Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	10.0	464.0	46.0	-0.475	0.03	1000.0	-1000.0	-0.115	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.017	-1000.0	1000.0	-1000.0	-0.008	-1000.0
Glypican 2 network	9.0	38.0	4.0	-0.036	-0.008	1000.0	-1000.0	0.012	-1000.0
IL23-mediated signaling events	9.0	588.0	60.0	-0.44	0.027	1000.0	-1000.0	-0.108	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	286.0	34.0	-0.083	0.027	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by the Hedgehog family	8.0	421.0	52.0	-0.116	0.034	1000.0	-1000.0	-0.036	-1000.0
Syndecan-1-mediated signaling events	6.0	212.0	34.0	-0.113	0.028	1000.0	-1000.0	-0.047	-1000.0
Ephrin A  reverse signaling	6.0	48.0	7.0	-0.043	-0.0	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	6.0	634.0	105.0	-0.112	0.052	1000.0	-1000.0	-0.05	-1000.0
IL4-mediated signaling events	6.0	554.0	91.0	-0.427	0.338	1000.0	-1000.0	-0.115	-1000.0
PDGFR-alpha signaling pathway	6.0	280.0	44.0	-0.111	0.03	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	6.0	468.0	67.0	-0.158	0.099	1000.0	-1000.0	-0.042	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	574.0	88.0	-0.161	0.034	1000.0	-1000.0	-0.071	-1000.0
E-cadherin signaling events	6.0	32.0	5.0	-0.043	0.027	1000.0	-1000.0	0.01	-1000.0
Arf6 signaling events	5.0	319.0	62.0	-0.055	0.058	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	5.0	400.0	76.0	-0.061	0.053	1000.0	-1000.0	-0.042	-1000.0
BMP receptor signaling	5.0	480.0	81.0	-0.165	0.052	1000.0	-1000.0	-0.054	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	508.0	97.0	-0.106	0.047	1000.0	-1000.0	-0.065	-1000.0
Endothelins	5.0	520.0	96.0	-0.148	0.028	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	5.0	37.0	7.0	-0.044	0.027	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	411.0	78.0	-0.124	0.08	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	4.0	403.0	87.0	-0.184	0.06	1000.0	-1000.0	-0.072	-1000.0
p75(NTR)-mediated signaling	4.0	534.0	125.0	-0.071	0.067	1000.0	-1000.0	-0.072	-1000.0
Glypican 1 network	4.0	223.0	48.0	-0.08	0.044	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	4.0	370.0	82.0	-0.143	0.036	1000.0	-1000.0	-0.044	-1000.0
Reelin signaling pathway	4.0	270.0	56.0	-0.088	0.068	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	176.0	44.0	-0.102	0.027	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	4.0	343.0	84.0	-0.088	0.051	1000.0	-1000.0	-0.05	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	439.0	93.0	-0.158	0.196	1000.0	-1000.0	-0.052	-1000.0
TCGA08_retinoblastoma	4.0	32.0	8.0	-0.013	0.018	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Rods	4.0	219.0	52.0	-0.058	0.027	1000.0	-1000.0	-0.031	-1000.0
FOXM1 transcription factor network	4.0	217.0	51.0	-0.115	0.034	1000.0	-1000.0	-0.137	-1000.0
Caspase cascade in apoptosis	3.0	236.0	74.0	-0.112	0.044	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Cones	3.0	125.0	38.0	-0.058	0.02	1000.0	-1000.0	-0.021	-1000.0
Osteopontin-mediated events	3.0	151.0	38.0	-0.055	0.028	1000.0	-1000.0	-0.046	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	175.0	54.0	-0.067	0.038	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	3.0	92.0	26.0	-0.051	0.027	1000.0	-1000.0	-0.049	-1000.0
HIF-1-alpha transcription factor network	3.0	254.0	76.0	-0.185	0.039	1000.0	-1000.0	-0.1	-1000.0
Glucocorticoid receptor regulatory network	3.0	423.0	114.0	-0.191	0.072	1000.0	-1000.0	-0.048	-1000.0
ceramide signaling pathway	3.0	163.0	49.0	-0.047	0.038	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	3.0	169.0	48.0	-0.047	0.027	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	56.0	15.0	-0.034	0.028	1000.0	-1000.0	-0.037	-1000.0
Syndecan-3-mediated signaling events	3.0	108.0	35.0	-0.071	0.067	1000.0	-1000.0	-0.034	-1000.0
EPHB forward signaling	3.0	311.0	85.0	-0.084	0.066	1000.0	-1000.0	-0.067	-1000.0
