 -0.107 0.187 -9999.0 0.0 -0.486 52.0 52.0 SHH Np/Cholesterol/Hhip -0.055 0.142 -9999.0 0.0 -0.346 66.0 66.0 LRP2 -0.047 0.196 -9999.0 0.0 -0.542 62.0 62.0 receptor-mediated endocytosis -0.132 0.209 -9999.0 0.0 -0.523 67.0 67.0 SHH Np/Cholesterol/BOC -0.002 0.091 -9999.0 0.0 -0.321 27.0 27.0 SHH Np/Cholesterol/CDO -0.007 0.109 -9999.0 0.0 -0.364 31.0 31.0 mesenchymal cell differentiation 0.054 0.141 0.343 66.0 -9999.0 0.0 66.0 mol:Vitamin D3 -0.093 0.175 -9999.0 0.0 -0.44 50.0 50.0 IHH N/PTCH2 -0.087 0.177 -9999.0 0.0 -0.38 103.0 103.0 CDON 0.012 0.103 -9999.0 0.0 -0.545 15.0 15.0 IHH N/PTCH1 -0.116 0.189 -9999.0 0.0 -0.43 76.0 76.0 Megalin/LRPAP1 -0.018 0.153 -9999.0 0.0 -0.396 63.0 63.0 PTCH2 -0.004 0.127 -9999.0 0.0 -0.449 33.0 33.0 SHH Np/Cholesterol -0.008 0.082 -9999.0 0.0 -0.322 23.0 23.0 PTCH1 -0.119 0.184 -9999.0 0.0 -0.427 76.0 76.0 HHIP -0.085 0.203 -9999.0 0.0 -0.419 118.0 118.0