Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.073 -9999.0 0.0 -0.211 7.0 7.0 epithelial cell differentiation 0.006 0.092 -9999.0 0.0 -0.218 7.0 7.0 CYFIP2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.034 0.116 0.727 1.0 -0.286 1.0 2.0 EGFR 0.002 0.093 -9999.0 0.0 -0.411 3.0 3.0 EPHA2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.027 0.105 0.226 6.0 -0.213 7.0 13.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.019 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.074 0.146 -9999.0 0.0 -0.49 6.0 6.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.024 0.107 0.216 7.0 -9999.0 0.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.107 0.236 5.0 -9999.0 0.0 5.0 EGF -0.005 0.109 -9999.0 0.0 -0.365 5.0 5.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.076 0.133 -9999.0 0.0 -0.441 5.0 5.0 cortical microtubule organization 0.006 0.092 -9999.0 0.0 -0.218 7.0 7.0 GO:0000145 -0.023 0.101 0.326 2.0 -0.201 7.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.01 0.095 -9999.0 0.0 -0.22 7.0 7.0 MLLT4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.058 0.065 -9999.0 0.0 -0.233 6.0 6.0 ARF6 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.045 -9999.0 0.0 -0.234 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.074 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.035 0.075 0.168 3.0 -0.213 6.0 9.0 ARF6/GTP 0.06 0.048 -9999.0 0.0 -0.222 1.0 1.0 CDH1 -0.043 0.144 -9999.0 0.0 -0.305 13.0 13.0 EGFR/EGFR/EGF/EGF -0.025 0.106 -9999.0 0.0 -0.237 10.0 10.0 RhoA/GDP 0.007 0.091 -9999.0 0.0 -0.212 7.0 7.0 actin cytoskeleton organization -0.028 0.101 0.323 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.065 -9999.0 0.0 -0.257 3.0 3.0 DIAPH1 0.026 0.12 -9999.0 0.0 -0.562 1.0 1.0 Wnt receptor signaling pathway -0.006 0.092 0.218 7.0 -9999.0 0.0 7.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.059 0.065 -9999.0 0.0 -0.368 1.0 1.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.102 0.325 2.0 -9999.0 0.0 2.0 EFNA1 0.02 0.055 -9999.0 0.0 -0.411 1.0 1.0 LPP -0.03 0.093 0.185 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 -0.001 0.097 -9999.0 0.0 -0.237 7.0 7.0 SEC6/SEC8 -0.049 0.059 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.032 0.108 0.237 5.0 -9999.0 0.0 5.0 HGF/MET -0.015 0.089 -9999.0 0.0 -0.21 8.0 8.0 HGF -0.005 0.098 -9999.0 0.0 -0.319 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.014 0.073 -9999.0 0.0 -0.213 7.0 7.0 actin cable formation 0.01 0.164 0.563 4.0 -9999.0 0.0 4.0 KIAA1543 -0.023 0.102 0.203 7.0 -0.204 7.0 14.0 KIFC3 -0.044 0.073 0.168 2.0 -9999.0 0.0 2.0 NCK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.023 0.108 0.217 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.006 0.092 -9999.0 0.0 -0.218 7.0 7.0 EXOC4 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.046 0.068 0.168 1.0 -0.213 7.0 8.0 PIP5K1C -0.024 0.108 0.217 7.0 -9999.0 0.0 7.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.017 0.154 0.474 4.0 -0.33 1.0 5.0 adherens junction assembly -0.006 0.125 0.334 5.0 -9999.0 0.0 5.0 IGF-1R heterotetramer/IGF1 -0.008 0.093 -9999.0 0.0 -0.212 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.024 0.108 0.217 7.0 -0.213 7.0 14.0 mol:GTP 0.056 0.044 -9999.0 0.0 -0.233 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.027 0.097 0.315 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.014 0.073 -9999.0 0.0 -0.211 7.0 7.0 regulation of cell-cell adhesion -0.028 0.101 0.323 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.014 0.073 -9999.0 0.0 -0.213 7.0 7.0