Effects of Botulinum toxin	3.0	96.0	26.0	-0.091	0.04	1000.0	-1000.0	-0.019	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	95.0	31.0	-0.082	0.027	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	3.0	191.0	52.0	-0.07	0.04	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	3.0	316.0	102.0	-0.111	0.032	1000.0	-1000.0	-0.057	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	249.0	68.0	-0.172	0.069	1000.0	-1000.0	-0.086	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	284.0	74.0	-0.076	0.06	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	270.0	76.0	-0.052	0.049	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by STAT5	3.0	66.0	22.0	-0.074	0.028	1000.0	-1000.0	-0.04	-1000.0
BCR signaling pathway	3.0	364.0	99.0	-0.077	0.045	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	479.0	120.0	-0.124	0.103	1000.0	-1000.0	-0.049	-1000.0
LPA4-mediated signaling events	2.0	32.0	12.0	-0.06	-0.0	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	2.0	187.0	65.0	-0.131	0.036	1000.0	-1000.0	-0.057	-1000.0
Coregulation of Androgen receptor activity	2.0	152.0	76.0	-0.08	0.048	1000.0	-1000.0	-0.032	-1000.0
ErbB4 signaling events	2.0	139.0	69.0	-0.138	0.07	1000.0	-1000.0	-0.047	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	69.0	28.0	-0.04	0.031	1000.0	-1000.0	-0.031	-1000.0
Syndecan-2-mediated signaling events	2.0	167.0	69.0	-0.049	0.043	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	2.0	114.0	39.0	-0.102	0.027	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	199.0	85.0	-0.082	0.109	1000.0	-1000.0	-0.045	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	130.0	61.0	-0.029	0.067	1000.0	-1000.0	-0.043	-1000.0
Arf6 downstream pathway	2.0	115.0	43.0	-0.034	0.035	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	2.0	205.0	85.0	-0.02	0.041	1000.0	-1000.0	-0.035	-1000.0
Ceramide signaling pathway	2.0	227.0	76.0	-0.046	0.066	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	2.0	133.0	48.0	-0.036	0.052	1000.0	-1000.0	-0.037	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	233.0	82.0	-0.053	0.028	1000.0	-1000.0	-0.06	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	118.0	52.0	-0.126	0.064	1000.0	-1000.0	-0.043	-1000.0
S1P1 pathway	2.0	107.0	36.0	-0.046	0.027	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	2.0	16.0	7.0	-0.027	0.027	1000.0	-1000.0	-0.017	-1000.0
FoxO family signaling	2.0	170.0	64.0	-0.132	0.065	1000.0	-1000.0	-0.065	-1000.0
IL2 signaling events mediated by PI3K	2.0	168.0	58.0	-0.057	0.042	1000.0	-1000.0	-0.045	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	112.0	45.0	-0.047	0.067	1000.0	-1000.0	-0.05	-1000.0
Canonical Wnt signaling pathway	2.0	121.0	51.0	-0.02	0.051	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	2.0	139.0	54.0	-0.048	0.053	1000.0	-1000.0	-0.048	-1000.0
IL27-mediated signaling events	2.0	108.0	51.0	-0.149	0.056	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	2.0	56.0	26.0	-0.063	0.061	1000.0	-1000.0	-0.017	-1000.0
IL6-mediated signaling events	2.0	186.0	75.0	-0.18	0.036	1000.0	-1000.0	-0.059	-1000.0
EGFR-dependent Endothelin signaling events	2.0	54.0	21.0	-0.036	0.037	1000.0	-1000.0	-0.047	-1000.0
Plasma membrane estrogen receptor signaling	2.0	248.0	86.0	-0.071	0.062	1000.0	-1000.0	-0.055	-1000.0
S1P3 pathway	2.0	90.0	42.0	-0.025	0.031	1000.0	-1000.0	-0.037	-1000.0
PDGFR-beta signaling pathway	2.0	197.0	97.0	-0.051	0.064	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling in keratinocytes	2.0	106.0	43.0	-0.05	0.029	1000.0	-1000.0	-0.036	-1000.0
Regulation of Androgen receptor activity	2.0	153.0	70.0	-0.106	0.04	1000.0	-1000.0	-0.057	-1000.0
Aurora B signaling	2.0	183.0	67.0	-0.134	0.032	1000.0	-1000.0	-0.034	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	203.0	136.0	-0.129	0.127	1000.0	-1000.0	-0.05	-1000.0
