E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.068 0.203 -9999.0 0.0 -0.487 19.0 19.0 KLHL20 -0.035 0.063 -9999.0 0.0 -0.288 2.0 2.0 CYFIP2 0.01 0.054 -9999.0 0.0 -0.553 1.0 1.0 Rac1/GDP -0.011 0.136 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.068 0.203 -9999.0 0.0 -0.487 19.0 19.0 AP1M1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.051 0.083 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.023 0.043 -9999.0 0.0 -0.186 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.122 0.181 -9999.0 0.0 -0.414 20.0 20.0 RAPGEF1 -0.041 0.179 -9999.0 0.0 -0.409 19.0 19.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.109 0.191 -9999.0 0.0 -0.509 19.0 19.0 CRK -0.055 0.192 -9999.0 0.0 -0.451 19.0 19.0 E-cadherin/gamma catenin/alpha catenin -0.118 0.19 -9999.0 0.0 -0.395 33.0 33.0 alphaE/beta7 Integrin -0.035 0.119 -9999.0 0.0 -0.431 9.0 9.0 IQGAP1 0.005 0.076 -9999.0 0.0 -0.553 2.0 2.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.068 0.203 -9999.0 0.0 -0.487 19.0 19.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.038 0.06 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.047 0.076 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.141 0.224 -9999.0 0.0 -0.469 33.0 33.0 TIAM1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.09 0.142 -9999.0 0.0 -0.339 19.0 19.0 AKT1 -0.027 0.043 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.167 0.286 -9999.0 0.0 -0.611 32.0 32.0 RhoA/GDP -0.011 0.136 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.026 0.047 -9999.0 0.0 -0.205 2.0 2.0 CDC42/GDP -0.011 0.136 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.055 0.14 -9999.0 0.0 -0.311 20.0 20.0 ITGB7 -0.035 0.168 -9999.0 0.0 -0.597 9.0 9.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.096 0.151 -9999.0 0.0 -0.359 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.093 0.146 -9999.0 0.0 -0.319 32.0 32.0 mol:GDP -0.025 0.154 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 -0.006 0.045 -9999.0 0.0 -0.335 2.0 2.0 JUP -0.003 0.109 -9999.0 0.0 -0.652 3.0 3.0 p120 catenin/RhoA/GDP -0.062 0.107 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.006 0.045 -9999.0 0.0 -0.335 2.0 2.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.068 -9999.0 0.0 -0.224 6.0 6.0 NME1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.068 0.203 -9999.0 0.0 -0.487 19.0 19.0 regulation of cell-cell adhesion -0.045 0.073 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.011 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.059 0.095 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.122 0.182 -9999.0 0.0 -0.682 5.0 5.0 CCND1 0.006 0.084 -9999.0 0.0 -0.281 6.0 6.0 VAV2 -0.048 0.188 -9999.0 0.0 -0.477 2.0 2.0 RAP1/GDP -0.057 0.101 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.065 0.197 -9999.0 0.0 -0.471 19.0 19.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.081 0.194 -9999.0 0.0 -0.651 5.0 5.0 E-cadherin/beta catenin -0.097 0.163 -9999.0 0.0 -0.416 19.0 19.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.069 0.203 -9999.0 0.0 -0.487 19.0 19.0 PIK3CA 0.009 0.063 -9999.0 0.0 -0.652 1.0 1.0 Rac1/GTP -0.057 0.103 -9999.0 0.0 -0.5 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.108 0.17 -9999.0 0.0 -0.371 32.0 32.0 ITGAE 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.111 0.196 -9999.0 0.0 -0.521 19.0 19.0