Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.144 0.305 -9999.0 0.0 -0.787 46.0 46.0 IHH -0.121 0.257 -9999.0 0.0 -0.646 64.0 64.0 SHH Np/Cholesterol/GAS1 -0.097 0.215 -9999.0 0.0 -0.491 64.0 64.0 LRPAP1 0.01 0.038 -9999.0 0.0 -0.71 1.0 1.0 dorsoventral neural tube patterning 0.096 0.213 0.487 64.0 -9999.0 0.0 64.0 SMO/beta Arrestin2 -0.103 0.233 -9999.0 0.0 -0.661 32.0 32.0 SMO -0.115 0.247 -9999.0 0.0 -0.692 34.0 34.0 AKT1 -0.031 0.103 -9999.0 0.0 -0.358 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.099 -9999.0 0.0 -0.648 8.0 8.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.241 -9999.0 0.0 -0.676 34.0 34.0 STIL -0.138 0.253 -9999.0 0.0 -0.625 50.0 50.0 DHH N/PTCH2 -0.029 0.151 -9999.0 0.0 -0.506 31.0 31.0 DHH N/PTCH1 -0.101 0.211 -9999.0 0.0 -0.655 24.0 24.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.018 0.14 -9999.0 0.0 -0.677 15.0 15.0 PTHLH -0.181 0.369 -9999.0 0.0 -0.975 46.0 46.0 determination of left/right symmetry -0.113 0.241 -9999.0 0.0 -0.676 34.0 34.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.178 0.363 -9999.0 0.0 -0.959 46.0 46.0 IHH N/Hhip -0.221 0.299 -9999.0 0.0 -0.583 129.0 129.0 DHH N/Hhip -0.155 0.25 -9999.0 0.0 -0.494 119.0 119.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.241 -9999.0 0.0 -0.676 34.0 34.0 pancreas development -0.191 0.304 -9999.0 0.0 -0.637 110.0 110.0 HHAT -0.013 0.131 -9999.0 0.0 -0.71 12.0 12.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.036 0.169 -9999.0 0.0 -0.619 27.0 27.0 somite specification -0.113 0.241 -9999.0 0.0 -0.676 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.15 0.261 -9999.0 0.0 -0.614 59.0 59.0 SHH Np/Cholesterol/PTCH2 -0.089 0.198 -9999.0 0.0 -0.451 67.0 67.0 SHH Np/Cholesterol/Megalin -0.209 0.264 -9999.0 0.0 -0.523 116.0 116.0 SHH -0.096 0.225 -9999.0 0.0 -0.511 77.0 77.0 catabolic process -0.101 0.218 -9999.0 0.0 -0.546 45.0 45.0 SMO/Vitamin D3 -0.152 0.274 -9999.0 0.0 -0.664 53.0 53.0 SHH Np/Cholesterol/Hhip -0.188 0.258 -9999.0 0.0 -0.509 108.0 108.0 LRP2 -0.228 0.318 -9999.0 0.0 -0.64 130.0 130.0 receptor-mediated endocytosis -0.252 0.28 -9999.0 0.0 -0.693 78.0 78.0 SHH Np/Cholesterol/BOC -0.079 0.19 -9999.0 0.0 -0.45 59.0 59.0 SHH Np/Cholesterol/CDO -0.087 0.206 -9999.0 0.0 -0.468 63.0 63.0 mesenchymal cell differentiation 0.186 0.255 0.505 108.0 -9999.0 0.0 108.0 mol:Vitamin D3 -0.148 0.263 -9999.0 0.0 -0.615 59.0 59.0 IHH N/PTCH2 -0.089 0.2 -9999.0 0.0 -0.444 77.0 77.0 CDON -0.019 0.137 -9999.0 0.0 -0.623 17.0 17.0 IHH N/PTCH1 -0.102 0.221 -9999.0 0.0 -0.553 45.0 45.0 Megalin/LRPAP1 -0.164 0.242 -9999.0 0.0 -0.475 130.0 130.0 PTCH2 -0.02 0.143 -9999.0 0.0 -0.652 17.0 17.0 SHH Np/Cholesterol -0.088 0.174 -9999.0 0.0 -0.406 77.0 77.0 PTCH1 -0.101 0.219 -9999.0 0.0 -0.549 45.0 45.0 HHIP -0.191 0.304 -9999.0 0.0 -0.638 110.0 110.0