Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	107.0	4965.0	46.0	-0.852	0.035	1000.0	-1000.0	-0.105	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	77.0	2646.0	34.0	-0.13	0.031	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	77.0	5220.0	67.0	-0.339	0.063	1000.0	-1000.0	-0.046	-1000.0
Ephrin A  reverse signaling	72.0	504.0	7.0	-0.084	0.01	1000.0	-1000.0	-0.007	-1000.0
Glypican 2 network	67.0	270.0	4.0	-0.034	-0.006	1000.0	-1000.0	0.002	-1000.0
PDGFR-alpha signaling pathway	66.0	2915.0	44.0	-0.138	0.038	1000.0	-1000.0	-0.053	-1000.0
IL4-mediated signaling events	55.0	5015.0	91.0	-0.69	0.535	1000.0	-1000.0	-0.132	-1000.0
Syndecan-1-mediated signaling events	54.0	1860.0	34.0	-0.157	0.031	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	52.0	370.0	7.0	-0.092	0.028	1000.0	-1000.0	-0.02	-1000.0
LPA4-mediated signaling events	50.0	606.0	12.0	-0.138	0.009	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by the Hedgehog family	50.0	2627.0	52.0	-0.264	0.054	1000.0	-1000.0	-0.048	-1000.0
IL23-mediated signaling events	50.0	3050.0	60.0	-0.482	0.031	1000.0	-1000.0	-0.131	-1000.0
EPO signaling pathway	49.0	2713.0	55.0	-0.206	0.031	1000.0	-1000.0	-0.051	-1000.0
Endothelins	47.0	4561.0	96.0	-0.191	0.031	1000.0	-1000.0	-0.069	-1000.0
amb2 Integrin signaling	46.0	3795.0	82.0	-0.226	0.04	1000.0	-1000.0	-0.047	-1000.0
BMP receptor signaling	43.0	3541.0	81.0	-0.196	0.054	1000.0	-1000.0	-0.065	-1000.0
EGFR-dependent Endothelin signaling events	42.0	896.0	21.0	-0.11	0.045	1000.0	-1000.0	-0.048	-1000.0
HIF-1-alpha transcription factor network	41.0	3136.0	76.0	-0.379	0.044	1000.0	-1000.0	-0.128	-1000.0
Signaling mediated by p38-alpha and p38-beta	40.0	1803.0	44.0	-0.14	0.03	1000.0	-1000.0	-0.03	-1000.0
IL6-mediated signaling events	40.0	3042.0	75.0	-0.508	0.04	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	39.0	1030.0	26.0	-0.092	0.03	1000.0	-1000.0	-0.049	-1000.0
TCR signaling in naïve CD8+ T cells	36.0	3436.0	93.0	-0.108	0.074	1000.0	-1000.0	-0.066	-1000.0
p75(NTR)-mediated signaling	35.0	4488.0	125.0	-0.272	0.08	1000.0	-1000.0	-0.071	-1000.0
IL12-mediated signaling events	33.0	2875.0	87.0	-0.245	0.053	1000.0	-1000.0	-0.092	-1000.0
Calcium signaling in the CD4+ TCR pathway	33.0	1031.0	31.0	-0.213	0.03	1000.0	-1000.0	-0.059	-1000.0
Angiopoietin receptor Tie2-mediated signaling	33.0	2959.0	88.0	-0.193	0.039	1000.0	-1000.0	-0.09	-1000.0
Fc-epsilon receptor I signaling in mast cells	32.0	3140.0	97.0	-0.23	0.038	1000.0	-1000.0	-0.062	-1000.0
Reelin signaling pathway	31.0	1739.0	56.0	-0.133	0.077	1000.0	-1000.0	-0.049	-1000.0
Effects of Botulinum toxin	31.0	827.0	26.0	-0.114	0.031	1000.0	-1000.0	-0.02	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	31.0	2158.0	68.0	-0.288	0.087	1000.0	-1000.0	-0.118	-1000.0
Visual signal transduction: Rods	31.0	1657.0	52.0	-0.09	0.031	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	30.0	3160.0	105.0	-0.11	0.031	1000.0	-1000.0	-0.052	-1000.0
Arf6 signaling events	29.0	1859.0	62.0	-0.11	0.061	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	29.0	1487.0	51.0	-0.13	0.072	1000.0	-1000.0	-0.054	-1000.0
LPA receptor mediated events	29.0	3016.0	102.0	-0.107	0.031	1000.0	-1000.0	-0.069	-1000.0
Glucocorticoid receptor regulatory network	28.0	3257.0	114.0	-0.362	0.09	1000.0	-1000.0	-0.066	-1000.0
Glypican 1 network	27.0	1311.0	48.0	-0.089	0.038	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	26.0	1388.0	52.0	-0.076	0.047	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	26.0	1510.0	56.0	-0.074	0.031	1000.0	-1000.0	-0.053	-1000.0
Signaling events regulated by Ret tyrosine kinase	25.0	2097.0	82.0	-0.08	0.031	1000.0	-1000.0	-0.071	-1000.0
HIF-2-alpha transcription factor network	25.0	1095.0	43.0	-0.222	0.063	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	25.0	3180.0	125.0	-0.05	0.045	1000.0	-1000.0	-0.055	-1000.0
