Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.116 0.328 -9999.0 0.0 -0.783 16.0 16.0 IHH -0.016 0.095 -9999.0 0.0 -0.572 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.113 0.184 -9999.0 0.0 -0.377 33.0 33.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.112 0.183 0.375 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.044 0.193 -9999.0 0.0 -0.889 2.0 2.0 SMO -0.054 0.204 -9999.0 0.0 -0.661 5.0 5.0 AKT1 -0.002 0.107 -9999.0 0.0 -0.623 1.0 1.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.098 -9999.0 0.0 -0.586 3.0 3.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.053 0.2 -9999.0 0.0 -0.646 5.0 5.0 STIL -0.105 0.26 -9999.0 0.0 -0.683 13.0 13.0 DHH N/PTCH2 -0.073 0.166 -9999.0 0.0 -0.445 18.0 18.0 DHH N/PTCH1 -0.081 0.214 -9999.0 0.0 -0.63 7.0 7.0 PIK3CA 0.009 0.063 -9999.0 0.0 -0.652 1.0 1.0 DHH -0.058 0.199 -9999.0 0.0 -0.598 13.0 13.0 PTHLH -0.126 0.368 -9999.0 0.0 -0.928 15.0 15.0 determination of left/right symmetry -0.053 0.2 -9999.0 0.0 -0.646 5.0 5.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.123 0.362 -9999.0 0.0 -0.913 15.0 15.0 IHH N/Hhip -0.148 0.242 -9999.0 0.0 -0.496 35.0 35.0 DHH N/Hhip -0.183 0.256 -9999.0 0.0 -0.502 40.0 40.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.053 0.2 -9999.0 0.0 -0.646 5.0 5.0 pancreas development -0.176 0.288 -9999.0 0.0 -0.604 34.0 34.0 HHAT 0.003 0.089 -9999.0 0.0 -0.652 2.0 2.0 PI3K -0.004 0.045 -9999.0 0.0 -0.479 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.037 0.166 -9999.0 0.0 -0.562 10.0 10.0 somite specification -0.053 0.2 -9999.0 0.0 -0.646 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.107 0.259 -9999.0 0.0 -0.643 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.102 0.182 -9999.0 0.0 -0.374 30.0 30.0 SHH Np/Cholesterol/Megalin -0.196 0.231 -9999.0 0.0 -0.408 53.0 53.0 SHH -0.092 0.212 -9999.0 0.0 -0.457 27.0 27.0 catabolic process -0.051 0.198 -9999.0 0.0 -0.582 7.0 7.0 SMO/Vitamin D3 -0.098 0.258 -9999.0 0.0 -0.677 12.0 12.0 SHH Np/Cholesterol/Hhip -0.188 0.22 -9999.0 0.0 -0.391 53.0 53.0 LRP2 -0.19 0.296 -9999.0 0.0 -0.613 36.0 36.0 receptor-mediated endocytosis -0.194 0.249 -9999.0 0.0 -0.627 21.0 21.0 SHH Np/Cholesterol/BOC -0.094 0.158 -9999.0 0.0 -0.385 17.0 17.0 SHH Np/Cholesterol/CDO -0.101 0.162 -9999.0 0.0 -0.347 32.0 32.0 mesenchymal cell differentiation 0.187 0.218 0.388 53.0 -9999.0 0.0 53.0 mol:Vitamin D3 -0.104 0.261 -9999.0 0.0 -0.642 15.0 15.0 IHH N/PTCH2 -0.017 0.132 -9999.0 0.0 -0.503 7.0 7.0 CDON -0.013 0.131 -9999.0 0.0 -0.612 5.0 5.0 IHH N/PTCH1 -0.052 0.199 -9999.0 0.0 -0.587 7.0 7.0 Megalin/LRPAP1 -0.146 0.21 -9999.0 0.0 -0.445 36.0 36.0 PTCH2 -0.015 0.139 -9999.0 0.0 -0.652 5.0 5.0 SHH Np/Cholesterol -0.088 0.158 -9999.0 0.0 -0.358 27.0 27.0 PTCH1 -0.052 0.199 -9999.0 0.0 -0.585 7.0 7.0 HHIP -0.177 0.288 -9999.0 0.0 -0.605 34.0 34.0