Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.097 -9999.0 0.0 -0.245 7.0 7.0 epithelial cell differentiation -0.057 0.112 -9999.0 0.0 -0.279 7.0 7.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.013 0.094 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.023 0.14 -9999.0 0.0 -0.562 4.0 4.0 EPHA2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.112 0.172 -9999.0 0.0 -0.519 7.0 7.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.025 0.117 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.061 0.153 -9999.0 0.0 -0.523 2.0 2.0 EGF -0.042 0.168 -9999.0 0.0 -0.56 6.0 6.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.085 0.15 -9999.0 0.0 -0.492 5.0 5.0 cortical microtubule organization -0.057 0.112 -9999.0 0.0 -0.279 7.0 7.0 GO:0000145 -0.024 0.112 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.033 0.125 -9999.0 0.0 -0.281 7.0 7.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.046 0.096 -9999.0 0.0 -0.456 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.042 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.112 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.032 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.105 0.231 -9999.0 0.0 -0.557 13.0 13.0 EGFR/EGFR/EGF/EGF -0.091 0.137 -9999.0 0.0 -0.525 2.0 2.0 RhoA/GDP -0.053 0.103 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.018 0.114 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.014 0.121 -9999.0 0.0 -0.555 3.0 3.0 DIAPH1 0.002 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.057 0.112 0.279 7.0 -9999.0 0.0 7.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.047 0.096 -9999.0 0.0 -0.457 1.0 1.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.116 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.004 0.072 -9999.0 0.0 -0.562 1.0 1.0 LPP -0.018 0.114 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.055 0.112 -9999.0 0.0 -0.523 1.0 1.0 SEC6/SEC8 -0.045 0.089 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.062 0.155 -9999.0 0.0 -0.533 2.0 2.0 HGF/MET -0.082 0.116 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.059 0.19 -9999.0 0.0 -0.558 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.019 0.098 -9999.0 0.0 -0.246 7.0 7.0 actin cable formation 0.03 0.089 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.018 0.114 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.057 0.112 -9999.0 0.0 -0.279 7.0 7.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.004 0.106 -9999.0 0.0 -0.394 1.0 1.0 adherens junction assembly 0.0 0.108 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.062 0.106 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.025 0.119 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.027 0.041 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.002 0.107 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.019 0.097 -9999.0 0.0 -0.245 7.0 7.0 regulation of cell-cell adhesion -0.018 0.114 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.019 0.098 -9999.0 0.0 -0.246 7.0 7.0