Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.14 -9999.0 0.0 -0.464 3.0 3.0 IHH -0.109 0.207 -9999.0 0.0 -0.385 21.0 21.0 SHH Np/Cholesterol/GAS1 -0.007 0.072 -9999.0 0.0 -0.239 5.0 5.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.007 0.072 0.238 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 -0.064 0.171 -9999.0 0.0 -0.337 13.0 13.0 SMO -0.084 0.16 -9999.0 0.0 -0.34 16.0 16.0 AKT1 -0.044 0.133 -9999.0 0.0 -0.525 3.0 3.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.096 -9999.0 0.0 -0.353 4.0 4.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.083 0.158 -9999.0 0.0 -0.336 16.0 16.0 STIL -0.045 0.128 -9999.0 0.0 -0.276 3.0 3.0 DHH N/PTCH2 0.023 0.055 -9999.0 0.0 -0.295 1.0 1.0 DHH N/PTCH1 -0.061 0.127 -9999.0 0.0 -0.241 18.0 18.0 PIK3CA 0.021 0.055 -9999.0 0.0 -0.411 1.0 1.0 DHH 0.003 0.07 -9999.0 0.0 -0.238 4.0 4.0 PTHLH -0.107 0.211 -9999.0 0.0 -0.759 3.0 3.0 determination of left/right symmetry -0.083 0.158 -9999.0 0.0 -0.336 16.0 16.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.106 0.209 -9999.0 0.0 -0.75 3.0 3.0 IHH N/Hhip -0.116 0.171 -9999.0 0.0 -0.314 24.0 24.0 DHH N/Hhip -0.038 0.123 -9999.0 0.0 -0.288 10.0 10.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.083 0.158 -9999.0 0.0 -0.336 16.0 16.0 pancreas development -0.063 0.157 -9999.0 0.0 -0.302 17.0 17.0 HHAT 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.043 -9999.0 0.0 -0.295 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.02 0.037 -9999.0 0.0 -0.18 2.0 2.0 somite specification -0.083 0.158 -9999.0 0.0 -0.336 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.06 0.111 -9999.0 0.0 -0.264 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.005 0.068 -9999.0 0.0 -0.229 5.0 5.0 SHH Np/Cholesterol/Megalin -0.042 0.108 -9999.0 0.0 -0.233 15.0 15.0 SHH -0.037 0.078 -9999.0 0.0 -0.296 5.0 5.0 catabolic process -0.065 0.129 -9999.0 0.0 -0.264 17.0 17.0 SMO/Vitamin D3 -0.077 0.138 -9999.0 0.0 -0.339 6.0 6.0 SHH Np/Cholesterol/Hhip -0.034 0.108 -9999.0 0.0 -0.248 11.0 11.0 LRP2 -0.042 0.16 -9999.0 0.0 -0.411 10.0 10.0 receptor-mediated endocytosis -0.103 0.175 -9999.0 0.0 -0.431 10.0 10.0 SHH Np/Cholesterol/BOC -0.009 0.075 -9999.0 0.0 -0.229 6.0 6.0 SHH Np/Cholesterol/CDO -0.008 0.07 -9999.0 0.0 -0.229 5.0 5.0 mesenchymal cell differentiation 0.034 0.107 0.246 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.03 0.148 0.365 1.0 -0.265 6.0 7.0 IHH N/PTCH2 -0.052 0.131 -9999.0 0.0 -0.257 17.0 17.0 CDON 0.02 0.037 -9999.0 0.0 -0.18 2.0 2.0 IHH N/PTCH1 -0.056 0.138 -9999.0 0.0 -0.264 18.0 18.0 Megalin/LRPAP1 -0.012 0.122 -9999.0 0.0 -0.293 10.0 10.0 PTCH2 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.064 -9999.0 0.0 -0.223 5.0 5.0 PTCH1 -0.065 0.129 -9999.0 0.0 -0.265 17.0 17.0 HHIP -0.064 0.157 -9999.0 0.0 -0.302 17.0 17.0