Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.05 0.2 -9999.0 0.0 -0.621 10.0 10.0 IHH 0.005 0.059 -9999.0 0.0 -0.197 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.011 0.091 -9999.0 0.0 -0.241 13.0 13.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.091 0.239 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 -0.002 0.108 -9999.0 0.0 -0.391 3.0 3.0 SMO -0.017 0.104 -9999.0 0.0 -0.408 3.0 3.0 AKT1 0.001 0.105 -9999.0 0.0 -0.54 3.0 3.0 ARRB2 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.053 -9999.0 0.0 -0.268 3.0 3.0 ADRBK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.103 -9999.0 0.0 -0.403 3.0 3.0 STIL -0.009 0.143 -9999.0 0.0 -0.326 10.0 10.0 DHH N/PTCH2 0.006 0.085 -9999.0 0.0 -0.311 6.0 6.0 DHH N/PTCH1 -0.026 0.13 -9999.0 0.0 -0.326 12.0 12.0 PIK3CA 0.023 0.045 -9999.0 0.0 -0.442 1.0 1.0 DHH -0.013 0.116 -9999.0 0.0 -0.302 13.0 13.0 PTHLH -0.059 0.249 -9999.0 0.0 -0.818 9.0 9.0 determination of left/right symmetry -0.017 0.103 -9999.0 0.0 -0.403 3.0 3.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.058 0.245 -9999.0 0.0 -0.769 10.0 10.0 IHH N/Hhip -0.051 0.139 -9999.0 0.0 -0.346 16.0 16.0 DHH N/Hhip -0.059 0.154 -9999.0 0.0 -0.334 22.0 22.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.103 -9999.0 0.0 -0.403 3.0 3.0 pancreas development -0.068 0.166 -9999.0 0.0 -0.307 31.0 31.0 HHAT 0.019 0.063 -9999.0 0.0 -0.442 2.0 2.0 PI3K 0.038 0.035 -9999.0 0.0 -0.315 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.07 -9999.0 0.0 -0.211 9.0 9.0 somite specification -0.017 0.103 -9999.0 0.0 -0.403 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.036 0.123 -9999.0 0.0 -0.307 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.016 0.087 -9999.0 0.0 -0.253 12.0 12.0 SHH Np/Cholesterol/Megalin -0.059 0.129 -9999.0 0.0 -0.27 25.0 25.0 SHH -0.03 0.106 -9999.0 0.0 -0.323 12.0 12.0 catabolic process -0.018 0.12 -9999.0 0.0 -0.359 9.0 9.0 SMO/Vitamin D3 -0.031 0.118 -9999.0 0.0 -0.354 6.0 6.0 SHH Np/Cholesterol/Hhip -0.052 0.122 -9999.0 0.0 -0.262 23.0 23.0 LRP2 -0.09 0.185 -9999.0 0.0 -0.338 35.0 35.0 receptor-mediated endocytosis -0.068 0.139 -9999.0 0.0 -0.412 9.0 9.0 SHH Np/Cholesterol/BOC -0.017 0.089 -9999.0 0.0 -0.246 13.0 13.0 SHH Np/Cholesterol/CDO -0.022 0.09 -9999.0 0.0 -0.24 14.0 14.0 mesenchymal cell differentiation 0.052 0.121 0.26 23.0 -9999.0 0.0 23.0 mol:Vitamin D3 0.001 0.154 -9999.0 0.0 -0.329 11.0 11.0 IHH N/PTCH2 0.028 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.009 0.081 -9999.0 0.0 -0.338 5.0 5.0 IHH N/PTCH1 -0.012 0.124 -9999.0 0.0 -0.361 9.0 9.0 Megalin/LRPAP1 -0.049 0.14 -9999.0 0.0 -0.314 21.0 21.0 PTCH2 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.02 0.082 -9999.0 0.0 -0.245 12.0 12.0 PTCH1 -0.018 0.121 -9999.0 0.0 -0.36 9.0 9.0 HHIP -0.069 0.166 -9999.0 0.0 -0.308 31.0 31.0