BARD1 signaling events	1.0	82.0	57.0	-0.045	0.049	1000.0	-1000.0	-0.047	-1000.0
PLK2 and PLK4 events	1.0	3.0	3.0	-0.022	0.024	1000.0	-1000.0	-0.033	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	23.0	17.0	-0.0	0.032	1000.0	-1000.0	-0.033	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	93.0	65.0	-0.101	0.068	1000.0	-1000.0	-0.048	-1000.0
Aurora C signaling	1.0	12.0	7.0	-0.001	0.014	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	1.0	76.0	55.0	-0.006	0.052	1000.0	-1000.0	-0.042	-1000.0
Insulin-mediated glucose transport	1.0	53.0	32.0	-0.098	0.046	1000.0	-1000.0	-0.032	-1000.0
mTOR signaling pathway	1.0	80.0	53.0	-0.024	0.045	1000.0	-1000.0	-0.041	-1000.0
IFN-gamma pathway	1.0	92.0	68.0	-0.064	0.051	1000.0	-1000.0	-0.06	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	127.0	68.0	-0.098	0.052	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	1.0	117.0	63.0	-0.043	0.05	1000.0	-1000.0	-0.044	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	67.0	37.0	-0.039	0.064	1000.0	-1000.0	-0.043	-1000.0
IL1-mediated signaling events	1.0	114.0	62.0	-0.057	0.055	1000.0	-1000.0	-0.072	-1000.0
S1P5 pathway	1.0	27.0	17.0	-0.009	0.027	1000.0	-1000.0	-0.017	-1000.0
HIF-2-alpha transcription factor network	1.0	60.0	43.0	-0.059	0.045	1000.0	-1000.0	-0.052	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	115.0	83.0	-0.098	0.051	1000.0	-1000.0	-0.041	-1000.0
FAS signaling pathway (CD95)	1.0	78.0	47.0	-0.119	0.04	1000.0	-1000.0	-0.042	-1000.0
Retinoic acid receptors-mediated signaling	1.0	64.0	58.0	-0.023	0.055	1000.0	-1000.0	-0.043	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	-0.016	0.034	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	199.0	125.0	-0.044	0.056	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	1.0	114.0	73.0	-0.089	0.044	1000.0	-1000.0	-0.04	-1000.0
Arf6 trafficking events	1.0	121.0	71.0	-0.039	0.044	1000.0	-1000.0	-0.032	-1000.0
Regulation of Telomerase	1.0	129.0	102.0	-0.066	0.064	1000.0	-1000.0	-0.052	-1000.0
Insulin Pathway	1.0	85.0	74.0	-0.042	0.06	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	1.0	36.0	34.0	-0.045	0.039	1000.0	-1000.0	-0.046	-1000.0
S1P4 pathway	1.0	48.0	25.0	-0.023	0.031	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	1.0	67.0	44.0	-0.064	0.044	1000.0	-1000.0	-0.031	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	29.0	17.0	-0.015	0.047	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	-0.017	0.045	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	0.0	25.0	39.0	-0.04	0.056	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class II	0.0	38.0	75.0	-0.026	0.065	1000.0	-1000.0	-0.037	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.009	0.04	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.013	0.039	1000.0	-1000.0	0.009	-1000.0
Aurora A signaling	0.0	49.0	60.0	-0.041	0.058	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	0.0	23.0	40.0	-0.05	0.05	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class I	0.0	83.0	104.0	-0.052	0.067	1000.0	-1000.0	-0.037	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	22.0	36.0	-0.051	0.055	1000.0	-1000.0	-0.04	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.018	0.063	1000.0	-1000.0	-0.042	-1000.0
IGF1 pathway	0.0	48.0	57.0	-0.033	0.067	1000.0	-1000.0	-0.062	-1000.0
VEGFR1 specific signals	0.0	42.0	56.0	-0.029	0.044	1000.0	-1000.0	-0.049	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	31.0	33.0	-0.023	0.058	1000.0	-1000.0	-0.038	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	-0.015	0.026	1000.0	-1000.0	-0.017	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.01	0.049	1000.0	-1000.0	-0.022	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.068	1000.0	-1000.0	-0.0	-1000.0
Total	340	22407	7203	-10.2127133845	-993.562411306	131000	-131000	-5.7122675603	-131000