Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.115 0.224 -9999.0 0.0 -0.63 6.0 6.0 IHH -0.206 0.29 -9999.0 0.0 -0.585 23.0 23.0 SHH Np/Cholesterol/GAS1 -0.018 0.121 -9999.0 0.0 -0.346 7.0 7.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.12 0.344 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 -0.114 0.21 -9999.0 0.0 -0.502 7.0 7.0 SMO -0.127 0.22 -9999.0 0.0 -0.533 7.0 7.0 AKT1 -0.044 0.106 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.023 0.14 -9999.0 0.0 -0.559 4.0 4.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.125 0.217 -9999.0 0.0 -0.525 7.0 7.0 STIL -0.096 0.171 -9999.0 0.0 -0.444 6.0 6.0 DHH N/PTCH2 -0.015 0.113 -9999.0 0.0 -0.4 5.0 5.0 DHH N/PTCH1 -0.114 0.19 -9999.0 0.0 -0.532 5.0 5.0 PIK3CA 0.004 0.072 -9999.0 0.0 -0.562 1.0 1.0 DHH -0.025 0.138 -9999.0 0.0 -0.555 4.0 4.0 PTHLH -0.157 0.29 -9999.0 0.0 -0.877 5.0 5.0 determination of left/right symmetry -0.125 0.217 -9999.0 0.0 -0.525 7.0 7.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.156 0.287 -9999.0 0.0 -0.865 5.0 5.0 IHH N/Hhip -0.231 0.252 -9999.0 0.0 -0.446 34.0 34.0 DHH N/Hhip -0.121 0.206 -9999.0 0.0 -0.416 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.125 0.217 -9999.0 0.0 -0.525 7.0 7.0 pancreas development -0.141 0.252 -9999.0 0.0 -0.556 17.0 17.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.013 0.053 -9999.0 0.0 -0.404 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.099 -9999.0 0.0 -0.552 2.0 2.0 somite specification -0.125 0.217 -9999.0 0.0 -0.525 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.102 0.174 -9999.0 0.0 -0.445 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.013 0.103 -9999.0 0.0 -0.305 7.0 7.0 SHH Np/Cholesterol/Megalin -0.065 0.156 -9999.0 0.0 -0.324 16.0 16.0 SHH -0.019 0.125 -9999.0 0.0 -0.403 6.0 6.0 catabolic process -0.112 0.192 -9999.0 0.0 -0.532 4.0 4.0 SMO/Vitamin D3 -0.115 0.197 -9999.0 0.0 -0.487 7.0 7.0 SHH Np/Cholesterol/Hhip -0.095 0.183 -9999.0 0.0 -0.348 20.0 20.0 LRP2 -0.087 0.218 -9999.0 0.0 -0.562 11.0 11.0 receptor-mediated endocytosis -0.143 0.249 -9999.0 0.0 -0.546 14.0 14.0 SHH Np/Cholesterol/BOC -0.029 0.12 -9999.0 0.0 -0.305 10.0 10.0 SHH Np/Cholesterol/CDO -0.023 0.114 -9999.0 0.0 -0.303 9.0 9.0 mesenchymal cell differentiation 0.095 0.181 0.346 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 -0.102 0.177 -9999.0 0.0 -0.448 7.0 7.0 IHH N/PTCH2 -0.122 0.185 -9999.0 0.0 -0.355 24.0 24.0 CDON -0.014 0.12 -9999.0 0.0 -0.552 3.0 3.0 IHH N/PTCH1 -0.113 0.195 -9999.0 0.0 -0.539 4.0 4.0 Megalin/LRPAP1 -0.054 0.161 -9999.0 0.0 -0.404 11.0 11.0 PTCH2 0.004 0.072 -9999.0 0.0 -0.562 1.0 1.0 SHH Np/Cholesterol -0.016 0.096 -9999.0 0.0 -0.312 6.0 6.0 PTCH1 -0.113 0.193 -9999.0 0.0 -0.534 4.0 4.0 HHIP -0.141 0.253 -9999.0 0.0 -0.557 17.0 17.0