Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.091 -9999.0 0.0 -0.218 18.0 18.0 epithelial cell differentiation -0.003 0.104 -9999.0 0.0 -0.225 16.0 16.0 CYFIP2 0.026 0.02 -9999.0 0.0 -0.182 1.0 1.0 ENAH -0.031 0.074 0.26 2.0 -9999.0 0.0 2.0 EGFR 0.004 0.09 -9999.0 0.0 -0.39 5.0 5.0 EPHA2 0.008 0.065 -9999.0 0.0 -0.219 7.0 7.0 MYO6 -0.023 0.093 -9999.0 0.0 -0.217 16.0 16.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.07 0.168 -9999.0 0.0 -0.475 13.0 13.0 CTNND1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.024 0.092 -9999.0 0.0 -0.214 16.0 16.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.094 -9999.0 0.0 -0.213 17.0 17.0 EGF -0.014 0.125 -9999.0 0.0 -0.371 11.0 11.0 NCKAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.029 0.108 -9999.0 0.0 -0.452 3.0 3.0 cortical microtubule organization -0.003 0.104 -9999.0 0.0 -0.225 16.0 16.0 GO:0000145 -0.036 0.083 0.166 5.0 -0.204 16.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.107 -9999.0 0.0 -0.227 16.0 16.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.049 0.068 -9999.0 0.0 -0.259 1.0 1.0 ARF6 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.054 -9999.0 0.0 -0.242 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.035 0.099 -9999.0 0.0 -0.332 6.0 6.0 PVRL2 0.019 0.046 -9999.0 0.0 -0.442 1.0 1.0 ZYX -0.017 0.084 -9999.0 0.0 -0.217 13.0 13.0 ARF6/GTP 0.051 0.055 -9999.0 0.0 -0.226 1.0 1.0 CDH1 -0.074 0.177 -9999.0 0.0 -0.333 31.0 31.0 EGFR/EGFR/EGF/EGF -0.036 0.122 -9999.0 0.0 -0.253 22.0 22.0 RhoA/GDP -0.0 0.101 -9999.0 0.0 -0.215 16.0 16.0 actin cytoskeleton organization -0.027 0.091 -9999.0 0.0 -0.219 16.0 16.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.008 0.09 -9999.0 0.0 -0.39 5.0 5.0 DIAPH1 0.03 0.101 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.003 0.104 0.225 16.0 -9999.0 0.0 16.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.069 -9999.0 0.0 -0.26 1.0 1.0 CTNNA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.028 0.092 -9999.0 0.0 -0.223 16.0 16.0 EFNA1 0.026 0.02 -9999.0 0.0 -0.182 1.0 1.0 LPP -0.044 0.088 0.173 4.0 -0.244 4.0 8.0 Ephrin A1/EPHA2 -0.017 0.097 -9999.0 0.0 -0.209 17.0 17.0 SEC6/SEC8 -0.024 0.074 -9999.0 0.0 -0.226 8.0 8.0 MGAT3 -0.026 0.095 -9999.0 0.0 -0.216 17.0 17.0 HGF/MET -0.049 0.119 -9999.0 0.0 -0.256 22.0 22.0 HGF -0.002 0.081 -9999.0 0.0 -0.234 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.022 0.092 -9999.0 0.0 -0.22 18.0 18.0 actin cable formation -0.009 0.092 0.277 3.0 -9999.0 0.0 3.0 KIAA1543 -0.038 0.08 0.168 3.0 -0.207 15.0 18.0 KIFC3 -0.024 0.094 -9999.0 0.0 -0.217 16.0 16.0 NCK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.032 0.098 -9999.0 0.0 -0.225 17.0 17.0 NCK1/GIT1 0.041 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.003 0.104 -9999.0 0.0 -0.225 16.0 16.0 EXOC4 0.021 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.024 0.094 -9999.0 0.0 -0.217 16.0 16.0 PIP5K1C -0.024 0.093 -9999.0 0.0 -0.217 16.0 16.0 LIMA1 0.019 0.063 -9999.0 0.0 -0.442 2.0 2.0 ABI1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.03 0.09 0.286 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.013 0.088 0.29 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.012 0.108 -9999.0 0.0 -0.231 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.037 -9999.0 0.0 -0.315 1.0 1.0 MET -0.045 0.141 -9999.0 0.0 -0.3 22.0 22.0 PLEKHA7 -0.025 0.091 -9999.0 0.0 -0.216 16.0 16.0 mol:GTP 0.044 0.053 -9999.0 0.0 -0.241 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.011 0.12 0.3 4.0 -0.377 1.0 5.0 cortical actin cytoskeleton stabilization -0.022 0.091 -9999.0 0.0 -0.218 18.0 18.0 regulation of cell-cell adhesion -0.027 0.091 -9999.0 0.0 -0.219 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.022 0.092 -9999.0 0.0 -0.22 18.0 18.0