EPHB forward signaling	24.0	2076.0	85.0	-0.093	0.045	1000.0	-1000.0	-0.07	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	22.0	822.0	37.0	-0.208	0.065	1000.0	-1000.0	-0.037	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	22.0	2713.0	120.0	-0.108	0.084	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Cones	21.0	816.0	38.0	-0.066	0.041	1000.0	-1000.0	-0.021	-1000.0
IFN-gamma pathway	21.0	1429.0	68.0	-0.121	0.043	1000.0	-1000.0	-0.061	-1000.0
Integrins in angiogenesis	21.0	1811.0	84.0	-0.185	0.067	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by PTP1B	20.0	1556.0	76.0	-0.11	0.037	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	20.0	731.0	36.0	-0.073	0.03	1000.0	-1000.0	-0.046	-1000.0
BCR signaling pathway	20.0	2041.0	99.0	-0.076	0.061	1000.0	-1000.0	-0.068	-1000.0
Plasma membrane estrogen receptor signaling	20.0	1772.0	86.0	-0.136	0.054	1000.0	-1000.0	-0.065	-1000.0
FOXM1 transcription factor network	20.0	1026.0	51.0	-0.015	0.11	1000.0	-1000.0	-0.142	-1000.0
JNK signaling in the CD4+ TCR pathway	19.0	333.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.044	-1000.0
ErbB2/ErbB3 signaling events	18.0	1204.0	65.0	-0.162	0.044	1000.0	-1000.0	-0.065	-1000.0
Ephrin B reverse signaling	18.0	888.0	48.0	-0.037	0.031	1000.0	-1000.0	-0.042	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	17.0	945.0	54.0	-0.089	0.043	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	17.0	884.0	51.0	-0.073	0.042	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	17.0	1402.0	78.0	-0.208	0.037	1000.0	-1000.0	-0.057	-1000.0
Aurora B signaling	17.0	1174.0	67.0	-0.183	0.059	1000.0	-1000.0	-0.041	-1000.0
Ceramide signaling pathway	16.0	1284.0	76.0	-0.11	0.076	1000.0	-1000.0	-0.047	-1000.0
IL1-mediated signaling events	16.0	1042.0	62.0	-0.102	0.055	1000.0	-1000.0	-0.059	-1000.0
Class IB PI3K non-lipid kinase events	16.0	48.0	3.0	-0.015	0.015	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	949.0	61.0	-0.073	0.08	1000.0	-1000.0	-0.056	-1000.0
PLK1 signaling events	15.0	1328.0	85.0	-0.108	0.044	1000.0	-1000.0	-0.038	-1000.0
FoxO family signaling	15.0	1001.0	64.0	-0.385	0.078	1000.0	-1000.0	-0.072	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	15.0	1112.0	74.0	-0.11	0.073	1000.0	-1000.0	-0.07	-1000.0
Ras signaling in the CD4+ TCR pathway	15.0	260.0	17.0	-0.017	0.052	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	14.0	1124.0	76.0	-0.185	0.056	1000.0	-1000.0	-0.024	-1000.0
Cellular roles of Anthrax toxin	14.0	565.0	39.0	-0.054	0.031	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by PI3K	14.0	820.0	58.0	-0.036	0.048	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	13.0	1033.0	74.0	-0.094	0.062	1000.0	-1000.0	-0.048	-1000.0
FAS signaling pathway (CD95)	13.0	646.0	47.0	-0.213	0.045	1000.0	-1000.0	-0.046	-1000.0
Syndecan-3-mediated signaling events	13.0	465.0	35.0	-0.057	0.08	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	13.0	293.0	22.0	-0.049	0.031	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling events	13.0	68.0	5.0	0.005	0.024	1000.0	-1000.0	0.008	-1000.0
Syndecan-2-mediated signaling events	12.0	870.0	69.0	-0.111	0.052	1000.0	-1000.0	-0.044	-1000.0
ceramide signaling pathway	12.0	615.0	49.0	-0.026	0.043	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events	12.0	918.0	73.0	-0.056	0.073	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	12.0	98.0	8.0	-0.004	0.028	1000.0	-1000.0	-0.007	-1000.0
Regulation of Telomerase	12.0	1268.0	102.0	-0.218	0.064	1000.0	-1000.0	-0.072	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	12.0	419.0	33.0	-0.103	0.057	1000.0	-1000.0	-0.042	-1000.0
PDGFR-beta signaling pathway	12.0	1222.0	97.0	-0.055	0.058	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	12.0	842.0	70.0	-0.182	0.051	1000.0	-1000.0	-0.047	-1000.0
ErbB4 signaling events	11.0	765.0	69.0	-0.072	0.043	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-gamma and p38-delta	11.0	173.0	15.0	-0.043	0.028	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	11.0	495.0	45.0	-0.039	0.078	1000.0	-1000.0	-0.059	-1000.0
