Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.056 -9999.0 0.0 -0.277 12.0 12.0 epithelial cell differentiation 0.028 0.068 -9999.0 0.0 -0.297 12.0 12.0 CYFIP2 0.016 0.069 -9999.0 0.0 -0.529 7.0 7.0 ENAH 0.03 0.104 0.359 13.0 -0.385 5.0 18.0 EGFR 0.007 0.106 -9999.0 0.0 -0.512 18.0 18.0 EPHA2 0.023 0.06 -9999.0 0.0 -0.488 6.0 6.0 MYO6 0.049 0.105 0.395 9.0 -0.301 13.0 22.0 CTNNB1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.04 0.054 -9999.0 0.0 -0.348 6.0 6.0 AQP5 0.019 0.097 -9999.0 0.0 -0.518 5.0 5.0 CTNND1 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.048 0.106 0.424 8.0 -0.281 14.0 22.0 regulation of calcium-dependent cell-cell adhesion 0.026 0.135 0.384 7.0 -0.343 33.0 40.0 EGF -0.11 0.227 -9999.0 0.0 -0.453 135.0 135.0 NCKAP1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.001 0.156 -9999.0 0.0 -0.564 25.0 25.0 cortical microtubule organization 0.028 0.068 -9999.0 0.0 -0.297 12.0 12.0 GO:0000145 0.036 0.104 0.391 9.0 -0.268 14.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.032 0.071 -9999.0 0.0 -0.299 12.0 12.0 MLLT4 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.009 0.068 -9999.0 0.0 -0.484 6.0 6.0 ARF6 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.075 -9999.0 0.0 -0.384 9.0 9.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.028 0.083 0.29 2.0 -0.302 2.0 4.0 PVRL2 0.028 0.039 -9999.0 0.0 -0.559 2.0 2.0 ZYX 0.037 0.093 0.358 4.0 -0.286 14.0 18.0 ARF6/GTP 0.066 0.072 -9999.0 0.0 -0.376 7.0 7.0 CDH1 0.005 0.115 -9999.0 0.0 -0.501 22.0 22.0 EGFR/EGFR/EGF/EGF -0.048 0.138 -9999.0 0.0 -0.322 60.0 60.0 RhoA/GDP 0.03 0.066 -9999.0 0.0 -0.28 12.0 12.0 actin cytoskeleton organization 0.038 0.096 0.341 8.0 -0.299 10.0 18.0 IGF-1R heterotetramer 0.027 0.047 -9999.0 0.0 -0.559 3.0 3.0 GIT1 0.028 0.039 -9999.0 0.0 -0.559 2.0 2.0 IGF1R 0.027 0.048 -9999.0 0.0 -0.559 3.0 3.0 IGF1 0.004 0.107 -9999.0 0.0 -0.406 28.0 28.0 DIAPH1 0.031 0.119 -9999.0 0.0 -0.687 8.0 8.0 Wnt receptor signaling pathway -0.028 0.068 0.297 12.0 -9999.0 0.0 12.0 RHOA 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.069 -9999.0 0.0 -0.506 6.0 6.0 CTNNA1 0.024 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.039 0.097 0.343 8.0 -0.305 10.0 18.0 EFNA1 0.021 0.069 -9999.0 0.0 -0.529 7.0 7.0 LPP 0.032 0.095 0.372 4.0 -0.311 11.0 15.0 Ephrin A1/EPHA2 0.019 0.084 -9999.0 0.0 -0.412 11.0 11.0 SEC6/SEC8 -0.001 0.058 -9999.0 0.0 -0.519 2.0 2.0 MGAT3 0.026 0.137 0.386 7.0 -0.349 33.0 40.0 HGF/MET 0.005 0.099 -9999.0 0.0 -0.419 10.0 10.0 HGF -0.011 0.133 -9999.0 0.0 -0.441 38.0 38.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.057 -9999.0 0.0 -0.279 12.0 12.0 actin cable formation 0.073 0.126 0.277 72.0 -0.38 4.0 76.0 KIAA1543 0.032 0.11 0.332 8.0 -0.341 15.0 23.0 KIFC3 0.038 0.099 -9999.0 0.0 -0.318 15.0 15.0 NCK1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.047 -9999.0 0.0 -0.452 4.0 4.0 ACTN1 0.042 0.102 0.468 5.0 -0.314 11.0 16.0 NCK1/GIT1 0.042 0.032 -9999.0 0.0 -0.411 2.0 2.0 mol:GDP 0.028 0.068 -9999.0 0.0 -0.297 12.0 12.0 EXOC4 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.04 0.092 -9999.0 0.0 -0.286 14.0 14.0 PIP5K1C 0.048 0.107 0.427 8.0 -0.285 14.0 22.0 LIMA1 0.029 0.025 -9999.0 0.0 -0.345 2.0 2.0 ABI1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.049 0.116 0.39 15.0 -0.438 6.0 21.0 adherens junction assembly 0.042 0.161 0.45 14.0 -0.632 11.0 25.0 IGF-1R heterotetramer/IGF1 0.014 0.083 -9999.0 0.0 -0.377 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.033 -9999.0 0.0 -0.411 2.0 2.0 MET 0.023 0.054 -9999.0 0.0 -0.474 5.0 5.0 PLEKHA7 0.043 0.113 0.36 7.0 -0.347 17.0 24.0 mol:GTP 0.058 0.074 -9999.0 0.0 -0.381 9.0 9.0 establishment of epithelial cell apical/basal polarity 0.062 0.136 0.367 43.0 -0.71 2.0 45.0 cortical actin cytoskeleton stabilization 0.009 0.056 -9999.0 0.0 -0.277 12.0 12.0 regulation of cell-cell adhesion 0.038 0.096 0.341 8.0 -0.299 10.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.057 -9999.0 0.0 -0.279 12.0 12.0