Regulation of p38-alpha and p38-beta	11.0	612.0	54.0	-0.077	0.066	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	11.0	298.0	26.0	-0.109	0.062	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	282.0	28.0	-0.005	0.048	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	10.0	400.0	38.0	-0.032	0.055	1000.0	-1000.0	-0.052	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	866.0	85.0	-0.083	0.051	1000.0	-1000.0	-0.057	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	659.0	65.0	-0.212	0.08	1000.0	-1000.0	-0.046	-1000.0
Nectin adhesion pathway	10.0	666.0	63.0	-0.016	0.053	1000.0	-1000.0	-0.057	-1000.0
S1P3 pathway	10.0	437.0	42.0	-0.026	0.041	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in keratinocytes	10.0	450.0	43.0	-0.058	0.033	1000.0	-1000.0	-0.045	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1323.0	136.0	-0.1	0.1	1000.0	-1000.0	-0.058	-1000.0
Insulin-mediated glucose transport	9.0	314.0	32.0	-0.081	0.057	1000.0	-1000.0	-0.04	-1000.0
mTOR signaling pathway	9.0	529.0	53.0	-0.079	0.045	1000.0	-1000.0	-0.043	-1000.0
Insulin Pathway	9.0	675.0	74.0	-0.047	0.067	1000.0	-1000.0	-0.048	-1000.0
S1P4 pathway	9.0	229.0	25.0	-0.002	0.046	1000.0	-1000.0	-0.027	-1000.0
p38 MAPK signaling pathway	9.0	413.0	44.0	-0.077	0.05	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	8.0	25.0	3.0	0.008	0.027	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	8.0	61.0	7.0	-0.001	0.033	1000.0	-1000.0	-0.009	-1000.0
S1P5 pathway	8.0	150.0	17.0	-0.008	0.031	1000.0	-1000.0	-0.016	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	465.0	52.0	-0.05	0.058	1000.0	-1000.0	-0.075	-1000.0
IGF1 pathway	8.0	480.0	57.0	-0.08	0.069	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PRL	8.0	275.0	34.0	-0.043	0.045	1000.0	-1000.0	-0.049	-1000.0
a4b1 and a4b7 Integrin signaling	7.0	37.0	5.0	0.019	0.035	1000.0	-1000.0	0.003	-1000.0
TRAIL signaling pathway	7.0	365.0	48.0	-0.0	0.068	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	7.0	49.0	7.0	-0.007	0.028	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling in the nascent adherens junction	7.0	603.0	76.0	-0.038	0.053	1000.0	-1000.0	-0.071	-1000.0
BARD1 signaling events	6.0	390.0	57.0	-0.057	0.071	1000.0	-1000.0	-0.052	-1000.0
Aurora A signaling	6.0	395.0	60.0	-0.102	0.06	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events mediated by Akt	6.0	441.0	68.0	-0.081	0.057	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	6.0	276.0	40.0	-0.055	0.056	1000.0	-1000.0	-0.022	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	559.0	83.0	-0.081	0.057	1000.0	-1000.0	-0.043	-1000.0
Arf6 trafficking events	6.0	465.0	71.0	-0.052	0.054	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	5.0	207.0	39.0	-0.027	0.06	1000.0	-1000.0	-0.037	-1000.0
Arf6 downstream pathway	5.0	226.0	43.0	-0.045	0.046	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	5.0	310.0	58.0	-0.03	0.053	1000.0	-1000.0	-0.043	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	190.0	36.0	-0.056	0.058	1000.0	-1000.0	-0.043	-1000.0
Atypical NF-kappaB pathway	5.0	178.0	31.0	-0.0	0.037	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	4.0	318.0	75.0	-0.038	0.058	1000.0	-1000.0	-0.03	-1000.0
Arf1 pathway	4.0	231.0	54.0	-0.001	0.051	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class I	3.0	359.0	104.0	-0.059	0.072	1000.0	-1000.0	-0.046	-1000.0
Rapid glucocorticoid signaling	3.0	68.0	20.0	-0.0	0.036	1000.0	-1000.0	-0.004	-1000.0
Alternative NF-kappaB pathway	3.0	40.0	13.0	0.0	0.055	1000.0	-1000.0	0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	67.0	23.0	-0.028	0.057	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	2.0	62.0	22.0	-0.01	0.058	1000.0	-1000.0	-0.056	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	21.0	27.0	-0.0	0.073	1000.0	-1000.0	-0.039	-1000.0
Total	2806	161047	7203	-15.1407654155	7.00697002179	131000	-131000	-6.35206742471	-131000